Details of the Target

General Information of Target

Target ID LDTP16026
Target Name Probable cysteine--tRNA ligase, mitochondrial (CARS2)
Gene Name CARS2
Gene ID 79587
Synonyms
Probable cysteine--tRNA ligase, mitochondrial; EC 6.1.1.16; Cysteinyl-tRNA synthetase; CysRS
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEELLRRELGCSSVRATGHSGGGCISQGRSYDTDQGRVFVKVNPKAEARRMFEGEMASLT
AILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADLHLDNKKLGEM
RLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMV
EKESGDREALQLWSALQLKIPDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYG
HSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWNHFGSGYRGSS
LNIMRNLVK
Target Bioclass
Enzyme
Family
Class-I aminoacyl-tRNA synthetase family
Subcellular location
Mitochondrion matrix
Function
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).; In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Uniprot ID
Q9HA77
Ensemble ID
ENST00000257347.9
HGNC ID
HGNC:25695

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K198(6.14); K407(6.72); K439(0.14)  LDD0277  [1]
BTD
 Probe Info  		C387(0.75)  LDD2089  [2]
DBIA
 Probe Info  		C387(1.11)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		C387(0.00); C526(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NHS
 Probe Info  		N.A.  LDD0010  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
1c-yne
 Probe Info  		N.A.  LDD0228  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
NAIA_5
 Probe Info  		C387(0.00); C526(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		25.46  LDD1845  [11]
C326
 Probe Info  		52.71  LDD1990  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]
DA-2
 Probe Info  		N.A.  LDD0071  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C387(0.44)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C387(0.65)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C387(0.81)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C387(1.11)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C387(0.83)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C387(0.66)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C387(1.21)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C387(1.14)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C387(0.77)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C387(1.20)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C387(1.26)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C387(1.38)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C387(1.05)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C387(0.95)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C387(1.21)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C387(1.54)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C387(1.21)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C387(1.50)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C387(1.15)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C387(1.29)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C387(1.68)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C387(1.30)  LDD0562  [3]
 LDCM0246  AC128 PaTu 8988t C526(1.26)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C526(1.41)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C526(1.50)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C526(1.30)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C526(1.08)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C526(1.71)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C526(1.49)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C526(1.22)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C526(1.30)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C526(1.56)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C526(1.32)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C526(1.14)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C387(1.01)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C526(1.69)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C526(1.35)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C526(1.63)  LDD1141  [3]
 LDCM0270  AC15 HCT 116 C387(1.20)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C387(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C387(1.15)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C387(0.74)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C387(1.21)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C387(0.91)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C387(0.79)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C387(0.85)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C387(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C387(0.89)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C387(0.90); C526(0.92)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C387(0.90)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C387(1.02)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C387(0.99); C526(0.96)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C387(1.03); C526(0.94)  LDD1528  [15]
 LDCM0290  AC3 HCT 116 C387(1.28)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C387(0.99); C526(0.81)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C387(1.07); C526(1.02)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C387(0.95); C526(0.96)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C387(0.96); C526(0.99)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C387(1.07)  LDD1534  [15]
 LDCM0296  AC35 PaTu 8988t C526(0.97)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C526(1.09)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C526(1.04)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C526(1.10)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C526(1.16)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C387(0.94)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C526(1.22)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C526(1.43)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C526(0.95)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C526(1.25)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C526(1.33)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C526(1.19)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C526(1.14)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C526(1.17)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C526(1.20)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C526(1.76)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C387(0.99)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C526(1.73)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C526(0.36)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C526(1.28)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C526(2.27)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C526(1.79)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C526(1.43)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C526(1.59)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C387(0.95); C526(1.00)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C387(1.06)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C387(1.09)  LDD1561  [15]
 LDCM0323  AC6 HCT 116 C387(1.08)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C387(1.03); C526(1.13)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C387(0.99); C526(0.92)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C387(1.02); C526(0.89)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C387(1.04); C526(1.03)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C387(1.05); C526(0.97)  LDD1567  [15]
 LDCM0332  AC68 HCT 116 C387(1.00)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C387(1.12)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C387(0.91)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C387(1.11)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C387(1.20)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C387(1.17)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C387(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C387(1.06)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C387(0.77)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C387(0.74)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C387(0.88)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C387(1.15)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C387(1.35)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C387(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C387(0.80)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C387(0.97)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C387(1.21)  LDD0665  [3]
 LDCM0545  Acetamide MDA-MB-231 C387(0.57)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C387(0.85)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C387(0.83)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C387(1.29)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 PaTu 8988t C526(0.91)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C526(1.40)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C387(1.12)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C387(1.07)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C387(1.21)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C387(0.68)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C387(1.33)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C387(0.76)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C387(1.01)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C387(0.96)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C387(1.01)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C387(0.85)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C526(0.98)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C387(1.14)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C387(1.03)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C387(0.94); C526(0.85)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C387(1.09); C526(1.03)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C387(0.89); C526(0.97)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C387(1.03); C526(1.04)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C387(0.91); C526(0.96)  LDD1590  [15]
 LDCM0387  CL117 PaTu 8988t C526(1.01)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C526(1.01)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C526(0.96)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C526(1.37)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C526(0.88)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C526(1.15)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C526(1.31)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C526(1.52)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C526(1.87)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C387(1.01); C526(0.98)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C387(1.02); C526(0.99)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C387(1.02); C526(0.96)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C387(0.98); C526(1.01)  LDD1603  [15]
 LDCM0400  CL13 PaTu 8988t C526(1.27)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C526(1.05)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C526(1.03)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C526(1.45)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C526(1.69)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C526(1.29)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C526(1.53)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C526(1.09)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C526(1.35)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C526(1.56)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C526(1.32)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C526(1.22)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C526(1.24)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C526(1.20)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C526(1.58)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C526(1.64)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C526(1.36)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C526(1.24)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C526(1.10)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C526(1.70)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C387(1.21)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C387(0.98)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C387(0.91)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C387(0.80)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C387(1.54)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C387(1.53)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C387(1.49)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C387(1.29)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C526(1.00)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C387(1.77)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C387(1.02)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C387(1.24)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C387(0.79)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C387(0.82)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C387(1.04)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C387(0.79)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C387(0.81)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C387(0.88)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C387(1.02)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C526(0.98)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C387(0.94)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C387(0.89)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C387(0.92)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C387(0.74)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C387(0.78)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C387(0.78)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C387(0.84)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C387(1.15)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C387(0.86)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C387(0.84)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C526(1.22)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C387(0.83)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C387(1.15)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C387(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C387(1.04)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C387(1.19)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C387(1.31)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C387(1.04)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C387(1.05)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C387(1.08)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C387(0.95)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C526(1.13)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C387(1.13)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C387(1.07)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C387(1.24)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C387(1.17)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C387(1.14)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C387(0.94); C526(0.99)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C387(0.88); C526(0.95)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C387(1.06)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C387(1.10)  LDD1675  [15]
 LDCM0473  CL8 PaTu 8988t C526(1.46)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C387(1.10); C526(1.07)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C387(1.13); C526(1.04)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C387(1.15); C526(0.92)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C387(1.07); C526(1.14)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C387(1.01); C526(1.06)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C387(1.01); C526(0.95)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C387(0.93); C526(0.80)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C387(1.00); C526(0.96)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C387(1.04); C526(0.86)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C387(0.96); C526(1.08)  LDD1686  [15]
 LDCM0484  CL9 PaTu 8988t C526(1.39)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C387(0.75)  LDD1688  [15]
 LDCM0486  CL91 HCT 116 C387(1.26)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C387(0.89)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C387(0.98)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C387(0.77)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C387(0.76)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C387(0.83)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C387(1.04)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C387(1.39)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C387(1.20)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C387(0.99); C526(1.04)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C387(1.24); C526(1.23)  LDD1702  [2]
 LDCM0625  F8 Ramos C387(0.90)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C387(0.74)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C387(0.80)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C387(0.85)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C387(2.27)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C387(0.98)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C387(0.69)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C387(1.00)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C387(1.01)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C387(0.96)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C387(0.44)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C387(1.22)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C387(1.25)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C387(0.74)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C387(1.16)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C387(1.15)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C387(0.77)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C387(1.63)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C387(1.53)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C387(1.60)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C387(0.62)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C387(0.69)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C387(0.95); C526(1.02)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C387(0.95); C526(0.98)  LDD1497  [15]
 LDCM0024  KB05 HMCB C387(1.01)  LDD3312  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C387(0.50)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C387(0.75)  LDD2089  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C387(0.89)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C387(0.64)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C387(0.98)  LDD2111  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C387(0.77)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C387(0.98)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C387(1.12)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C387(0.99)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C387(1.06)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C387(1.15)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C387(1.13)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C387(0.94)  LDD2137  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C387(0.97)  LDD2143  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C387(1.23)  LDD2147  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C387(0.53)  LDD2150  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cysteine Small molecular drug DB00151

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840