Details of the Target

General Information of Target

Target ID LDTP05822
Target Name Serine-protein kinase ATM (ATM)
Gene Name ATM
Gene ID 472
Synonyms
Serine-protein kinase ATM; EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV
FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL
LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ
DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL
KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK
GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED
TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL
LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH
SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM
DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR
LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM
QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM
LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP
LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT
VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD
NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN
PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET
FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH
FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK
IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ
VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK
LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ
LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI
LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE
NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN
LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK
RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG
SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA
MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK
RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ
EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ
YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV
CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK
RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR
SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT
QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK
IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL
SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF
MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE
QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ
SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, ATM subfamily
Subcellular location
Nucleus
Function
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor . Recognizes the substrate consensus sequence [ST]-Q . Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization. Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy.
TTD ID
T97196
Uniprot ID
Q13315
DrugMap ID
TTKBM7V
Ensemble ID
ENST00000278616.9
HGNC ID
HGNC:795
ChEMBL ID
CHEMBL3797

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.10  LDD0402  [1]
STPyne
 Probe Info  		K1109(9.09)  LDD0277  [2]
BTD
 Probe Info  		C2607(1.26)  LDD2090  [3]
AHL-Pu-1
 Probe Info  		C2286(2.40); C2021(4.62); C564(2.18)  LDD0170  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C384(1.04); C2021(0.98)  LDD0078  [6]
CY4
 Probe Info  		N.A.  LDD0247  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
NAIA_4
 Probe Info  		C74(0.00); C1396(0.00); C2092(0.00); C2770(0.00)  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
IPM
 Probe Info  		C2607(0.00); C489(0.00); C1821(0.00); C219(0.00)  LDD0005  [11]
TFBX
 Probe Info  		C2021(0.00); C1045(0.00); C1736(0.00); C2159(0.00)  LDD0148  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		8.50  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		2.56  LDD0213  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C2286(2.40); C2021(4.62); C564(2.18)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C2021(2.52); C564(3.59); C489(4.05)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C2021(1.25)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C2021(0.88)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C564(1.35); C198(0.87); C199(0.87); C2021(1.15)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C564(1.19); C198(1.00); C199(1.00); C2021(1.09)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C564(1.40); C198(1.05); C199(1.05); C2021(1.07)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C564(1.56); C198(0.93); C199(0.93); C2021(1.34)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C564(1.26); C198(0.87); C199(0.87); C2021(1.10)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C564(0.78); C198(1.07); C199(1.07); C2021(1.03)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C564(0.83); C198(1.10); C199(1.10); C2021(0.97)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C564(1.38); C198(0.95); C199(0.95); C2021(1.12)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C564(0.88); C198(0.94); C199(0.94); C2021(1.00)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C564(0.92); C198(1.00); C199(1.00); C2021(1.20)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C2021(0.88)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C564(2.78); C198(1.10); C199(1.10); C2021(1.80)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C564(3.62); C198(0.89); C199(0.89); C2021(1.76)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C564(2.47); C198(0.99); C199(0.99); C2021(1.51)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C564(1.06); C2021(1.15); C2112(0.89); C2323(0.90)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C564(1.15); C2021(1.01); C2112(1.18); C2323(0.83)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C564(1.23); C2021(1.03); C2112(1.03); C2323(0.88)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C564(1.96); C2021(1.32); C2112(0.79); C2323(0.86)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C564(1.18); C2021(1.33); C2112(0.98); C2323(0.58)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C564(1.34); C2021(1.31); C2112(1.18); C2323(0.56)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C564(1.56); C2021(1.31); C2112(1.11); C2323(0.51)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C2021(0.94)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C564(1.24); C2021(1.39); C2112(1.16); C2323(0.58)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C564(1.73); C2021(1.68); C2112(1.13); C2323(0.49)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C564(2.34); C2021(2.22); C2112(1.41); C2323(0.34)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C564(3.22); C2021(1.88); C2112(1.11); C2323(0.36)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C564(1.57); C2021(1.57); C2112(1.17); C2323(0.47)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C564(2.42); C2021(2.07); C2112(1.12); C2323(0.37)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C564(3.83); C2021(2.59); C2112(1.24); C2323(0.32)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C564(4.01); C2021(2.88); C2112(1.02); C2323(0.31)  LDD0843  [6]
 LDCM0246  AC128 HCT 116 C2021(0.78)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C2021(0.89)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C2021(0.88)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C2021(0.76)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C2021(0.92)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C2021(0.93)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C2021(0.98)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C2021(0.84)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C2021(0.97)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C2021(0.86)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C2021(0.88)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C2021(0.94)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C2021(0.90)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C2021(1.01)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C2021(0.94)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C2021(0.86)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C786(0.90); C790(0.90)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C786(0.70); C790(0.70)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C786(0.84); C790(0.84)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C786(0.86); C790(0.86)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C786(0.83); C790(0.83)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C786(0.98); C790(0.98)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C786(1.00); C790(1.00)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C2021(1.02)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C786(0.86); C790(0.86)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C786(0.85); C790(0.85)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C786(0.80); C790(0.80)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C786(0.92); C790(0.92)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C786(0.73); C790(0.73)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C786(0.75); C790(0.75)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C786(0.81); C790(0.81)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C786(0.89); C790(0.89)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C786(0.76); C790(0.76)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C786(0.61); C790(0.61)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C786(0.67); C790(0.67)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C2021(1.33)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C786(0.72); C790(0.72)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C786(0.72); C790(0.72)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C786(0.66); C790(0.66)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C786(0.79); C790(0.79)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C786(0.75); C790(0.75)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C786(0.93); C790(0.93); C755(0.95); C2021(1.14)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C786(0.99); C790(0.99); C755(1.07); C2021(1.12)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C755(0.86); C786(0.91); C790(0.91); C2021(1.09)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C786(0.76); C790(0.76); C755(1.01); C2021(1.16)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C786(0.91); C790(0.91); C2021(1.27); C755(2.02)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C2021(1.38)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C786(0.85); C790(0.85); C2021(1.19); C755(1.38)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C786(0.87); C790(0.87); C2021(1.01); C755(1.29)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C786(1.02); C790(1.02); C2021(1.24); C755(1.74)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C786(0.94); C790(0.94); C2021(1.12); C755(1.51)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C786(0.89); C790(0.89); C2021(0.99); C755(1.76)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C786(0.95); C790(0.95)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C786(0.93); C790(0.93)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C786(0.90); C790(0.90)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C786(0.95); C790(0.95)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C786(1.11); C790(1.11)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C2021(1.49)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C786(0.99); C790(0.99)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C786(1.07); C790(1.07)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C786(1.06); C790(1.06)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C786(0.98); C790(0.98)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C786(1.09); C790(1.09)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C786(1.20); C790(1.20)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C2021(1.00); C786(1.02); C790(1.02); C755(1.28)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C2021(1.01); C786(1.05); C790(1.05); C755(1.08)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C2021(1.07); C786(1.19); C790(1.19); C755(1.19)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C786(1.20); C790(1.20); C2021(1.31); C755(1.35)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C2021(1.49)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C786(1.07); C790(1.07); C2021(1.23); C755(1.32)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C2021(0.78); C755(1.27); C786(1.32); C790(1.32)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C2021(0.90); C786(1.14); C790(1.14); C755(1.23)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C755(0.97); C786(1.06); C790(1.06); C2021(1.15)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C755(1.11); C786(1.13); C790(1.13); C2021(1.17)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C755(0.93); C786(1.01); C790(1.01); C2021(1.28)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C755(1.19); C786(1.27); C790(1.27); C2021(1.56)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C786(1.03); C790(1.03)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C786(1.00); C790(1.00)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C786(0.99); C790(0.99)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C2021(0.99)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C786(1.00); C790(1.00)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C786(0.97); C790(0.97)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C786(0.97); C790(0.97)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C786(1.04); C790(1.04)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C786(1.07); C790(1.07)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C786(1.20); C790(1.20)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C786(1.07); C790(1.07)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C786(1.16); C790(1.16)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C786(1.05); C790(1.05)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C786(0.96); C790(0.96)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C2021(0.87)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C786(0.95); C790(0.95)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C786(1.06); C790(1.06)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C786(0.94); C790(0.94)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C786(1.08); C790(1.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C786(1.08); C790(1.08)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C786(1.17); C790(1.17)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C786(0.95); C790(0.95)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C786(0.92); C790(0.92)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C786(0.89); C790(0.89)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C786(0.97); C790(0.97)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C2021(0.99)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C786(0.95); C790(0.95)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C786(1.08); C790(1.08)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C786(1.11); C790(1.11)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C786(0.67); C790(0.67); C755(1.26); C2021(1.37)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C786(1.16); C790(1.16); C755(1.24); C2021(1.38)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C786(0.93); C790(0.93); C755(1.20); C2021(1.34)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C786(0.89); C790(0.89); C755(1.24); C2021(1.29)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C786(1.10); C790(1.10); C755(1.29); C2021(1.35)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C786(0.93); C790(0.93); C755(1.23); C2021(1.39)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C2021(1.21); C755(1.27); C786(1.33); C790(1.33)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C2021(1.23); C755(1.35); C786(1.80); C790(1.80)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C755(1.05); C2021(1.12); C786(1.30); C790(1.30)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C786(1.16); C790(1.16); C755(1.21); C2021(1.44)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C786(0.87); C790(0.87); C2021(1.16); C755(1.27)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C755(1.01); C786(1.08); C790(1.08); C2021(1.40)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C786(1.00); C790(1.00); C2021(1.20); C755(1.36)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C755(0.96); C2021(1.13); C786(1.34); C790(1.34)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C786(1.06); C790(1.06); C755(1.26); C2021(1.29)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C564(1.03); C198(1.05); C199(1.05); C2021(1.15)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C564(0.89); C198(0.92); C199(0.92); C2021(0.85)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C2021(0.83)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C2021(1.19)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C2021(0.90)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C384(1.04); C2021(0.98)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C564(0.87); C198(1.12); C199(1.12); C2021(1.12)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C564(4.05); C198(1.18); C199(1.18); C2021(3.23)  LDD0966  [6]
 LDCM0369  CL100 HCT 116 C2021(1.39)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C2021(0.89)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C2021(1.38)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C2021(0.98)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C2021(0.88)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C786(0.75); C790(0.75)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C786(0.75); C790(0.75)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C786(0.71); C790(0.71)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C786(0.78); C790(0.78)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C786(0.85); C790(0.85)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C564(3.20); C198(0.79); C199(0.79); C2021(1.56)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C786(0.96); C790(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C786(0.85); C790(0.85)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C786(0.89); C790(0.89); C755(0.94); C2021(1.20)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C786(0.82); C790(0.82); C2021(1.15); C755(1.60)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C786(0.98); C790(0.98); C2021(1.13); C755(1.27)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C786(0.98); C790(0.98); C2021(1.09); C755(1.56)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C786(1.00); C790(1.00); C755(1.04); C2021(1.09)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C786(1.23); C790(1.23)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C786(1.18); C790(1.18)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C786(0.99); C790(0.99)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C564(1.12); C198(0.89); C199(0.89); C2021(1.05)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C786(0.97); C790(0.97)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C2021(0.70); C755(1.02); C786(1.38); C790(1.38)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C2021(1.03); C755(1.12); C786(1.18); C790(1.18)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C755(1.00); C2021(1.38); C786(1.49); C790(1.49)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C2021(1.16); C786(1.24); C790(1.24); C755(1.24)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C786(1.18); C790(1.18)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C786(1.19); C790(1.19)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C786(1.06); C790(1.06)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C786(1.01); C790(1.01)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C564(1.34); C198(0.89); C199(0.89); C2021(0.87)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C564(1.34); C198(1.04); C199(1.04); C2021(1.24)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C564(1.98); C198(1.18); C199(1.18); C2021(2.50)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C2021(1.00)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C2021(0.77)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C2021(0.81)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C2021(0.94)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C564(1.50); C198(1.04); C199(1.04); C2021(1.38)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C2021(0.75)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C2021(1.19)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C2021(0.90)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C2021(0.91)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C2021(0.87)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C2021(0.79)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C2021(1.11)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C2021(0.77)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C2021(0.95)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C2021(0.81)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C564(0.98); C198(0.87); C199(0.87); C2021(0.88)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C2021(0.79)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C564(0.86); C198(0.90); C199(0.90); C2021(0.87)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C564(1.17); C198(0.85); C199(0.85); C2021(1.03)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C564(1.56); C198(1.19); C199(1.19); C2021(1.29)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C564(1.13); C198(0.79); C199(0.79); C2021(0.93)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C564(1.09); C198(0.83); C199(0.83); C2021(1.19)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C564(1.38); C198(0.83); C199(0.83); C2021(1.06)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C564(1.31); C198(0.81); C199(0.81); C2021(1.11)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C564(3.58); C198(0.94); C199(0.94); C2021(1.76)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C564(1.19); C198(1.08); C199(1.08); C2021(1.26)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C564(1.50); C198(0.90); C199(0.90); C2021(1.47)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C564(2.26); C198(0.89); C199(0.89); C2021(2.08)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C564(2.53); C198(0.79); C199(0.79); C2021(1.79)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C564(2.26); C198(0.89); C199(0.89); C2021(1.89)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C564(1.37); C198(1.18); C199(1.18); C2021(1.08)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C564(1.88); C198(1.11); C199(1.11); C2021(1.49)  LDD1033  [6]
 LDCM0436  CL46 HCT 116 C755(0.77)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C755(0.80)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C755(0.74)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C755(0.80)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C564(1.35); C198(0.88); C199(0.88); C2021(1.13)  LDD1038  [6]
 LDCM0441  CL50 HCT 116 C755(0.82)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C755(0.65)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C755(0.90)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C755(0.83)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C755(0.67)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C755(0.73)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C755(0.83)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C755(0.85)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C755(0.93)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C755(0.80)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C564(1.17); C198(1.08); C199(1.08); C2021(1.77)  LDD1049  [6]
 LDCM0452  CL60 HCT 116 C755(0.99)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C2021(1.09); C786(0.99); C790(0.99)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C2021(1.27); C786(1.11); C790(1.11)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C2021(1.26); C786(0.97); C790(0.97)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C2021(1.67); C786(1.17); C790(1.17)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C2021(1.28); C786(1.09); C790(1.09)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C2021(1.42); C786(1.22); C790(1.22)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C2021(1.50); C786(1.04); C790(1.04)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C2021(1.49); C786(1.26); C790(1.26)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C2021(1.25); C786(1.07); C790(1.07)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C564(1.54); C198(0.83); C199(0.83); C2021(1.53)  LDD1060  [6]
 LDCM0463  CL70 HCT 116 C2021(1.27); C786(0.92); C790(0.92)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C2021(1.23); C786(1.15); C790(1.15)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C2021(1.23); C786(1.01); C790(1.01)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C2021(1.30); C786(1.08); C790(1.08)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C2021(1.29); C786(0.95); C790(0.95)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C2021(0.99); C755(1.05)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C2021(1.13); C755(0.99)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C2021(0.91); C755(0.90)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C2021(1.27); C755(1.09)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C198(0.85); C199(0.91); C2021(1.64); C2770(0.84)  LDD1071  [6]
 LDCM0474  CL80 HCT 116 C2021(0.95); C755(1.01)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C2021(1.13); C755(1.07)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C2021(1.32); C755(0.89)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C2021(1.35); C755(0.94)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C2021(1.59); C755(1.05)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C2021(1.05); C755(0.98)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C2021(0.98); C755(1.04)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C2021(1.17); C755(1.25)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C2021(1.30); C755(1.21)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C2021(1.51); C755(1.09)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C198(0.88); C199(0.98); C2021(1.36); C2770(1.20)  LDD1082  [6]
 LDCM0485  CL90 HCT 116 C2021(0.74); C755(0.90)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C2021(1.11)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C2021(1.15)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C2021(1.01)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C2021(1.22)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C2021(1.42)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C2021(1.23)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C2021(1.61)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C2021(1.38)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C2021(1.65)  LDD0811  [6]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C532(4.53)  LDD0513  [16]
 LDCM0495  E2913 HEK-293T C2159(1.14); C384(1.23); C2323(0.97); C1736(0.94)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C790(2.24); C2607(1.83)  LDD1702  [3]
 LDCM0201  EV-3 T cell C1396(8.85)  LDD0515  [16]
 LDCM0203  EV-96 T cell C1396(13.45)  LDD0523  [16]
 LDCM0204  EV-97 T cell C1396(8.05)  LDD0525  [16]
 LDCM0625  F8 Ramos C74(1.42); C2991(4.05)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C2021(1.70); C2991(0.71)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C2021(4.46); C2991(2.18)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C2021(3.45); C2991(1.61)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C74(0.68); C2021(1.06); C2991(0.78)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C2021(1.01); C2991(0.87)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C2991(0.95)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C74(0.75); C2021(1.37); C2991(0.64)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C74(0.55); C2021(1.03); C2991(1.67)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C74(0.65); C2021(1.14); C2991(1.15)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C74(0.80); C2021(0.90); C2991(0.72)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C74(0.97); C2021(1.14); C2991(0.96)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C74(1.04); C2021(1.64); C2991(0.29)  LDD2200  [18]
 LDCM0468  Fragment33 HCT 116 C2021(1.33); C786(1.19); C790(1.19)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C74(0.64); C2021(1.48); C2991(0.78)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C2021(1.04); C2991(1.99)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C564(1.38); C198(0.90); C199(0.90); C2021(1.03)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C2021(1.02); C2991(0.59)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C74(0.98); C2991(0.48)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C2991(1.22)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C2991(0.48)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C489(2.36); C384(4.27); C564(3.27)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C489(1.80); C384(1.92); C564(2.23)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C489(3.80); C384(3.10); C564(2.19)  LDD0082  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C2607(1.26)  LDD2090  [3]
 LDCM0090  Rapamycin JHH-7 2.56  LDD0213  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arylamine N-acetyltransferase 2 (NAT2) Arylamine N-acetyltransferase family P11245
Histone-lysine N-methyltransferase NSD3 (NSD3) Histone-lysine methyltransferase family Q9BZ95
F-box only protein 31 (FBXO31) FBXO31 family Q5XUX0
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) Ribonucleoside diphosphate reductase small chain family Q7LG56
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neurogenic locus notch homolog protein 1 (NOTCH1) NOTCH family P46531
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-24 (IL24) IL-10 family Q13007
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AATF (AATF) AATF family Q9NY61
SOSS complex subunit B1 (NABP2) SOSS-B family Q9BQ15
Telomere length regulation protein TEL2 homolog (TELO2) TEL2 family Q9Y4R8
TELO2-interacting protein 1 homolog (TTI1) Tti1 family O43156
ATM interactor (ATMIN) . O43313
BRCA1-associated ATM activator 1 (BRAT1) . Q6PJG6
Mediator of DNA damage checkpoint protein 1 (MDC1) . Q14676
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Nibrin (NBN) . O60934
Telomeric repeat-binding factor 1 (TERF1) . P54274
Telomeric repeat-binding factor 2 (TERF2) . Q15554
TP53-binding protein 1 (TP53BP1) . Q12888

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caffeine Small molecular drug DB00201
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd0156 . D0XD4I
Azd1390 . D0L6XO
M3541 . D0NW8C
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ku-60019 Small molecular drug D02NUT
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cgk733 Small molecular drug D00PXO

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
16 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578