Details of the Target

General Information of Target

Target ID LDTP00941
Target Name Zinc finger C3H1 domain-containing protein (ZFC3H1)
Gene Name ZFC3H1
Gene ID 196441
Synonyms
CCDC131; KIAA0546; PSRC2; Zinc finger C3H1 domain-containing protein; Coiled-coil domain-containing protein 131; Proline/serine-rich coiled-coil protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHS
ARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMP
SSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGA
GSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELE
CINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFE
LKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEK
KLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSA
KKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSN
QEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETS
SPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPP
LPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLN
NSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESD
GEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRL
LKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILL
MKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQ
QRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAE
LIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQD
KLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKP
ELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKP
CPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQ
WQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQ
MAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPE
NQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECS
ESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTF
LHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAI
LQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFV
MPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEA
AMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFF
ILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMF
NHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSR
NKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTL
ERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKG
QREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLN
SNKTESKNH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.
Uniprot ID
O60293
Ensemble ID
ENST00000378743.9
HGNC ID
HGNC:28328

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.E108Ter DBIA    Probe Info 
HCT15 SNV: p.H1531Q; p.D1548N .
HEC1B SNV: p.N1400I .
HEPG2 SNV: p.G339E .
HUH7 SNV: p.P579L .
IPC298 Substitution: p.L1749P DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Insertion: p.H836TfsTer2 DBIA    Probe Info 
JHH4 SNV: p.K870R DBIA    Probe Info 
JHH7 SNV: p.R316P .
L428 SNV: p.C220S DBIA    Probe Info 
LS180 Deletion: p.K385NfsTer9 DBIA    Probe Info 
MOLM16 SNV: p.H1442Y .
MOLT4 SNV: p.A1348T IA-alkyne    Probe Info 
NALM6 SNV: p.R1522Q DBIA    Probe Info 
NCIH1299 SNV: p.E844G .
NCIH2172 SNV: p.E625Ter .
OVK18 SNV: p.Q408H DBIA    Probe Info 
REH SNV: p.H1015R DBIA    Probe Info 
RH41 SNV: p.A1913G DBIA    Probe Info 
RKO SNV: p.V590A DBIA    Probe Info 
RL952 Insertion: p.Y559VfsTer35 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K441(10.00)  LDD0277  [2]
BTD
 Probe Info  		C1068(1.16)  LDD2094  [3]
AHL-Pu-1
 Probe Info  		C1379(2.02)  LDD0168  [4]
DBIA
 Probe Info  		C1864(19.59)  LDD0209  [5]
N1
 Probe Info  		N.A.  LDD0245  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1494(0.00); C1938(0.00); C220(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C1494(0.00); C1587(0.00); C1864(0.00); C1601(0.00)  LDD0037  [7]
IPM
 Probe Info  		C1379(0.00); C1141(0.00)  LDD0147  [8]
TFBX
 Probe Info  		C1778(0.00); C1494(0.00); C1864(0.00)  LDD0148  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		14.60  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1379(2.02)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C1405(2.20); C1379(3.26)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C1864(0.89); C1938(1.00)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C1184(0.52); C1186(0.52); C1405(0.89); C1864(1.30)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C1184(0.69); C1186(0.69); C1405(1.05); C1864(1.07)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C1184(0.81); C1186(0.81); C1405(1.17); C1864(0.86)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C1184(0.81); C1186(0.81); C1405(0.97); C1864(1.10)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C1184(0.82); C1186(0.82); C1405(1.10); C1864(1.15)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C1184(0.96); C1186(0.96); C1405(1.13); C1864(1.08)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C1184(0.98); C1186(0.98); C1405(1.01); C1864(1.38)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C1184(1.03); C1186(1.03); C1405(1.04); C1864(1.14)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C1184(0.79); C1186(0.79); C1405(1.05); C1864(0.81)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C1184(0.96); C1186(0.96); C1405(0.98); C1864(1.12)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C1184(0.95); C1186(0.95); C1405(0.99); C1864(0.88)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C1184(0.80); C1186(0.80); C1405(0.98); C1864(0.99)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C1184(0.82); C1186(0.82); C1405(1.05); C1864(1.13)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C1184(0.88); C1186(0.88); C1405(1.27); C1864(0.88)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C1184(0.99); C1186(0.99); C1405(1.25); C1864(1.26)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C1864(0.77)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C1864(1.09)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C1864(1.00)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C1864(0.99)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C1864(0.91)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C1864(0.99)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C1864(1.00)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C1184(0.67); C1186(0.67); C1405(1.09); C1864(1.32)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C1864(1.02)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C1864(1.11)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C1864(0.97)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C1864(1.06)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C1864(1.00)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C1864(1.17)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C1864(1.07)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C1864(1.02)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C1864(0.91)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C1864(0.96)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C1864(1.16)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C1864(1.32)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C1864(1.25)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C1864(1.30)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C1864(1.43)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C1864(1.54)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C1864(1.42)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C1864(1.10)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C1864(1.71)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C1864(1.16)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C1184(0.62); C1186(0.62); C1405(1.33); C1864(1.59)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C1864(1.70)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C1864(1.37)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C1864(1.51)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C1405(0.85); C1184(0.97); C1186(0.97)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C1184(0.79); C1186(0.79); C1405(0.82)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C1405(0.77); C1184(0.84); C1186(0.84)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C1405(0.77); C1184(1.00); C1186(1.00)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C1405(0.78); C1184(0.83); C1186(0.83)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C1405(0.76); C1184(1.04); C1186(1.04)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C1184(1.03); C1186(1.03); C1405(1.07)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C1184(0.69); C1186(0.69); C1864(0.90); C1405(1.23)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C1405(0.72); C1184(0.97); C1186(0.97)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C1405(0.75); C1184(0.86); C1186(0.86)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C1405(0.77); C1184(0.82); C1186(0.82)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C1405(0.86); C1184(0.95); C1186(0.95)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C1184(0.86); C1186(0.86); C1405(1.03)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C1184(0.76); C1186(0.76); C1405(0.98)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C1184(0.79); C1186(0.79); C1405(0.89)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C1184(0.80); C1186(0.80); C1405(0.80)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C1864(1.04)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C1864(1.24)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C1864(1.18)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C1864(0.74); C1938(0.86)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C1864(0.94)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C1864(1.26)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C1864(1.05)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C1864(1.08)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C1864(1.13)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C1864(0.87)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C1864(0.85)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C1864(0.74)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C1864(0.86)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C1864(0.84)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C1938(0.91); C1864(0.98)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C1864(0.80)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C1864(0.76)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C1864(0.85)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C1864(0.83)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C1864(0.80)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C1184(0.86); C1186(0.86); C1405(0.91)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C1405(0.76); C1184(0.92); C1186(0.92)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C1405(1.01); C1184(1.04); C1186(1.04)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C1184(0.83); C1186(0.83); C1405(0.99)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C1184(1.03); C1186(1.03); C1405(1.05)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C1864(0.95); C1938(1.01)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C1405(0.90); C1184(1.18); C1186(1.18)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C1405(0.91); C1184(0.93); C1186(0.93)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C1405(0.99); C1184(1.21); C1186(1.21)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C1405(0.78); C1184(0.79); C1186(0.79)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C1184(0.77); C1186(0.77); C1405(0.81)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C1405(0.67); C1184(1.19); C1186(1.19)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C1938(0.84); C1864(1.11)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C1864(1.01); C1938(1.02)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C1864(1.01); C1938(1.10)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C1938(0.93); C1864(1.03)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C1864(0.82); C1938(0.96)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C1864(1.21); C1938(1.33)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C1864(1.08); C1938(1.16)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C1938(0.99); C1864(1.07)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C1864(1.03); C1938(1.17)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C1864(1.00); C1938(1.19)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C1938(0.90); C1864(1.33)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C1938(1.09); C1864(1.35)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C1184(0.92); C1186(0.92)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C1184(1.09); C1186(1.09)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C1184(0.79); C1186(0.79)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C1184(0.60); C1186(0.60); C1864(0.89); C1405(1.11)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C1184(0.99); C1186(0.99)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C1184(1.19); C1186(1.19)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C1184(0.88); C1186(0.88)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C1184(0.93); C1186(0.93)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C1184(1.12); C1186(1.12)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C1184(0.85); C1186(0.85)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C1184(0.91); C1186(0.91)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C1184(0.75); C1186(0.75)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C1864(0.97); C1938(1.24)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C1938(1.11); C1864(1.24)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C1184(0.62); C1186(0.62); C1405(1.03); C1864(1.07)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C1864(0.96); C1938(1.01)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C1864(1.03); C1938(1.49)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C1938(1.09); C1864(1.21)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C1938(0.86); C1864(1.17)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C1864(1.10); C1938(1.26)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C1938(1.04); C1864(1.37)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C1864(0.89); C1938(1.07)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C1864(1.16); C1938(1.27)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C1938(0.88); C1864(1.05)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C1864(0.99); C1938(1.02)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C1184(0.48); C1186(0.48); C1405(1.06); C1864(1.20)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C1938(0.85); C1864(0.97)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C1864(1.04); C1938(1.05)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C1938(1.07); C1864(1.35)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C1864(0.62); C1184(0.79)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C1864(0.65); C1184(1.02)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C1864(0.76); C1184(0.82)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C1184(0.64); C1864(0.78)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C1184(0.79); C1864(0.84)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C1184(0.72); C1864(0.89)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C1184(0.66); C1864(0.77)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C1184(0.67); C1864(0.79)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C1864(0.68); C1184(0.75)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C1864(0.62); C1184(0.77)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C1184(0.92); C1864(0.94)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C1864(0.66); C1184(1.09)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C1864(0.92); C1184(1.05)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C1864(0.65); C1184(1.04)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C1184(0.70); C1864(0.92)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C1864(0.80); C1184(0.88); C1186(0.88); C1405(1.29)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C1184(0.84); C1186(0.84); C1405(0.87); C1864(0.88)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C1184(0.70); C1186(0.70); C1405(1.06); C1864(1.01)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C1184(0.60); C1186(0.60); C1405(1.13); C1864(1.56)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C1184(0.57); C1186(0.57); C1405(1.08); C1864(1.48)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.93  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C1184(0.60); C1186(0.60); C1938(0.97); C1864(1.04)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C1938(0.68); C1184(0.84); C1186(0.84); C1864(1.00)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C1938(0.80); C1864(0.97)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C1184(0.63); C1186(0.63); C1405(1.16); C1864(1.21)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C1184(0.54); C1186(0.54); C1405(0.82); C1864(1.66)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C1184(0.65); C1186(0.65); C1405(1.19); C1864(1.87)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C1184(0.59); C1186(0.59); C1405(1.07); C1864(1.69)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C1864(1.23)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C1864(1.37)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C1864(1.14)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C1864(1.02)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C1864(1.18)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C1184(0.64); C1186(0.64); C1938(0.81); C1864(1.10)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C1864(1.20)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C1864(0.93)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C1864(0.77)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C1864(0.80)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C1864(0.74)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C1864(0.80)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C1864(0.82)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C1405(0.82); C1184(1.15); C1186(1.15)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C1405(0.96); C1184(1.06); C1186(1.06)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C1405(0.94); C1184(1.16); C1186(1.16)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C1184(0.55); C1186(0.55); C1938(0.76); C1864(1.19)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C1405(0.92); C1184(1.04); C1186(1.04)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C1938(0.69); C1864(0.94)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C1938(0.92); C1864(1.05)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C1864(0.95); C1938(0.96)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C1938(0.99); C1864(1.01)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C1184(0.76); C1186(0.76)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C1184(1.16); C1186(1.16)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C1184(1.20); C1186(1.20)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C1184(0.77); C1186(0.77)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C1184(0.76); C1186(0.76); C1864(0.88); C1938(0.98)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C1184(0.86); C1186(0.86); C1938(0.90); C1864(1.09)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C1184(0.82); C1186(0.82); C1864(1.00); C1938(1.18)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C1864(0.68)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C1864(0.91)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C1864(0.86)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C1864(1.05)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C1184(0.68); C1186(0.68); C1938(1.08); C1864(1.10)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C1864(0.99)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C1864(0.81)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C1864(1.16)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C1864(0.84)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C1864(0.86)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C1864(0.93)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C1864(1.06)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C1864(0.82)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C1864(1.00)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C1864(1.03)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C1184(0.67); C1186(0.67); C1864(1.10); C1938(0.96)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C1864(1.23)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C1938(1.21)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C1864(0.77); C1938(1.04)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C1864(1.12); C1938(0.95)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C1864(0.84); C1938(0.95)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C1864(1.03); C1938(1.03)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C1864(1.15); C1938(0.56)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C1864(1.13); C1938(1.20)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C1864(1.25); C1938(1.41)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C1184(0.93); C1186(0.93); C1864(1.04); C1938(1.04)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C1864(0.54); C1938(1.17)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C1864(0.82); C1938(1.29)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C1864(1.20); C1938(1.20)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C1864(1.18); C1938(1.24)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C1864(0.57); C1938(1.15)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C1864(1.42); C1938(1.10)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C1405(1.02); C1864(1.36); C1938(0.68)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C1405(1.08); C1864(1.01); C1938(0.72)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C1405(1.33); C1864(1.16); C1938(0.78)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C1405(1.37); C1864(1.34); C1938(1.06)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C1184(0.73); C1186(0.73); C1864(1.06); C1938(1.21)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C1405(1.53); C1864(1.18); C1938(0.98)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C1405(0.98); C1864(1.47); C1938(0.83)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C1405(1.16); C1864(1.40); C1938(0.89)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C1405(2.25); C1864(1.19); C1938(1.06)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C1405(1.41); C1864(1.22); C1938(0.76)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C1405(1.30); C1864(1.06); C1938(0.90)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C1405(1.54); C1864(1.29); C1938(0.94)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C1405(1.14); C1864(1.03); C1938(1.01)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C1405(1.14); C1864(1.39); C1938(0.87)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C1405(1.03); C1864(1.14); C1938(0.95)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C1184(0.74); C1186(0.74); C1864(0.91); C1938(0.61)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C1405(1.15); C1864(1.41); C1938(0.85)  LDD0769  [11]
 LDCM0453  CL61 HEK-293T C1379(0.67); C1405(0.87)  LDD1051  [11]
 LDCM0454  CL62 HEK-293T C1379(0.80); C1405(1.14)  LDD1052  [11]
 LDCM0455  CL63 HEK-293T C1379(1.05); C1405(1.13)  LDD1053  [11]
 LDCM0456  CL64 HEK-293T C1379(0.89); C1405(1.13)  LDD1054  [11]
 LDCM0457  CL65 HEK-293T C1379(1.38); C1405(1.18)  LDD1055  [11]
 LDCM0458  CL66 HEK-293T C1379(1.05); C1405(1.29)  LDD1056  [11]
 LDCM0459  CL67 HEK-293T C1379(0.92); C1405(1.19)  LDD1057  [11]
 LDCM0460  CL68 HEK-293T C1379(1.37); C1405(1.17)  LDD1058  [11]
 LDCM0461  CL69 HEK-293T C1379(0.90); C1405(1.00)  LDD1059  [11]
 LDCM0462  CL7 HCT 116 C1184(0.65); C1186(0.65); C1864(0.99); C1938(0.94)  LDD0779  [11]
 LDCM0463  CL70 HEK-293T C1379(0.95); C1405(1.04)  LDD1061  [11]
 LDCM0464  CL71 HEK-293T C1379(1.04); C1405(1.10)  LDD1062  [11]
 LDCM0465  CL72 HEK-293T C1379(1.02); C1405(1.17)  LDD1063  [11]
 LDCM0466  CL73 HEK-293T C1379(1.16); C1405(1.07)  LDD1064  [11]
 LDCM0467  CL74 HEK-293T C1379(1.50); C1405(1.03)  LDD1065  [11]
 LDCM0469  CL76 HCT 116 C1184(1.06); C1186(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C1184(1.47); C1186(1.47)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C1184(0.88); C1186(0.88)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C1184(1.05); C1186(1.05)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C1184(0.66); C1186(0.66); C1864(1.12); C1938(1.17)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C1184(1.43); C1186(1.43)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C1184(1.23); C1186(1.23)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C1184(0.87); C1186(0.87)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C1184(1.17); C1186(1.17)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C1184(1.03); C1186(1.03)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C1184(1.02); C1186(1.02)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C1184(0.89); C1186(0.89)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C1184(1.05); C1186(1.05)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C1184(1.20); C1186(1.20)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C1184(1.15); C1186(1.15)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C1184(1.74); C1186(1.74); C1864(1.20); C1938(0.83)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C1184(1.27); C1186(1.27)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C1864(0.81); C1938(1.15)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C1864(0.87); C1938(1.46)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C1864(0.89); C1938(1.14)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C1864(0.85); C1938(1.26)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C1864(0.83); C1938(1.10)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C1864(0.82); C1938(1.12)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C1864(0.82); C1938(0.96)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C1864(1.04); C1938(0.86)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C1864(0.90); C1938(0.90)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C172(1.10); C1864(0.94); C241(1.21); C1938(1.04)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1494(3.38); C1816(1.48)  LDD1702  [3]
 LDCM0203  EV-96 T cell C1778(10.78)  LDD0523  [13]
 LDCM0204  EV-97 T cell C1778(20.00)  LDD0525  [13]
 LDCM0206  EV-99 T cell C1778(7.95)  LDD0521  [13]
 LDCM0574  Fragment12 Ramos C1379(0.89)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C1379(0.98)  LDD2192  [14]
 LDCM0579  Fragment20 Ramos C1379(0.81)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C1379(0.78)  LDD2195  [14]
 LDCM0578  Fragment27 Ramos C1379(0.68)  LDD2197  [14]
 LDCM0468  Fragment33 HEK-293T C1379(1.45); C1405(0.97)  LDD1066  [11]
 LDCM0596  Fragment38 Ramos C1379(0.72)  LDD2203  [14]
 LDCM0427  Fragment51 HCT 116 C1864(1.92); C1938(2.02)  LDD0744  [11]
 LDCM0022  KB02 HEK-293T C1587(1.00); C172(1.07); C1405(0.96); C1864(0.99)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C1864(19.59)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C1864(3.09)  LDD3310  [15]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1068(1.16)  LDD2094  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional activator Myb (MYB) . P10242

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840