Details of the Target

General Information of Target

Target ID LDTP01649
Target Name Phosphatidate cytidylyltransferase 2 (CDS2)
Gene Name CDS2
Gene ID 8760
Synonyms
Phosphatidate cytidylyltransferase 2; EC 2.7.7.41; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALS
NLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSY
DLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCM
FVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAY
MFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSF
TVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGF
KRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQ
QLHIFNTLRSHLIDKGMLTSTTEDE
Target Bioclass
Enzyme
Family
CDS family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid. Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis.
Uniprot ID
O95674
Ensemble ID
ENST00000450570.1
HGNC ID
HGNC:1801

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.F139L .
NCIH1048 SNV: p.F225L .
RKO SNV: p.G378C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
Johansson_61
 Probe Info  		_(9.26)  LDD1487  [2]
HPAP
 Probe Info  		3.28  LDD0064  [3]
IA-alkyne
 Probe Info  		19.39  LDD0432  [4]
DBIA
 Probe Info  		C286(1.30); C304(1.30)  LDD1094  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.22  LDD1740  [8]
C091
 Probe Info  		14.42  LDD1782  [8]
C092
 Probe Info  		49.52  LDD1783  [8]
C094
 Probe Info  		48.17  LDD1785  [8]
C112
 Probe Info  		17.88  LDD1799  [8]
C134
 Probe Info  		21.11  LDD1816  [8]
C159
 Probe Info  		7.26  LDD1839  [8]
C161
 Probe Info  		9.99  LDD1841  [8]
C201
 Probe Info  		29.24  LDD1877  [8]
C218
 Probe Info  		19.70  LDD1892  [8]
C219
 Probe Info  		5.03  LDD1893  [8]
C220
 Probe Info  		17.63  LDD1894  [8]
C231
 Probe Info  		15.24  LDD1904  [8]
C238
 Probe Info  		37.27  LDD1911  [8]
C246
 Probe Info  		19.84  LDD1919  [8]
C285
 Probe Info  		26.17  LDD1955  [8]
C287
 Probe Info  		13.09  LDD1957  [8]
C288
 Probe Info  		6.68  LDD1958  [8]
C289
 Probe Info  		62.68  LDD1959  [8]
C343
 Probe Info  		14.72  LDD2005  [8]
C362
 Probe Info  		40.50  LDD2023  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
OEA-DA
 Probe Info  		7.44  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C286(1.30); C304(1.30)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C286(1.01); C304(1.01)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C286(1.19); C304(1.19)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C286(1.85); C304(1.85)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C286(1.23); C304(1.23)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C286(1.20); C304(1.20)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C286(1.25); C304(1.25)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C286(1.36); C304(1.36)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C286(1.18); C304(1.18)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C286(0.95); C304(0.95)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C286(1.15); C304(1.15)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C286(0.84); C304(0.84)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C286(1.03); C304(1.03)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C286(1.02); C304(1.02)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C286(1.06); C304(1.06)  LDD1108  [5]
 LDCM0237  AC12 PaTu 8988t C286(0.71); C304(0.71)  LDD1116  [5]
 LDCM0259  AC14 PaTu 8988t C286(0.67); C304(0.67)  LDD1138  [5]
 LDCM0263  AC143 PaTu 8988t C286(0.54); C304(0.54)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C286(0.56); C304(0.56)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C286(0.76); C304(0.76)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C286(0.38); C304(0.38)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C286(0.36); C304(0.36)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C286(0.29); C304(0.29)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C286(0.37); C304(0.37)  LDD1148  [5]
 LDCM0270  AC15 PaTu 8988t C286(0.87); C304(0.87)  LDD1149  [5]
 LDCM0271  AC150 PaTu 8988t C286(0.64); C304(0.64)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C286(0.42); C304(0.42)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C286(0.42); C304(0.42)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C286(0.38); C304(0.38)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C286(0.34); C304(0.34)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C286(0.33); C304(0.33)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C286(0.33); C304(0.33)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C286(0.38); C304(0.38)  LDD2169  [5]
 LDCM0277  AC18 HEK-293T C286(0.89)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C286(1.06)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C286(0.89)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C286(1.40)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C286(0.98)  LDD1520  [11]
 LDCM0283  AC23 HEK-293T C286(0.93)  LDD1522  [11]
 LDCM0286  AC26 HEK-293T C286(0.93)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C286(1.07)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C286(0.86)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C286(1.13)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C286(0.92)  LDD1529  [11]
 LDCM0292  AC31 HEK-293T C286(0.87)  LDD1531  [11]
 LDCM0295  AC34 HEK-293T C286(1.00)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C286(0.98)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C286(1.03)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C286(1.08)  LDD1537  [11]
 LDCM0300  AC39 HEK-293T C286(1.27)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C286(1.20)  LDD1540  [11]
 LDCM0304  AC42 HEK-293T C286(1.00)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C286(0.85)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C286(1.15)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C286(1.00)  LDD1546  [11]
 LDCM0309  AC47 HEK-293T C286(0.89)  LDD1548  [11]
 LDCM0312  AC5 HEK-293T C286(1.15)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C286(0.93)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C286(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C286(0.98)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C286(0.89)  LDD1555  [11]
 LDCM0318  AC55 HEK-293T C286(1.04)  LDD1557  [11]
 LDCM0321  AC58 HEK-293T C286(0.89)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C286(0.97)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C286(0.45); C304(0.45)  LDD1202  [5]
 LDCM0324  AC60 HEK-293T C286(1.51)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C286(1.16)  LDD1564  [11]
 LDCM0327  AC63 HEK-293T C286(1.26)  LDD1566  [11]
 LDCM0334  AC7 PaTu 8988t C286(1.10); C304(1.10)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C286(0.93); C304(0.93)  LDD1224  [5]
 LDCM0365  AC98 PaTu 8988t C286(1.10); C304(1.10)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C286(1.52); C304(1.52)  LDD1245  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C286(0.91); C304(0.91)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C286(0.74); C304(0.74)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C286(0.97); C304(0.97)  LDD1154  [5]
 LDCM0367  CL1 PaTu 8988t C286(1.62); C304(1.62)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C286(2.81); C304(2.81)  LDD1247  [5]
 LDCM0369  CL100 HEK-293T C105(1.00); C286(1.10)  LDD1573  [11]
 LDCM0370  CL101 PaTu 8988t C286(0.92); C304(0.92)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C286(3.22); C304(3.22)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C286(0.83); C304(0.83)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C286(0.86); C304(0.86)  LDD1252  [5]
 LDCM0374  CL105 HEK-293T C286(0.89)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C286(1.05)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C286(1.01)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C105(0.96); C286(0.93)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C286(1.35)  LDD1582  [11]
 LDCM0379  CL11 PaTu 8988t C286(0.85); C304(0.85)  LDD1258  [5]
 LDCM0380  CL110 HEK-293T C286(1.69)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C286(0.90)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C105(1.09); C286(0.95)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C286(1.24)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C286(1.00)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C286(1.05)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C105(1.00); C286(0.71)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C286(0.86)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C286(0.99)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C286(1.09)  LDD1593  [11]
 LDCM0390  CL12 PaTu 8988t C286(1.49); C304(1.49)  LDD1269  [5]
 LDCM0391  CL120 HEK-293T C105(1.05); C286(0.97)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C286(1.14)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C286(0.87)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C286(1.13)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C105(0.94); C286(0.97)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C286(1.04)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C286(0.92)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C286(1.17)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C105(1.12); C286(0.95)  LDD1603  [11]
 LDCM0400  CL13 PaTu 8988t C286(1.12); C304(1.12)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C286(1.13); C304(1.13)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C286(1.58); C304(1.58)  LDD1281  [5]
 LDCM0403  CL16 HEK-293T C105(1.22); C286(1.06)  LDD1607  [11]
 LDCM0405  CL18 HEK-293T C286(1.12)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C286(0.85)  LDD1610  [11]
 LDCM0407  CL2 PaTu 8988t C286(0.87); C304(0.87)  LDD1286  [5]
 LDCM0408  CL20 HEK-293T C286(1.15)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C286(1.60)  LDD1613  [11]
 LDCM0411  CL23 HEK-293T C286(1.35)  LDD1615  [11]
 LDCM0413  CL25 HEK-293T C286(1.17)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C286(1.00)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C286(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C105(0.95); C286(1.07)  LDD1620  [11]
 LDCM0418  CL3 PaTu 8988t C286(1.44); C304(1.44)  LDD1297  [5]
 LDCM0419  CL30 HEK-293T C286(0.95)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C286(1.10)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C286(1.01)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C286(1.51)  LDD1626  [11]
 LDCM0424  CL35 HEK-293T C286(1.11)  LDD1628  [11]
 LDCM0426  CL37 HEK-293T C286(1.00)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C286(1.12)  LDD1632  [11]
 LDCM0429  CL4 PaTu 8988t C286(1.24); C304(1.24)  LDD1308  [5]
 LDCM0430  CL40 HEK-293T C105(0.96); C286(0.88)  LDD1634  [11]
 LDCM0432  CL42 HEK-293T C286(0.91)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C286(1.08)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C286(0.95)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C286(1.34)  LDD1639  [11]
 LDCM0436  CL46 PaTu 8988t C304(0.79)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C304(0.57)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C304(0.76)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C304(0.84)  LDD1318  [5]
 LDCM0440  CL5 PaTu 8988t C286(1.24); C304(1.24)  LDD1319  [5]
 LDCM0441  CL50 PaTu 8988t C304(0.68)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C304(0.82)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C304(0.54)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C304(0.50)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C304(0.62)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C304(0.74)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C304(0.19)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C304(0.46)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C304(0.71)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C304(0.54)  LDD1329  [5]
 LDCM0451  CL6 PaTu 8988t C286(1.15); C304(1.15)  LDD1330  [5]
 LDCM0452  CL60 PaTu 8988t C304(0.54)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C286(0.73); C304(0.73)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C286(1.49); C304(1.49)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C286(1.21); C304(1.21)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C286(2.49); C304(2.49)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C286(1.05); C304(1.05)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C286(1.11); C304(1.11)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C286(1.17); C304(1.17)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C286(1.31); C304(1.31)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C286(1.40); C304(1.40)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C286(0.78); C304(0.78)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C286(1.09); C304(1.09)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C286(0.96); C304(0.96)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C286(2.17); C304(2.17)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C286(3.46); C304(3.46)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C286(1.93); C304(1.93)  LDD1346  [5]
 LDCM0469  CL76 HEK-293T C105(1.02); C286(0.87)  LDD1672  [11]
 LDCM0471  CL78 HEK-293T C286(0.98)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C286(1.19)  LDD1675  [11]
 LDCM0473  CL8 PaTu 8988t C286(4.65); C304(4.65)  LDD1352  [5]
 LDCM0474  CL80 HEK-293T C286(1.23)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C286(1.29)  LDD1678  [11]
 LDCM0477  CL83 HEK-293T C286(1.29)  LDD1680  [11]
 LDCM0479  CL85 HEK-293T C286(1.35)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C286(1.03)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C286(0.86)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C105(1.10); C286(1.12)  LDD1685  [11]
 LDCM0484  CL9 PaTu 8988t C286(1.11); C304(1.11)  LDD1363  [5]
 LDCM0485  CL90 HEK-293T C286(1.15)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C286(1.04)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C286(0.79)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C286(1.30)  LDD1691  [11]
 LDCM0490  CL95 HEK-293T C286(1.42)  LDD1693  [11]
 LDCM0492  CL97 HEK-293T C286(1.16)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C286(0.90)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C286(1.07)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C286(0.26)  LDD1698  [11]
 LDCM0201  EV-3 T cell C286, C289(5.10)  LDD0528  [12]
 LDCM0202  EV-93 T cell C286, C289(10.76)  LDD0527  [12]
 LDCM0468  Fragment33 PaTu 8988t C286(1.21); C304(1.21)  LDD1347  [5]
 LDCM0427  Fragment51 HEK-293T C286(0.95)  LDD1631  [11]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [2]
 LDCM0615  Fragment63-R Jurkat _(9.26)  LDD1487  [2]
 LDCM0022  KB02 T cell C286, C289(11.47)  LDD1707  [12]
 LDCM0024  KB05 T cell C286, C289(20.00)  LDD1709  [12]
 LDCM0169  KB63 Ramos 19.39  LDD0432  [4]
 LDCM0014  Panhematin hPBMC 3.28  LDD0064  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
RING finger protein 122 (RNF122) . Q9H9V4
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Huntingtin (HTT) Huntingtin family P42858
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Tetraspanin-12 (TSPAN12) Tetraspanin (TM4SF) family O95859
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Gelsolin (GSN) Villin/gelsolin family P06396
Junctional sarcoplasmic reticulum protein 1 (JSRP1) . Q96MG2
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Stress-induced-phosphoprotein 1 (STIP1) . P31948
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.