Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name BPK-25  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05409  Antigen peptide transporter 2 (TAP2) C641 20.0
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) C21 20.0
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) C261 20.0
 LDTP12835  Large ribosomal subunit protein mL39 (MRPL39) C133 20.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C96 15.7
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 15.6
 LDTP00697  Cytochrome b5 type B (CYB5B) C115 8.0
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C431 7.1
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 4.9
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) C714 4.4
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210, C227 20.0
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870 5.3
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) C142 4.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C440 8.7
Other
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 19.9
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 14.6
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C157 12.9
 LDTP10992  Myeloid differentiation primary response protein MyD88 (MYD88) C203 11.8
 LDTP07718  MICOS complex subunit MIC27 (APOOL) C74 8.4
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C135 7.0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.