Details of the Target

General Information of Target

Target ID LDTP05535
Target Name Son of sevenless homolog 1 (SOS1)
Gene Name SOS1
Gene ID 6654
Synonyms
Son of sevenless homolog 1; SOS-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
Target Bioclass
Other
Function
Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
Uniprot ID
Q07889
Ensemble ID
ENST00000402219.8
HGNC ID
HGNC:11187
ChEMBL ID
CHEMBL2079846

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.F1248C DBIA    Probe Info 
A431 SNV: p.E891Q .
AGS SNV: p.E783G .
AU565 SNV: p.E906Q DBIA    Probe Info 
CAL51 Deletion: p.K1030NfsTer6 .
CHL1 SNV: p.G21R DBIA    Probe Info 
DU145 SNV: p.R854P .
G415 SNV: p.T1315R .
HEC1 SNV: p.Q800H .
HSC4 Deletion: p.E864SfsTer2 .
HT115 SNV: p.R660C .
MCC13 SNV: p.M166I .
MFE319 SNV: p.E433D; p.R739K .
OCIAML5 SNV: p.N233Y .
RL952 SNV: p.N233I .
SNU1079 SNV: p.E841K .
SUPT1 SNV: p.H1109R DBIA    Probe Info 
TKKK SNV: p.H1114L .
TOV21G SNV: p.P7H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C405(2.11)  LDD0169  [1]
DBIA
 Probe Info  		C440(0.93); C441(0.93)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		C693(0.00); C405(0.00)  LDD0148  [6]
AOyne
 Probe Info  		13.50  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C405(2.11)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C440(1.38)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C440(0.92); C441(0.92); C470(0.96)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C440(0.93); C441(0.93)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C440(0.94); C441(0.94)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C440(0.93); C441(0.93)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C440(1.05); C441(1.05)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C440(0.89); C441(0.89)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C440(0.86); C441(0.86)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C440(1.11); C441(1.11)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C440(0.89); C441(0.89)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C440(1.01); C441(1.01)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C440(1.17); C441(1.17)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C440(1.11); C441(1.11); C470(1.12)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C440(1.01); C441(1.01)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C440(1.00); C441(1.00)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C440(0.89); C441(0.89)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C440(0.88); C441(0.88)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C440(1.01); C441(1.01)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C440(0.86); C441(0.86)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C440(0.79); C441(0.79)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C440(1.00); C441(1.00)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C440(0.90); C441(0.90)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C440(0.81); C441(0.81)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C440(1.08); C441(1.08); C470(1.06)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C440(0.94); C441(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C440(0.79); C441(0.79)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C440(0.91); C441(0.91)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C440(0.81); C441(0.81)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C440(0.82); C441(0.82)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C440(1.00); C441(1.00)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C440(0.98); C441(0.98)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C440(0.86); C441(0.86)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C440(1.20); C441(1.20)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C440(1.11); C441(1.11)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C440(1.11); C441(1.11)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C440(1.23); C441(1.23)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C440(1.25); C441(1.25)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C440(1.11); C441(1.11)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C440(1.24); C441(1.24)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C440(1.02); C441(1.02)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C440(0.97); C441(0.97)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C440(1.12); C441(1.12)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C440(1.17); C441(1.17)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C440(1.10); C441(1.10)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C440(0.89); C441(0.89); C470(0.82)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C440(1.22); C441(1.22)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C440(1.24); C441(1.24)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C440(1.07); C441(1.07)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C440(0.80); C441(0.80)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C440(0.96); C441(0.96)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C440(1.06); C441(1.06)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C440(1.01); C441(1.01)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C440(1.01); C441(1.01)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C440(1.14); C441(1.14)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C440(0.76); C441(0.76)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C440(0.97); C441(0.97); C470(0.99)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C440(0.87); C441(0.87)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C440(1.02); C441(1.02)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C440(0.73); C441(0.73)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C440(0.99); C441(0.99)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C440(1.06); C441(1.06)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C440(1.21); C441(1.21)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C440(0.86); C441(0.86)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C440(1.20); C441(1.20)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C440(0.74); C441(0.74)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C440(0.49); C441(0.49)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C440(0.77); C441(0.77)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C440(1.23)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C440(0.89); C441(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C440(0.71); C441(0.71)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C440(0.94); C441(0.94)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C440(0.88); C441(0.88)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C440(0.89); C441(0.89)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C441(1.49); C470(0.84)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C441(1.44); C470(0.72)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C441(1.84); C470(0.76)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C441(1.28); C470(0.74)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C441(1.63); C470(0.69)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C440(1.30)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C441(1.67); C470(0.62)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C441(1.51); C470(0.82)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C441(1.38); C470(0.77)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C441(1.45); C470(0.71)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C441(2.23); C470(0.71)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C440(0.98); C441(0.98)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C440(1.02); C441(1.02)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C440(0.99); C441(0.99)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C440(1.18); C441(1.18)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C440(1.15); C441(1.15)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C440(1.08)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C440(0.89); C441(0.89)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C440(1.24); C441(1.24)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C440(1.16); C441(1.16)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C440(1.91); C441(1.91)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C440(1.05); C441(1.05)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C440(1.01); C441(1.01)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C440(1.13); C441(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C440(0.95); C441(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C440(1.15); C441(1.15)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C440(1.08); C441(1.08)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C440(1.14)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C440(1.02); C441(1.02)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C440(1.02); C441(1.02)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C440(0.76); C441(0.76)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C440(0.94); C441(0.94)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C440(0.80); C441(0.80)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C440(0.99); C441(0.99)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C440(1.67); C441(1.67)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C440(0.45); C441(0.45)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C440(0.39); C441(0.39)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C440(0.40); C441(0.40)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C440(1.03); C441(1.03); C470(0.85)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C440(0.31); C441(0.31)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C440(0.41); C441(0.41)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C440(0.43); C441(0.43)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C440(0.36); C441(0.36)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C440(0.50); C441(0.50)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C440(0.49); C441(0.49)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C440(0.55); C441(0.55)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C440(0.47); C441(0.47)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C440(0.78); C441(0.78)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C440(0.97); C441(0.97)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C440(0.98); C441(0.98); C470(0.97)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C440(0.86); C441(0.86)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C440(0.93); C441(0.93)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C440(0.75); C441(0.75)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C440(0.98); C441(0.98)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C440(0.97); C441(0.97)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C440(1.04); C441(1.04)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C440(0.96); C441(0.96)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C440(0.98); C441(0.98)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C440(1.01); C441(1.01)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C440(1.07); C441(1.07)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C440(0.96); C441(0.96); C470(0.76)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C440(0.67); C441(0.67)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C440(0.75); C441(0.75)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C440(1.42); C441(1.42)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C440(0.91); C441(0.91)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C440(0.91); C441(0.91)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C440(0.81); C441(0.81)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C440(0.98); C441(0.98)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C440(1.01); C441(1.01)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C440(0.87); C441(0.87)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C440(0.79); C441(0.79)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C440(1.30); C441(1.30)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C440(0.87); C441(0.87)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C440(0.99); C441(0.99)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C440(1.02); C441(1.02)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C440(0.74); C441(0.74)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C440(0.69); C441(0.69)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C440(0.87); C441(0.87)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C440(1.01); C441(1.01)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C440(0.95); C441(0.95)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C440(1.10); C441(1.10)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C440(1.01); C441(1.01); C470(0.97)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C440(1.07); C441(1.07); C470(1.03)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C440(0.81); C441(0.81); C470(0.76)  LDD0873  [2]
 LDCM0367  CL1 PaTu 8988t C470(0.99); C471(0.99)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C470(0.78); C471(0.78)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C440(1.46)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C440(0.86); C441(0.86); C470(0.73)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C440(0.85); C441(0.85); C470(0.79)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C440(1.09); C441(1.09); C470(0.71)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C440(1.01); C441(1.01); C470(0.93)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C440(0.78); C441(0.78)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C440(0.61); C441(0.61)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C440(0.69); C441(0.69)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C440(0.63); C441(0.63)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C440(0.76); C441(0.76)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C470(0.81); C471(0.81)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C440(0.74); C441(0.74)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C440(0.80); C441(0.80)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C441(1.82); C470(0.75)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C441(1.96); C470(0.74)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C441(1.67); C470(0.67)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C441(1.81); C470(0.67)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C441(2.45); C470(0.68)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C440(0.99); C441(0.99)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C440(1.04); C441(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C440(1.34); C441(1.34)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C470(0.85); C471(0.85)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C440(1.68); C441(1.68)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C440(2.52); C441(2.52)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C440(0.84); C441(0.84)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C440(0.85); C441(0.85)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C440(1.03); C441(1.03)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C440(0.76); C441(0.76)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C440(0.42); C441(0.42)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C440(0.41); C441(0.41)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C440(0.43); C441(0.43)  LDD0716  [2]
 LDCM0400  CL13 PaTu 8988t C470(0.98); C471(0.98)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C470(0.97); C471(0.97)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C470(0.87); C471(0.87)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C440(0.90); C441(0.90)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C440(0.92); C441(0.92)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C440(0.78); C441(0.78)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C440(0.99); C441(0.99)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C470(0.74); C471(0.74)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C440(0.78); C441(0.78)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C440(0.92); C441(0.92)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C440(0.88); C441(0.88)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C440(0.75); C441(0.75)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C440(0.88); C441(0.88)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C440(0.68); C441(0.68)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C440(0.75); C441(0.75)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C440(0.92); C441(0.92)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C440(0.81); C441(0.81)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C440(0.87); C441(0.87)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C470(0.71); C471(0.71)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C440(0.87); C441(0.87)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C470(0.87); C471(0.87)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C470(0.78); C471(0.78)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C470(0.91); C471(0.91)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C470(0.83); C471(0.83)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C470(0.77); C471(0.77)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C470(0.51); C471(0.51)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C470(0.86); C471(0.86)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C470(0.78); C471(0.78)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C470(0.71); C471(0.71)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C470(0.79); C471(0.79)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C470(0.80); C471(0.80)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C470(0.91); C471(0.91)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C470(1.03); C471(1.03)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C470(0.77); C471(0.77)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C470(0.72); C471(0.72)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C440(1.04); C441(1.04)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C440(0.88); C441(0.88)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C440(1.00); C441(1.00)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C440(1.04); C441(1.04)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C470(0.92); C471(0.92)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C440(0.86); C441(0.86)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C440(0.96); C441(0.96)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C440(1.10); C441(1.10)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C440(0.90); C441(0.90)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C440(0.99); C441(0.99)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C440(1.50); C441(1.50)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C440(0.93); C441(0.93)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C440(0.77); C441(0.77)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C440(0.99); C441(0.99)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C440(1.14); C441(1.14)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C470(0.98); C471(0.98)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C440(0.90); C441(0.90)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C440(1.03); C441(1.16); C470(0.83)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C440(1.13); C441(1.06); C470(0.78)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C440(1.17); C441(1.31); C470(0.64)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C440(0.73); C441(0.69); C470(0.83)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C440(1.19); C441(1.13); C470(0.90)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C440(1.15); C441(1.02); C470(0.82)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C440(0.96); C441(0.88); C470(0.90)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C440(1.68); C441(1.35); C470(0.85)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C440(0.95); C441(0.94); C470(0.81)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C470(0.95); C471(0.95)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C440(1.17); C441(1.11); C470(0.93)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C440(1.51); C441(1.16); C470(0.83)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C440(0.85); C441(0.73); C470(0.96)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C440(1.36); C441(0.85); C470(0.83)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C440(1.23); C441(0.84); C470(0.91)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C470(0.92)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C470(0.81)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C470(0.64)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C470(0.64)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C470(0.78); C471(0.78)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C470(0.74)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C470(0.71)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C470(1.00)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C470(0.92)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C470(0.70)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C470(0.68)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C470(0.59)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C470(0.66)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C470(0.81)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C470(0.77)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C470(0.92); C471(0.92)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C470(0.83)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C440(0.86)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C440(1.18)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C440(1.04)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C440(1.26)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C440(1.35)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C440(1.11)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C440(1.03)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C440(1.12)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C440(1.09)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C167(1.05); C350(0.93); C838(1.01); C440(0.96)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C405(2.30)  LDD1702  [10]
 LDCM0203  EV-96 T cell C405(7.45)  LDD0523  [11]
 LDCM0468  Fragment33 HEK-293T C440(1.14); C441(0.66); C470(0.80)  LDD1066  [2]
 LDCM0427  Fragment51 PaTu 8988t C470(0.80); C471(0.80)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C167(1.05); C838(1.10); C635(1.00); C350(1.11)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C167(1.03); C838(1.26); C635(1.01); C350(0.90)  LDD1497  [9]
 LDCM0024  KB05 IGR37 C167(2.76)  LDD3314  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
GTPase HRas (HRAS) Ras family P01112
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) PACSIN family Q9UKS6
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Sorting nexin-9 (SNX9) Sorting nexin family Q9Y5X1
Nebulin (NEB) . P20929
SH2/SH3 adapter protein NCK1 (NCK1) . P16333
SHC-transforming protein 1 (SHC1) . P29353

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840