Details of the Target

General Information of Target

Target ID LDTP15154
Target Name Dehydrogenase/reductase SDR family member 13 (DHRS13)
Gene Name DHRS13
Gene ID 147015
Synonyms
SDR7C5; Dehydrogenase/reductase SDR family member 13; EC 1.1.-.-; Short chain dehydrogenase/reductase family 7C member 5; Protein SDR7C5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRSRLFSVTSAISTIGILCLPLFQLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVL
VAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAVSPTVGIHLQTQTP
DLYPVPAPCFGPLGSPPPYEEIVKTT
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Secreted
Function Putative oxidoreductase.
Uniprot ID
Q6UX07
Ensemble ID
ENST00000378895.9
HGNC ID
HGNC:28326

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS123 SNV: p.V168L .
MEWO SNV: p.W252L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K201(10.00)  LDD0277  [1]
m-APA
 Probe Info  		13.32  LDD0403  [2]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [3]
AHL-Pu-1
 Probe Info  		C174(3.09)  LDD0169  [4]
Alkyne-RA190
 Probe Info  		7.68  LDD0299  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C28(1.15)  LDD0625  [7]
IA-alkyne
 Probe Info  		C174(0.00); C156(0.00); C128(0.00)  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		C128(0.00); C174(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [11]
TFBX
 Probe Info  		C28(0.00); C174(0.00); C128(0.00)  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		C28(0.00); C174(0.00)  LDD0005  [13]
AOyne
 Probe Info  		11.50  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.28  LDD1740  [15]
C106
 Probe Info  		16.68  LDD1793  [15]
C210
 Probe Info  		39.12  LDD1884  [15]
C388
 Probe Info  		43.11  LDD2047  [15]
C389
 Probe Info  		5.06  LDD2048  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C174(3.09)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C28(1.11); C285(1.11)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C28(0.76); C285(0.76)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C28(1.04); C285(1.04)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C28(1.11); C285(1.11)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C28(1.23); C285(1.23)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C28(1.37); C285(1.37)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C28(1.49); C285(1.49)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C28(1.42); C285(1.42)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C28(0.95); C285(0.95)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C28(1.19); C285(1.19)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C28(1.13); C285(1.13)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C28(1.17); C285(1.17)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C28(0.82); C285(0.82)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C28(1.67); C285(1.67)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C28(1.83); C285(1.83)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C28(1.69); C285(1.69)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C28(0.94); C285(0.94)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C28(1.05); C285(1.05)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C28(0.93); C285(0.93)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C28(1.05); C285(1.05)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C28(0.96); C285(0.96)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C28(0.97); C285(0.97)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C28(1.21); C285(1.21)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C28(0.80); C285(0.80)  LDD0835  [7]
 LDCM0238  AC120 HEK-293T C28(1.05); C285(1.05)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C28(1.39); C285(1.39)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C28(1.63); C285(1.63)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C28(1.67); C285(1.67)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C28(1.09); C285(1.09)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C28(1.50); C285(1.50)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C28(1.59); C285(1.59)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C28(1.68); C285(1.68)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C28(0.87); C285(0.87)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C28(0.96); C285(0.96)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C28(0.98); C285(0.98)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C28(0.85); C285(0.85)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C28(1.00); C285(1.00)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C28(1.04); C285(1.04)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C28(1.04); C285(1.04)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C28(1.18); C285(1.18)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C28(1.00); C285(1.00)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C28(1.27); C285(1.27)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C28(1.13); C285(1.13)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C28(1.61); C285(1.61)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C28(0.73); C285(0.73)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C28(1.19); C285(1.19)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C28(1.13); C285(1.13)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C28(1.33); C285(1.33)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C28(0.95); C285(0.95)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C28(1.48); C285(1.48)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C28(1.31); C285(1.31)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C28(1.54); C285(1.54)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C28(1.29); C285(1.29)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C28(1.20); C285(1.20)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C28(0.92); C285(0.92)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C28(0.90); C285(0.90)  LDD0868  [7]
 LDCM0271  AC150 HEK-293T C28(1.01); C285(1.01)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C28(1.18); C285(1.18)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C28(0.97); C285(0.97)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C28(1.12); C285(1.12)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C28(0.98); C285(0.98)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C28(1.23); C285(1.23)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C28(1.30); C285(1.30)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C28(1.80); C285(1.80)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C28(1.18); C285(1.18)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C28(1.10); C285(1.10)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C28(1.09); C285(1.09)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C28(1.06); C285(1.06)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C28(1.26); C285(1.26)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C28(1.13); C285(1.13)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C28(1.06); C285(1.06)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C28(1.49); C285(1.49)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C28(1.04); C285(1.04)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C28(1.19); C285(1.19)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C28(1.43); C285(1.43)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C28(1.42); C285(1.42)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C28(1.81); C285(1.81)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C28(1.49); C285(1.49)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C28(0.99); C285(0.99)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C28(1.39); C285(1.39)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C28(1.52); C285(1.52)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C28(1.33); C285(1.33)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C28(1.44); C285(1.44)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C28(1.27); C285(1.27)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C28(1.13); C285(1.13)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C28(1.40); C285(1.40)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C28(1.59); C285(1.59)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C28(1.20); C285(1.20)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C28(1.19); C285(1.19)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C28(1.06); C285(1.06)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C28(1.32); C285(1.32)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C28(1.20); C285(1.20)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C28(1.58); C285(1.58)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C28(1.33); C285(1.33)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C28(1.47); C285(1.47)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C28(1.48); C285(1.48)  LDD0905  [7]
 LDCM0308  AC46 HCT 116 C28(1.15)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C28(0.93)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C28(1.09)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C28(1.00)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C28(1.11); C285(1.11)  LDD0910  [7]
 LDCM0313  AC50 HCT 116 C28(1.05)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C28(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C28(0.90)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C28(0.84)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C28(0.84)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C28(0.91)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C28(0.89)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C28(0.98); C285(0.98)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C28(0.92); C285(0.92)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C28(0.87); C285(0.87)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C28(1.11); C285(1.11)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C28(1.57); C285(1.57)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C28(1.07); C285(1.07)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C28(1.22); C285(1.22)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C28(1.01); C285(1.01)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C28(1.10); C285(1.10)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C28(1.48); C285(1.48)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C28(0.88); C285(0.88)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C28(1.04); C285(1.04)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C28(0.87); C285(0.87)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C28(0.85); C285(0.85)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C28(1.09); C285(1.09)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C28(0.95); C285(0.95)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C28(0.97); C285(0.97)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C28(0.93); C285(0.93)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C28(0.95); C285(0.95)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C28(0.96); C285(0.96)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C28(0.94); C285(0.94)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C28(0.86); C285(0.86)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C28(0.69); C285(0.69)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C28(0.88); C285(0.88)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C28(0.88); C285(0.88)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C28(0.99); C285(0.99)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C28(0.91); C285(0.91)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C28(0.96); C285(0.96)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C28(1.15); C285(1.15)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C28(0.89); C285(0.89)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C28(1.55); C285(1.55)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C28(1.00); C285(1.00)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C28(1.06); C285(1.06)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C28(1.05); C285(1.05)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C28(1.07); C285(1.07)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C28(1.24); C285(1.24)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C28(1.70); C285(1.70)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C28(1.28); C285(1.28)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C28(1.35); C285(1.35)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C28(1.88); C285(1.88)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C28(1.43); C285(1.43)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C28(1.12); C285(1.12)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C28(1.20); C285(1.20)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C28(2.96); C285(2.96)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C28(1.08); C285(1.08)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C28(1.25); C285(1.25)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C28(1.03); C285(1.03)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C28(0.97); C285(0.97)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C28(1.03); C285(1.03)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 13.32  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C28(1.27)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C28(1.14)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C28(1.05); C285(1.05)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C28(1.49); C285(1.49)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C28(1.49); C285(1.49)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C28(1.23); C285(1.23)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C28(1.06); C285(1.06)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C28(1.13); C285(1.13)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C28(1.09); C285(1.09)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C28(1.01); C285(1.01)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C28(0.95); C285(0.95)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C28(1.22); C285(1.22)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C28(1.11)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C28(1.87); C285(1.87)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C28(1.74); C285(1.74)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C28(1.81); C285(1.81)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C28(1.45); C285(1.45)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C28(2.61); C285(2.61)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C28(1.58); C285(1.58)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C28(1.45); C285(1.45)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C28(1.47); C285(1.47)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C28(1.24); C285(1.24)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C28(1.54); C285(1.54)  LDD0987  [7]
 LDCM0390  CL12 HCT 116 C28(1.29)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C28(1.16); C285(1.16)  LDD0989  [7]
 LDCM0392  CL121 HCT 116 C28(0.95)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C28(0.95)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C28(1.01)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C28(0.98)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C28(1.08); C285(1.08)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C28(1.06); C285(1.06)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C28(0.78); C285(0.78)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C28(0.89); C285(0.89)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C28(1.18)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C28(1.24)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C28(1.09)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C28(1.69); C285(1.69)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C28(2.18); C285(2.18)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C28(1.23); C285(1.23)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C28(1.32); C285(1.32)  LDD1004  [7]
 LDCM0407  CL2 HCT 116 C28(1.14)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C28(1.36); C285(1.36)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C28(1.80); C285(1.80)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C28(1.97); C285(1.97)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C28(1.00); C285(1.00)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C28(1.43); C285(1.43)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C28(1.77); C285(1.77)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C28(1.18); C285(1.18)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C28(1.24); C285(1.24)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C28(1.05); C285(1.05)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C28(1.31); C285(1.31)  LDD1015  [7]
 LDCM0418  CL3 HCT 116 C28(1.00)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C28(1.69); C285(1.69)  LDD1017  [7]
 LDCM0420  CL31 HCT 116 C28(1.16)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C28(0.94)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C28(1.21)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C28(1.26)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C28(1.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C28(1.28)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C28(1.03)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C28(0.94)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C28(1.13)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C28(1.40)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C28(1.28)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C28(1.04)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C28(1.42)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C28(1.09)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C28(1.70)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C28(0.97)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C28(0.86)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C28(1.09)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C28(0.98)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C28(1.17)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C28(0.98)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C28(0.92)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C28(1.06)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C28(0.76)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C28(0.92)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C28(0.93)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C28(1.01)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C28(1.04)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C28(1.00)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C28(0.97)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C28(1.25)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C28(0.91)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C128(1.09)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C128(0.82)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C128(0.88)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C128(0.94)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C128(1.12)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C128(1.19)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C128(1.15)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C128(1.36)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C128(1.08)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C28(1.46)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C128(1.05)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C128(0.79)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C128(1.02)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C128(1.30)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C128(0.88)  LDD1346  [7]
 LDCM0469  CL76 HEK-293T C174(0.88); C28(0.92); C128(0.94); C222(0.97)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C174(1.17); C28(1.51); C128(1.33); C222(0.96)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C174(0.99); C28(1.03); C128(0.97); C222(0.92)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C174(0.92); C28(0.92); C128(0.92); C222(0.98)  LDD1675  [16]
 LDCM0473  CL8 HCT 116 C28(1.04)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C174(0.88); C28(0.98); C128(0.94); C222(0.94)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C28(1.08); C128(1.06); C222(0.87); C268(1.04)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C174(0.97); C28(0.94); C128(1.04); C222(0.93)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C174(0.78); C28(0.96); C128(1.24); C222(0.80)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C174(0.96); C28(1.07); C128(1.05); C222(0.98)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C174(0.94); C28(0.95); C128(0.90); C222(0.97)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C174(1.12); C28(1.13); C128(1.00); C222(1.09)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C174(0.96); C28(1.24); C128(1.03); C222(1.16)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C174(1.01); C28(1.02); C128(0.82); C222(1.07)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C174(0.86); C28(1.09); C128(1.07); C222(0.96)  LDD1686  [16]
 LDCM0484  CL9 HCT 116 C28(1.07)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C174(1.61); C28(1.35); C128(1.41); C222(0.98)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C28(1.83); C285(1.83)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C28(2.04); C285(2.04)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C28(1.44); C285(1.44)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C28(1.45); C285(1.45)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C28(2.94); C285(2.94)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C28(1.58); C285(1.58)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C28(1.32); C285(1.32)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C28(0.89); C285(0.89)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C28(1.12); C285(1.12)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C174(0.94); C28(1.02); C128(1.06); C222(1.13)  LDD1698  [16]
 LDCM0203  EV-96 T cell C174(6.24)  LDD0523  [17]
 LDCM0204  EV-97 T cell C174(5.48)  LDD0525  [17]
 LDCM0573  Fragment11 Ramos C156(20.00)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C156(2.92)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C156(0.79)  LDD2198  [18]
 LDCM0468  Fragment33 PaTu 8988t C128(0.99)  LDD1347  [7]
 LDCM0566  Fragment4 Ramos C156(2.75)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C28(1.60)  LDD0744  [7]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [3]
 LDCM0149  GA MCF-7 C174(11.22)  LDD0379  [19]
 LDCM0022  KB02 HEK-293T C174(0.87); C28(0.81); C128(0.96); C268(1.09)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C174(0.78); C28(0.92); C128(0.90); C268(0.96)  LDD1497  [16]
 LDCM0024  KB05 IGR37 C78(2.55)  LDD3314  [20]
 LDCM0131  RA190 MM1.R 7.68  LDD0299  [5]

References

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Mass spectrometry data entry: PXD028270
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4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840