Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Alkyne-RA190  Probe Info 
Probe concentration 30 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name RA190  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Cutaneous melanoma [ICD-11:2B00]
Model Name Human cutaneous melanoma cells (SK-MEL-5)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) 35.0
 LDTP03599  Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) 31.3
 LDTP18083  Probable N-acetyltransferase 14 (NAT14) 28.0
 LDTP13367  Glutathione hydrolase 7 (GGT7) 16.4
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 7.1
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 5.1
 LDTP17587  Catechol O-methyltransferase domain-containing protein 1 (COMTD1) 4.4
 LDTP03676  ATP-binding cassette sub-family D member 1 (ABCD1) 3.8
 LDTP07323  Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2) 3.6
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 3.6
 LDTP01065  E3 ubiquitin-protein ligase TRIM13 (TRIM13) 3.4
 LDTP11127  ADP-dependent glucokinase (ADPGK) 3.0
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 2.7
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) 2.4
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 2.2
 LDTP09060  Ubiquitin-associated domain-containing protein 2 (UBAC2) 2.1
 LDTP12057  ATPase PAAT (PAAT) 2.1
 LDTP04303  Presenilin-1 (PSEN1) 2.1
Transporter and channel
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09502  Nuclear pore membrane glycoprotein 210 (NUP210) 30.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 7.1
 LDTP06490  Vesicle-associated membrane protein 3 (VAMP3) 5.9
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 2.6
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06495  Upstream stimulatory factor 2 (USF2) 2.9
 LDTP00351  Class E basic helix-loop-helix protein 40 (BHLHE40) 2.1
Other
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 132.4
 LDTP19425  Uncharacterized protein C12orf60 (C12orf60) 24.7
 LDTP13664  Syntaxin-8 (STX8) 5.0
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 2.8
 LDTP15110  Protein C3orf33 (C3orf33) 2.7
 LDTP16142  BET1-like protein (BET1L) 2.6
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 2.5
 LDTP15973  Melanoma-associated antigen H1 (MAGEH1) 2.5
 LDTP18863  Uncharacterized protein C15orf61 (C15orf61) 2.5
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 2.3
 LDTP00632  Syntaxin-7 (STX7) 2.2

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.