Details of the Target

General Information of Target

Target ID LDTP05758
Target Name S-methyl-5'-thioadenosine phosphorylase (MTAP)
Gene Name MTAP
Gene ID 4507
Synonyms
MSAP; S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
PNP/MTAP phosphorylase family, MTAP subfamily
Subcellular location
Cytoplasm
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. {|HAMAP-Rule:MF_03155}.
TTD ID
T40787
Uniprot ID
Q13126
DrugMap ID
TTDBX7N
Ensemble ID
ENST00000580900.5
HGNC ID
HGNC:7413
ChEMBL ID
CHEMBL4941

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.V89A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.42  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K248(1.92)  LDD2218  [4]
BTD
 Probe Info  		C55(1.24)  LDD1699  [5]
DBIA
 Probe Info  		C131(1.33)  LDD3310  [6]
HHS-482
 Probe Info  		Y125(0.32)  LDD0285  [7]
HHS-475
 Probe Info  		Y125(0.87)  LDD0264  [8]
W1
 Probe Info  		C145(0.67)  LDD0239  [9]
5E-2FA
 Probe Info  		H137(0.00); H268(0.00); H129(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K241(0.00); K40(0.00); K166(0.00); K157(0.00)  LDD0199  [11]
IA-alkyne
 Probe Info  		C211(0.00); C55(0.00); C131(0.00); C136(0.00)  LDD0162  [12]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
PF-06672131
 Probe Info  		N.A.  LDD0017  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Ox-W18
 Probe Info  		W224(0.00); W263(0.00)  LDD2175  [16]
1c-yne
 Probe Info  		K248(0.00); K271(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C131(0.00); C136(0.00); C145(0.00); H129(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
AOyne
 Probe Info  		12.80  LDD0443  [19]
PAL-AfBPP Probe
Click To Hide/Show 158 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.57  LDD1714  [20]
C007
 Probe Info  		5.28  LDD1716  [20]
C010
 Probe Info  		7.84  LDD1719  [20]
C011
 Probe Info  		15.35  LDD1720  [20]
C018
 Probe Info  		5.86  LDD1726  [20]
C022
 Probe Info  		20.82  LDD1728  [20]
C026
 Probe Info  		7.46  LDD1732  [20]
C027
 Probe Info  		14.22  LDD1733  [20]
C039
 Probe Info  		6.92  LDD1739  [20]
C040
 Probe Info  		8.28  LDD1740  [20]
C041
 Probe Info  		12.73  LDD1741  [20]
C044
 Probe Info  		7.73  LDD1743  [20]
C055
 Probe Info  		14.52  LDD1752  [20]
C056
 Probe Info  		23.43  LDD1753  [20]
C059
 Probe Info  		16.00  LDD1756  [20]
C064
 Probe Info  		6.82  LDD1761  [20]
C070
 Probe Info  		13.74  LDD1766  [20]
C075
 Probe Info  		5.06  LDD1770  [20]
C082
 Probe Info  		5.54  LDD1774  [20]
C085
 Probe Info  		12.30  LDD1777  [20]
C087
 Probe Info  		30.70  LDD1779  [20]
C091
 Probe Info  		11.24  LDD1782  [20]
C094
 Probe Info  		23.43  LDD1785  [20]
C095
 Probe Info  		6.59  LDD1786  [20]
C098
 Probe Info  		6.54  LDD1787  [20]
C100
 Probe Info  		7.26  LDD1789  [20]
C107
 Probe Info  		8.17  LDD1794  [20]
C108
 Probe Info  		31.12  LDD1795  [20]
C122
 Probe Info  		6.11  LDD1808  [20]
C129
 Probe Info  		15.89  LDD1811  [20]
C130
 Probe Info  		15.03  LDD1812  [20]
C135
 Probe Info  		13.55  LDD1817  [20]
C139
 Probe Info  		12.21  LDD1821  [20]
C140
 Probe Info  		11.79  LDD1822  [20]
C141
 Probe Info  		25.28  LDD1823  [20]
C145
 Probe Info  		17.39  LDD1827  [20]
C147
 Probe Info  		21.41  LDD1829  [20]
C153
 Probe Info  		28.84  LDD1834  [20]
C156
 Probe Info  		19.29  LDD1836  [20]
C159
 Probe Info  		8.94  LDD1839  [20]
C163
 Probe Info  		11.24  LDD1843  [20]
C166
 Probe Info  		8.51  LDD1846  [20]
C174
 Probe Info  		6.73  LDD1854  [20]
C177
 Probe Info  		8.94  LDD1856  [20]
C178
 Probe Info  		30.48  LDD1857  [20]
C183
 Probe Info  		9.06  LDD1861  [20]
C185
 Probe Info  		8.69  LDD1863  [20]
C187
 Probe Info  		24.76  LDD1865  [20]
C191
 Probe Info  		14.52  LDD1868  [20]
C193
 Probe Info  		16.22  LDD1869  [20]
C194
 Probe Info  		9.85  LDD1870  [20]
C198
 Probe Info  		16.56  LDD1874  [20]
C199
 Probe Info  		5.28  LDD1875  [20]
C201
 Probe Info  		48.17  LDD1877  [20]
C204
 Probe Info  		6.15  LDD1879  [20]
C205
 Probe Info  		15.24  LDD1880  [20]
C211
 Probe Info  		8.75  LDD1885  [20]
C212
 Probe Info  		31.12  LDD1886  [20]
C213
 Probe Info  		32.00  LDD1887  [20]
C217
 Probe Info  		6.23  LDD1891  [20]
C218
 Probe Info  		26.91  LDD1892  [20]
C219
 Probe Info  		5.66  LDD1893  [20]
C220
 Probe Info  		23.92  LDD1894  [20]
C222
 Probe Info  		11.16  LDD1896  [20]
C228
 Probe Info  		29.86  LDD1901  [20]
C229
 Probe Info  		9.78  LDD1902  [20]
C231
 Probe Info  		14.12  LDD1904  [20]
C233
 Probe Info  		18.51  LDD1906  [20]
C234
 Probe Info  		5.54  LDD1907  [20]
C236
 Probe Info  		24.25  LDD1909  [20]
C241
 Probe Info  		5.78  LDD1914  [20]
C243
 Probe Info  		11.88  LDD1916  [20]
C246
 Probe Info  		13.74  LDD1919  [20]
C249
 Probe Info  		32.90  LDD1922  [20]
C252
 Probe Info  		17.39  LDD1925  [20]
C255
 Probe Info  		6.06  LDD1928  [20]
C264
 Probe Info  		26.72  LDD1935  [20]
C266
 Probe Info  		10.48  LDD1937  [20]
C269
 Probe Info  		28.44  LDD1939  [20]
C270
 Probe Info  		8.88  LDD1940  [20]
C274
 Probe Info  		5.39  LDD1944  [20]
C277
 Probe Info  		34.30  LDD1947  [20]
C280
 Probe Info  		11.24  LDD1950  [20]
C282
 Probe Info  		27.67  LDD1952  [20]
C284
 Probe Info  		48.50  LDD1954  [20]
C286
 Probe Info  		7.94  LDD1956  [20]
C287
 Probe Info  		11.88  LDD1957  [20]
C288
 Probe Info  		16.80  LDD1958  [20]
C289
 Probe Info  		25.63  LDD1959  [20]
C292
 Probe Info  		7.78  LDD1962  [20]
C293
 Probe Info  		26.72  LDD1963  [20]
C296
 Probe Info  		46.85  LDD1966  [20]
C297
 Probe Info  		18.64  LDD1967  [20]
C299
 Probe Info  		9.71  LDD1968  [20]
C301
 Probe Info  		11.55  LDD1970  [20]
C303
 Probe Info  		7.67  LDD1972  [20]
C305
 Probe Info  		17.75  LDD1974  [20]
C307
 Probe Info  		6.28  LDD1975  [20]
C317
 Probe Info  		7.31  LDD1983  [20]
C326
 Probe Info  		13.36  LDD1990  [20]
C327
 Probe Info  		12.55  LDD1991  [20]
C333
 Probe Info  		7.31  LDD1996  [20]
C338
 Probe Info  		15.03  LDD2001  [20]
C343
 Probe Info  		14.72  LDD2005  [20]
C346
 Probe Info  		14.72  LDD2007  [20]
C347
 Probe Info  		5.74  LDD2008  [20]
C349
 Probe Info  		36.25  LDD2010  [20]
C351
 Probe Info  		5.35  LDD2012  [20]
C354
 Probe Info  		25.11  LDD2015  [20]
C355
 Probe Info  		30.70  LDD2016  [20]
C356
 Probe Info  		8.22  LDD2017  [20]
C361
 Probe Info  		19.03  LDD2022  [20]
C362
 Probe Info  		62.25  LDD2023  [20]
C363
 Probe Info  		32.00  LDD2024  [20]
C364
 Probe Info  		42.22  LDD2025  [20]
C366
 Probe Info  		5.24  LDD2027  [20]
C368
 Probe Info  		10.85  LDD2029  [20]
C373
 Probe Info  		17.15  LDD2033  [20]
C376
 Probe Info  		12.47  LDD2036  [20]
C380
 Probe Info  		7.31  LDD2039  [20]
C382
 Probe Info  		12.91  LDD2041  [20]
C383
 Probe Info  		99.73  LDD2042  [20]
C385
 Probe Info  		15.78  LDD2044  [20]
C386
 Probe Info  		30.06  LDD2045  [20]
C387
 Probe Info  		27.47  LDD2046  [20]
C388
 Probe Info  		84.45  LDD2047  [20]
C389
 Probe Info  		12.82  LDD2048  [20]
C391
 Probe Info  		17.88  LDD2050  [20]
C393
 Probe Info  		8.63  LDD2052  [20]
C399
 Probe Info  		18.90  LDD2058  [20]
C402
 Probe Info  		5.82  LDD2060  [20]
C403
 Probe Info  		18.77  LDD2061  [20]
C405
 Probe Info  		5.17  LDD2063  [20]
C407
 Probe Info  		24.08  LDD2064  [20]
C408
 Probe Info  		5.86  LDD2065  [20]
C409
 Probe Info  		7.26  LDD2066  [20]
C414
 Probe Info  		5.82  LDD2070  [20]
C416
 Probe Info  		18.38  LDD2071  [20]
C420
 Probe Info  		31.12  LDD2075  [20]
C421
 Probe Info  		17.75  LDD2076  [20]
C422
 Probe Info  		34.06  LDD2077  [20]
C424
 Probe Info  		8.11  LDD2079  [20]
C428
 Probe Info  		9.85  LDD2083  [20]
C430
 Probe Info  		11.55  LDD2085  [20]
C431
 Probe Info  		25.11  LDD2086  [20]
C432
 Probe Info  		8.57  LDD2087  [20]
C433
 Probe Info  		8.63  LDD2088  [20]
FFF probe11
 Probe Info  		13.05  LDD0471  [21]
FFF probe13
 Probe Info  		12.95  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe15
 Probe Info  		20.00  LDD0490  [21]
FFF probe2
 Probe Info  		13.28  LDD0463  [21]
FFF probe3
 Probe Info  		7.79  LDD0464  [21]
FFF probe6
 Probe Info  		10.89  LDD0482  [21]
FFF probe7
 Probe Info  		20.00  LDD0483  [21]
A-DA
 Probe Info  		3.85  LDD0330  [22]
AEA-DA
 Probe Info  		7.83  LDD0333  [22]
OEA-DA
 Probe Info  		10.21  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C131(0.96); C145(0.97); C223(1.02); C136(0.92)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C131(0.96); C145(1.00); C223(1.07); C136(0.99)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C131(0.94); C145(1.05); C223(1.03); C136(0.96)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C131(0.94); C145(1.04); C223(0.96); C136(1.01)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C131(1.02); C145(0.96); C223(0.99); C136(0.99)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C131(1.01); C145(0.97); C223(1.01); C136(0.98)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C131(0.93); C145(0.93); C223(0.91); C136(0.95)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C131(0.95); C145(1.01); C223(0.98); C136(0.98)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C131(0.64); C145(0.64); C223(1.13); C136(0.58)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C131(1.01); C145(1.09); C223(1.00); C136(1.00)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C131(0.95); C145(1.05); C223(0.98); C136(1.02)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C131(0.94); C145(1.00); C223(1.05); C136(0.96)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C131(1.05); C145(0.83); C223(1.31); C136(0.97)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C131(1.01); C145(1.02); C223(0.98); C136(1.02)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C131(1.01); C145(0.94); C223(1.01); C86(0.99)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C131(1.00); C145(0.91); C223(1.15); C136(1.02)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C131(0.98); C145(1.08); C223(0.99); C136(0.99)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C131(0.94); C145(1.07); C223(1.09); C136(0.95)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C131(0.95); C145(0.98); C223(0.99); C136(1.03)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C131(0.95); C145(0.95); C223(1.02); C136(0.98)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C131(0.93); C145(1.01); C223(1.02); C136(1.04)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C131(1.02); C145(0.94); C223(1.03); C136(1.02)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C131(1.12); C145(1.03); C223(1.42); C136(1.15)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C131(0.97); C145(0.99); C223(1.04); C86(1.06)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C131(1.00); C145(1.00); C223(1.02); C136(0.95)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C131(0.99); C145(1.17); C223(1.06); C136(0.98)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C131(0.97); C145(1.04); C223(1.05); C136(1.00)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C131(0.99); C145(0.98); C223(0.97); C136(1.05)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C131(1.03); C145(1.00); C223(0.95); C136(1.04)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C131(1.11); C145(1.04); C223(1.46); C136(1.17)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C131(1.01); C145(1.07); C223(1.04); C136(1.02)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C131(0.97); C145(0.97); C223(0.91); C136(1.01)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C131(1.01); C145(0.95); C223(0.94); C86(1.02)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C131(0.98); C145(0.95); C223(0.97); C136(0.92)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C131(0.96); C145(1.08); C223(0.92); C136(0.94)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C131(1.00); C145(1.00); C223(1.05); C136(1.05)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C131(1.00); C145(1.05); C223(0.92); C136(1.05)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C131(1.01); C145(0.84); C223(0.79); C136(1.03)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C131(0.97); C145(1.06); C223(1.02); C136(1.14)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C131(1.02); C145(1.00); C223(0.97); C136(1.14)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C131(0.98); C145(1.04); C223(1.01); C86(0.93)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C131(1.02); C145(1.05); C223(1.02); C136(0.93)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C131(1.01); C145(0.90); C223(1.21); C136(1.07)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C131(1.01); C145(1.11); C223(1.00); C136(1.03)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C131(1.03); C145(1.04); C223(1.03); C136(0.99)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C131(0.94); C145(1.02); C223(0.98); C136(1.08)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C131(1.03); C145(0.94); C223(1.02); C136(1.00)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C131(1.03); C145(0.94); C223(1.01); C136(1.02)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C131(0.97); C145(0.95); C223(1.02); C136(1.10)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C131(1.04); C145(0.95); C223(0.94); C86(1.00)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C131(0.94); C145(0.95); C223(0.97); C136(0.88)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C131(0.95); C145(1.08); C223(1.07); C136(1.03)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C131(0.97); C145(1.11); C223(1.18); C136(0.98)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C131(1.05); C145(0.99); C223(0.97); C136(1.00)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C131(0.93); C145(0.98); C223(0.97); C136(1.04)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C131(0.95); C145(0.84); C223(1.02); C136(0.92)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C131(1.01); C145(0.96); C223(1.05); C136(1.08)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C131(0.95); C145(0.96); C223(1.00); C136(1.03)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C131(0.98); C145(1.00); C223(0.97); C86(1.19)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C131(1.00); C145(1.04); C223(0.99); C136(1.10)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C131(0.96); C145(0.92); C223(1.03); C86(1.09)  LDD1569  [23]
 LDCM0248  AKOS034007472 HEK-293T C131(1.02); C145(0.92); C223(1.03); C136(1.06)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C131(1.01); C145(0.94); C223(0.93); C136(0.93)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C131(1.03); C145(0.91); C223(0.96); C86(1.03)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.63  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H268(0.00); C131(0.00); C86(0.00)  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C131(0.94); C145(0.93); C223(0.93); C136(0.96)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C131(0.54); C145(0.71); C223(14.53); C136(0.59)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C131(0.99); C223(0.94); C136(0.99); C211(1.05)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C131(0.94); C145(1.00); C223(0.93); C136(0.94)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C131(0.85); C145(0.99); C223(1.00); C136(0.79)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C131(1.04); C223(0.98); C136(1.03); C211(0.91)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C131(1.02); C223(0.98); C136(1.02); C211(0.99)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C131(0.97); C145(0.92); C223(0.91); C136(0.96)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C131(0.94); C145(0.90); C223(1.02); C136(1.00)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C131(0.97); C223(0.92); C136(1.00); C211(0.92)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C131(1.02); C223(0.99); C136(1.02); C211(1.02)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C131(0.91); C145(0.98); C223(0.97); C136(0.99)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C131(0.95); C145(1.05); C223(0.97); C136(0.92)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C131(0.88); C145(0.84); C223(1.00); C136(0.82)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C131(0.97); C223(1.09); C136(1.00); C211(0.79)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C131(0.97); C223(0.96); C136(0.92); C211(0.90)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C131(1.03); C145(1.01); C223(1.01); C136(0.98)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C131(0.88); C145(0.90); C223(0.97); C136(0.81)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C131(1.00); C223(0.89); C136(1.00); C211(0.95)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C131(1.03); C223(0.92); C136(0.99); C211(1.08)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C131(0.99); C145(0.93); C223(0.94); C136(0.98)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C131(0.96); C145(0.89); C223(1.01); C136(0.96)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C131(0.94); C223(0.93); C136(1.03); C211(1.03)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C131(0.97); C145(1.03); C223(1.07); C86(1.26)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C131(1.02); C223(0.92); C136(0.94); C211(1.03)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C131(0.94); C145(0.95); C223(0.89); C136(0.97)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C131(1.08); C145(0.90); C223(1.33); C136(1.40)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C131(0.70); C223(1.00); C136(0.72); C211(1.02)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C131(0.97); C223(0.90); C136(0.94); C211(1.05)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C131(0.89); C145(0.89); C223(0.95); C136(0.96)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C131(0.84); C145(1.04); C223(0.99); C136(0.92)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C131(0.90); C223(0.93); C136(1.04); C211(0.96)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C131(0.89); C223(1.02); C136(0.98); C211(1.19)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C131(0.93); C145(0.94); C223(0.92); C136(0.94)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C131(0.96); C145(1.02); C223(1.18); C136(0.98)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C131(0.87); C223(0.97); C136(0.99); C211(0.71)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C131(1.00); C223(0.98); C136(0.99); C211(1.04)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C131(0.85); C145(0.79); C223(1.15); C136(0.87)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C131(0.98); C145(1.16); C223(1.03); C136(1.04)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C131(0.99); C145(1.21); C223(1.04); C136(1.01)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C131(0.91); C145(1.01); C223(1.20); C136(1.01)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C131(1.01); C145(1.10); C223(1.00); C136(1.06)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C131(0.85); C145(0.87); C223(1.09); C136(0.86)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C131(0.99); C145(0.86); C223(1.14); C136(0.96)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C131(1.01); C145(1.00); C223(1.12); C136(1.07)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C131(0.95); C145(1.13); C223(1.13); C86(1.33)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C131(0.90); C145(0.99); C223(1.04); C136(0.96)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C131(0.97); C145(1.04); C223(1.02); C136(1.01)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C131(1.02); C223(1.14); C136(1.12); C211(0.89)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C131(1.01); C223(0.96); C136(1.01); C211(1.01)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C131(1.00); C145(0.94); C223(1.10); C136(1.01)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C131(0.90); C223(1.07); C136(1.06); C211(0.82)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C131(0.98); C145(1.09); C223(1.09); C136(1.03)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C131(1.00); C145(1.15); C223(1.02); C136(1.00)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C131(0.95); C145(1.04); C223(1.00); C136(1.02)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C131(0.80); C145(0.83); C223(0.93); C136(0.77)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C131(1.02); C145(0.91); C223(1.12); C136(1.07)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C131(0.98); C145(1.04); C223(1.06); C136(0.98)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C131(0.98); C145(1.08); C223(1.08); C86(1.31)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C131(0.95); C145(0.95); C223(1.17); C136(1.00)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C131(0.94); C223(1.17); C136(0.93); C211(1.00)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C131(0.91); C223(0.99); C136(0.97); C211(1.11)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C131(1.06); C223(1.02); C136(1.08); C211(1.10)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C131(0.93); C145(0.92); C223(1.00); C136(0.85)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C131(0.94); C145(1.16); C223(1.08); C136(1.00)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C131(1.03); C145(1.05); C223(1.10); C136(0.96)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C131(0.95); C145(1.03); C223(1.00); C136(0.98)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C131(0.83); C145(0.84); C223(1.05); C136(0.88)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C131(0.91); C145(0.93); C223(1.52); C136(1.02)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C131(0.97); C145(0.99); C223(1.03); C136(0.87)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C131(0.99); C145(1.04); C223(1.05); C86(1.37)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C131(0.94); C145(0.94); C223(1.06); C136(1.04)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C131(0.92); C145(0.94); C223(1.08); C136(1.02)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C131(0.92); C145(1.01); C223(1.05); C136(0.93)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C131(1.05); C223(0.95); C136(0.96); C211(1.02)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C131(0.91); C145(0.94); C223(1.09); C136(0.79)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C131(0.81); C145(1.16); C223(0.91); C136(0.81)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C131(0.97); C145(1.09); C223(1.03); C136(0.98)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C131(0.91); C145(1.03); C223(0.95); C136(1.00)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C131(0.85); C145(0.85); C223(0.95); C136(0.79)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C131(0.91); C145(0.91); C223(1.14); C136(0.86)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C131(1.01); C145(1.04); C223(1.32); C136(0.96)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C131(0.87); C145(1.07); C223(0.83); C136(0.97)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C131(1.00); C145(1.12); C223(1.12); C86(1.44)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C131(1.01); C145(0.91); C223(1.00); C136(1.02)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C131(0.99); C145(0.88); C223(1.05); C136(1.05)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C131(0.97); C223(1.01); C136(1.04); C211(0.93)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C131(0.95); C223(1.07); C136(0.93); C211(1.02)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C131(1.00); C145(1.00); C223(0.95); C136(0.95)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C131(0.95); C145(1.12); C223(1.04); C136(0.94)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C131(1.01); C145(1.09); C223(0.99); C136(1.00)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C131(0.93); C145(1.14); C223(1.07); C136(0.97)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C131(0.87); C145(0.83); C223(1.31); C136(0.88)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C131(0.92); C145(1.12); C223(1.04); C136(0.94)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C131(0.92); C145(0.87); C223(1.07); C136(1.02)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C131(0.91); C145(1.02); C223(1.01); C136(0.99)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C131(0.97); C145(1.04); C223(1.07); C86(1.65)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C131(0.92); C145(0.99); C223(1.04); C136(1.01)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C131(0.94); C145(0.83); C223(1.07); C136(0.98)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C131(1.00); C223(1.03); C136(1.06); C211(1.15)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C131(0.84); C145(0.86); C223(0.98); C136(0.84)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C131(0.97); C145(1.14); C223(1.06); C136(1.04)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C131(0.91); C145(0.97); C223(1.12); C136(0.91)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C131(0.57); C145(0.84); C223(0.93); C136(0.74)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C131(0.99); C145(1.04); C223(1.06); C136(1.06)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C131(0.93); C145(0.89); C223(1.13); C136(0.98)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C131(0.95); C145(0.98); C223(1.04); C136(1.08)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C131(0.99); C145(0.96); C223(1.19); C136(1.06)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C131(0.87); C145(0.96); C223(0.97); C86(1.53)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C131(0.93); C145(0.94); C223(0.96); C136(1.07)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C131(0.86); C145(0.89); C223(1.09); C136(0.98)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C131(0.87); C223(0.98); C136(1.03); C211(0.86)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C131(0.93); C223(0.97); C136(1.04); C211(1.12)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C131(0.94); C145(1.04); C223(0.96); C136(0.92)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C131(0.94); C145(0.95); C223(1.05); C136(0.95)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C131(0.66); C145(1.13); C223(1.01); C136(1.26)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C131(0.88); C145(1.06); C223(1.06); C136(1.08)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C131(0.85); C145(1.02); C223(0.91); C136(0.98)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C131(0.91); C145(0.94); C223(1.08); C136(0.99)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C131(0.87); C145(0.93); C223(1.04); C136(0.99)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C131(0.78); C145(0.87); C223(0.81); C136(0.93)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C131(0.83); C145(0.93); C223(0.97); C86(1.17)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C131(0.90); C145(0.97); C223(0.85); C136(0.88)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C131(0.92); C145(0.99); C223(1.08); C136(0.92)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C131(0.88); C223(0.99); C136(0.98); C211(0.91)  LDD1697  [23]
 LDCM0189  Compound 16 HEK-293T 29.60  LDD0492  [21]
 LDCM0182  Compound 18 HEK-293T 4.71  LDD0501  [21]
 LDCM0191  Compound 21 HEK-293T 6.21  LDD0493  [21]
 LDCM0190  Compound 34 HEK-293T 8.31  LDD0497  [21]
 LDCM0192  Compound 35 HEK-293T 4.03  LDD0491  [21]
 LDCM0193  Compound 36 HEK-293T 4.66  LDD0494  [21]
 LDCM0194  Compound 37 HEK-293T 14.96  LDD0498  [21]
 LDCM0195  Compound 38 HEK-293T 5.15  LDD0499  [21]
 LDCM0196  Compound 39 HEK-293T 6.97  LDD0496  [21]
 LDCM0183  Compound 42 HEK-293T 3.72  LDD0500  [21]
 LDCM0495  E2913 HEK-293T C131(0.98); C223(1.19); C136(0.97); C211(0.82)  LDD1698  [23]
 LDCM0625  F8 Ramos C131(4.02)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C131(1.27)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C131(0.24)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C131(0.74)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C131(3.02)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C131(0.73)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C131(0.69)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C131(2.54)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C131(1.43)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C131(2.88)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C131(0.53)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C131(3.14)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C131(2.45)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C131(0.83)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C131(0.82); C223(1.30); C136(0.82); C211(1.22)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C131(2.19)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C131(1.28)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C131(1.03); C145(0.91); C223(1.09); C136(1.04)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C131(1.62)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C131(1.70)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C131(0.43)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C131(0.74)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y125(0.87)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y125(1.14)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y125(0.60)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y125(0.84)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y125(1.30)  LDD0268  [8]
 LDCM0107  IAA HeLa H268(0.00); H227(0.00); C86(0.00); C131(0.00)  LDD0221  [18]
 LDCM0123  JWB131 DM93 Y125(0.32)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y125(0.20)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y125(0.53)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y125(2.31)  LDD0288  [7]
 LDCM0129  JWB202 DM93 Y125(0.14)  LDD0291  [7]
 LDCM0022  KB02 HEK-293T C131(1.02); C136(0.98); C145(0.91); C223(1.01)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C131(1.06); C136(1.03); C145(1.06); C223(0.92)  LDD1497  [23]
 LDCM0024  KB05 COLO792 C131(1.33)  LDD3310  [6]
 LDCM0109  NEM HeLa H227(0.00); H268(0.00)  LDD0223  [18]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C55(1.41)  LDD2090  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C55(0.25)  LDD2145  [5]
 LDCM0136  SR-4559 HEK-293T 3.85  LDD0330  [22]
 LDCM0137  SR-4995 HEK-293T 3.03  LDD0331  [22]
 LDCM0112  W16 Hep-G2 C145(0.67)  LDD0239  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ER membrane protein complex subunit 3 (EMC3) EMC3 family Q9P0I2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenine Small molecular drug DB00173
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5'-deoxy-5'-(Methylthio)-tubercidin Small molecular drug D02JUP
5'-s-methyl-5'-thioadenosine Small molecular drug DB02282
Formycin Small molecular drug D0NH1Y
(2s3s4r5s)-2-(4-amino-45-dihydro-1h-pyrrolo[32-d]Pyrimidin-7-yl)-5-[(Methylsulfanyl)Methyl]-34-pyrrolidinediol . DB02158
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Methylthioadenosine Small molecular drug D0E4WF

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578