Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name EV-93  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32, C33 20.0
 LDTP12911  Adenosine deaminase 2 (ADA2) C408 20.0
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) C296 20.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C96 20.0
 LDTP06211  Caspase-8 (CASP8) C360 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) C115 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) C261 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) C265 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 20.0
 LDTP05943  Myotubularin-related protein 1 (MTMR1) C117 20.0
 LDTP07268  Palmitoyltransferase ZDHHC20 (ZDHHC20) C263 20.0
 LDTP08619  Probable ATP-dependent RNA helicase DDX60 (DDX60) C1051 20.0
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C431 20.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 19.9
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 19.2
 LDTP11127  ADP-dependent glucokinase (ADPGK) C40 19.1
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120, C124 18.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 15.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 13.8
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 13.4
 LDTP06120  Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH) C11 12.8
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) C56 11.3
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) C286, C289 10.8
 LDTP02788  15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD) C182 6.3
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 5.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50, C68 5.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) C255, C258 4.5
 LDTP14074  Ribosomal biogenesis protein LAS1L (LAS1L) C140 4.3
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C335 4.3
 LDTP06441  Rho-related GTP-binding protein RhoH (RHOH) C108 4.1
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210, C227 18.1
 LDTP01680  Transmembrane protein 50A (TMEM50A) C87 15.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) C385 8.3
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) C142 6.3
 LDTP01060  PRA1 family protein 2 (PRAF2) C28 6.0
 LDTP11397  Solute carrier family 12 member 9 (SLC12A9) C911 6.0
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 5.8
 LDTP03450  Retinoic acid receptor RXR-beta (RXRB) C340 4.5
Immunoglobulin
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C440 20.0
 LDTP02338  CD48 antigen (CD48) C148 11.7
 LDTP02338  CD48 antigen (CD48) C193, C196 4.7
 LDTP02358  T-cell antigen CD7 (CD7) C219 4.7
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 6.7
Other
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10140  Calcineurin B homologous protein 3 (TESC) C213 20.0
 LDTP00809  Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) C305 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 16.0
 LDTP15887  Lipase maturation factor 2 (LMF2) C659 14.0
 LDTP07718  MICOS complex subunit MIC27 (APOOL) C74 13.0
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C135 5.8
 LDTP17157  OCIA domain-containing protein 2 (OCIAD2) C27 5.5
 LDTP11895  Lck-interacting transmembrane adapter 1 (LIME1) C69 4.8
 LDTP19831  Protein THEM6 (THEM6) C29 4.7

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.