Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe15  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 20.0
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 20.0
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 20.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP01769  Dihydrofolate reductase (DHFR) 20.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 20.0
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 20.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 20.0
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 20.0
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 20.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 20.0
 LDTP03842  Squalene synthase (FDFT1) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 18.2
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) 17.9
 LDTP02141  Alpha-galactosidase A (GLA) 17.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 16.6
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 16.2
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 16.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 16.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 14.5
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 14.2
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 14.1
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 13.9
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 13.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 11.2
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 10.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 10.4
 LDTP00988  Protein O-GlcNAcase (OGA) 7.6
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 7.1
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 5.9
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 5.5
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.3
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP04707  Protein SEC13 homolog (SEC13) 16.7
 LDTP04501  Importin subunit alpha-1 (KPNA2) 15.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 12.6
 LDTP09949  Transportin-1 (TNPO1) 12.5
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 12.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 8.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 5.6
Other
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 20.0
 LDTP00887  Calumenin (CALU) 20.0
 LDTP01652  Centrosomal protein 43 (CEP43) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 20.0
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 20.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 20.0
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 20.0
 LDTP06352  Reticulocalbin-1 (RCN1) 20.0
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 20.0
 LDTP13630  Neudesin (NENF) 19.0
 LDTP12412  Reticulon-4 (RTN4) 13.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 13.1
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 12.1
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 5.8
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 5.6
 LDTP02297  Vimentin (VIM) 5.1

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.