Details of the Target

General Information of Target

Target ID LDTP05623
Target Name Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2)
Gene Name GALNT2
Gene ID 2590
Synonyms
Polypeptide N-acetylgalactosaminyltransferase 2; EC 2.4.1.41; Polypeptide GalNAc transferase 2; GalNAc-T2; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSN
GEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPD
TRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSND
PEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLER
VAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAP
IKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHV
FRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKK
LSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQ
EWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCL
DSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
Target Bioclass
Enzyme
Family
Glycosyltransferase 2 family, GalNAc-T subfamily
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism.
Uniprot ID
Q10471
Ensemble ID
ENST00000366672.5
HGNC ID
HGNC:4124
ChEMBL ID
CHEMBL3713355

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R532M .
CMK SNV: p.G27V .
COLO320 Insertion: p.V133GfsTer11 .
HCT116 SNV: p.F369S .
HCT15 SNV: p.Ter572QextTer19 .
HGC27 Deletion: p.N102TfsTer40 .
MFE319 SNV: p.S225T DBIA    Probe Info 
RKO SNV: p.R154W .
SBC5 SNV: p.Q561Ter DBIA    Probe Info 
SKMEL2 SNV: p.V209I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y408(13.82); Y99(12.16); Y434(6.81); Y367(6.16)  LDD0260  [1]
STPyne
 Probe Info  		K103(8.30); K363(7.33)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K103(2.75); K111(3.05); K509(3.50); K363(3.95)  LDD3494  [3]
THZ1-DTB
 Probe Info  		C229(1.11)  LDD0460  [4]
BTD
 Probe Info  		C126(0.65)  LDD2092  [5]
D5yne
 Probe Info  		1.98  LDD0055  [6]
Jackson_14
 Probe Info  		2.08  LDD0123  [7]
HPAP
 Probe Info  		3.29  LDD0062  [8]
DBIA
 Probe Info  		C345(0.94); C354(0.94)  LDD0078  [9]
ATP probe
 Probe Info  		K363(0.00); K491(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C496(0.00); C539(0.00); C423(0.00); C555(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C496(0.00); C539(0.00); C423(0.00); C555(0.00)  LDD0037  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
IPM
 Probe Info  		N.A.  LDD0147  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
Acrolein
 Probe Info  		C539(0.00); H145(0.00); H533(0.00); C496(0.00)  LDD0217  [17]
Cinnamaldehyde
 Probe Info  		C539(0.00); C126(0.00)  LDD0220  [17]
Crotonaldehyde
 Probe Info  		H57(0.00); C539(0.00); C126(0.00); H533(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C539(0.00); H57(0.00); C496(0.00); C126(0.00)  LDD0218  [17]
NAIA_5
 Probe Info  		C126(0.00); C496(0.00); C539(0.00); C229(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		8.69  LDD1977  [19]
FFF probe11
 Probe Info  		13.65  LDD0471  [20]
FFF probe12
 Probe Info  		20.00  LDD0473  [20]
FFF probe13
 Probe Info  		15.52  LDD0475  [20]
FFF probe9
 Probe Info  		20.00  LDD0470  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
OEA-DA
 Probe Info  		16.90  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C126(0.47)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C539(1.10)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C229(0.88)  LDD0812  [9]
 LDCM0215  AC10 HCT 116 C345(1.03); C354(1.03)  LDD0532  [9]
 LDCM0216  AC100 HEK-293T C227(1.09); C229(0.85)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C227(1.02); C229(0.91)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C227(0.97); C229(0.83)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C227(0.86); C229(0.72)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C227(1.01); C229(0.71)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C227(1.22); C229(2.36)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C227(1.36); C229(2.91)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C227(1.13); C229(0.76)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C227(1.62); C229(1.80)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C227(1.15); C229(1.24)  LDD0823  [9]
 LDCM0226  AC11 HCT 116 C345(0.82); C354(0.82)  LDD0543  [9]
 LDCM0227  AC110 HEK-293T C227(0.89); C229(1.11)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C227(0.76); C229(1.29)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C227(0.69); C229(1.04)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C227(1.11); C229(1.00); C345(1.61)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C227(1.19); C229(0.77); C345(1.76)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C227(0.93); C229(0.92); C345(0.79)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C227(0.98); C229(0.79); C345(0.96)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C227(0.86); C229(0.41); C345(0.37)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C227(0.95); C229(0.34); C345(0.50)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C227(0.77); C229(0.32); C345(0.40)  LDD0834  [9]
 LDCM0237  AC12 HCT 116 C345(1.03); C354(1.03)  LDD0554  [9]
 LDCM0238  AC120 HEK-293T C227(1.18); C229(0.36); C345(0.45)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C227(0.90); C229(0.39); C345(0.56)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C227(0.73); C229(0.40); C345(0.33)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C227(0.64); C229(0.40); C345(0.30)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C227(0.90); C229(0.35); C345(0.35)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C227(0.72); C229(0.36); C345(0.33)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C227(0.82); C229(0.50); C345(0.31)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C227(0.63); C229(0.55); C345(0.32)  LDD0843  [9]
 LDCM0246  AC128 HCT 116 C345(1.13); C354(1.13)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C345(1.07); C354(1.07)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C345(1.10); C354(1.10)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C345(1.14); C354(1.14)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C345(1.49); C354(1.49)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C345(1.37); C354(1.37)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C345(1.16); C354(1.16)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C345(1.10); C354(1.10)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C345(1.19); C354(1.19)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C345(1.14); C354(1.14)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C345(1.00); C354(1.00)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C345(1.28); C354(1.28)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C345(1.01); C354(1.01)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C345(1.15); C354(1.15)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C345(1.01); C354(1.01)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C345(1.25); C354(1.25)  LDD0579  [9]
 LDCM0263  AC143 HEK-293T C227(1.27)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C227(0.73)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C227(0.79)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C227(0.77)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C227(0.69)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C227(0.77)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C227(1.10)  LDD0867  [9]
 LDCM0270  AC15 HCT 116 C345(1.07); C354(1.07)  LDD0587  [9]
 LDCM0271  AC150 HEK-293T C227(0.91)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C227(0.80)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C227(0.95)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C227(0.89)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C227(0.95)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C227(0.95)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C227(0.71)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C227(0.69)  LDD2165  [9]
 LDCM0276  AC17 HCT 116 C345(1.15); C354(1.15)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C345(0.78); C354(0.78)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C345(1.04); C354(1.04)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C229(0.66)  LDD0877  [9]
 LDCM0280  AC20 HCT 116 C345(0.93); C354(0.93)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C345(1.03); C354(1.03)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C345(0.99); C354(0.99)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C345(1.06); C354(1.06)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C345(1.23); C354(1.23)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C345(1.09); C354(1.09)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C345(1.01); C354(1.01)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C345(0.89); C354(0.89)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C345(0.92); C354(0.92)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C345(1.12); C354(1.12)  LDD0606  [9]
 LDCM0290  AC3 HEK-293T C229(0.97)  LDD0888  [9]
 LDCM0291  AC30 HCT 116 C345(1.45); C354(1.45)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C345(1.17); C354(1.17)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C345(0.77); C354(0.77)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C345(0.88); C354(0.88)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C345(0.67); C354(0.67)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C345(0.92); C354(0.92)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C345(1.36); C354(1.36)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C345(1.15); C354(1.15)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C345(1.28); C354(1.28)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C345(1.10); C354(1.10)  LDD0617  [9]
 LDCM0301  AC4 HEK-293T C229(1.10)  LDD0899  [9]
 LDCM0302  AC40 HCT 116 C345(0.55); C354(0.55)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C345(1.04); C354(1.04)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C345(1.13); C354(1.13)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C345(1.36); C354(1.36)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C345(0.89); C354(0.89)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C345(0.53); C354(0.53)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C345(0.77); C354(0.77)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C345(0.94); C354(0.94)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C345(1.13); C354(1.13)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C345(0.24); C354(0.24)  LDD0628  [9]
 LDCM0312  AC5 HEK-293T C229(0.91)  LDD0910  [9]
 LDCM0313  AC50 HCT 116 C345(0.29); C354(0.29)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C345(1.47); C354(1.47)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C345(0.89); C354(0.89)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C345(0.54); C354(0.54)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C345(0.52); C354(0.52)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C345(0.32); C354(0.32)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C345(0.17); C354(0.17)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C227(1.03); C229(0.68); C345(0.94); C354(0.94)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C227(1.15); C229(0.69); C345(0.95); C354(0.95)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C227(1.15); C229(0.80); C345(0.97); C354(0.97)  LDD0920  [9]
 LDCM0323  AC6 HCT 116 C345(1.00); C354(1.00)  LDD0640  [9]
 LDCM0324  AC60 HEK-293T C227(0.82); C229(0.41); C345(0.81); C354(0.81)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C227(1.07); C229(0.41); C345(0.97); C354(0.97)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C227(1.15); C229(0.68); C345(1.05); C354(1.05)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C227(1.13); C229(0.50); C345(1.02); C354(1.02)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C227(1.12); C229(0.60); C345(1.14); C354(1.14)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C227(1.08); C229(0.43); C345(1.03); C354(1.03)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C227(1.03); C229(0.60); C345(0.93); C354(0.93)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C227(1.05); C229(0.59); C345(1.04); C354(1.04)  LDD0929  [9]
 LDCM0332  AC68 HCT 116 C345(1.16); C354(1.16)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C345(1.07); C354(1.07)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C345(1.11); C354(1.11)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C345(0.55); C354(0.55)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C345(1.95); C354(1.95)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C345(0.95); C354(0.95)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C345(0.25); C354(0.25)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C345(0.35); C354(0.35)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C345(0.22); C354(0.22)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C345(0.60); C354(0.60)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C345(0.68); C354(0.68)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C345(1.74); C354(1.74)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C345(1.38); C354(1.38)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C345(0.86); C354(0.86)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C345(0.76); C354(0.76)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C345(1.21); C354(1.21)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C345(0.21); C354(0.21)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C345(1.41); C354(1.41)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C345(1.20); C354(1.20)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C345(1.06); C354(1.06)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C345(1.14); C354(1.14)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C345(1.04); C354(1.04)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C345(1.21); C354(1.21)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C345(1.08); C354(1.08)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C345(1.17); C354(1.17)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C345(1.48); C354(1.48)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C345(1.35); C354(1.35)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C345(1.26); C354(1.26)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C345(0.97); C354(0.97)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C345(1.23); C354(1.23)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C345(1.32); C354(1.32)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C345(1.28); C354(1.28)  LDD0681  [9]
 LDCM0365  AC98 HEK-293T C227(1.21); C229(1.25)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C227(2.05); C229(1.83)  LDD0964  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C126(0.96)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C345(1.23); C354(1.23)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C345(1.10); C354(1.10)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C345(0.35); C354(0.35)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C345(0.94); C354(0.94)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C555(0.00); C539(0.00); C496(0.00); H145(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C227(0.83); C229(0.76); C354(0.73)  LDD0965  [9]
 LDCM0368  CL10 HEK-293T C227(0.59); C229(0.46); C354(0.76)  LDD0966  [9]
 LDCM0369  CL100 HEK-293T C229(0.75)  LDD0967  [9]
 LDCM0370  CL101 HCT 116 C345(1.02); C354(1.02)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C345(1.18); C354(1.18)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C345(1.17); C354(1.17)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C345(1.16); C354(1.16)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C345(1.06); C354(1.06)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C345(0.72); C354(0.72)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C345(0.76); C354(0.76)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C345(0.54); C354(0.54)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C345(1.17); C354(1.17)  LDD0695  [9]
 LDCM0379  CL11 HEK-293T C227(0.50); C229(0.33); C354(0.87)  LDD0977  [9]
 LDCM0380  CL110 HCT 116 C345(1.21); C354(1.21)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C345(1.11); C354(1.11)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C345(1.02); C354(1.02)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C345(0.93); C354(0.93)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C345(0.89); C354(0.89)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C345(1.11); C354(1.11)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C345(1.06); C354(1.06)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C345(0.25); C354(0.25)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C345(1.00); C354(1.00)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C345(0.74); C354(0.74)  LDD0706  [9]
 LDCM0390  CL12 HEK-293T C227(1.07); C229(0.72); C354(0.91)  LDD0988  [9]
 LDCM0391  CL120 HCT 116 C345(1.28); C354(1.28)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C345(0.84); C354(0.84)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C345(0.86); C354(0.86)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C345(0.51); C354(0.51)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C345(0.31); C354(0.31)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C227(0.87); C229(1.15); C345(0.93); C354(0.93)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C227(0.92); C229(0.51); C345(1.03); C354(1.03)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C227(1.42); C229(0.59); C345(0.96); C354(0.96)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C227(1.05); C229(0.70); C345(1.01); C354(1.01)  LDD0997  [9]
 LDCM0400  CL13 HEK-293T C227(0.89); C229(0.84); C354(0.95)  LDD0998  [9]
 LDCM0401  CL14 HEK-293T C227(0.81); C229(0.67); C354(1.45)  LDD0999  [9]
 LDCM0402  CL15 HEK-293T C227(0.61); C229(0.27); C354(0.84)  LDD1000  [9]
 LDCM0403  CL16 HEK-293T C227(1.16); C229(1.04)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C227(1.14); C229(0.83)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C227(1.28); C229(0.51)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C227(1.03); C229(0.71)  LDD1004  [9]
 LDCM0407  CL2 HEK-293T C227(0.89); C229(0.84); C354(1.06)  LDD1005  [9]
 LDCM0408  CL20 HEK-293T C227(1.21); C229(0.69)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C227(0.93); C229(0.41)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C227(1.00); C229(0.38)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C227(1.45); C229(0.85)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C227(1.58); C229(0.82)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C227(1.16); C229(0.63)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C227(1.40); C229(1.01)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C227(1.12); C229(0.72)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C227(2.31); C229(0.82)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C227(1.65); C229(0.72)  LDD1015  [9]
 LDCM0418  CL3 HEK-293T C227(0.78); C229(0.91); C354(1.04)  LDD1016  [9]
 LDCM0419  CL30 HEK-293T C227(1.02); C229(0.43)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C227(0.69); C354(0.87)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C227(0.92); C354(1.04)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C227(0.70); C354(1.56)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C227(0.85); C354(0.98)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C227(0.81); C354(0.97)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C227(0.85); C354(1.26)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C227(0.83); C354(0.96)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C227(0.58); C354(0.85)  LDD1026  [9]
 LDCM0429  CL4 HEK-293T C227(1.04); C229(0.73); C354(0.78)  LDD1027  [9]
 LDCM0430  CL40 HEK-293T C227(0.88); C354(0.83)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C227(0.61); C354(0.81)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C227(0.68); C354(0.92)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C227(0.65); C354(0.85)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C227(0.86); C354(0.94)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C227(0.62); C354(0.84)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C227(0.76); C229(0.51)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C227(0.88); C229(0.74)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C227(0.84); C229(0.88)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C227(0.85); C229(0.66)  LDD1037  [9]
 LDCM0440  CL5 HEK-293T C227(0.92); C229(0.52); C354(1.07)  LDD1038  [9]
 LDCM0441  CL50 HEK-293T C227(0.51); C229(0.37)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C227(0.82); C229(0.49)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C227(0.94); C229(1.33)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C227(0.75); C229(1.22)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C227(0.76); C229(0.59)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C227(0.76); C229(0.52)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C227(0.93); C229(0.88)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C227(0.82); C229(0.91)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C227(0.88); C229(0.90)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C227(0.75); C229(0.41)  LDD1048  [9]
 LDCM0451  CL6 HEK-293T C227(1.03); C229(0.70); C354(1.43)  LDD1049  [9]
 LDCM0452  CL60 HEK-293T C227(0.52); C229(0.41)  LDD1050  [9]
 LDCM0453  CL61 HCT 116 C345(0.97); C354(0.97)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C345(0.79); C354(0.79)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C345(0.83); C354(0.83)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C345(0.71); C354(0.71)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C345(0.99); C354(0.99)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C345(0.34); C354(0.34)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C345(0.60); C354(0.60)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C345(0.84); C354(0.84)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C345(1.27); C354(1.27)  LDD0778  [9]
 LDCM0462  CL7 HEK-293T C227(0.92); C229(0.30); C354(0.83)  LDD1060  [9]
 LDCM0463  CL70 HCT 116 C345(0.91); C354(0.91)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C345(0.72); C354(0.72)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C345(0.90); C354(0.90)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C345(0.91); C354(0.91)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C345(0.75); C354(0.75)  LDD0784  [9]
 LDCM0469  CL76 HEK-293T C227(1.16); C345(0.81); C354(0.81)  LDD1067  [9]
 LDCM0470  CL77 HEK-293T C227(0.78); C345(0.82); C354(0.82)  LDD1068  [9]
 LDCM0471  CL78 HEK-293T C227(1.13); C345(1.04); C354(1.04)  LDD1069  [9]
 LDCM0472  CL79 HEK-293T C227(1.26); C345(0.85); C354(0.85)  LDD1070  [9]
 LDCM0473  CL8 HEK-293T C229(0.68); C354(2.16)  LDD1071  [9]
 LDCM0474  CL80 HEK-293T C227(1.36); C345(0.77); C354(0.77)  LDD1072  [9]
 LDCM0475  CL81 HEK-293T C227(1.35); C345(0.72); C354(0.72)  LDD1073  [9]
 LDCM0476  CL82 HEK-293T C227(1.03); C345(0.87); C354(0.87)  LDD1074  [9]
 LDCM0477  CL83 HEK-293T C227(0.72); C345(0.95); C354(0.95)  LDD1075  [9]
 LDCM0478  CL84 HEK-293T C227(0.85); C345(0.82); C354(0.82)  LDD1076  [9]
 LDCM0479  CL85 HEK-293T C227(1.14); C345(0.80); C354(0.80)  LDD1077  [9]
 LDCM0480  CL86 HEK-293T C227(1.57); C345(0.90); C354(0.90)  LDD1078  [9]
 LDCM0481  CL87 HEK-293T C227(0.98); C345(0.89); C354(0.89)  LDD1079  [9]
 LDCM0482  CL88 HEK-293T C227(1.05); C345(0.76); C354(0.76)  LDD1080  [9]
 LDCM0483  CL89 HEK-293T C227(0.98); C345(1.22); C354(1.22)  LDD1081  [9]
 LDCM0484  CL9 HEK-293T C229(0.73); C354(1.27)  LDD1082  [9]
 LDCM0485  CL90 HEK-293T C227(0.72); C345(0.83); C354(0.83)  LDD1083  [9]
 LDCM0486  CL91 HEK-293T C229(1.00)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C229(0.84)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C229(0.94)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C229(0.44)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C229(0.31)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C229(0.84)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C229(0.95)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C229(0.93)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C229(1.01)  LDD1092  [9]
 LDCM0095  DC-LC3IN-D5 HeLa 1.98  LDD0055  [6]
 LDCM0495  E2913 HEK-293T C539(1.14); C354(1.07); C227(0.89)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C539(2.14)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C345(0.76); C354(0.76)  LDD0785  [9]
 LDCM0427  Fragment51 HEK-293T C227(1.07); C354(0.80)  LDD1025  [9]
 LDCM0107  IAA HeLa C539(0.00); H145(0.00); H58(0.00); H492(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C354(0.93); C229(1.11)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C354(0.87); C229(0.96)  LDD1497  [23]
 LDCM0024  KB05 COLO792 C496(1.44); C555(1.38)  LDD3310  [24]
 LDCM0109  NEM HeLa H57(0.00); H533(0.00); C539(0.00); H145(0.00)  LDD0223  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C126(0.65)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C126(0.39)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C126(1.02)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C126(0.74)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C126(0.71)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C126(0.90)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C539(1.63)  LDD2101  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C126(0.99)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C539(1.00)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C126(0.51)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C126(0.58)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C539(0.64); C126(0.56)  LDD2115  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C126(0.34)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C539(0.70); C126(0.50)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C539(0.67); C126(0.56)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C539(0.94); C126(0.34)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C539(0.82)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C539(1.01); C126(0.65)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C126(1.08)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C126(0.48)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C126(0.70)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C539(0.90)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C126(1.94)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C539(0.68)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C126(0.61)  LDD2148  [5]
 LDCM0014  Panhematin HEK-293T 3.29  LDD0062  [8]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [7]
 LDCM0021  THZ1 HeLa S3 C229(1.11)  LDD0460  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 3, mitochondrial (MRM3) RNA methyltransferase TrmH family Q9HC36
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) . Q9HC29
Protein KASH5 (KASH5) . Q8N6L0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840