Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | FFF probe3 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 20 uM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
SILAC
|
|||||
| Competitor Name | Compound 38 | Competitor Info | ||||
| Competitor Concentration | 160 uM | |||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP02198 | Cathepsin D (CTSD) | 28.2 | ||||
| LDTP16032 | Retinoid-inducible serine carboxypeptidase (SCPEP1) | 26.7 | ||||
| LDTP13702 | E3 ubiquitin-protein ligase TRIM33 (TRIM33) | 19.2 | ||||
| LDTP03189 | Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) | 19.2 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 17.9 | ||||
| LDTP06648 | Lanosterol 14-alpha demethylase (CYP51A1) | 17.1 | ||||
| LDTP04211 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | 16.3 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 15.7 | ||||
| LDTP07003 | Presequence protease, mitochondrial (PITRM1) | 15.7 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 15.6 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 14.1 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 14.0 | ||||
| LDTP01773 | Cytochrome c oxidase subunit 2 (MT-CO2) | 13.9 | ||||
| LDTP03139 | Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) | 13.1 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 12.9 | ||||
| LDTP05862 | NAD(P) transhydrogenase, mitochondrial (NNT) | 12.7 | ||||
| LDTP12588 | Isoleucine--tRNA ligase, mitochondrial (IARS2) | 12.6 | ||||
| LDTP05476 | 3-ketodihydrosphingosine reductase (KDSR) | 12.5 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 12.3 | ||||
| LDTP15988 | Probable serine carboxypeptidase CPVL (CPVL) | 12.3 | ||||
| LDTP03912 | Trifunctional enzyme subunit alpha, mitochondrial (HADHA) | 11.8 | ||||
| LDTP06901 | Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) | 10.1 | ||||
| LDTP05724 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) | 9.8 | ||||
| LDTP13751 | Exonuclease 1 (EXO1) | 8.8 | ||||
| LDTP06150 | DNA replication licensing factor MCM6 (MCM6) | 8.2 | ||||
| LDTP06384 | Ribosomal protein S6 kinase alpha-1 (RPS6KA1) | 7.6 | ||||
| LDTP04471 | Ribosomal protein S6 kinase alpha-3 (RPS6KA3) | 7.4 | ||||
| LDTP02602 | Histidine--tRNA ligase, cytoplasmic (HARS1) | 7.2 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 7.2 | ||||
| LDTP02150 | ATP synthase subunit beta, mitochondrial (ATP5F1B) | 7.1 | ||||
| LDTP04183 | Lanosterol synthase (LSS) | 6.8 | ||||
| LDTP03419 | Proteasome subunit beta type-5 (PSMB5) | 6.7 | ||||
| LDTP01333 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) | 6.6 | ||||
| LDTP08979 | Prostaglandin reductase 2 (PTGR2) | 6.2 | ||||
| LDTP03689 | Serine hydroxymethyltransferase, mitochondrial (SHMT2) | 5.9 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 5.1 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 4.9 | ||||
| LDTP07504 | Lysophospholipid acyltransferase 5 (LPCAT3) | 4.3 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 3.9 | ||||
| LDTP12628 | Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) | 3.8 | ||||
| LDTP03680 | DNA replication licensing factor MCM4 (MCM4) | 3.0 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 21.7 | ||||
| LDTP02215 | Prosaposin (PSAP) | 20.6 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 16.3 | ||||
| LDTP01745 | Putative lipid scramblase CLPTM1 (CLPTM1) | 15.6 | ||||
| LDTP11213 | Nucleoporin NDC1 (NDC1) | 14.2 | ||||
| LDTP13824 | Voltage-dependent anion-selective channel protein 3 (VDAC3) | 12.8 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 12.4 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 5.8 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 5.3 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP09920 | Golgi apparatus protein 1 (GLG1) | 18.5 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 15.5 | ||||
| LDTP02756 | Junction plakoglobin (JUP) | 14.7 | ||||
| LDTP13630 | Neudesin (NENF) | 11.4 | ||||
| LDTP05922 | Dynactin subunit 2 (DCTN2) | 10.9 | ||||
| LDTP08224 | Protein LYRIC (MTDH) | 10.9 | ||||
| LDTP13755 | Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) | 10.1 | ||||
| LDTP05076 | Tubulin beta-4B chain (TUBB4B) | 7.3 | ||||
| LDTP11233 | Tubulin beta-6 chain (TUBB6) | 7.2 | ||||
| LDTP11277 | Tubulin beta-2B chain (TUBB2B) | 7.0 | ||||
| LDTP09881 | TATA-binding protein-associated factor 2N (TAF15) | 7.0 | ||||
| LDTP02205 | Tubulin beta chain (TUBB) | 6.9 | ||||
| LDTP05904 | Tubulin beta-3 chain (TUBB3) | 6.7 | ||||
| LDTP15705 | BTB/POZ domain-containing protein KCTD12 (KCTD12) | 4.8 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 4.6 | ||||