Details of the Target

General Information of Target

Target ID LDTP09841
Target Name Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3)
Gene Name ALG3
Gene ID 10195
Synonyms
NOT; NOT56L; Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; EC 2.4.1.258; Asparagine-linked glycosylation protein 3 homolog; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; Not56-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASA
EFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQG
LKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQ
QKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECS
GCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEI
LNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELH
ELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAI
SVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKT
SNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRE
NVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGN
ADLALLVLLAKNIVVPT
Target Bioclass
Enzyme
Family
Glycosyltransferase 58 family
Subcellular location
Endoplasmic reticulum membrane
Function Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
Uniprot ID
Q92685
Ensemble ID
ENST00000397676.8
HGNC ID
HGNC:23056

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q225Ter .
CHL1 SNV: p.Y257Ter .
HCT15 SNV: p.R311M DBIA    Probe Info 
HT SNV: p.A215T .
HT115 SNV: p.K327N DBIA    Probe Info 
NCIH716 SNV: p.Y257Ter .
SW620 SNV: p.Q26E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		14.12  LDD0196  [1]
STPyne
 Probe Info  		K22(10.00)  LDD0277  [2]
BTD
 Probe Info  		C21(1.06)  LDD2093  [3]
Johansson_61
 Probe Info  		_(15.05)  LDD1485  [4]
Alkyne-RA190
 Probe Info  		35.03  LDD0303  [5]
DBIA
 Probe Info  		C21(1.04)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		8.21  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C21(0.94)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C21(1.49)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C21(1.16)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C21(0.89)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C21(1.16)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C21(1.27)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C21(1.18)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C21(1.48)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C21(1.08)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C21(1.17)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C21(1.16)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C21(0.97)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C21(1.17)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C21(1.05)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C21(0.98)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C21(1.28)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C21(1.12)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C21(1.26)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C21(0.87)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C21(0.96)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C21(0.87)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C21(1.00)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C21(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C21(0.95)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C21(0.98)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C21(0.98)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C21(0.97)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C21(0.94)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C21(0.85)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C21(0.81)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C21(1.11)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C21(0.97)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C21(0.99)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C21(0.84)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C21(0.93)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C21(1.12)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C21(1.64)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C21(1.09)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C21(1.32)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C21(1.18)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C21(1.27)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C21(1.21)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C21(1.31)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C21(1.18)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C21(1.29)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C21(1.43)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C21(0.86)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C21(1.36)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C21(1.25)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C21(1.46)  LDD0579  [6]
 LDCM0263  AC143 HEK-293T C21(1.00)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C21(1.04)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C21(0.96)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C21(1.01)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C21(1.01)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C21(1.00)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C21(0.99)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C21(0.86)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C21(0.92)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C21(0.89)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C21(0.94)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C21(1.03)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C21(0.95)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C21(1.01)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C21(0.99)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C21(0.93)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C21(1.32)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C21(1.03)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C21(1.07)  LDD1517  [15]
 LDCM0279  AC2 HCT 116 C21(1.12)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C21(1.07)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C21(1.07)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C21(0.97)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C21(0.95)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C21(1.02)  LDD1523  [15]
 LDCM0285  AC25 HCT 116 C21(0.81)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C21(0.93)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C21(0.95)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C21(1.27)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C21(1.06)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C21(1.31)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C21(1.10)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C21(0.98)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C21(1.11)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C21(0.81)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C21(0.79)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C21(1.01)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C21(0.64)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C21(0.81)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C21(0.90)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C21(0.94)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C21(1.24)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C21(0.86)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C21(0.94)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C21(0.91)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C21(0.89)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C21(0.90)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C21(1.04)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C21(1.18)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C21(0.95)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C21(1.14)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C21(1.04)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C21(1.31)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C21(1.05)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C21(0.98)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C21(1.13)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C21(1.36)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C21(1.03)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C21(1.08)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C21(1.17)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C21(1.24)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C21(0.94)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C21(0.97)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C21(0.90)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C21(1.06)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C21(0.98)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C21(0.99)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C21(0.97)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C21(1.01)  LDD1567  [15]
 LDCM0332  AC68 HCT 116 C21(1.23)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C21(1.05)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C21(0.93)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C21(1.05)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C21(1.28)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C21(1.42)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C21(1.45)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C21(1.31)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C21(0.99)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C21(1.09)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C21(1.13)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C21(1.09)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C21(1.01)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C21(0.84)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C21(1.26)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C21(1.17)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C21(1.28)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C21(0.88)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C21(0.95)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C21(0.92)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C21(1.09)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C21(0.80)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C21(0.83)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C21(0.76)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C21(0.74)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C21(0.83)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C21(1.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C21(0.83)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C21(0.82)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C21(0.69)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C21(0.74)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C21(0.85)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C21(1.30)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C21(1.07)  LDD0683  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C21(0.75)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C21(0.89)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C21(0.88)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C21(0.88)  LDD0873  [6]
 LDCM0020  ARS-1620 HCC44 C21(1.04)  LDD0078  [6]
 LDCM0200  BPK-25 T cell C21(7.10)  LDD0516  [16]
 LDCM0367  CL1 HCT 116 C21(0.97)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C21(0.87)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C21(1.17)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C21(1.07)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C21(0.95)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C21(0.89)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C21(0.87)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C21(0.86)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C21(1.27)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C21(1.09)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C21(1.05)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C21(1.14)  LDD1582  [15]
 LDCM0379  CL11 HCT 116 C21(0.94)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C21(1.81)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C21(1.19)  LDD1585  [15]
 LDCM0382  CL112 HCT 116 C21(0.90)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C21(0.98)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C21(1.27)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C21(1.02)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C21(0.86)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C21(0.89)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C21(0.89)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C21(0.98)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C21(0.96)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C21(1.14)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C21(1.11)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C21(1.27)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C21(1.22)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C21(1.20)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C21(0.96)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C21(1.05)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C21(0.89)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C21(0.94)  LDD1603  [15]
 LDCM0400  CL13 HCT 116 C21(0.93)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C21(0.94)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C21(0.92)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C21(1.43)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C21(1.16)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C21(1.04)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C21(1.05)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C21(0.82)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C21(1.06)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C21(1.54)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C21(1.09)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C21(1.00)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C21(1.05)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C21(1.07)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C21(1.17)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C21(1.14)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C21(1.06)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C21(0.97)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C21(0.91)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C21(1.00)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C21(1.30)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C21(0.93)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C21(1.04)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C21(1.04)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C21(0.96)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C21(1.68)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C21(0.99)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C21(0.95)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C21(2.06)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C21(1.81)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C21(0.98)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C21(1.01)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C21(0.96)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C21(1.10)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C21(2.52)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C21(0.96)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C21(0.92)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C21(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C21(1.07)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C21(1.04)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C21(1.06)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C21(1.13)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C21(0.95)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C21(1.13)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C21(1.11)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C21(0.88)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C21(0.98)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C21(1.10)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C21(0.89)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C21(1.04)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C21(1.05)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C21(1.17)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C21(1.11)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C21(1.07)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C21(1.23)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C21(1.09)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C21(1.18)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C21(1.25)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C21(1.03)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C21(0.98)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C21(1.10)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C21(0.99)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C21(1.00)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C21(1.08)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C21(1.14)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C21(1.07)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C21(1.19)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C21(0.95)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C21(1.22)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C21(1.12)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C21(0.85)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C21(0.93)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C21(0.91)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C21(0.96)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C21(1.01)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C21(1.51)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C21(1.43)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C21(1.16)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C21(1.01)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C21(1.02)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C21(1.19)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C21(1.13)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C21(1.09)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C21(1.43)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C21(1.21)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C21(1.11)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C21(1.15)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C21(0.94)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C21(1.16)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C21(1.08)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C21(1.17)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C21(1.08)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C21(1.09)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C21(0.89)  LDD1698  [15]
 LDCM0202  EV-93 T cell C21(7.55)  LDD0514  [16]
 LDCM0203  EV-96 T cell C21(4.79)  LDD0523  [16]
 LDCM0625  F8 Ramos C21(1.85)  LDD2187  [17]
 LDCM0573  Fragment11 Ramos C21(4.71)  LDD2190  [17]
 LDCM0575  Fragment13 Ramos C21(0.84)  LDD2192  [17]
 LDCM0580  Fragment21 Ramos C21(0.95)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C21(0.48)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C21(0.50)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C21(0.33)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C21(1.38)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C21(1.23)  LDD2200  [17]
 LDCM0468  Fragment33 HCT 116 C21(1.21)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C21(2.33)  LDD2203  [17]
 LDCM0427  Fragment51 HCT 116 C21(4.93)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C21(1.46)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C21(0.96)  LDD2205  [17]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [4]
 LDCM0569  Fragment7 Jurkat _(15.05)  LDD1485  [4]
 LDCM0149  GA MCF-7 C21(2.77)  LDD0379  [18]
 LDCM0022  KB02 HEK-293T C21(0.71)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C21(23.58)  LDD0209  [19]
 LDCM0024  KB05 MEWO C21(3.41)  LDD3319  [20]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C21(1.06)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C21(0.64)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C21(0.86)  LDD2097  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C21(1.07)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C21(0.77)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C21(1.10)  LDD2107  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C21(1.38)  LDD2111  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C21(1.44)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C21(2.62)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C21(0.84)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C21(0.96)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C21(1.47)  LDD2124  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C21(1.37)  LDD2127  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C21(0.41)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C21(2.81)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C21(1.70)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C21(0.89)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C21(2.78)  LDD2140  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C21(0.84)  LDD2149  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C21(0.07)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C21(0.76)  LDD2207  [21]
 LDCM0131  RA190 SK-MEL-5 35.03  LDD0303  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDLR family Q07954
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3 (CREB3) BZIP family O43889
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterol-binding protein 1 (OSBP) OSBP family P22059
Oxysterol-binding protein-related protein 9 (OSBPL9) OSBP family Q96SU4
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Synaptophysin-like protein 1 (SYPL1) Synaptophysin/synaptobrevin family Q16563
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
19 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.