Details of the Target

General Information of Target

Target ID LDTP00671
Target Name Tapasin (TAPBP)
Gene Name TAPBP
Gene ID 6892
Synonyms
NGS17; TAPA; Tapasin; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSLSLLLAVALGLATAVSAGPAVIECWFVEDASGKGLAKRPGALLLRQGPGEPPPRPDL
DPELYLSVHDPAGALQAAFRRYPRGAPAPHCEMSRFVPLPASAKWASGLTPAQNCPRALD
GAWLMVSISSPVLSLSSLLRPQPEPQQEPVLITMATVVLTVLTHTPAPRVRLGQDALLDL
SFAYMPPTSEAASSLAPGPPPFGLEWRRQHLGKGHLLLAATPGLNGQMPAAQEGAVAFAA
WDDDEPWGPWTGNGTFWLPTVQPFQEGTYLATIHLPYLQGQVTLELAVYKPPKVSLMPAT
LARAAPGEAPPELLCLVSHFYPSGGLEVEWELRGGPGGRSQKAEGQRWLSALRHHSDGSV
SLSGHLQPPPVTTEQHGARYACRIHHPSLPASGRSAEVTLEVAGLSGPSLEDSVGLFLSA
FLLLGLFKALGWAAVYLSTCKDSKKKAE
Target Bioclass
Immunoglobulin
Subcellular location
Endoplasmic reticulum membrane
Function Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Uniprot ID
O15533
Ensemble ID
ENST00000374572.7
HGNC ID
HGNC:11566

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH7 SNV: p.H355Y .
JURKAT Deletion: p.P311RfsTer92 Compound 10    Probe Info 
LNCaP clone FGC SNV: p.P263L DBIA    Probe Info 
NCIH1993 SNV: p.A235T .
TOV21G SNV: p.A343D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.55  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
STPyne
 Probe Info  		K104(10.00); K40(10.00)  LDD0277  [3]
BTD
 Probe Info  		C91(0.90)  LDD2089  [4]
Johansson_61
 Probe Info  		_(12.32)  LDD1490  [5]
AHL-Pu-1
 Probe Info  		C115(3.28)  LDD0170  [6]
EA-probe
 Probe Info  		C115(1.04)  LDD2210  [7]
DBIA
 Probe Info  		C115(4.31)  LDD0209  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C91(0.00); C115(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C115(0.00); C91(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C115(0.87)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C91(0.54)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C91(0.75)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C91(1.05); C115(0.84)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C115(1.02)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C91(0.53)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C91(0.54)  LDD2131  [4]
 LDCM0025  4SU-RNA DM93 C115(3.28)  LDD0170  [6]
 LDCM0214  AC1 HEK-293T C115(1.00); C440(0.93)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C115(1.07); C440(0.97)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C115(1.01); C440(0.89)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C115(1.09); C440(0.91)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C115(1.07); C440(0.88)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C115(1.05)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C115(1.08); C440(0.86)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C115(0.91); C440(0.93)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C115(0.95); C440(1.02)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C115(1.07); C440(0.88)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C115(1.07); C440(0.91)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C115(1.01); C440(0.91)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C115(0.96); C440(0.90)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C115(1.02)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C115(0.98); C91(0.94); C440(0.86)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C115(1.17); C440(0.90)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C115(1.00); C440(0.87)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C115(0.99); C440(0.83)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C115(1.03); C440(0.84)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C115(0.93); C440(0.95)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C115(1.07); C440(0.97)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C115(1.08); C440(0.80)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C115(0.98)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C115(0.98); C91(0.98); C440(0.91)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C115(1.02); C440(0.93)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C115(1.06); C440(0.85)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C115(1.00); C440(0.85)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C115(1.04); C440(0.85)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C115(0.89); C440(0.82)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C115(0.98); C440(0.85)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C115(1.10)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C115(1.00); C440(0.93)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C115(0.97); C91(1.02); C440(0.89)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C115(1.12); C440(1.03)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C115(1.06); C440(0.82)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C115(1.10); C440(0.93)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C115(1.00); C440(0.90)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C115(0.90); C440(0.93)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C115(0.98); C440(0.81)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C115(0.97)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C115(0.92); C91(0.95); C440(0.94)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C115(0.98); C440(1.08)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C115(0.99); C440(0.93)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C115(0.95); C440(0.86)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C115(1.09); C440(1.02)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C115(0.99); C440(0.89)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C115(0.99); C440(0.97)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C115(0.98); C440(0.79)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C115(1.08)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C115(0.90); C91(1.03); C440(0.98)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C115(1.11); C440(1.13)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C115(1.01); C440(1.06)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C115(1.00); C440(0.91)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C115(1.10); C440(0.91)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C115(1.05); C440(0.99)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C115(0.96); C440(0.98)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C115(1.12); C440(0.89)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C115(1.04)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C115(0.96); C91(1.09); C440(0.94)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C115(0.97)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C115(1.02); C91(1.02); C440(0.82)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C91(0.55)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C115(0.98); C440(0.96)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C115(1.19); C440(0.96)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C115(0.93); C91(1.02); C440(1.04)  LDD1514  [17]
 LDCM0199  BPK-21 T cell C440(6.45)  LDD0530  [18]
 LDCM0200  BPK-25 T cell C440(4.52)  LDD0516  [18]
 LDCM0498  BS-3668 MDA-MB-231 C91(0.63)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa H355(0.00); C115(0.00); C91(0.00); H90(0.00)  LDD0222  [14]
 LDCM0367  CL1 HEK-293T C115(1.05); C91(1.45); C440(1.23)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C115(1.51); C440(1.05)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C115(0.89); C440(0.82)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C115(1.14); C91(1.33); C440(1.05)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C115(1.25); C91(1.24); C440(0.89)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C115(1.04); C440(0.88)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C115(0.91); C440(0.72)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C115(1.01); C91(1.21); C440(1.01)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C115(1.04); C91(1.11); C440(0.92)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C115(0.97); C440(0.88)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C115(0.89); C440(0.80)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C115(0.95); C91(1.78); C440(0.98)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C115(1.35)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C115(1.17); C91(1.35); C440(0.99)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C115(1.07); C440(0.95)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C115(1.02); C440(0.80)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C115(0.98); C91(1.00); C440(1.09)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C115(1.10); C91(1.24); C440(1.04)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C115(1.05); C440(0.93)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C115(0.94); C440(0.72)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C115(1.05); C91(1.38); C440(0.72)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C115(1.04); C91(1.12); C440(0.88)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C115(0.95); C440(0.92)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C115(1.02); C91(1.10); C440(1.08)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C115(0.79); C440(0.74)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C115(0.97); C91(0.96); C440(0.95)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C115(0.99); C91(1.02); C440(0.94)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C115(1.10); C440(1.02)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C115(0.87); C440(0.75)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C115(1.06); C91(1.00); C440(1.09)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C115(1.00); C91(0.97); C440(1.12)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C115(1.09); C440(1.11)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C115(0.90); C440(1.05)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C115(1.12); C91(1.14); C440(1.29)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C115(1.24); C91(1.19); C440(0.96)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C115(1.31); C440(1.20)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C115(0.93); C440(0.73)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C115(2.07); C440(1.05)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C115(1.11); C440(1.05)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C115(0.88); C440(0.95)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C115(1.06); C91(0.97); C440(1.14)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C115(1.14); C440(0.90)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C115(1.24); C440(0.87)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C115(1.06); C440(0.83)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C115(1.06)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C115(1.03); C91(1.06); C440(1.09)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C115(1.02); C91(0.97); C440(1.19)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C115(1.15); C91(0.91); C440(0.90)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C115(0.90); C440(0.89)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C115(0.89); C440(0.88)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C115(0.98); C440(0.87)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C115(1.12); C440(1.23)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C115(1.04); C440(0.93)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C115(1.00); C440(0.88)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C115(1.20); C440(0.90)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C115(1.36); C440(1.13)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C115(1.09); C440(0.79)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C115(0.95)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C115(1.02); C91(0.99); C440(0.93)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C115(0.93); C91(1.83); C440(1.18)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C115(1.14); C440(0.90)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C115(0.97); C440(0.93)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C115(0.96); C440(0.68)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C115(1.11); C440(0.88)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C115(0.93); C440(0.94)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C115(0.89); C440(0.85)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C115(1.20); C440(0.87)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C115(1.30); C440(1.03)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C115(1.06); C440(0.73)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C115(1.30)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C115(1.03); C91(1.04); C440(1.00)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C115(0.93); C91(1.65); C440(1.29)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C115(1.20); C440(1.19)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C115(1.07); C91(1.01); C440(0.90)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C115(0.89); C440(0.79)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C115(1.26); C440(0.89)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C115(1.05); C440(0.89)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C115(0.91); C440(0.81)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C115(1.15); C440(0.81)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C115(1.42); C440(0.81)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C115(1.25); C440(0.71)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C115(1.15)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C115(1.22); C440(1.26)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C115(1.13); C91(1.00); C440(0.94)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C115(1.00); C91(1.43); C440(1.20)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C115(1.08); C91(0.74); C440(0.91)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C115(0.96); C440(0.93)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C115(0.92); C440(0.82)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C115(0.98); C440(0.99)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C115(1.14); C440(0.88)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C115(1.07); C440(0.99)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C115(1.16); C440(0.93)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C115(1.22); C440(0.89)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C115(0.99); C440(1.13)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C115(1.15); C440(0.81)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C115(1.06)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C115(1.12); C91(0.96); C440(0.87)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C115(1.01); C91(1.47); C440(1.14)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C115(1.05); C91(0.93); C440(1.04)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C115(0.88); C440(0.88)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C115(1.57); C440(0.92)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C115(1.01); C440(0.82)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C115(1.04); C440(0.87)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C115(2.11); C440(1.26)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C115(0.96); C440(0.93)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C115(1.05); C440(0.90)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C115(1.10); C440(0.80)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C115(1.25)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C115(1.09); C91(0.97); C440(0.95)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C115(0.94); C91(1.30); C440(1.39)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C115(1.03); C91(0.95); C440(1.13)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C115(0.98); C440(1.15)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C115(0.82); C440(1.06)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C115(1.15); C440(1.22)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C115(1.17); C440(0.99)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C115(1.39); C440(1.17)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C115(0.99); C440(1.01)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C115(1.20); C440(1.08)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C115(0.98); C440(0.94)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C115(1.34); C440(0.85)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C115(1.37)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C115(1.26); C91(1.13); C440(1.07)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C115(1.05); C91(1.28); C440(1.13)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C115(1.15); C91(0.87); C440(1.06)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C115(1.21); C440(0.98)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C115(1.29); C440(0.90)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C91(3.07); C115(2.80)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa C115(1.04)  LDD2210  [7]
 LDCM0202  EV-93 T cell C440(12.47)  LDD0514  [18]
 LDCM0203  EV-96 T cell C440(16.94)  LDD0523  [18]
 LDCM0204  EV-97 T cell C440(20.00)  LDD0525  [18]
 LDCM0625  F8 Ramos C115(3.02); C440(0.62)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C115(2.28)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C115(1.24); C440(14.15)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C115(1.21)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C115(0.96)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C115(0.71); C440(3.62)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C115(2.23)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C115(1.01)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C115(0.38)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C115(0.69)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C115(0.32); C440(3.08)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C115(1.65)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C115(1.00)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C115(2.93)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C115(1.04); C440(0.92)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C115(0.55)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C115(1.80)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C115(0.99); C91(0.80); C440(0.94)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C115(0.53)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C115(0.77)  LDD2205  [19]
 LDCM0617  Fragment63-S Jurkat _(12.32)  LDD1490  [5]
 LDCM0569  Fragment7 Ramos C115(2.02)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C115(2.37)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 T cell C440(5.37)  LDD1703  [18]
 LDCM0023  KB03 Jurkat C115(4.31)  LDD0209  [8]
 LDCM0024  KB05 COLO792 C91(3.33); C115(2.98)  LDD3310  [20]
 LDCM0169  KB63 Ramos 7.79  LDD0432  [21]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C91(0.76); C115(0.83)  LDD2121  [4]
 LDCM0109  NEM HeLa H354(0.00); H90(0.00)  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C91(0.90)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C91(0.98); C115(0.90)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C115(1.24)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C115(0.92)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C91(0.98); C115(1.14)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C115(0.91)  LDD2099  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C91(0.69); C115(1.12)  LDD2104  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C91(1.09); C115(0.72)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C91(0.57)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C91(1.86)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C115(1.58)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C91(1.14); C115(1.01)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C115(0.87)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C115(0.61)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C115(0.98)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C115(0.92)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C115(1.01)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C91(0.95); C115(0.95)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C115(1.12)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C115(0.55)  LDD2141  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C91(0.48)  LDD2150  [4]
 LDCM0131  RA190 MM1.R C440(8.26); C115(1.33)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Antigen peptide transporter 1 (TAP1) ABCB family Q03518
Antigen peptide transporter 2 (TAP2) ABCB family Q03519

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.