Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C326  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 106 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 66.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 64.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 64.4
 LDTP16026  Probable cysteine--tRNA ligase, mitochondrial (CARS2) 52.7
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 48.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 34.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 34.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 34.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 34.1
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 33.8
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 33.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 31.1
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 28.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 27.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 26.0
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 25.6
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 23.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 23.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 22.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.8
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 19.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 18.5
 LDTP02837  Beta-galactosidase (GLB1) 18.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 17.5
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 17.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 17.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.9
 LDTP05905  Acid ceramidase (ASAH1) 16.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 15.8
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 15.7
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 15.3
 LDTP02223  Cathepsin B (CTSB) 15.2
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 14.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 14.3
 LDTP06147  ATP-dependent RNA helicase DHX8 (DHX8) 14.1
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 14.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 13.9
 LDTP00988  Protein O-GlcNAcase (OGA) 13.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 13.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 13.4
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 13.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 13.2
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 12.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 12.4
 LDTP02505  Lysosomal protective protein (CTSA) 12.1
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 11.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 11.6
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 11.4
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 11.2
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 11.1
 LDTP02713  Macrophage migration inhibitory factor (MIF) 11.1
 LDTP02539  Lysosomal acid phosphatase (ACP2) 10.9
 LDTP10329  Ceramide synthase 2 (CERS2) 10.9
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 10.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 10.5
 LDTP02141  Alpha-galactosidase A (GLA) 10.3
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 10.3
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 10.1
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 9.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 9.4
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 9.4
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 9.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 9.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 9.2
 LDTP01769  Dihydrofolate reductase (DHFR) 9.1
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 9.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 9.1
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 8.8
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 8.8
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 8.7
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.4
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 8.3
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 8.3
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 8.2
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 8.2
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.1
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 8.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 7.9
 LDTP00316  Ribonuclease T2 (RNASET2) 7.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.6
 LDTP13793  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) 7.6
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 7.5
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 7.4
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 7.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.4
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 7.4
 LDTP03001  E3 ubiquitin-protein ligase TRIM21 (TRIM21) 7.4
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 7.3
 LDTP04581  Holocytochrome c-type synthase (HCCS) 7.3
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 7.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 7.3
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 7.2
 LDTP03730  Sepiapterin reductase (SPR) 7.2
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 7.2
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 7.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.0
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 7.0
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 7.0
 LDTP01803  Adenosine deaminase (ADA) 6.9
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 6.8
Transporter and channel
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 74.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 59.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 45.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 35.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 29.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 29.2
 LDTP16813  Tetraspanin-3 (TSPAN3) 28.6
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 27.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 24.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 22.0
 LDTP01804  ATP synthase subunit a (MT-ATP6) 21.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 21.0
 LDTP02215  Prosaposin (PSAP) 20.5
 LDTP05900  Metaxin-1 (MTX1) 18.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 18.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 16.4
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 16.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 16.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.9
 LDTP15648  BRI3-binding protein (BRI3BP) 15.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 15.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 14.6
 LDTP07236  Protein GPR107 (GPR107) 13.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.9
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 13.4
 LDTP01969  Transferrin receptor protein 1 (TFRC) 12.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 12.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 11.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 11.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 11.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 10.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 10.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 10.0
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 9.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 9.6
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 9.6
 LDTP10065  Transmembrane protein 230 (TMEM230) 9.6
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.3
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 9.3
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 8.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 8.9
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.8
 LDTP09949  Transportin-1 (TNPO1) 8.3
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 8.2
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 7.8
 LDTP11245  Derlin-1 (DERL1) 7.8
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.8
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 7.7
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 7.6
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 7.6
 LDTP06549  Hsp90 co-chaperone Cdc37 (CDC37) 7.5
 LDTP10513  Exocyst complex component 2 (EXOC2) 7.5
 LDTP14068  Cysteine protease ATG4B (ATG4B) 7.4
 LDTP06633  Reticulon-1 (RTN1) 7.4
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.3
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 7.2
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 7.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 6.9
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14205  Neuroplastin (NPTN) 8.2
Other
Click to Show/Hide to Show 66 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 60.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 48.2
 LDTP12891  Glycolipid transfer protein (GLTP) 46.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 31.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 23.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 22.9
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 19.2
 LDTP13086  Syntaxin-18 (STX18) 18.0
 LDTP08716  Abnormal spindle-like microcephaly-associated protein (ASPM) 16.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 16.4
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 14.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 14.5
 LDTP11825  Phosducin-like protein 3 (PDCL3) 14.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 14.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 13.7
 LDTP00105  Protein unc-119 homolog B (UNC119B) 13.7
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 13.6
 LDTP11643  Superkiller complex protein 8 (SKIC8) 13.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 13.1
 LDTP01652  Centrosomal protein 43 (CEP43) 13.0
 LDTP11076  Apolipoprotein L2 (APOL2) 12.9
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 12.1
 LDTP13630  Neudesin (NENF) 11.7
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 11.4
 LDTP01522  Reticulon-3 (RTN3) 11.3
 LDTP00417  Programmed cell death protein 5 (PDCD5) 11.2
 LDTP06097  Reticulocalbin-2 (RCN2) 11.1
 LDTP12412  Reticulon-4 (RTN4) 11.1
 LDTP00573  Prefoldin subunit 6 (PFDN6) 11.0
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 10.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 10.5
 LDTP01075  Protein CutA (CUTA) 10.2
 LDTP10056  Protein FAM162A (FAM162A) 10.1
 LDTP00859  Synaptogyrin-2 (SYNGR2) 9.7
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 9.6
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 9.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 9.4
 LDTP00887  Calumenin (CALU) 9.4
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 9.3
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 9.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 8.8
 LDTP14259  Testis-expressed protein 264 (TEX264) 8.8
 LDTP00691  TELO2-interacting protein 1 homolog (TTI1) 8.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 8.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 8.5
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 8.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.4
 LDTP01359  Dynactin subunit 3 (DCTN3) 8.3
 LDTP03775  RNA-binding protein FUS (FUS) 8.3
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 8.2
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 8.2
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 8.0
 LDTP02927  Ganglioside GM2 activator (GM2A) 7.8
 LDTP05226  RNA-binding protein 3 (RBM3) 7.8
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 7.7
 LDTP06210  Golgin subfamily B member 1 (GOLGB1) 7.6
 LDTP05375  Nucleobindin-1 (NUCB1) 7.5
 LDTP05277  Protein SET (SET) 7.4
 LDTP05868  Protein unc-119 homolog A (UNC119) 7.3
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 7.3
 LDTP11695  Kinesin light chain 2 (KLC2) 7.2
 LDTP01167  Reticulon-2 (RTN2) 7.1
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 7.0
 LDTP02180  Neurofilament light polypeptide (NEFL) 6.9
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 6.8
 LDTP04703  Tumor protein D52 (TPD52) 6.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587