Details of the Target

General Information of Target

Target ID LDTP09060
Target Name Ubiquitin-associated domain-containing protein 2 (UBAC2)
Gene Name UBAC2
Gene ID 337867
Synonyms
PHGDHL1; Ubiquitin-associated domain-containing protein 2; UBA domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFTSTGSSGLYKAPLSKSLLLVPSALSLLLALLLPHCQKLFVYDLHAVKNDFQIWRLICG
RIICLDLKDTFCSSLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFLLIEAMQYFFGI
TAASNLPSGFLAPVFALFVPFYCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIW
IVAISGLMSGLCYDSKMFQVHQVLCIPSWMAKFFSWTLEPIFSSSEPTSEARIGMGATLD
IQRQQRMELLDRQLMFSQFAQGRRQRQQQGGMINWNRLFPPLRQRQNVNYQGGRQSEPAA
PPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
Uniprot ID
Q8NBM4
Ensemble ID
ENST00000376440.6
HGNC ID
HGNC:20486

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L28H; p.G98S .
DOTC24510 SNV: p.D107H .
DU145 SNV: p.G98V .
HCT116 SNV: p.G270E .
HUH7 Insertion: p.T238PfsTer18 .
SNGM SNV: p.L29M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.31  LDD0403  [1]
Curcusone 37
 Probe Info  		3.67  LDD0188  [2]
Alkyne-RA190
 Probe Info  		2.12  LDD0303  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
IA-alkyne
 Probe Info  		C205(3.74)  LDD2185  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C72(0.71)  LDD0532  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		14.03  LDD1782  [10]
C092
 Probe Info  		21.86  LDD1783  [10]
C094
 Probe Info  		41.64  LDD1785  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
OEA-DA
 Probe Info  		10.01  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C37(1.21)  LDD0812  [7]
 LDCM0215  AC10 HCT 116 C72(0.71)  LDD0532  [7]
 LDCM0216  AC100 HEK-293T C37(0.79)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C37(1.22)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C37(0.90)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C37(0.91)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C37(0.87)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C37(0.96)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C37(0.63)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C37(0.86)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C37(0.83)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C37(0.97)  LDD0823  [7]
 LDCM0226  AC11 HCT 116 C72(0.62)  LDD0543  [7]
 LDCM0227  AC110 HEK-293T C37(0.83)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C37(2.20)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C37(1.14)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C37(0.97)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C37(1.26)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C37(1.19)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C37(1.65)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C37(1.57)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C37(1.26)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C37(1.45)  LDD0834  [7]
 LDCM0237  AC12 HCT 116 C72(0.75)  LDD0554  [7]
 LDCM0238  AC120 HEK-293T C37(3.61)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C37(1.20)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C37(1.22)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C37(1.76)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C37(1.18)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C37(1.33)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C37(2.53)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C37(2.53)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C37(0.91)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C37(1.65)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C37(1.39)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C37(1.32)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C37(1.16)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C37(1.56)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C37(1.64)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C37(1.47)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C37(1.53)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C37(1.28)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C37(1.92)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C37(1.98)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C72(0.69)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C37(1.64)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C37(1.79)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C37(1.59)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C37(1.23)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C37(0.63)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C37(0.67)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C37(0.89)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C37(0.72)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C37(0.78)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C37(1.38)  LDD0867  [7]
 LDCM0270  AC15 HCT 116 C72(0.71)  LDD0587  [7]
 LDCM0271  AC150 HEK-293T C37(0.93)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C37(0.79)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C37(0.91)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C37(1.14)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C37(0.99)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C37(0.92)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C37(0.71)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C37(0.42)  LDD2165  [7]
 LDCM0276  AC17 PaTu 8988t C37(0.77)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C37(0.76)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C37(0.72)  LDD1157  [7]
 LDCM0279  AC2 HEK-293T C37(1.11)  LDD0877  [7]
 LDCM0280  AC20 PaTu 8988t C37(0.72)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C37(0.80)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C37(1.00)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C37(0.94)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C37(0.71)  LDD1163  [7]
 LDCM0285  AC25 HCT 116 C72(0.96)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C72(0.86)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C72(0.90)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C72(0.77)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C72(0.85)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C37(1.26)  LDD0888  [7]
 LDCM0291  AC30 HCT 116 C72(0.86)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C72(0.85)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C72(0.75)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C72(0.98)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C72(1.18)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C72(0.90)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C72(0.82)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C72(1.16)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C72(1.04)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C72(0.87)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C37(1.27)  LDD0899  [7]
 LDCM0302  AC40 HCT 116 C72(1.08)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C72(0.88)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C72(0.89)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C72(0.87)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C72(0.87)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C72(0.93)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C37(0.49)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C37(0.93)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C37(1.02)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C37(1.09)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C37(0.95)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C37(0.98)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C37(1.11)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C37(0.95)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C37(1.22)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C37(1.08)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C37(1.21)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C37(0.97)  LDD0917  [7]
 LDCM0320  AC57 HCT 116 C72(1.04)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C72(1.00)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C72(0.91)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C72(0.74)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C72(1.15)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C72(1.00)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C72(1.27)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C72(0.99)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C72(0.89)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C72(0.99)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C72(1.07)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C72(1.11)  LDD0648  [7]
 LDCM0332  AC68 HEK-293T C37(0.41)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C37(0.68)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C72(0.88)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C37(0.60)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C37(0.43)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C37(0.40)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C37(0.60)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C37(0.63)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C37(0.32)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C37(0.41)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C37(0.46)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C37(0.43)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C37(0.40)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C72(0.74)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C37(0.44)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C37(0.46)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C37(1.11)  LDD0946  [7]
 LDCM0349  AC83 HCT 116 C72(0.72)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C72(0.87)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C72(0.67)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C72(0.61)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C72(0.62)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C72(0.74)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C72(0.68)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C72(0.75)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C72(0.73)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C72(0.59)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C72(0.71)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C72(0.89)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C72(0.69)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C72(0.82)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C72(0.76)  LDD0681  [7]
 LDCM0365  AC98 HEK-293T C37(0.74)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C37(0.99)  LDD0964  [7]
 LDCM0248  AKOS034007472 HCT 116 C72(0.78)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C72(0.86)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C72(0.75)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.31  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 PaTu 8988t C37(0.88)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C37(0.88)  LDD1247  [7]
 LDCM0369  CL100 HEK-293T C37(1.35)  LDD0967  [7]
 LDCM0370  CL101 HCT 116 C72(0.67)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C72(0.70)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C72(0.93)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C72(0.80)  LDD0690  [7]
 LDCM0374  CL105 PaTu 8988t C37(0.75)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C37(0.69)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C37(1.10)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C37(0.90)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C37(0.87)  LDD1257  [7]
 LDCM0379  CL11 PaTu 8988t C37(1.27)  LDD1258  [7]
 LDCM0380  CL110 PaTu 8988t C37(0.83)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C37(0.84)  LDD1260  [7]
 LDCM0382  CL112 HCT 116 C72(0.90)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C72(0.91)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C72(0.87)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C72(0.88)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C72(0.89)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C72(1.03)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C72(0.93)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C72(1.22)  LDD0706  [7]
 LDCM0390  CL12 PaTu 8988t C37(0.81)  LDD1269  [7]
 LDCM0391  CL120 HCT 116 C72(0.99)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C37(1.03)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C37(0.92)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C37(1.37)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C37(1.71)  LDD0993  [7]
 LDCM0396  CL125 HCT 116 C72(1.24)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C72(1.08)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C72(0.98)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C72(1.47)  LDD0716  [7]
 LDCM0400  CL13 PaTu 8988t C37(1.28)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C37(0.96)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C37(0.92)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C37(0.65)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C37(0.89)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C37(1.04)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C37(1.05)  LDD1004  [7]
 LDCM0407  CL2 PaTu 8988t C37(0.91)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C37(1.88)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C37(1.89)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C37(2.09)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C37(1.10)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C37(1.29)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C37(0.94)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C37(2.61)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C37(1.05)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C37(1.10)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C37(2.30)  LDD1015  [7]
 LDCM0418  CL3 PaTu 8988t C37(0.70)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C37(2.09)  LDD1017  [7]
 LDCM0420  CL31 HCT 116 C72(1.28)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C72(0.84)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C72(1.29)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C72(1.58)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C72(2.23)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C72(1.30)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C72(1.46)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C72(1.16)  LDD0745  [7]
 LDCM0429  CL4 PaTu 8988t C37(1.00)  LDD1308  [7]
 LDCM0430  CL40 HCT 116 C72(1.27)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C72(1.04)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C72(1.46)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C72(1.55)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C72(1.41)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C72(1.14)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C37(0.81)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C37(0.71)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C37(0.71)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C37(0.72)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C37(1.09)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C37(0.65)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C37(0.76)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C37(0.65)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C37(0.66)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C37(0.70)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C37(0.73)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C37(0.25)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C37(0.84)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C37(0.82)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C37(0.82)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C37(0.84)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C37(0.74)  LDD1331  [7]
 LDCM0453  CL61 HEK-293T C37(1.17)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C37(1.34)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C37(1.31)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C37(2.42)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C37(1.13)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C37(1.53)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C37(1.06)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C37(1.55)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C37(1.54)  LDD1059  [7]
 LDCM0462  CL7 PaTu 8988t C37(1.08)  LDD1341  [7]
 LDCM0463  CL70 HEK-293T C37(1.52)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C37(1.86)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C37(1.49)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C37(1.58)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C37(1.64)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C37(0.95)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C37(1.70)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C37(1.04)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C37(1.29)  LDD1070  [7]
 LDCM0473  CL8 PaTu 8988t C37(1.31)  LDD1352  [7]
 LDCM0474  CL80 HEK-293T C37(1.06)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C37(1.19)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C37(0.99)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C37(0.98)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C37(1.23)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C37(1.02)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C37(1.13)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C37(1.03)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C37(1.19)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C37(1.06)  LDD1081  [7]
 LDCM0484  CL9 PaTu 8988t C37(0.89)  LDD1363  [7]
 LDCM0485  CL90 HEK-293T C37(1.35)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C37(1.50)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C37(5.49)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C37(1.21)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C37(1.86)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C37(2.61)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C37(1.72)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C37(1.55)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C37(1.39)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C37(1.76)  LDD1092  [7]
 LDCM0033  Curcusone1d MCF-7 3.67  LDD0188  [2]
 LDCM0495  E2913 HEK-293T C64(0.91); C205(0.92); C72(1.03)  LDD1698  [13]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0625  F8 Ramos C205(1.79)  LDD2187  [5]
 LDCM0468  Fragment33 HEK-293T C37(1.45)  LDD1066  [7]
 LDCM0427  Fragment51 HCT 116 C72(1.64)  LDD0744  [7]
 LDCM0569  Fragment7 Ramos C205(1.21)  LDD2186  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C64(0.87); C205(0.96); C72(1.00); C37(1.01)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C64(1.05); C205(0.99); C72(0.91); C37(0.92)  LDD1497  [13]
 LDCM0024  KB05 NCI-H1975 C64(6.78)  LDD3352  [14]
 LDCM0109  NEM HeLa N.A.  LDD0227  [6]
 LDCM0131  RA190 SK-MEL-5 2.12  LDD0303  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
FAS-associated factor 2 (FAF2) . Q96CS3
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840