General Information of Experiment

Probe Name D5yne  Probe Info 
Probe concentration 5 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name DC-LC3IN-D5  Competitor Info 
Competitor Concentration 25 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 2.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 2.6
 LDTP05623  Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) 2.0
 LDTP03818  Phosphoglucomutase-1 (PGM1) 1.9
 LDTP03011  Casein kinase II subunit alpha' (CSNK2A2) 1.6
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 11.4
 LDTP05302  Interferon-induced transmembrane protein 3 (IFITM3) 1.6
Other
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11637  Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) 100.0
 LDTP00632  Syntaxin-7 (STX7) 3.8
 LDTP12891  Glycolipid transfer protein (GLTP) 3.7
 LDTP08389  Syntaxin-12 (STX12) 2.3
 LDTP09787  Nicastrin (NCSTN) 1.7
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) 1.7
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 1.6
 LDTP11210  Transmembrane protein 43 (TMEM43) 1.5

References

1 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874