Details of the Target

General Information of Target

Target ID	LDTP01745
Target Name	Putative lipid scramblase CLPTM1 (CLPTM1)
Gene Name	CLPTM1
Gene ID	1209
Synonyms	Putative lipid scramblase CLPTM1; Cleft lip and palate transmembrane protein 1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAAQEADGARSAVVAAGGGSSGQVTSNGSIGRDPPAETQPQNPPAQPAPNAWQVIKGVL FRIFIIWAISSWFRRGPAPQDQAGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNA TSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPR QKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHP NITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLAS LPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETNPYLLALT IIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQ VSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPRLSFKDKSTYIESSTKVYDDMAFRYLS WILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLP WRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGM SGEDPTAAAPVAEVPTAAGALTPTPAPTTTTATREEASTSLPTKPTQGASSASEPQEAPP KPAEDKKKD
Target Bioclass	Transporter and channel
Family	CLPTM1 family
Subcellular location	Membrane
Function	Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development.
Uniprot ID	O96005
Ensemble ID	ENST00000337392.10
HGNC ID	HGNC:2087

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A2058	SNV: p.D459N	DBIA Probe Info
FTC133	SNV: p.V590I	.
HEC1	SNV: p.D130G	DBIA Probe Info
Ishikawa (Heraklio) 02 ER	SNV: p.T121A	DBIA Probe Info
JURKAT	SNV: p.H106Y	.
LNCaP clone FGC	Deletion: p.L287CfsTer59	.
MFE319	SNV: p.G144D	DBIA Probe Info
NCIH446	SNV: p.R94L	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 16 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
HDSF-alk Probe Info	2.75	LDD0197	[1]
FBPP2 Probe Info	2.08	LDD0318	[2]
CHEMBL5175495 Probe Info	7.48	LDD0196	[3]
CY-1 Probe Info	100.00	LDD0243	[4]
CY4 Probe Info	100.00	LDD0244	[4]
N1 Probe Info	100.00	LDD0242	[4]
YN-1 Probe Info	100.00	LDD0444	[5]
STPyne Probe Info	K182(7.43); K209(6.70); K224(10.00); K460(10.00)	LDD0277	[6]
IPM Probe Info	N.A.	LDD0241	[7]
OPA-S-S-alkyne Probe Info	K224(1.69)	LDD3494	[8]
Probe 1 Probe Info	Y318(6.64); Y335(11.98)	LDD3495	[9]
AHL-Pu-1 Probe Info	C308(3.07)	LDD0171	[10]
DBIA Probe Info	C308(0.59)	LDD0531	[11]
IA-alkyne Probe Info	N.A.	LDD0032	[12]
AOyne Probe Info	9.20	LDD0443	[13]
NAIA_5 Probe Info	N.A.	LDD2223	[14]

PAL-AfBPP Probe

Click To Hide/Show 133 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
DR-1 Probe Info	4.43	LDD0398	[15]
C004 Probe Info	7.57	LDD1714	[16]
C017 Probe Info	19.29	LDD1725	[16]
C022 Probe Info	16.91	LDD1728	[16]
C027 Probe Info	6.63	LDD1733	[16]
C040 Probe Info	22.78	LDD1740	[16]
C041 Probe Info	8.11	LDD1741	[16]
C049 Probe Info	7.84	LDD1747	[16]
C053 Probe Info	6.45	LDD1751	[16]
C055 Probe Info	20.97	LDD1752	[16]
C056 Probe Info	43.71	LDD1753	[16]
C063 Probe Info	19.70	LDD1760	[16]
C070 Probe Info	12.55	LDD1766	[16]
C072 Probe Info	7.52	LDD1768	[16]
C082 Probe Info	12.13	LDD1774	[16]
C087 Probe Info	10.06	LDD1779	[16]
C091 Probe Info	35.26	LDD1782	[16]
C092 Probe Info	68.59	LDD1783	[16]
C094 Probe Info	76.11	LDD1785	[16]
C095 Probe Info	7.46	LDD1786	[16]
C100 Probe Info	6.54	LDD1789	[16]
C106 Probe Info	30.06	LDD1793	[16]
C107 Probe Info	9.00	LDD1794	[16]
C108 Probe Info	11.00	LDD1795	[16]
C112 Probe Info	29.04	LDD1799	[16]
C130 Probe Info	8.46	LDD1812	[16]
C134 Probe Info	40.22	LDD1816	[16]
C135 Probe Info	13.55	LDD1817	[16]
C139 Probe Info	16.11	LDD1821	[16]
C141 Probe Info	15.14	LDD1823	[16]
C143 Probe Info	24.42	LDD1825	[16]
C145 Probe Info	9.99	LDD1827	[16]
C147 Probe Info	6.73	LDD1829	[16]
C153 Probe Info	26.54	LDD1834	[16]
C159 Probe Info	13.36	LDD1839	[16]
C160 Probe Info	11.55	LDD1840	[16]
C161 Probe Info	18.38	LDD1841	[16]
C163 Probe Info	8.06	LDD1843	[16]
C165 Probe Info	16.22	LDD1845	[16]
C166 Probe Info	8.88	LDD1846	[16]
C169 Probe Info	39.67	LDD1849	[16]
C174 Probe Info	8.40	LDD1854	[16]
C178 Probe Info	18.51	LDD1857	[16]
C186 Probe Info	7.57	LDD1864	[16]
C187 Probe Info	49.52	LDD1865	[16]
C191 Probe Info	17.15	LDD1868	[16]
C193 Probe Info	8.75	LDD1869	[16]
C194 Probe Info	13.45	LDD1870	[16]
C196 Probe Info	13.36	LDD1872	[16]
C198 Probe Info	17.39	LDD1874	[16]
C201 Probe Info	66.26	LDD1877	[16]
C206 Probe Info	23.10	LDD1881	[16]
C210 Probe Info	85.63	LDD1884	[16]
C218 Probe Info	24.08	LDD1892	[16]
C219 Probe Info	7.16	LDD1893	[16]
C220 Probe Info	20.39	LDD1894	[16]
C225 Probe Info	5.90	LDD1898	[16]
C226 Probe Info	7.46	LDD1899	[16]
C228 Probe Info	28.44	LDD1901	[16]
C231 Probe Info	27.47	LDD1904	[16]
C232 Probe Info	41.93	LDD1905	[16]
C234 Probe Info	6.11	LDD1907	[16]
C235 Probe Info	39.12	LDD1908	[16]
C238 Probe Info	21.86	LDD1911	[16]
C240 Probe Info	9.78	LDD1913	[16]
C243 Probe Info	18.00	LDD1916	[16]
C246 Probe Info	24.93	LDD1919	[16]
C249 Probe Info	14.12	LDD1922	[16]
C252 Probe Info	12.64	LDD1925	[16]
C264 Probe Info	29.45	LDD1935	[16]
C265 Probe Info	17.63	LDD1936	[16]
C270 Probe Info	8.46	LDD1940	[16]
C273 Probe Info	6.32	LDD1943	[16]
C277 Probe Info	11.00	LDD1947	[16]
C278 Probe Info	51.63	LDD1948	[16]
C282 Probe Info	20.82	LDD1952	[16]
C287 Probe Info	12.73	LDD1957	[16]
C289 Probe Info	42.22	LDD1959	[16]
C293 Probe Info	30.48	LDD1963	[16]
C296 Probe Info	24.08	LDD1966	[16]
C299 Probe Info	11.88	LDD1968	[16]
C305 Probe Info	11.88	LDD1974	[16]
C310 Probe Info	12.47	LDD1977	[16]
C314 Probe Info	17.75	LDD1981	[16]
C322 Probe Info	7.36	LDD1988	[16]
C326 Probe Info	8.82	LDD1990	[16]
C338 Probe Info	17.39	LDD2001	[16]
C339 Probe Info	10.27	LDD2002	[16]
C343 Probe Info	21.71	LDD2005	[16]
C348 Probe Info	13.83	LDD2009	[16]
C349 Probe Info	15.89	LDD2010	[16]
C350 Probe Info	45.89	LDD2011	[16]
C355 Probe Info	37.01	LDD2016	[16]
C356 Probe Info	11.47	LDD2017	[16]
C357 Probe Info	6.54	LDD2018	[16]
C362 Probe Info	49.18	LDD2023	[16]
C364 Probe Info	16.22	LDD2025	[16]
C373 Probe Info	8.28	LDD2033	[16]
C376 Probe Info	7.06	LDD2036	[16]
C382 Probe Info	13.00	LDD2041	[16]
C383 Probe Info	33.82	LDD2042	[16]
C388 Probe Info	81.57	LDD2047	[16]
C390 Probe Info	54.57	LDD2049	[16]
C391 Probe Info	16.91	LDD2050	[16]
C399 Probe Info	9.13	LDD2058	[16]
C403 Probe Info	28.05	LDD2061	[16]
C407 Probe Info	54.19	LDD2064	[16]
C409 Probe Info	8.69	LDD2066	[16]
C413 Probe Info	21.71	LDD2069	[16]
C419 Probe Info	11.96	LDD2074	[16]
C420 Probe Info	13.93	LDD2075	[16]
C424 Probe Info	8.51	LDD2079	[16]
C426 Probe Info	17.51	LDD2081	[16]
C429 Probe Info	16.45	LDD2084	[16]
C431 Probe Info	22.01	LDD2086	[16]
FFF probe11 Probe Info	20.00	LDD0471	[17]
FFF probe13 Probe Info	20.00	LDD0475	[17]
FFF probe14 Probe Info	20.00	LDD0477	[17]
FFF probe15 Probe Info	13.21	LDD0478	[17]
FFF probe2 Probe Info	20.00	LDD0463	[17]
FFF probe3 Probe Info	20.00	LDD0464	[17]
FFF probe4 Probe Info	20.00	LDD0466	[17]
FFF probe6 Probe Info	20.00	LDD0467	[17]
JN0003 Probe Info	20.00	LDD0469	[17]
STS-1 Probe Info	N.A.	LDD0136	[18]
STS-2 Probe Info	N.A.	LDD0138	[18]
VE-P Probe Info	N.A.	LDD0396	[19]
A-DA Probe Info	2.06	LDD0145	[20]
Alk-rapa Probe Info	4.87	LDD0213	[21]
BD-F Probe Info	S338(0.00); Q337(0.00); Y335(0.00); E333(0.00)	LDD0024	[22]
LD-F Probe Info	D339(0.00); S338(0.00); D554(0.00); Y335(0.00)	LDD0015	[22]
TM-F Probe Info	E336(0.00); E333(0.00)	LDD0020	[22]
OEA-DA Probe Info	20.00	LDD0046	[23]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0026	4SU-RNA+native RNA	DM93	C308(3.07)	LDD0171	[10]
LDCM0214	AC1	HCT 116	C308(0.59)	LDD0531	[11]
LDCM0215	AC10	HCT 116	C308(0.48)	LDD0532	[11]
LDCM0216	AC100	HCT 116	C308(0.73)	LDD0533	[11]
LDCM0217	AC101	HCT 116	C308(0.68)	LDD0534	[11]
LDCM0218	AC102	HCT 116	C308(0.56)	LDD0535	[11]
LDCM0219	AC103	HCT 116	C308(0.29)	LDD0536	[11]
LDCM0220	AC104	HCT 116	C308(0.38)	LDD0537	[11]
LDCM0221	AC105	HCT 116	C308(0.34)	LDD0538	[11]
LDCM0222	AC106	HCT 116	C308(0.33)	LDD0539	[11]
LDCM0223	AC107	HCT 116	C308(0.31)	LDD0540	[11]
LDCM0224	AC108	HCT 116	C308(0.47)	LDD0541	[11]
LDCM0225	AC109	HCT 116	C308(0.58)	LDD0542	[11]
LDCM0226	AC11	HCT 116	C308(0.51)	LDD0543	[11]
LDCM0227	AC110	HCT 116	C308(0.45)	LDD0544	[11]
LDCM0228	AC111	HCT 116	C308(0.50)	LDD0545	[11]
LDCM0229	AC112	HCT 116	C308(0.39)	LDD0546	[11]
LDCM0230	AC113	PaTu 8988t	C308(1.77)	LDD1109	[11]
LDCM0231	AC114	PaTu 8988t	C308(1.45)	LDD1110	[11]
LDCM0232	AC115	PaTu 8988t	C308(0.80)	LDD1111	[11]
LDCM0233	AC116	PaTu 8988t	C308(1.39)	LDD1112	[11]
LDCM0234	AC117	PaTu 8988t	C308(1.33)	LDD1113	[11]
LDCM0235	AC118	PaTu 8988t	C308(1.12)	LDD1114	[11]
LDCM0236	AC119	PaTu 8988t	C308(0.59)	LDD1115	[11]
LDCM0237	AC12	HCT 116	C308(0.65)	LDD0554	[11]
LDCM0238	AC120	PaTu 8988t	C308(0.88)	LDD1117	[11]
LDCM0239	AC121	PaTu 8988t	C308(0.67)	LDD1118	[11]
LDCM0240	AC122	PaTu 8988t	C308(1.28)	LDD1119	[11]
LDCM0241	AC123	PaTu 8988t	C308(1.03)	LDD1120	[11]
LDCM0242	AC124	PaTu 8988t	C308(0.69)	LDD1121	[11]
LDCM0243	AC125	PaTu 8988t	C308(1.06)	LDD1122	[11]
LDCM0244	AC126	PaTu 8988t	C308(0.83)	LDD1123	[11]
LDCM0245	AC127	PaTu 8988t	C308(0.46)	LDD1124	[11]
LDCM0246	AC128	HCT 116	C308(0.71)	LDD0563	[11]
LDCM0247	AC129	HCT 116	C308(4.14)	LDD0564	[11]
LDCM0249	AC130	HCT 116	C308(1.43)	LDD0566	[11]
LDCM0250	AC131	HCT 116	C308(3.81)	LDD0567	[11]
LDCM0251	AC132	HCT 116	C308(1.74)	LDD0568	[11]
LDCM0252	AC133	HCT 116	C308(1.33)	LDD0569	[11]
LDCM0253	AC134	HCT 116	C308(1.27)	LDD0570	[11]
LDCM0254	AC135	HCT 116	C308(0.84)	LDD0571	[11]
LDCM0255	AC136	HCT 116	C308(1.51)	LDD0572	[11]
LDCM0256	AC137	HCT 116	C308(2.00)	LDD0573	[11]
LDCM0257	AC138	HCT 116	C308(0.86)	LDD0574	[11]
LDCM0258	AC139	HCT 116	C308(1.19)	LDD0575	[11]
LDCM0259	AC14	HCT 116	C308(0.52)	LDD0576	[11]
LDCM0260	AC140	HCT 116	C308(0.94)	LDD0577	[11]
LDCM0261	AC141	HCT 116	C308(1.25)	LDD0578	[11]
LDCM0262	AC142	HCT 116	C308(2.53)	LDD0579	[11]
LDCM0263	AC143	HCT 116	C308(0.69)	LDD0580	[11]
LDCM0264	AC144	HCT 116	C308(0.38)	LDD0581	[11]
LDCM0265	AC145	HCT 116	C308(0.72)	LDD0582	[11]
LDCM0266	AC146	HCT 116	C308(0.49)	LDD0583	[11]
LDCM0267	AC147	HCT 116	C308(0.27)	LDD0584	[11]
LDCM0268	AC148	HCT 116	C308(0.22)	LDD0585	[11]
LDCM0269	AC149	HCT 116	C308(0.28)	LDD0586	[11]
LDCM0270	AC15	HCT 116	C308(0.52)	LDD0587	[11]
LDCM0271	AC150	HCT 116	C308(0.86)	LDD0588	[11]
LDCM0272	AC151	HCT 116	C308(0.74)	LDD0589	[11]
LDCM0273	AC152	HCT 116	C308(0.28)	LDD0590	[11]
LDCM0274	AC153	HCT 116	C308(0.21)	LDD0591	[11]
LDCM0621	AC154	HCT 116	C308(0.44)	LDD2158	[11]
LDCM0622	AC155	HCT 116	C308(0.44)	LDD2159	[11]
LDCM0623	AC156	HCT 116	C308(1.05)	LDD2160	[11]
LDCM0624	AC157	HCT 116	C308(1.14)	LDD2161	[11]
LDCM0276	AC17	HCT 116	C308(1.26)	LDD0593	[11]
LDCM0277	AC18	HCT 116	C308(0.53)	LDD0594	[11]
LDCM0278	AC19	HCT 116	C308(1.01)	LDD0595	[11]
LDCM0279	AC2	HCT 116	C308(0.84)	LDD0596	[11]
LDCM0280	AC20	HCT 116	C308(1.30)	LDD0597	[11]
LDCM0281	AC21	HCT 116	C308(0.95)	LDD0598	[11]
LDCM0282	AC22	HCT 116	C308(1.20)	LDD0599	[11]
LDCM0283	AC23	HCT 116	C308(1.08)	LDD0600	[11]
LDCM0284	AC24	HCT 116	C308(1.40)	LDD0601	[11]
LDCM0285	AC25	HCT 116	C308(0.73)	LDD0602	[11]
LDCM0286	AC26	HCT 116	C308(0.61)	LDD0603	[11]
LDCM0287	AC27	HCT 116	C308(0.66)	LDD0604	[11]
LDCM0288	AC28	HCT 116	C308(0.62)	LDD0605	[11]
LDCM0289	AC29	HCT 116	C308(0.71)	LDD0606	[11]
LDCM0290	AC3	HCT 116	C308(0.78)	LDD0607	[11]
LDCM0291	AC30	HCT 116	C308(0.63)	LDD0608	[11]
LDCM0292	AC31	HCT 116	C308(0.61)	LDD0609	[11]
LDCM0293	AC32	HCT 116	C308(0.38)	LDD0610	[11]
LDCM0294	AC33	HCT 116	C308(0.46)	LDD0611	[11]
LDCM0295	AC34	HCT 116	C308(0.37)	LDD0612	[11]
LDCM0296	AC35	HCT 116	C308(1.28)	LDD0613	[11]
LDCM0297	AC36	HCT 116	C308(1.78)	LDD0614	[11]
LDCM0298	AC37	HCT 116	C308(1.77)	LDD0615	[11]
LDCM0299	AC38	HCT 116	C308(0.99)	LDD0616	[11]
LDCM0300	AC39	HCT 116	C308(0.75)	LDD0617	[11]
LDCM0301	AC4	HCT 116	C308(0.65)	LDD0618	[11]
LDCM0302	AC40	HCT 116	C308(0.73)	LDD0619	[11]
LDCM0303	AC41	HCT 116	C308(0.99)	LDD0620	[11]
LDCM0304	AC42	HCT 116	C308(0.67)	LDD0621	[11]
LDCM0305	AC43	HCT 116	C308(0.95)	LDD0622	[11]
LDCM0306	AC44	HCT 116	C308(0.69)	LDD0623	[11]
LDCM0307	AC45	HCT 116	C308(0.52)	LDD0624	[11]
LDCM0308	AC46	HCT 116	C308(0.83)	LDD0625	[11]
LDCM0309	AC47	HCT 116	C308(0.77)	LDD0626	[11]
LDCM0310	AC48	HCT 116	C308(0.81)	LDD0627	[11]
LDCM0311	AC49	HCT 116	C308(0.39)	LDD0628	[11]
LDCM0312	AC5	HCT 116	C308(0.62)	LDD0629	[11]
LDCM0313	AC50	HCT 116	C308(0.41)	LDD0630	[11]
LDCM0314	AC51	HCT 116	C308(1.39)	LDD0631	[11]
LDCM0315	AC52	HCT 116	C308(0.81)	LDD0632	[11]
LDCM0316	AC53	HCT 116	C308(0.46)	LDD0633	[11]
LDCM0317	AC54	HCT 116	C308(0.60)	LDD0634	[11]
LDCM0318	AC55	HCT 116	C308(0.44)	LDD0635	[11]
LDCM0319	AC56	HCT 116	C308(0.38)	LDD0636	[11]
LDCM0320	AC57	HCT 116	C308(1.55)	LDD0637	[11]
LDCM0321	AC58	HCT 116	C308(1.10)	LDD0638	[11]
LDCM0322	AC59	HCT 116	C308(1.71)	LDD0639	[11]
LDCM0323	AC6	HCT 116	C308(0.93)	LDD0640	[11]
LDCM0324	AC60	HCT 116	C308(2.13)	LDD0641	[11]
LDCM0325	AC61	HCT 116	C308(1.03)	LDD0642	[11]
LDCM0326	AC62	HCT 116	C308(1.87)	LDD0643	[11]
LDCM0327	AC63	HCT 116	C308(2.15)	LDD0644	[11]
LDCM0328	AC64	HCT 116	C308(1.77)	LDD0645	[11]
LDCM0329	AC65	HCT 116	C308(0.80)	LDD0646	[11]
LDCM0330	AC66	HCT 116	C308(0.82)	LDD0647	[11]
LDCM0331	AC67	HCT 116	C308(1.37)	LDD0648	[11]
LDCM0332	AC68	HCT 116	C308(0.63)	LDD0649	[11]
LDCM0333	AC69	HCT 116	C308(0.69)	LDD0650	[11]
LDCM0334	AC7	HCT 116	C308(0.75)	LDD0651	[11]
LDCM0335	AC70	HCT 116	C308(0.45)	LDD0652	[11]
LDCM0336	AC71	HCT 116	C308(1.02)	LDD0653	[11]
LDCM0337	AC72	HCT 116	C308(0.65)	LDD0654	[11]
LDCM0338	AC73	HCT 116	C308(0.52)	LDD0655	[11]
LDCM0339	AC74	HCT 116	C308(0.79)	LDD0656	[11]
LDCM0340	AC75	HCT 116	C308(0.47)	LDD0657	[11]
LDCM0341	AC76	HCT 116	C308(0.66)	LDD0658	[11]
LDCM0342	AC77	HCT 116	C308(0.52)	LDD0659	[11]
LDCM0343	AC78	HCT 116	C308(0.79)	LDD0660	[11]
LDCM0344	AC79	HCT 116	C308(0.70)	LDD0661	[11]
LDCM0345	AC8	HCT 116	C308(0.50)	LDD0662	[11]
LDCM0346	AC80	HCT 116	C308(0.80)	LDD0663	[11]
LDCM0347	AC81	HCT 116	C308(0.85)	LDD0664	[11]
LDCM0348	AC82	HCT 116	C308(0.59)	LDD0665	[11]
LDCM0349	AC83	HCT 116	C308(0.38)	LDD0666	[11]
LDCM0350	AC84	HCT 116	C308(0.36)	LDD0667	[11]
LDCM0351	AC85	HCT 116	C308(0.73)	LDD0668	[11]
LDCM0352	AC86	HCT 116	C308(0.81)	LDD0669	[11]
LDCM0353	AC87	HCT 116	C308(0.93)	LDD0670	[11]
LDCM0354	AC88	HCT 116	C308(0.86)	LDD0671	[11]
LDCM0355	AC89	HCT 116	C308(0.58)	LDD0672	[11]
LDCM0357	AC90	HCT 116	C308(1.55)	LDD0674	[11]
LDCM0358	AC91	HCT 116	C308(0.35)	LDD0675	[11]
LDCM0359	AC92	HCT 116	C308(0.39)	LDD0676	[11]
LDCM0360	AC93	HCT 116	C308(0.70)	LDD0677	[11]
LDCM0361	AC94	HCT 116	C308(0.79)	LDD0678	[11]
LDCM0362	AC95	HCT 116	C308(1.08)	LDD0679	[11]
LDCM0363	AC96	HCT 116	C308(0.65)	LDD0680	[11]
LDCM0364	AC97	HCT 116	C308(0.49)	LDD0681	[11]
LDCM0365	AC98	HCT 116	C308(0.15)	LDD0682	[11]
LDCM0366	AC99	HCT 116	C308(0.72)	LDD0683	[11]
LDCM0248	AKOS034007472	HCT 116	C308(0.64)	LDD0565	[11]
LDCM0356	AKOS034007680	HCT 116	C308(0.73)	LDD0673	[11]
LDCM0275	AKOS034007705	HCT 116	C308(0.25)	LDD0592	[11]
LDCM0367	CL1	HCT 116	C308(1.50)	LDD0684	[11]
LDCM0368	CL10	HCT 116	C308(0.73)	LDD0685	[11]
LDCM0369	CL100	HCT 116	C308(0.65)	LDD0686	[11]
LDCM0370	CL101	HCT 116	C308(0.62)	LDD0687	[11]
LDCM0371	CL102	HCT 116	C308(0.88)	LDD0688	[11]
LDCM0372	CL103	HCT 116	C308(0.79)	LDD0689	[11]
LDCM0373	CL104	HCT 116	C308(0.70)	LDD0690	[11]
LDCM0374	CL105	HCT 116	C308(0.72)	LDD0691	[11]
LDCM0375	CL106	HCT 116	C308(0.41)	LDD0692	[11]
LDCM0376	CL107	HCT 116	C308(0.41)	LDD0693	[11]
LDCM0377	CL108	HCT 116	C308(0.38)	LDD0694	[11]
LDCM0378	CL109	HCT 116	C308(0.80)	LDD0695	[11]
LDCM0379	CL11	HCT 116	C308(0.56)	LDD0696	[11]
LDCM0380	CL110	HCT 116	C308(0.52)	LDD0697	[11]
LDCM0381	CL111	HCT 116	C308(0.98)	LDD0698	[11]
LDCM0382	CL112	HCT 116	C308(0.74)	LDD0699	[11]
LDCM0383	CL113	HCT 116	C308(0.51)	LDD0700	[11]
LDCM0384	CL114	HCT 116	C308(0.80)	LDD0701	[11]
LDCM0385	CL115	HCT 116	C308(0.64)	LDD0702	[11]
LDCM0386	CL116	HCT 116	C308(0.65)	LDD0703	[11]
LDCM0387	CL117	HCT 116	C308(0.50)	LDD0704	[11]
LDCM0388	CL118	HCT 116	C308(0.78)	LDD0705	[11]
LDCM0389	CL119	HCT 116	C308(0.72)	LDD0706	[11]
LDCM0390	CL12	HCT 116	C308(0.49)	LDD0707	[11]
LDCM0391	CL120	HCT 116	C308(1.75)	LDD0708	[11]
LDCM0392	CL121	HCT 116	C308(0.36)	LDD0709	[11]
LDCM0393	CL122	HCT 116	C308(0.76)	LDD0710	[11]
LDCM0394	CL123	HCT 116	C308(0.53)	LDD0711	[11]
LDCM0395	CL124	HCT 116	C308(0.42)	LDD0712	[11]
LDCM0396	CL125	HCT 116	C308(1.11)	LDD0713	[11]
LDCM0397	CL126	HCT 116	C308(1.53)	LDD0714	[11]
LDCM0398	CL127	HCT 116	C308(1.21)	LDD0715	[11]
LDCM0399	CL128	HCT 116	C308(1.23)	LDD0716	[11]
LDCM0400	CL13	HCT 116	C308(0.74)	LDD0717	[11]
LDCM0401	CL14	HCT 116	C308(1.54)	LDD0718	[11]
LDCM0402	CL15	HCT 116	C308(0.84)	LDD0719	[11]
LDCM0403	CL16	HCT 116	C308(0.91)	LDD0720	[11]
LDCM0404	CL17	HCT 116	C308(1.01)	LDD0721	[11]
LDCM0405	CL18	HCT 116	C308(0.87)	LDD0722	[11]
LDCM0406	CL19	HCT 116	C308(0.62)	LDD0723	[11]
LDCM0407	CL2	HCT 116	C308(1.43)	LDD0724	[11]
LDCM0408	CL20	HCT 116	C308(0.44)	LDD0725	[11]
LDCM0409	CL21	HCT 116	C308(0.35)	LDD0726	[11]
LDCM0410	CL22	HCT 116	C308(0.28)	LDD0727	[11]
LDCM0411	CL23	HCT 116	C308(0.66)	LDD0728	[11]
LDCM0412	CL24	HCT 116	C308(0.32)	LDD0729	[11]
LDCM0413	CL25	HCT 116	C308(0.31)	LDD0730	[11]
LDCM0414	CL26	HCT 116	C308(0.53)	LDD0731	[11]
LDCM0415	CL27	HCT 116	C308(0.50)	LDD0732	[11]
LDCM0416	CL28	HCT 116	C308(0.50)	LDD0733	[11]
LDCM0417	CL29	HCT 116	C308(0.41)	LDD0734	[11]
LDCM0418	CL3	HCT 116	C308(1.34)	LDD0735	[11]
LDCM0419	CL30	HCT 116	C308(0.82)	LDD0736	[11]
LDCM0420	CL31	HCT 116	C308(0.73)	LDD0737	[11]
LDCM0421	CL32	HCT 116	C308(0.60)	LDD0738	[11]
LDCM0422	CL33	HCT 116	C308(0.72)	LDD0739	[11]
LDCM0423	CL34	HCT 116	C308(0.35)	LDD0740	[11]
LDCM0424	CL35	HCT 116	C308(0.43)	LDD0741	[11]
LDCM0425	CL36	HCT 116	C308(0.42)	LDD0742	[11]
LDCM0426	CL37	HCT 116	C308(0.38)	LDD0743	[11]
LDCM0428	CL39	HCT 116	C308(0.35)	LDD0745	[11]
LDCM0429	CL4	HCT 116	C308(1.49)	LDD0746	[11]
LDCM0430	CL40	HCT 116	C308(0.38)	LDD0747	[11]
LDCM0431	CL41	HCT 116	C308(0.41)	LDD0748	[11]
LDCM0432	CL42	HCT 116	C308(0.32)	LDD0749	[11]
LDCM0433	CL43	HCT 116	C308(0.37)	LDD0750	[11]
LDCM0434	CL44	HCT 116	C308(0.48)	LDD0751	[11]
LDCM0435	CL45	HCT 116	C308(0.31)	LDD0752	[11]
LDCM0436	CL46	HCT 116	C308(2.22)	LDD0753	[11]
LDCM0437	CL47	HCT 116	C308(1.85)	LDD0754	[11]
LDCM0438	CL48	HCT 116	C308(2.56)	LDD0755	[11]
LDCM0439	CL49	HCT 116	C308(2.13)	LDD0756	[11]
LDCM0440	CL5	HCT 116	C308(1.04)	LDD0757	[11]
LDCM0441	CL50	HCT 116	C308(1.95)	LDD0758	[11]
LDCM0442	CL51	HCT 116	C308(1.79)	LDD0759	[11]
LDCM0443	CL52	HCT 116	C308(1.57)	LDD0760	[11]
LDCM0444	CL53	HCT 116	C308(2.20)	LDD0761	[11]
LDCM0445	CL54	HCT 116	C308(2.04)	LDD0762	[11]
LDCM0446	CL55	HCT 116	C308(2.30)	LDD0763	[11]
LDCM0447	CL56	HCT 116	C308(1.19)	LDD0764	[11]
LDCM0448	CL57	HCT 116	C308(1.93)	LDD0765	[11]
LDCM0449	CL58	HCT 116	C308(2.07)	LDD0766	[11]
LDCM0450	CL59	HCT 116	C308(1.42)	LDD0767	[11]
LDCM0451	CL6	HCT 116	C308(1.19)	LDD0768	[11]
LDCM0452	CL60	HCT 116	C308(1.78)	LDD0769	[11]
LDCM0453	CL61	PaTu 8988t	C308(1.26)	LDD1332	[11]
LDCM0454	CL62	PaTu 8988t	C308(0.67)	LDD1333	[11]
LDCM0455	CL63	PaTu 8988t	C308(0.67)	LDD1334	[11]
LDCM0456	CL64	PaTu 8988t	C308(0.57)	LDD1335	[11]
LDCM0457	CL65	PaTu 8988t	C308(0.89)	LDD1336	[11]
LDCM0458	CL66	PaTu 8988t	C308(0.61)	LDD1337	[11]
LDCM0459	CL67	PaTu 8988t	C308(0.69)	LDD1338	[11]
LDCM0460	CL68	PaTu 8988t	C308(0.49)	LDD1339	[11]
LDCM0461	CL69	PaTu 8988t	C308(0.34)	LDD1340	[11]
LDCM0462	CL7	HCT 116	C308(0.64)	LDD0779	[11]
LDCM0463	CL70	PaTu 8988t	C308(0.38)	LDD1342	[11]
LDCM0464	CL71	PaTu 8988t	C308(0.72)	LDD1343	[11]
LDCM0465	CL72	PaTu 8988t	C308(0.69)	LDD1344	[11]
LDCM0466	CL73	PaTu 8988t	C308(0.52)	LDD1345	[11]
LDCM0467	CL74	PaTu 8988t	C308(0.78)	LDD1346	[11]
LDCM0469	CL76	HCT 116	C308(0.72)	LDD0786	[11]
LDCM0470	CL77	HCT 116	C308(1.63)	LDD0787	[11]
LDCM0471	CL78	HCT 116	C308(0.67)	LDD0788	[11]
LDCM0472	CL79	HCT 116	C308(0.47)	LDD0789	[11]
LDCM0473	CL8	HCT 116	C308(0.60)	LDD0790	[11]
LDCM0474	CL80	HCT 116	C308(1.25)	LDD0791	[11]
LDCM0475	CL81	HCT 116	C308(0.65)	LDD0792	[11]
LDCM0476	CL82	HCT 116	C308(0.34)	LDD0793	[11]
LDCM0477	CL83	HCT 116	C308(0.35)	LDD0794	[11]
LDCM0478	CL84	HCT 116	C308(0.35)	LDD0795	[11]
LDCM0479	CL85	HCT 116	C308(0.65)	LDD0796	[11]
LDCM0480	CL86	HCT 116	C308(1.05)	LDD0797	[11]
LDCM0481	CL87	HCT 116	C308(0.60)	LDD0798	[11]
LDCM0482	CL88	HCT 116	C308(0.31)	LDD0799	[11]
LDCM0483	CL89	HCT 116	C308(0.29)	LDD0800	[11]
LDCM0484	CL9	HCT 116	C308(0.99)	LDD0801	[11]
LDCM0485	CL90	HCT 116	C308(1.14)	LDD0802	[11]
LDCM0486	CL91	HCT 116	C308(0.79)	LDD0803	[11]
LDCM0487	CL92	HCT 116	C308(1.01)	LDD0804	[11]
LDCM0488	CL93	HCT 116	C308(0.98)	LDD0805	[11]
LDCM0489	CL94	HCT 116	C308(0.73)	LDD0806	[11]
LDCM0490	CL95	HCT 116	C308(0.66)	LDD0807	[11]
LDCM0491	CL96	HCT 116	C308(0.72)	LDD0808	[11]
LDCM0492	CL97	HCT 116	C308(0.78)	LDD0809	[11]
LDCM0493	CL98	HCT 116	C308(0.63)	LDD0810	[11]
LDCM0494	CL99	HCT 116	C308(0.63)	LDD0811	[11]
LDCM0189	Compound 16	HEK-293T	21.28	LDD0492	[17]
LDCM0184	Compound 20	HEK-293T	11.40	LDD0503	[17]
LDCM0191	Compound 21	HEK-293T	9.17	LDD0493	[17]
LDCM0186	Compound 31	HEK-293T	8.89	LDD0506	[17]
LDCM0188	Compound 33	HEK-293T	10.47	LDD0505	[17]
LDCM0190	Compound 34	HEK-293T	18.35	LDD0497	[17]
LDCM0192	Compound 35	HEK-293T	15.38	LDD0491	[17]
LDCM0194	Compound 37	HEK-293T	12.12	LDD0498	[17]
LDCM0195	Compound 38	HEK-293T	15.63	LDD0499	[17]
LDCM0196	Compound 39	HEK-293T	13.42	LDD0496	[17]
LDCM0197	Compound 40	HEK-293T	14.29	LDD0495	[17]
LDCM0181	Compound 41	HEK-293T	12.82	LDD0502	[17]
LDCM0495	E2913	HEK-293T	C308(1.05); C571(1.31)	LDD1698	[24]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C308(2.65)	LDD1702	[25]
LDCM0468	Fragment33	PaTu 8988t	C308(0.49)	LDD1347	[11]
LDCM0427	Fragment51	HCT 116	C308(0.28)	LDD0744	[11]
LDCM0022	KB02	HEK-293T	C308(0.83)	LDD1492	[24]
LDCM0023	KB03	HEK-293T	C308(0.92)	LDD1497	[24]
LDCM0024	KB05	MEL167	C308(2.01)	LDD3316	[26]
LDCM0090	Rapamycin	JHH-7	4.87	LDD0213	[21]
LDCM0084	Ro 48-8071	A-549	2.06	LDD0145	[20]

References

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3	Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
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6	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
7	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8	A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w. Mass spectrometry data entry: PXD042888
9	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
11	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
15	Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
16	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
17	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19	Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21	Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
22	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
23	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
24	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
25	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
26	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni