Details of the Target

General Information of Target

Target ID LDTP11874
Target Name Thioredoxin-related transmembrane protein 1 (TMX1)
Gene Name TMX1
Gene ID 81542
Synonyms
TMX; TXNDC; TXNDC1; Thioredoxin-related transmembrane protein 1; Protein disulfide-isomerase TMX1; EC 5.3.4.1; Thioredoxin domain-containing protein 1; Transmembrane Trx-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS
QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC
VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV
SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN
HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS
GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD
SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
Target Bioclass
Enzyme
Subcellular location
Membrane
Function
Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux.
Uniprot ID
Q9H3N1
Ensemble ID
ENST00000457354.7
HGNC ID
HGNC:15487
ChEMBL ID
CHEMBL4295941

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.51  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y219(5.86); Y104(20.00)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K120(4.27); K121(9.44); K133(1.14); K222(8.85)  LDD0277  [5]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [6]
P12
 Probe Info  		16.63  LDD0202  [7]
THZ1-DTB
 Probe Info  		C106(1.03)  LDD0460  [8]
BTD
 Probe Info  		C106(2.02)  LDD2094  [9]
AHL-Pu-1
 Probe Info  		C106(2.14)  LDD0169  [10]
HPAP
 Probe Info  		5.18  LDD0062  [11]
BDBM50514113
 Probe Info  		1.59  LDD0041  [12]
DBIA
 Probe Info  		C106(0.74)  LDD0531  [13]
ATP probe
 Probe Info  		K223(0.00); K130(0.00); K133(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		N.A.  LDD0147  [17]
NHS
 Probe Info  		N.A.  LDD0010  [18]
SF
 Probe Info  		Y217(0.00); K222(0.00)  LDD0028  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
AOyne
 Probe Info  		10.40  LDD0443  [23]
NAIA_5
 Probe Info  		N.A.  LDD2223  [24]
TER-AC
 Probe Info  		N.A.  LDD0426  [25]
PAL-AfBPP Probe
Click To Hide/Show 64 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		2.41  LDD0398  [26]
C022
 Probe Info  		6.82  LDD1728  [27]
C040
 Probe Info  		11.24  LDD1740  [27]
C049
 Probe Info  		8.00  LDD1747  [27]
C055
 Probe Info  		13.55  LDD1752  [27]
C056
 Probe Info  		21.86  LDD1753  [27]
C063
 Probe Info  		9.78  LDD1760  [27]
C091
 Probe Info  		11.00  LDD1782  [27]
C092
 Probe Info  		22.78  LDD1783  [27]
C094
 Probe Info  		38.32  LDD1785  [27]
C112
 Probe Info  		23.26  LDD1799  [27]
C134
 Probe Info  		29.86  LDD1816  [27]
C158
 Probe Info  		13.09  LDD1838  [27]
C161
 Probe Info  		17.27  LDD1841  [27]
C169
 Probe Info  		20.68  LDD1849  [27]
C183
 Probe Info  		6.28  LDD1861  [27]
C187
 Probe Info  		21.26  LDD1865  [27]
C191
 Probe Info  		11.31  LDD1868  [27]
C193
 Probe Info  		5.31  LDD1869  [27]
C196
 Probe Info  		16.56  LDD1872  [27]
C201
 Probe Info  		32.00  LDD1877  [27]
C210
 Probe Info  		48.17  LDD1884  [27]
C218
 Probe Info  		16.56  LDD1892  [27]
C219
 Probe Info  		5.21  LDD1893  [27]
C220
 Probe Info  		16.80  LDD1894  [27]
C228
 Probe Info  		24.08  LDD1901  [27]
C231
 Probe Info  		26.17  LDD1904  [27]
C232
 Probe Info  		50.21  LDD1905  [27]
C233
 Probe Info  		11.79  LDD1906  [27]
C234
 Probe Info  		6.63  LDD1907  [27]
C235
 Probe Info  		32.00  LDD1908  [27]
C238
 Probe Info  		12.04  LDD1911  [27]
C246
 Probe Info  		13.83  LDD1919  [27]
C275
 Probe Info  		6.11  LDD1945  [27]
C278
 Probe Info  		57.68  LDD1948  [27]
C285
 Probe Info  		39.40  LDD1955  [27]
C287
 Probe Info  		10.70  LDD1957  [27]
C288
 Probe Info  		7.26  LDD1958  [27]
C289
 Probe Info  		66.26  LDD1959  [27]
C293
 Probe Info  		17.27  LDD1963  [27]
C299
 Probe Info  		10.63  LDD1968  [27]
C310
 Probe Info  		7.62  LDD1977  [27]
C322
 Probe Info  		6.06  LDD1988  [27]
C333
 Probe Info  		4.92  LDD1996  [27]
C338
 Probe Info  		11.79  LDD2001  [27]
C349
 Probe Info  		20.82  LDD2010  [27]
C350
 Probe Info  		40.22  LDD2011  [27]
C362
 Probe Info  		33.82  LDD2023  [27]
C388
 Probe Info  		60.55  LDD2047  [27]
C407
 Probe Info  		20.39  LDD2064  [27]
C420
 Probe Info  		11.47  LDD2075  [27]
C423
 Probe Info  		11.24  LDD2078  [27]
C429
 Probe Info  		57.28  LDD2084  [27]
FFF probe11
 Probe Info  		17.50  LDD0471  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe14
 Probe Info  		13.20  LDD0477  [28]
FFF probe15
 Probe Info  		9.89  LDD0478  [28]
FFF probe2
 Probe Info  		20.00  LDD0463  [28]
FFF probe3
 Probe Info  		20.00  LDD0464  [28]
FFF probe4
 Probe Info  		13.97  LDD0466  [28]
JN0003
 Probe Info  		20.00  LDD0469  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
DA-2
 Probe Info  		N.A.  LDD0072  [30]
OEA-DA
 Probe Info  		4.16  LDD0046  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C106(0.85)  LDD2117  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C106(2.14)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C106(0.74)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C106(0.80)  LDD0532  [13]
 LDCM0226  AC11 HCT 116 C106(1.04)  LDD0543  [13]
 LDCM0230  AC113 HCT 116 C106(0.86)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C106(0.79)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C106(0.68)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C106(0.69)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C106(0.74)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C106(0.80)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C106(0.69)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C106(1.26)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C106(1.11)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C106(1.08)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C106(0.77)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C106(1.38)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C106(0.97)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C106(1.01)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C106(0.95)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C106(0.94)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C106(0.59)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C106(1.15)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C106(0.72)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C106(1.33)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C106(1.24)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C106(0.89)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C106(0.83)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C106(0.80)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C106(0.91)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C106(0.96)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C106(0.91)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C106(0.88)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C106(1.42)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C106(0.79)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C106(0.94)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C106(1.02)  LDD0579  [13]
 LDCM0270  AC15 HCT 116 C106(1.62)  LDD0587  [13]
 LDCM0276  AC17 HCT 116 C106(1.11)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C106(0.89)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C106(0.99)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C106(0.86)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C106(1.06)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C106(1.09)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C106(0.99)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C106(0.85)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C106(1.09)  LDD0601  [13]
 LDCM0285  AC25 HEK-293T C106(0.70)  LDD0883  [13]
 LDCM0286  AC26 HEK-293T C106(0.69)  LDD0884  [13]
 LDCM0287  AC27 HEK-293T C106(0.70)  LDD0885  [13]
 LDCM0288  AC28 HEK-293T C106(1.13)  LDD0886  [13]
 LDCM0289  AC29 HEK-293T C106(0.71)  LDD0887  [13]
 LDCM0290  AC3 HCT 116 C106(1.03)  LDD0607  [13]
 LDCM0291  AC30 HEK-293T C106(0.63)  LDD0889  [13]
 LDCM0292  AC31 HEK-293T C106(0.69)  LDD0890  [13]
 LDCM0293  AC32 HEK-293T C106(0.66)  LDD0891  [13]
 LDCM0294  AC33 HEK-293T C106(0.62)  LDD0892  [13]
 LDCM0295  AC34 HEK-293T C106(0.69)  LDD0893  [13]
 LDCM0296  AC35 HCT 116 C106(1.45)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C106(1.74)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C106(1.25)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C106(1.28)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C106(0.86)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C106(0.79)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C106(0.80)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C106(1.08)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C106(0.95)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C106(0.80)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C106(0.97)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C106(0.82)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C106(0.64)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C106(0.71)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C106(0.57)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C106(0.64)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C106(0.80)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C106(0.50)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C106(0.69)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C106(0.65)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C106(0.68)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C106(0.70)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C106(0.68)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C106(0.51)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C106(0.69)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C106(0.78)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C106(0.64)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C106(0.76)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C106(0.46)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C106(0.53)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C106(0.50)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C106(0.46)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C106(0.52)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C106(0.56)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C106(0.87)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C106(0.39)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C106(0.93)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C106(0.85)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C106(0.90)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C106(0.66)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C106(1.18)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C106(0.83)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C106(0.73)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C106(1.43)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C106(0.65)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C106(1.40)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C106(0.82)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C106(0.78)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C106(0.67)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C106(0.90)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C106(1.38)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C106(0.64)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C106(1.18)  LDD0665  [13]
 LDCM0248  AKOS034007472 HCT 116 C106(1.05)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C106(1.09)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C106(0.82)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.89  LDD0403  [1]
 LDCM0088  C45 HEK-293T 16.63  LDD0202  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C106(20.00)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C106(0.75)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C106(0.43)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C106(0.74)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C106(0.88)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C106(0.79)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C106(0.94)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C106(0.88)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C106(0.73)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C106(0.87)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C106(0.76)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C106(0.67)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C106(0.63)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C106(0.51)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C106(0.55)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C106(0.59)  LDD0698  [13]
 LDCM0382  CL112 HEK-293T C106(0.63)  LDD0980  [13]
 LDCM0383  CL113 HEK-293T C106(0.64)  LDD0981  [13]
 LDCM0384  CL114 HEK-293T C106(0.62)  LDD0982  [13]
 LDCM0385  CL115 HEK-293T C106(0.70)  LDD0983  [13]
 LDCM0386  CL116 HEK-293T C106(0.63)  LDD0984  [13]
 LDCM0387  CL117 HCT 116 C106(0.44)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C106(0.94)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C106(0.84)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C106(0.53)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C106(0.93)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C106(0.66)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C106(0.60)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C106(0.41)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C106(0.46)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C106(0.66)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C106(0.79)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C106(0.70)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C106(0.70)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C106(0.77)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C106(0.86)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C106(0.74)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C106(0.92)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C106(0.56)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C106(0.65)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C106(0.80)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C106(0.89)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C106(0.63)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C106(0.36)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C106(1.16)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C106(0.75)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C106(0.74)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C106(0.48)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C106(0.89)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C106(0.89)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C106(0.53)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C106(0.77)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C106(0.65)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C106(1.00)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C106(0.85)  LDD0737  [13]
 LDCM0421  CL32 PaTu 8988t C106(0.62)  LDD1300  [13]
 LDCM0422  CL33 PaTu 8988t C106(0.58)  LDD1301  [13]
 LDCM0423  CL34 PaTu 8988t C106(0.53)  LDD1302  [13]
 LDCM0424  CL35 PaTu 8988t C106(0.63)  LDD1303  [13]
 LDCM0425  CL36 PaTu 8988t C106(0.33)  LDD1304  [13]
 LDCM0426  CL37 PaTu 8988t C106(0.49)  LDD1305  [13]
 LDCM0428  CL39 PaTu 8988t C106(0.63)  LDD1307  [13]
 LDCM0429  CL4 HCT 116 C106(0.76)  LDD0746  [13]
 LDCM0430  CL40 PaTu 8988t C106(0.76)  LDD1309  [13]
 LDCM0431  CL41 PaTu 8988t C106(0.69)  LDD1310  [13]
 LDCM0432  CL42 PaTu 8988t C106(0.64)  LDD1311  [13]
 LDCM0433  CL43 PaTu 8988t C106(0.55)  LDD1312  [13]
 LDCM0434  CL44 PaTu 8988t C106(0.48)  LDD1313  [13]
 LDCM0435  CL45 PaTu 8988t C106(0.68)  LDD1314  [13]
 LDCM0436  CL46 HCT 116 C106(0.46)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C106(0.64)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C106(0.64)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C106(0.69)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C106(0.97)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C106(0.55)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C106(0.48)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C106(0.52)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C106(1.25)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C106(0.58)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C106(0.84)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C106(0.85)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C106(0.74)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C106(0.69)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C106(0.91)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C106(0.65)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C106(0.54)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C106(0.63)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C106(0.61)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C106(0.55)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C106(0.73)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C106(0.89)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C106(0.60)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C106(1.30)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C106(1.02)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C106(0.51)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C106(0.60)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C106(0.73)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C106(0.70)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C106(0.53)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C106(0.62)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C106(0.76)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C106(0.67)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C106(0.95)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C106(0.79)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C106(0.59)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C106(0.67)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C106(0.96)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C106(0.64)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C106(0.43)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C106(0.51)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C106(0.36)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C106(0.55)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C106(0.97)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C106(0.44)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C106(0.50)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C106(0.31)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C106(0.64)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C106(0.86)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C106(0.92)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C106(0.85)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C106(0.86)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C106(0.91)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C106(0.67)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C106(0.68)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C106(0.63)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C106(0.53)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C106(0.55)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C106(0.67)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C106(0.29)  LDD1702  [9]
 LDCM0625  F8 Ramos C106(1.11)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C106(0.41)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C106(0.18)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C106(0.74)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C106(1.18)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C106(0.88)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C106(0.49)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C106(0.52)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C106(0.58)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C106(0.84)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C106(0.68)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C106(0.48)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C106(0.79)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C106(0.55)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C106(0.65)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C106(0.90)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C106(0.71)  LDD2184  [33]
 LDCM0427  Fragment51 PaTu 8988t C106(0.47)  LDD1306  [13]
 LDCM0610  Fragment52 Ramos C106(1.04)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C106(1.22)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C106(0.50)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C106(0.45)  LDD2188  [33]
 LDCM0022  KB02 HEK-293T C106(1.57)  LDD1492  [32]
 LDCM0023  KB03 HEK-293T C106(1.26)  LDD1497  [32]
 LDCM0024  KB05 COLO792 C106(2.29)  LDD3310  [34]
 LDCM0109  NEM HeLa N.A.  LDD0225  [21]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C106(2.02)  LDD2094  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C106(0.46)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C106(0.87)  LDD2110  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C106(0.81)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C106(0.66)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C106(1.84)  LDD2127  [9]
 LDCM0014  Panhematin HEK-293T 5.18  LDD0062  [11]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0390  [6]
 LDCM0021  THZ1 HeLa S3 C106(1.03)  LDD0460  [8]
 LDCM0002  Ward_cp1 U2OS 1.59  LDD0041  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C chemokine receptor type 1 (CCR1) G-protein coupled receptor 1 family P32246

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
26 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840