Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name EV-96  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) C261 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C302 20.0
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) C110 20.0
 LDTP03989  Tyrosine-protein kinase Tec (TEC) C449 20.0
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) C54 19.4
 LDTP05822  Serine-protein kinase ATM (ATM) C1396 13.5
 LDTP03985  Caspase-2 (CASP2) C366, C370 13.2
 LDTP00300  Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (USP9Y) C843 10.5
 LDTP11678  Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) C748 10.3
 LDTP00697  Cytochrome b5 type B (CYB5B) C115 8.1
 LDTP04573  LIM domain kinase 1 (LIMK1) C349 6.6
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) C174 6.2
 LDTP13302  Nuclear prelamin A recognition factor (NARF) C228 5.7
 LDTP04243  Fatty acid synthase (FASN) C1558 5.4
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) C714 5.2
 LDTP07283  E3 ubiquitin-protein ligase RNF213 (RNF213) C614 5.0
 LDTP10077  Patatin-like phospholipase domain-containing protein 2 (PNPLA2) C412 4.9
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) C21 4.8
 LDTP04559  Nucleoside diphosphate-linked moiety X motif 6 (NUDT6) C44 4.7
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C96 4.3
 LDTP07092  Probable arginine--tRNA ligase, mitochondrial (RARS2) C576 4.3
 LDTP11953  Histone-lysine N-methyltransferase SUV39H2 (SUV39H2) C201, C202 4.2
 LDTP00536  Mitochondrial ribonuclease P catalytic subunit (PRORP) C507 4.1
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) C275 4.1
Transporter and channel
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10378  Nuclear envelope pore membrane protein POM 121 (POM121) C28 20.0
 LDTP12548  Phospholipid scramblase 3 (PLSCR3) C125, C126 8.0
 LDTP11397  Solute carrier family 12 member 9 (SLC12A9) C911 5.9
 LDTP07456  Molybdate-anion transporter (MFSD5) C33 4.2
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05415  AT-rich interactive domain-containing protein 5A (ARID5A) C130 4.4
 LDTP01653  Bromodomain-containing protein 1 (BRD1) C441, C448 4.4
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C440 16.9
 LDTP01662  Cytotoxic and regulatory T-cell molecule (CRTAM) C357 5.7
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02747  Interleukin-2 receptor subunit beta (IL2RB) C280 5.7
Other
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06210  Golgin subfamily B member 1 (GOLGB1) C3197, C3213 20.0
 LDTP08248  NLR family member X1 (NLRX1) C331 20.0
 LDTP14047  Plexin-D1 (PLXND1) C1363 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C135 20.0
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C157 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 13.3
 LDTP00941  Zinc finger C3H1 domain-containing protein (ZFC3H1) C1778 10.8
 LDTP05535  Son of sevenless homolog 1 (SOS1) C405 7.5
 LDTP03994  Condensin-2 complex subunit D3 (NCAPD3) C631 7.2
 LDTP15852  Protein FAM118B (FAM118B) C319 6.6
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) C281, C286 5.9
 LDTP13307  Mediator of RNA polymerase II transcription subunit 13 (MED13) C244, C245 5.5
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 5.5
 LDTP13612  Spermatogenesis-associated protein 2 (SPATA2) C41 5.1
 LDTP15887  Lipase maturation factor 2 (LMF2) C659 4.9
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C513 4.8
 LDTP14053  Meiosis regulator and mRNA stability factor 1 (MARF1) C194 4.5
 LDTP09399  Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) C1266 4.3
 LDTP04602  Protein HIRA (HIRA) C295 4.2
 LDTP06962  RILP-like protein 1 (RILPL1) C47 4.2

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.