Details of the Target

General Information of Target

Target ID LDTP12891
Target Name Glycolipid transfer protein (GLTP)
Gene Name GLTP
Gene ID 51228
Synonyms
Glycolipid transfer protein; GLTP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVL
PTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRG
CVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGMMFVNMTPCQLNVDFVVLLVYVLFL
MALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQRQPQWDDP
VVCIALVTNAWVFLLLYIVPELCILYRSCRQECPLQGNACPVTAYQHSFQVENQELSRAR
DSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV
Target Bioclass
Other
Family
GLTP family
Subcellular location
Cytoplasm
Function
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Uniprot ID
Q9NZD2
Ensemble ID
ENST00000318348.9
HGNC ID
HGNC:24867

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K66(1.46)  LDD0277  [1]
DBIA
 Probe Info  		C36(1.52)  LDD3314  [2]
D5yne
 Probe Info  		3.73  LDD0055  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C176(0.00); C36(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C176(0.00); C36(0.00); C112(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		C176(0.00); C112(0.00)  LDD2156  [6]
SF
 Probe Info  		N.A.  LDD0028  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		C112(0.00); C176(0.00); C36(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		73.01  LDD1753  [9]
C249
 Probe Info  		37.53  LDD1922  [9]
C303
 Probe Info  		5.94  LDD1972  [9]
C305
 Probe Info  		17.75  LDD1974  [9]
C326
 Probe Info  		46.85  LDD1990  [9]
C388
 Probe Info  		99.73  LDD2047  [9]
C390
 Probe Info  		34.54  LDD2049  [9]
C399
 Probe Info  		6.82  LDD2058  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C112(0.39)  LDD1093  [10]
 LDCM0215  AC10 PaTu 8988t C36(0.92)  LDD1094  [10]
 LDCM0226  AC11 PaTu 8988t C36(1.10)  LDD1105  [10]
 LDCM0230  AC113 PaTu 8988t C36(0.94)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C36(0.92)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C36(0.85)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C36(1.12)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C36(0.86)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C36(0.82)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C36(0.96)  LDD1115  [10]
 LDCM0237  AC12 PaTu 8988t C36(0.94)  LDD1116  [10]
 LDCM0238  AC120 PaTu 8988t C36(0.83)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C36(0.97)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C36(0.72)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C36(0.89)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C36(0.87)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C36(0.78)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C36(0.94)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C36(1.29)  LDD1124  [10]
 LDCM0259  AC14 PaTu 8988t C36(1.63)  LDD1138  [10]
 LDCM0263  AC143 PaTu 8988t C36(1.18); C112(0.83)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C36(1.10); C112(0.95)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C36(1.12); C112(0.95)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C36(1.58); C112(1.05)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C36(1.07); C112(0.88)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C36(1.10); C112(0.76)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C36(1.30); C112(0.87)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C36(1.13)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C36(1.07); C112(1.16)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C36(1.08); C112(0.87)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C36(1.09); C112(0.93)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C36(1.25); C112(0.85)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C36(1.15); C112(0.89)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C36(1.12); C112(0.93)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C36(1.03); C112(0.93)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C36(1.01); C112(1.10)  LDD2169  [10]
 LDCM0276  AC17 PaTu 8988t C112(0.48)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C112(0.40)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C112(0.50)  LDD1157  [10]
 LDCM0279  AC2 PaTu 8988t C112(0.46)  LDD1158  [10]
 LDCM0280  AC20 PaTu 8988t C112(0.49)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C112(0.39)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C112(0.39)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C112(0.38)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C112(0.33)  LDD1163  [10]
 LDCM0285  AC25 PaTu 8988t C112(1.41)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C112(1.17)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C112(1.15)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C112(1.06)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C112(1.14)  LDD1168  [10]
 LDCM0290  AC3 PaTu 8988t C112(0.47)  LDD1169  [10]
 LDCM0291  AC30 PaTu 8988t C112(1.07)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C112(1.30)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C112(0.94)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C112(0.93)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C112(0.98)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C36(0.92); C112(0.60)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C36(1.26); C112(0.45)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C36(1.17); C112(0.59)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C36(1.45); C112(0.51)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C36(1.28); C112(0.46)  LDD1179  [10]
 LDCM0301  AC4 PaTu 8988t C112(0.55)  LDD1180  [10]
 LDCM0302  AC40 PaTu 8988t C36(1.37); C112(0.41)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C36(1.18); C112(0.64)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C36(1.26); C112(0.57)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C36(1.26); C112(0.61)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C36(1.38); C112(0.53)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C36(1.53); C112(0.52)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C36(0.77); C112(0.87)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C36(0.82); C112(0.97)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C36(0.95); C112(0.66)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C36(0.84); C112(0.72)  LDD1190  [10]
 LDCM0312  AC5 PaTu 8988t C112(0.43)  LDD1191  [10]
 LDCM0313  AC50 PaTu 8988t C36(0.90); C112(0.73)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C36(0.92); C112(0.90)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C36(0.95); C112(0.74)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C36(1.12); C112(0.74)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C36(1.13); C112(0.69)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C36(0.92); C112(0.86)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C36(0.96); C112(0.79)  LDD1198  [10]
 LDCM0320  AC57 PaTu 8988t C36(1.06); C112(0.89)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C36(0.98); C112(0.87)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C36(0.87); C112(1.05)  LDD1201  [10]
 LDCM0323  AC6 PaTu 8988t C36(1.24)  LDD1202  [10]
 LDCM0324  AC60 PaTu 8988t C36(0.90); C112(0.91)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C36(1.00); C112(1.14)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C36(1.02); C112(1.01)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C36(0.95); C112(1.03)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C36(0.98); C112(1.05)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C36(0.93); C112(1.21)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C36(0.87); C112(0.92)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C36(0.92); C112(1.13)  LDD1210  [10]
 LDCM0332  AC68 PaTu 8988t C36(0.78); C112(1.34)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C36(1.00); C112(1.24)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C36(1.43)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C36(1.01); C112(1.20)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C36(0.84); C112(1.18)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C36(0.91); C112(1.39)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C36(0.97); C112(1.41)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C36(0.84); C112(1.42)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C36(0.93); C112(1.31)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C36(0.82); C112(1.38)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C36(0.87); C112(0.92)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C36(0.81); C112(1.34)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C36(0.77); C112(1.09)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C36(0.99)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C36(0.90); C112(1.48)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C36(0.89); C112(1.54)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C36(0.82); C112(1.47)  LDD1227  [10]
 LDCM0349  AC83 PaTu 8988t C112(1.90)  LDD1228  [10]
 LDCM0350  AC84 PaTu 8988t C112(1.40)  LDD1229  [10]
 LDCM0351  AC85 PaTu 8988t C112(1.93)  LDD1230  [10]
 LDCM0352  AC86 PaTu 8988t C112(1.47)  LDD1231  [10]
 LDCM0353  AC87 PaTu 8988t C112(1.48)  LDD1232  [10]
 LDCM0354  AC88 PaTu 8988t C112(1.53)  LDD1233  [10]
 LDCM0355  AC89 PaTu 8988t C112(2.04)  LDD1234  [10]
 LDCM0357  AC90 PaTu 8988t C112(1.93)  LDD1236  [10]
 LDCM0358  AC91 PaTu 8988t C112(1.16)  LDD1237  [10]
 LDCM0359  AC92 PaTu 8988t C112(1.39)  LDD1238  [10]
 LDCM0360  AC93 PaTu 8988t C112(2.39)  LDD1239  [10]
 LDCM0361  AC94 PaTu 8988t C112(1.46)  LDD1240  [10]
 LDCM0362  AC95 PaTu 8988t C112(1.53)  LDD1241  [10]
 LDCM0363  AC96 PaTu 8988t C112(1.81)  LDD1242  [10]
 LDCM0364  AC97 PaTu 8988t C112(2.23)  LDD1243  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C36(1.88)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C36(1.14)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C36(1.26)  LDD1154  [10]
 LDCM0632  CL-Sc Hep-G2 C176(20.00)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C176(1.01); C112(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C112(0.95); C36(1.13)  LDD1572  [11]
 LDCM0369  CL100 PaTu 8988t C112(0.49)  LDD1248  [10]
 LDCM0370  CL101 PaTu 8988t C36(1.06)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C36(1.12)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C36(1.45)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C36(1.64)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C112(0.59)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C112(0.49)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C112(0.50)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C112(0.59)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C112(0.50)  LDD1257  [10]
 LDCM0379  CL11 HEK-293T C176(1.08); C112(0.79); C36(0.85)  LDD1583  [11]
 LDCM0380  CL110 PaTu 8988t C112(0.46)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C112(0.39)  LDD1260  [10]
 LDCM0382  CL112 PaTu 8988t C112(1.01)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C112(1.36)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C112(1.18)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C112(1.30)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C112(0.81)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C36(1.22); C112(0.72)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C36(1.12); C112(0.73)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C36(1.21); C112(0.54)  LDD1268  [10]
 LDCM0390  CL12 HEK-293T C176(1.23); C112(1.03)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C36(1.28); C112(0.54)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C36(0.77); C112(1.10)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C36(0.80); C112(0.97)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C36(1.03); C112(0.71)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C36(1.08); C112(0.80)  LDD1274  [10]
 LDCM0396  CL125 PaTu 8988t C36(0.91); C112(0.98)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C36(0.85); C112(1.04)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C36(0.95); C112(0.97)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C36(1.00); C112(0.98)  LDD1278  [10]
 LDCM0400  CL13 HEK-293T C176(1.00); C112(1.01)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C176(1.22); C112(0.94); C36(1.07)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C176(0.97); C112(1.15)  LDD1606  [11]
 LDCM0403  CL16 PaTu 8988t C112(0.67)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C112(0.72)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C112(0.55)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C112(0.64)  LDD1285  [10]
 LDCM0407  CL2 HEK-293T C176(1.07); C112(0.96); C36(1.28)  LDD1611  [11]
 LDCM0408  CL20 PaTu 8988t C112(0.63)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C112(0.53)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C112(0.58)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C112(0.72)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C112(0.74)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C112(0.64)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C112(0.66)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C112(0.82)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C112(0.71)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C112(0.79)  LDD1296  [10]
 LDCM0418  CL3 HEK-293T C176(1.07); C112(1.12)  LDD1622  [11]
 LDCM0419  CL30 PaTu 8988t C112(0.57)  LDD1298  [10]
 LDCM0420  CL31 PaTu 8988t C36(0.99)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C36(1.03)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C36(0.68)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C36(1.12)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C36(1.16)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C36(0.72)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C36(1.34)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C36(1.10)  LDD1307  [10]
 LDCM0429  CL4 HEK-293T C176(1.03); C112(0.99)  LDD1633  [11]
 LDCM0430  CL40 PaTu 8988t C36(1.22)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C36(1.29)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C36(1.31)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C36(1.39)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C36(1.55)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C36(1.59)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C36(0.60); C112(0.91)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C36(1.08); C112(0.91)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C36(0.83); C112(0.71)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C36(0.64); C112(0.81)  LDD1318  [10]
 LDCM0440  CL5 HEK-293T C176(1.10); C112(0.97)  LDD1644  [11]
 LDCM0441  CL50 PaTu 8988t C36(0.91); C112(0.72)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C36(0.74); C112(0.78)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C36(0.75); C112(0.73)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C36(0.85); C112(0.63)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C36(0.67); C112(0.95)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C36(0.89); C112(0.71)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C36(1.36); C112(0.67)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C36(1.05); C112(0.74)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C36(0.78); C112(0.71)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C36(0.68); C112(0.75)  LDD1329  [10]
 LDCM0451  CL6 HEK-293T C176(1.15); C112(0.99)  LDD1654  [11]
 LDCM0452  CL60 PaTu 8988t C36(0.71); C112(0.94)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C112(0.77)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C112(0.77)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C112(0.82)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C112(0.66)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C112(0.73)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C112(0.74)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C112(0.59)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C112(0.54)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C112(0.54)  LDD1340  [10]
 LDCM0462  CL7 HEK-293T C176(1.04)  LDD1665  [11]
 LDCM0463  CL70 PaTu 8988t C112(0.58)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C112(0.74)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C112(0.95)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C112(0.49)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C112(0.60)  LDD1346  [10]
 LDCM0469  CL76 PaTu 8988t C112(0.74)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C112(0.71)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C112(0.66)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C112(0.64)  LDD1351  [10]
 LDCM0473  CL8 HEK-293T C112(0.73); C36(1.47)  LDD1676  [11]
 LDCM0474  CL80 PaTu 8988t C112(0.60)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C112(0.65)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C112(0.59)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C112(0.56)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C112(0.64)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C112(0.69)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C112(0.54)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C112(0.55)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C112(0.55)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C112(0.69)  LDD1362  [10]
 LDCM0484  CL9 HEK-293T C176(0.90); C112(0.92); C36(1.03)  LDD1687  [11]
 LDCM0485  CL90 PaTu 8988t C112(0.62)  LDD1364  [10]
 LDCM0486  CL91 PaTu 8988t C112(0.56)  LDD1365  [10]
 LDCM0487  CL92 PaTu 8988t C112(0.47)  LDD1366  [10]
 LDCM0488  CL93 PaTu 8988t C112(0.46)  LDD1367  [10]
 LDCM0489  CL94 PaTu 8988t C112(0.45)  LDD1368  [10]
 LDCM0490  CL95 PaTu 8988t C112(0.37)  LDD1369  [10]
 LDCM0491  CL96 PaTu 8988t C112(0.49)  LDD1370  [10]
 LDCM0492  CL97 PaTu 8988t C112(0.55)  LDD1371  [10]
 LDCM0493  CL98 PaTu 8988t C112(0.37)  LDD1372  [10]
 LDCM0494  CL99 PaTu 8988t C112(0.46)  LDD1373  [10]
 LDCM0634  CY-0357 Hep-G2 C176(1.79)  LDD2228  [5]
 LDCM0095  DC-LC3IN-D5 HeLa 3.73  LDD0055  [3]
 LDCM0495  E2913 HEK-293T C176(1.19); C112(1.32)  LDD1698  [11]
 LDCM0625  F8 Ramos C176(0.94); C112(3.01)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C176(1.09)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C176(2.03); C112(0.57)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C176(1.59)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C176(1.08)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C176(1.25); C112(0.81)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C176(1.44)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C176(1.12)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C176(1.59)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C176(1.14)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C176(0.50)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C176(1.23)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C176(0.89)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C176(1.07)  LDD2201  [12]
 LDCM0468  Fragment33 PaTu 8988t C112(0.68)  LDD1347  [10]
 LDCM0596  Fragment38 Ramos C176(1.34)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C176(0.63); C112(0.56)  LDD2184  [12]
 LDCM0427  Fragment51 PaTu 8988t C36(1.32)  LDD1306  [10]
 LDCM0610  Fragment52 Ramos C176(1.56)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C176(1.30)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C176(0.73); C112(0.52)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C176(2.62)  LDD2188  [12]
 LDCM0022  KB02 Ramos C176(1.06); C112(0.52)  LDD2182  [12]
 LDCM0023  KB03 Ramos C176(1.06); C112(1.58)  LDD2183  [12]
 LDCM0024  KB05 IGR37 C36(1.52)  LDD3314  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycolipid transfer protein (GLTP) GLTP family Q9NZD2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lactose Small molecular drug DB04465
Lauric Acid Small molecular drug DB03017
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Capric Acid Small molecular drug DB03600
Sphingosine Small molecular drug DB03203

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578