Details of the Target

General Information of Target

Target ID LDTP14047
Target Name Plexin-D1 (PLXND1)
Gene Name PLXND1
Gene ID 23129
Synonyms
KIAA0620; Plexin-D1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLY
PPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLN
KVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRN
SSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATM
ESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTEL
LAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNG
RLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILL
RAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIR
TSTPTGHGASPAKQDELVISAR
Target Bioclass
Other
Family
Plexin family
Subcellular location
Cell membrane
Function
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E.
Uniprot ID
Q9Y4D7
Ensemble ID
ENST00000324093.9
HGNC ID
HGNC:9107

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.K1185SfsTer33
SNV: p.N1118S		 DBIA    Probe Info 
BXPC3 SNV: p.E1407G .
CAL51 SNV: p.P469T; p.T815M .
D283MED SNV: p.A63T .
DU145 SNV: p.Q1836Ter .
HCT116 Deletion: p.A1129PfsTer2 .
HCT15 SNV: p.T582I; p.Y1172C; p.G1241C .
HT SNV: p.A1590T .
IPC298 SNV: p.R119H .
JEKO1 Substitution: p.G135F .
JURKAT SNV: p.V950A .
KMCH1 SNV: p.H1233Q .
LNCaP clone FGC SNV: p.M1502L .
MFE319 SNV: p.P324S; p.R1053S DBIA    Probe Info 
NCIH1155 SNV: p.A1033T;p.E1328D
Substitution: p.Q108R		 DBIA    Probe Info 
NCIH1299 SNV: p.G861D .
NCIH1703 SNV: p.Q1843R DBIA    Probe Info 
ONS76 SNV: p.H325Q; p.S1131G .
OVCAR5 SNV: p.Q274H; p.A833S DBIA    Probe Info 
PC9 SNV: p.T1579M .
RD SNV: p.G352S DBIA    Probe Info 
RL Substitution: p.E431Ter .
TOV21G SNV: p.A477S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K1182(0.82); K310(3.11)  LDD3494  [1]
AHL-Pu-1
 Probe Info  		C1363(3.87)  LDD0171  [2]
IA-alkyne
 Probe Info  		C1363(20.00)  LDD0521  [3]
DBIA
 Probe Info  		C1363(1.10)  LDD0078  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0147  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C1363(3.87)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C1592(1.52)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C1592(3.20)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C1592(0.94)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C1592(0.88)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C1592(0.90)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C1592(1.42)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C1592(0.94)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C1592(1.72)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C1592(2.09)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C1592(1.31)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C1592(0.70)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C1592(0.59)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C1592(2.73)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C1592(0.61)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C1592(0.87)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C1592(0.63)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C1592(0.75)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C1592(0.79)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C1592(0.47)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C1592(0.80)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C1592(0.46)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C1592(0.71)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C1592(0.65)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C1592(1.99)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C1592(1.32)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C1592(1.37)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C1592(1.18)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C1592(1.20)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C1592(1.42)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C1592(1.24)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C1592(0.85)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C1592(2.73)  LDD1124  [4]
 LDCM0246  AC128 HCT 116 C1592(1.23)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C1592(1.36)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C1592(1.37)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C1592(1.15)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C1592(1.31)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C1592(1.22)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C1592(1.35)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C1592(1.22)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C1592(1.26)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C1592(1.44)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C1592(1.66)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C1592(1.49)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C1592(6.43)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C1592(1.52)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C1592(1.52)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C1592(1.39)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C1592(2.11)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C1592(1.61)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C1592(2.24)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C1592(0.62)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C1592(1.45)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C1592(2.32)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C1592(2.34)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C1592(2.85)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C1592(1.83)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C1592(1.84)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C1592(1.60)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C1592(3.00)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C1592(1.92)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C1592(1.65)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C1592(2.12)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C1592(1.37)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C1592(0.77)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C1592(1.26)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C1592(0.96)  LDD1157  [4]
 LDCM0279  AC2 HCT 116 C1592(2.33)  LDD0596  [4]
 LDCM0280  AC20 PaTu 8988t C1592(1.06)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C1592(0.81)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C1592(1.27)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C1592(1.47)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C1592(1.36)  LDD1163  [4]
 LDCM0285  AC25 HCT 116 C1592(0.96)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C1592(1.61)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C1592(1.72)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C1592(1.26)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C1592(0.87)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C1592(1.97)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C1592(2.24)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C1592(1.68)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C1592(2.02)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C1592(1.41)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C1592(1.95)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C1442(1.24)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C1592(1.15)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C1592(1.20)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C1592(0.97)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C1592(2.05)  LDD0618  [4]
 LDCM0303  AC41 HEK-293T C1592(1.18)  LDD1542  [6]
 LDCM0305  AC43 HEK-293T C1442(0.97)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C1592(0.83)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C1592(0.96)  LDD1546  [6]
 LDCM0308  AC46 PaTu 8988t C1592(1.12)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C1592(1.53)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C1592(1.39)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C1592(1.04)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C1592(4.43)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C1592(1.13)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C1592(0.72)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C1592(1.07)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C1592(1.13)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C1592(1.19)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C1592(0.82)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C1592(1.10)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C1592(2.25)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C1592(2.04)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C1592(2.28)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C1592(2.96)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C1592(2.28)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C1592(2.98)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C1592(2.54)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C1592(2.57)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C1592(4.13)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C1592(10.10)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C1592(9.16)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C1592(12.87)  LDD0648  [4]
 LDCM0332  AC68 PaTu 8988t C1592(1.24)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C1592(1.42)  LDD1212  [4]
 LDCM0334  AC7 HCT 116 C1592(3.09)  LDD0651  [4]
 LDCM0335  AC70 PaTu 8988t C1592(1.57)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C1592(1.40)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C1592(1.09)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C1592(1.10)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C1592(0.97)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C1592(1.50)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C1592(1.21)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C1592(1.14)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C1592(1.27)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C1592(1.16)  LDD1223  [4]
 LDCM0345  AC8 HCT 116 C1592(3.37)  LDD0662  [4]
 LDCM0346  AC80 PaTu 8988t C1592(1.24)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C1592(1.11)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C1592(1.08)  LDD1227  [4]
 LDCM0365  AC98 PaTu 8988t C1592(1.80)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C1592(1.36)  LDD1245  [4]
 LDCM0248  AKOS034007472 HCT 116 C1592(3.04)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C1592(2.89)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C1592(3.94)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C1363(1.10)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C1592(0.72)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C1592(1.08)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C1592(1.77)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C1592(4.03)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C1592(3.02)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C1592(1.80)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C1592(1.34)  LDD0690  [4]
 LDCM0374  CL105 PaTu 8988t C1592(0.92)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C1592(0.80)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C1592(0.91)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C1592(1.00)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C1592(1.09)  LDD1257  [4]
 LDCM0379  CL11 HCT 116 C1592(1.20)  LDD0696  [4]
 LDCM0380  CL110 PaTu 8988t C1592(0.95)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C1592(1.66)  LDD1260  [4]
 LDCM0382  CL112 HCT 116 C1592(1.45)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C1592(1.29)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C1592(1.38)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C1592(1.63)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C1592(3.95)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C1592(0.90)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C1592(1.39); C1442(1.05)  LDD1592  [6]
 LDCM0390  CL12 HCT 116 C1592(1.52)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C1442(1.02)  LDD1595  [6]
 LDCM0392  CL121 PaTu 8988t C1592(1.23)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C1592(1.11)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C1592(1.23)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C1592(1.63)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C1592(1.77)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C1592(0.90)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C1592(1.60)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C1592(2.17)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C1592(1.07)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C1592(0.59)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C1592(1.36)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C1592(1.65)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C1592(2.34)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C1592(2.32)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C1592(2.48)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C1592(1.11)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C1592(2.00)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C1592(2.06)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C1592(1.62)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C1592(2.28)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C1592(2.94)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C1592(2.29)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C1592(2.11)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C1592(1.97)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C1592(2.88)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C1592(2.61)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C1592(0.79)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C1592(2.54)  LDD1298  [4]
 LDCM0420  CL31 HCT 116 C1592(0.99)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C1592(1.23)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C1592(0.47)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C1592(1.18)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C1592(0.71)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C1592(0.90)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C1592(0.75)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C1592(0.84)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C1592(0.84)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C1592(1.27)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C1592(1.25)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C1592(2.25)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C1592(1.03)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C1592(0.90)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C1592(1.12)  LDD0752  [4]
 LDCM0436  CL46 PaTu 8988t C1592(1.21)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C1592(1.03)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C1592(0.72)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C1592(1.45)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C1592(0.87)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C1592(1.16)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C1592(0.84)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C1592(1.33)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C1592(3.25)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C1592(2.76)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C1592(1.52)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C1592(1.24)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C1592(2.31)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C1592(1.62)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C1592(2.66)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C1592(1.16)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C1592(1.58)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C1592(0.84)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C1592(0.52)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C1592(0.46)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C1592(0.53)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C1592(0.62)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C1592(0.73)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C1592(0.78)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C1592(0.93)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C1592(0.87)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C1592(0.96)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C1592(0.72)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C1592(0.55)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C1592(0.62)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C1592(0.82)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C1592(0.77)  LDD1346  [4]
 LDCM0469  CL76 HCT 116 C1592(1.28)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1592(0.85)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1592(1.55)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1592(1.33)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1592(0.95)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C1592(1.13)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1592(1.12)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1592(2.05)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1592(1.99)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1592(2.16)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1592(1.35)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1592(1.26)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1592(1.20)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1592(1.69)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1592(2.72)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1592(0.73)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C1592(0.67)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C1592(2.01)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C1592(1.67)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C1592(1.47)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C1592(1.78)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C1592(2.36)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C1592(1.83)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C1592(1.44)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C1592(1.29)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C1592(1.77)  LDD0811  [4]
 LDCM0203  EV-96 T cell C1363(12.61)  LDD0522  [3]
 LDCM0204  EV-97 T cell C1363(7.48)  LDD0525  [3]
 LDCM0206  EV-99 T cell C1363(20.00)  LDD0521  [3]
 LDCM0468  Fragment33 PaTu 8988t C1592(0.73)  LDD1347  [4]
 LDCM0427  Fragment51 HCT 116 C1592(1.08)  LDD0744  [4]
 LDCM0022  KB02 22RV1 C1592(1.40)  LDD2243  [7]
 LDCM0023  KB03 22RV1 C1592(1.27)  LDD2660  [7]
 LDCM0024  KB05 IGR37 C1363(3.07); C1519(17.35)  LDD3314  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) Nuclear hormone receptor family P22736
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Semaphorin-3E (SEMA3E) Semaphorin family O15041
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Semaphorin-4A (SEMA4A) Semaphorin family Q9H3S1

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840