Details of the Target

General Information of Target

Target ID LDTP15496
Target Name GTPase IMAP family member 8 (GIMAP8)
Gene Name GIMAP8
Gene ID 155038
Synonyms
IAN9; IANT; GTPase IMAP family member 8; Immune-associated nucleotide-binding protein 9; IAN-9; Protein IanT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGE
GEQRTGTEVKRRYLDWRALMKRKRMKANIKLVGSGFPLPSSDLDDSLTEEIDEKIGFRND
ANFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDF
PHIDEFFTLNSTPSRSAYDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERL
RHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLENELGQGEKSMLQPQDIETEKLKL
ERERLQLEKDRLQFLKFESEKLQIEKERLQVEKDRLRIQKEGHLQ
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
Subcellular location
Endoplasmic reticulum
Function Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Uniprot ID
Q8ND71
Ensemble ID
ENST00000307271.4
HGNC ID
HGNC:21792

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C166(2.36)  LDD2412  [1]
AHL-Pu-1
 Probe Info  		C521(2.67)  LDD0170  [2]
HPAP
 Probe Info  		3.28  LDD0064  [3]
IA-alkyne
 Probe Info  		C599(7.90)  LDD1705  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C521(2.67)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C521(3.07); C520(5.06)  LDD0171  [2]
 LDCM0022  KB02 Karpas-299 C166(2.36)  LDD2412  [1]
 LDCM0023  KB03 Karpas-299 C166(6.49)  LDD2829  [1]
 LDCM0024  KB05 T cell C599(7.90)  LDD1705  [4]
 LDCM0014  Panhematin hPBMC 3.28  LDD0064  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.