Details of the Target

General Information of Target

Target ID LDTP12318
Target Name Calcium-independent phospholipase A2-gamma (PNPLA8)
Gene Name PNPLA8
Gene ID 50640
Synonyms
IPLA22; IPLA2G; Calcium-independent phospholipase A2-gamma; EC 3.1.1.-; EC 3.1.1.5; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFL
SKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYT
ASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENED
AGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQ
PTPQTIPAIDPALFNTISQGDVRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALK
LLTTGRE
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
Uniprot ID
Q9NP80
Ensemble ID
ENST00000257694.13
HGNC ID
HGNC:28900
ChEMBL ID
CHEMBL2189126

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.L313S .
JHH6 SNV: p.V20I .
MFE319 Deletion: p.M221CfsTer21 .
RKO Deletion: p.M221CfsTer21 .
RL SNV: p.N682D .
SUPT1 SNV: p.F393S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K769(0.74)  LDD0277  [1]
m-APA
 Probe Info  		12.02  LDD0403  [2]
DBIA
 Probe Info  		C714(1.71)  LDD3312  [3]
BTD
 Probe Info  		C559(1.00)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C714(2.07)  LDD0168  [5]
IA-alkyne
 Probe Info  		C645(0.00); C597(0.00)  LDD0165  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
PF-06672131
 Probe Info  		N.A.  LDD0152  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C643(0.00); C559(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.66  LDD1714  [13]
C106
 Probe Info  		16.11  LDD1793  [13]
C228
 Probe Info  		19.43  LDD1901  [13]
C243
 Probe Info  		13.83  LDD1916  [13]
C246
 Probe Info  		13.00  LDD1919  [13]
C270
 Probe Info  		7.36  LDD1940  [13]
C288
 Probe Info  		8.63  LDD1958  [13]
C293
 Probe Info  		32.00  LDD1963  [13]
C296
 Probe Info  		15.14  LDD1966  [13]
C343
 Probe Info  		14.93  LDD2005  [13]
C382
 Probe Info  		8.94  LDD2041  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C714(2.07)  LDD0168  [5]
 LDCM0214  AC1 HEK-293T C714(1.07); C100(1.17)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C714(1.00); C100(0.91)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C714(1.00); C100(0.95)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C714(1.00); C100(1.03)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C714(1.07); C645(0.94)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C714(0.97)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C714(1.12); C100(1.19)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C714(1.07); C100(0.93)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C714(0.87); C100(0.85)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C714(1.00); C100(0.97)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C714(1.02); C100(1.00)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C714(1.06); C100(0.86)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C714(1.01); C645(0.97)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C714(1.00)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C714(1.01); C100(0.95)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C714(1.02); C100(1.10)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C714(1.09); C100(0.90)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C714(1.02); C100(0.90)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C714(0.95); C100(0.95)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C714(1.13); C100(1.05)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C714(1.21); C100(0.88)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C714(0.99); C645(0.98)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C714(1.01)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C714(0.88); C100(0.72)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C714(1.14); C100(0.86)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C714(1.09); C100(0.87)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C714(0.92); C100(1.17)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C714(1.02); C100(0.89)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C714(1.03); C100(0.83)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C714(1.06); C645(0.76)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C714(1.01)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C714(0.95); C100(0.96)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C714(0.92); C100(1.20)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C714(1.13); C100(1.58)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C714(1.11); C100(1.09)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C714(0.93); C100(0.96)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C714(0.98); C100(0.99)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C714(1.06); C100(1.23)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C714(1.07); C645(1.19)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C714(1.02)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C714(0.90); C100(0.97)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C714(1.08); C100(1.02)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C714(1.03); C100(1.22)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C714(1.11); C100(0.90)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C714(1.03); C100(0.89)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C714(1.00); C100(0.82)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C714(1.06); C100(0.93)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C714(1.10); C645(0.91)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C714(1.00)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C714(0.95); C100(1.04)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C714(1.13); C100(0.96)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C714(1.04); C100(0.85)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C714(1.04); C100(0.95)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C714(1.09); C645(0.84)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C714(1.09); C100(0.99)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C714(1.09); C100(0.89)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C714(1.08); C645(0.99)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C714(0.95)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C714(0.94); C100(0.85)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C714(0.94)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C714(0.96); C100(1.06)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C714(1.01); C100(1.17)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C714(1.15); C100(1.04)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C714(0.98); C100(0.89)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.02  LDD0403  [2]
 LDCM0200  BPK-25 T cell C714(4.38)  LDD0529  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C714(1.12)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C714(1.34); C645(0.92)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C714(1.04)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C714(0.96)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C714(1.03); C100(1.62)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C714(0.94); C100(1.10)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C714(1.17)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C714(1.02)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C714(0.95); C100(1.12)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C714(0.94); C100(0.91)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C714(0.96)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C714(0.91)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C714(1.15)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C714(0.99); C100(1.64)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C714(0.91); C100(1.40)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C714(1.14)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C714(0.99)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C714(0.97); C100(3.09)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C714(1.04); C100(1.12)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C714(0.99)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C714(1.03)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C714(0.94); C100(1.08)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C714(0.99); C100(0.98)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C714(0.88); C100(1.02)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C714(1.04)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C714(1.01)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C714(1.09); C100(0.98)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C714(0.93); C100(1.32)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C714(1.10)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C714(1.15)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C714(0.87); C100(1.20)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C714(1.06); C100(1.16)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C714(0.97)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C714(1.20)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C714(0.99); C100(0.95)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C714(0.97); C100(2.65)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C714(1.13)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C714(1.13); C100(2.04)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C714(1.18); C100(1.00)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C714(0.97); C100(0.95)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C714(1.05); C100(0.86)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C714(1.20); C100(0.88)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C714(1.20); C100(1.70)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C714(1.15); C645(0.99)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C714(1.22)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C714(0.94); C100(1.00)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C714(0.93)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C714(0.91); C100(0.92)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C714(0.99); C100(1.22)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C714(0.96)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C714(1.06); C100(0.92)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C714(1.04); C100(1.35)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C714(1.10); C100(1.00)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C714(1.01); C100(1.02)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C714(1.08); C100(0.86)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C714(0.58); C100(1.59)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C714(1.15); C645(0.78)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C714(1.10)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C714(0.93); C100(1.14)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C714(1.02)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C714(1.06); C100(1.56)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C714(1.12)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C714(0.98)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C714(1.06); C100(1.60)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C714(1.13); C100(0.86)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C714(0.91); C100(1.15)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C714(1.09); C100(1.04)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C714(1.09); C100(1.45)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C714(1.14); C645(0.87)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C714(1.04)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C714(0.79); C100(1.03)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C714(1.01)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C714(1.20); C100(1.03)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C714(0.96); C100(1.28)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C714(0.95)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C714(1.20); C100(2.28)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C714(0.93); C100(2.15)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C714(0.60); C100(0.96)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C714(1.15); C100(0.96)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C714(1.12); C100(1.56)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C714(1.22); C645(0.97)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C714(1.18)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C714(1.14); C100(1.57)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C714(0.95); C100(1.06)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C714(1.06)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C714(0.97); C100(0.82)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C714(1.02); C100(0.96)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C714(0.95)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C714(1.07); C100(1.15)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C714(1.16); C100(1.20)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C714(1.03); C100(1.00)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C714(1.04); C100(1.02)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C714(1.09); C100(1.13)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C714(0.99); C100(0.99)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C714(1.11); C645(1.19)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C714(1.20)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C714(0.91); C100(1.21)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C714(0.95)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C714(0.96); C100(0.96)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C714(1.01)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C714(1.14); C100(2.06)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C714(1.07); C100(0.95)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C714(1.00); C100(1.12)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C714(1.14); C100(2.60)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C714(1.03); C100(0.99)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C714(1.11); C100(1.05)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C714(1.10); C645(0.82)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C714(1.00)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C714(0.96); C100(1.16)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C714(0.99)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C714(0.97); C100(0.97)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C714(1.07); C100(1.18)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C714(1.09)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C714(1.11); C100(0.98)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C714(1.09); C100(1.03)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C714(1.04); C100(1.92)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C714(0.92); C100(1.05)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C714(1.03); C100(1.13)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C714(1.07); C100(1.01)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C714(1.09); C645(0.81)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C714(1.11)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C714(0.84); C100(1.56)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C714(1.02)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C714(0.96); C100(1.22)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C714(0.94); C100(1.47)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C714(1.05); C100(1.51)  LDD1698  [14]
 LDCM0203  EV-96 T cell C714(5.24)  LDD0523  [15]
 LDCM0625  F8 Ramos C714(0.78)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C714(0.83)  LDD2189  [16]
 LDCM0574  Fragment12 Ramos C714(0.88)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C714(0.80)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C714(1.05)  LDD2193  [16]
 LDCM0580  Fragment21 Ramos C714(0.56)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C714(0.63)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C714(0.76)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C714(0.77)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C714(0.64)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C714(0.56)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C714(1.91)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C714(0.96); C100(0.99)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C714(0.32)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C714(1.09)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C714(1.05); C100(1.04)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C714(0.62)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C714(0.69)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C714(3.14)  LDD2186  [16]
 LDCM0022  KB02 HEK-293T C714(0.98)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C714(1.07)  LDD1497  [14]
 LDCM0024  KB05 HMCB C714(1.71)  LDD3312  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C559(1.00)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C559(0.68)  LDD2109  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C559(0.76)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C559(0.82)  LDD2136  [4]
 LDCM0131  RA190 MM1.R C714(1.65)  LDD0304  [17]

References

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Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD031019
9 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
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Mass spectrometry data entry: PXD027578
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.