Details of the Target

General Information of Target

Target ID LDTP02358
Target Name T-cell antigen CD7 (CD7)
Gene Name CD7
Gene ID 924
Synonyms
T-cell antigen CD7; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41; CD antigen CD7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLR
QLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEV
NVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALP
AALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function Not yet known.
TTD ID
T66266
Uniprot ID
P09564
DrugMap ID
TTP6B8O
Ensemble ID
ENST00000312648.8
HGNC ID
HGNC:1695

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y222(20.00)  LDD0260  [1]
IPM
 Probe Info  		C230(0.00); C219(0.00)  LDD0241  [2]
BTD
 Probe Info  		C209(0.87)  LDD2090  [3]
DBIA
 Probe Info  		C219(4.52)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0202  EV-93 T cell C219(4.67)  LDD0527  [6]
 LDCM0023  KB03 Jurkat C219(4.52)  LDD0209  [4]
 LDCM0024  KB05 T cell C219(5.26)  LDD1705  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C209(0.87)  LDD2090  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C209(1.04)  LDD2094  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C209(1.18)  LDD2105  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-cd7 Car-t Cells CAR T Cell Therapy D09SBE
Cd7.Car/28zeta Car T Cells CAR T Cell Therapy D09ICH

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.