Details of the Target

General Information of Target

Target ID LDTP00632
Target Name Syntaxin-7 (STX7)
Gene Name STX7
Gene ID 8417
Synonyms
Syntaxin-7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTN
QLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVA
RVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEA
DIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCI
IILILVIGVAIISLIIWGLNH
Target Bioclass
Other
Family
Syntaxin family
Subcellular location
Early endosome membrane
Function
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
Uniprot ID
O15400
Ensemble ID
ENST00000367937.4
HGNC ID
HGNC:11442

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.39  LDD0402  [1]
TH211
 Probe Info  		Y230(5.74)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K55(4.89)  LDD0277  [4]
ONAyne
 Probe Info  		K55(10.00)  LDD0275  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
DBIA
 Probe Info  		C28(0.73)  LDD3312  [6]
BTD
 Probe Info  		C28(3.82)  LDD1700  [7]
D5yne
 Probe Info  		3.76  LDD0055  [8]
Curcusone 37
 Probe Info  		2.58  LDD0188  [9]
Alkyne-RA190
 Probe Info  		2.17  LDD0303  [10]
HHS-475
 Probe Info  		Y69(1.37)  LDD0264  [11]
Acrolein
 Probe Info  		N.A.  LDD0221  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
W1
 Probe Info  		N.A.  LDD0236  [5]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.59  LDD1728  [16]
C040
 Probe Info  		7.84  LDD1740  [16]
C056
 Probe Info  		16.11  LDD1753  [16]
C161
 Probe Info  		9.78  LDD1841  [16]
C170
 Probe Info  		7.36  LDD1850  [16]
C187
 Probe Info  		16.00  LDD1865  [16]
C201
 Probe Info  		27.10  LDD1877  [16]
C231
 Probe Info  		13.74  LDD1904  [16]
C246
 Probe Info  		12.38  LDD1919  [16]
C278
 Probe Info  		61.82  LDD1948  [16]
C310
 Probe Info  		14.52  LDD1977  [16]
C348
 Probe Info  		14.83  LDD2009  [16]
C349
 Probe Info  		13.36  LDD2010  [16]
C350
 Probe Info  		44.02  LDD2011  [16]
C354
 Probe Info  		9.06  LDD2015  [16]
C362
 Probe Info  		37.27  LDD2023  [16]
C364
 Probe Info  		16.80  LDD2025  [16]
C388
 Probe Info  		39.40  LDD2047  [16]
C390
 Probe Info  		45.25  LDD2049  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]
Alk-rapa
 Probe Info  		2.98  LDD0213  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C28(0.59)  LDD2142  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C28(0.88)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C28(1.21)  LDD2152  [7]
 LDCM0214  AC1 HEK-293T C28(0.95)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C28(0.86)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C28(1.00)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C28(0.93)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C28(1.09)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C28(0.97)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C28(0.96)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C28(0.95)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C28(0.88)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C28(0.92)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C28(0.89)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C28(0.95)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C28(0.98)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C28(0.99)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C28(1.05)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C28(0.95)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C28(0.97)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C28(0.94)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C28(0.87)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C28(1.05)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C28(0.95)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C28(0.98)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C28(0.92)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C28(1.02)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C28(1.00)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C28(0.94)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C28(1.12)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C28(0.98)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C28(1.09)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C28(1.14)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C28(0.94)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C28(0.91)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C28(0.95)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C28(0.94)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C28(0.90)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C28(1.02)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C28(1.00)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C28(1.07)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C28(1.03)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C28(1.07)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C28(1.07)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C28(0.92)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C28(1.03)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C28(0.94)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C28(1.12)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C28(0.89)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C28(1.13)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C28(1.00)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C28(1.00)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C28(1.02)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C28(0.89)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C28(0.92)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C28(1.12)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C28(0.94)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C28(0.88)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C28(0.95)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C28(1.01)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C28(0.96)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C28(1.02)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C28(0.98)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C28(0.89)  LDD1569  [19]
 LDCM0520  AKOS000195272 MDA-MB-231 C28(0.76)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C28(1.10)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C28(0.97)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C28(0.95)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 12.44  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C28(0.93)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C28(0.89)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C28(1.03)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C28(0.95)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C28(0.88)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C28(1.01)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C28(1.02)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C28(0.98)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C28(0.91)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C28(1.05)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C28(0.90)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C28(0.95)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C28(0.93)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C28(0.89)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C28(0.94)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C28(0.98)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C28(1.01)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C28(0.90)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C28(0.97)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C28(0.91)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C28(1.00)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C28(1.02)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C28(1.00)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C28(1.04)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C28(1.06)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C28(1.00)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C28(0.95)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C28(0.97)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C28(0.70)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C28(0.99)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C28(0.94)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C28(0.95)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C28(0.92)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C28(0.96)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C28(0.93)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C28(0.94)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C28(1.06)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C28(0.87)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C28(0.94)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C28(1.21)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C28(0.96)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C28(1.02)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C28(1.00)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C28(1.10)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C28(0.96)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C28(1.00)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C28(0.90)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C28(1.00)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C28(0.98)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C28(0.94)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C28(0.97)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C28(1.00)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C28(1.00)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C28(0.91)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C28(0.93)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C28(1.01)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C28(1.05)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C28(1.04)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C28(1.01)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C28(0.99)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C28(1.07)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C28(1.04)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C28(1.02)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C28(0.89)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C28(0.90)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C28(1.07)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C28(0.91)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C28(1.04)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C28(1.02)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C28(1.04)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C28(1.10)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C28(1.05)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C28(1.00)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C28(0.95)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C28(0.95)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C28(0.87)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C28(0.79)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C28(1.05)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C28(0.96)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C28(1.15)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C28(1.04)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C28(1.08)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C28(0.87)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C28(1.07)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C28(1.04)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C28(1.06)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C28(1.07)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C28(0.92)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C28(0.90)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C28(1.00)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C28(1.03)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C28(0.98)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C28(1.10)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C28(1.17)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C28(1.10)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C28(1.06)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C28(1.14)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C28(1.01)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C28(1.01)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C28(1.08)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C28(0.83)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C28(0.99)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C28(1.07)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C28(0.68)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C28(1.00)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C28(1.04)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C28(1.02)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C28(0.93)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C28(0.94)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C28(0.98)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C28(1.06)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C28(1.00)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C28(1.07)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C28(1.04)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C28(1.11)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C28(0.90)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C28(1.12)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C28(0.94)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C28(1.06)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C28(0.96)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C28(0.86)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C28(0.93)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C28(0.95)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C28(0.91)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C28(1.00)  LDD1697  [19]
 LDCM0033  Curcusone1d MCF-7 2.58  LDD0188  [9]
 LDCM0095  DC-LC3IN-D5 HeLa 3.76  LDD0055  [8]
 LDCM0495  E2913 HEK-293T C28(1.05)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C28(0.95)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C28(1.05)  LDD1631  [19]
 LDCM0116  HHS-0101 DM93 Y69(1.37)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y69(0.82)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y69(1.41)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y69(1.03)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y69(1.24)  LDD0268  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C28(0.98)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C28(0.96)  LDD1497  [19]
 LDCM0024  KB05 HMCB C28(0.73)  LDD3312  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C28(0.83)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C28(0.66)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C28(1.33)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C28(0.71)  LDD2101  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C28(0.80)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C28(0.51)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C28(0.32)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C28(0.89)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C28(0.31)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C28(0.35)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C28(3.41)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C28(0.73)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C28(0.86)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C28(0.88)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C28(0.95)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C28(0.67)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C28(0.36)  LDD2134  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C28(1.15)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C28(0.83)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C28(3.82)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C28(1.10)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C28(0.46)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C28(5.70)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C28(0.32)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C28(1.03)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C28(0.38)  LDD2148  [7]
 LDCM0131  RA190 SK-MEL-5 2.17  LDD0303  [10]
 LDCM0090  Rapamycin JHH-7 2.98  LDD0213  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Ceramide synthase 4 (CERS4) . Q9HA82
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transporter and channel
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Gap junction gamma-3 protein (GJC3) Connexin family Q8NFK1
Receptor expression-enhancing protein 1 (REEP1) DP1 family Q9H902
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Vesicle-associated membrane protein 8 (VAMP8) Synaptobrevin family Q9BV40
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 205 (TMEM205) TMEM205 family Q6UW68
UDP-N-acetylglucosamine transporter TMEM241 (TMEM241) TMEM241 family Q24JQ0
Protrudin (ZFYVE27) . Q5T4F4
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 18 homolog (VPS18) VPS18 family Q9P253
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Leucine-rich single-pass membrane protein 2 (LSMEM2) . Q8N112
Transmembrane protein 267 (TMEM267) . Q0VDI3
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
9 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402