Details of the Target

General Information of Target

Target ID LDTP04501
Target Name Importin subunit alpha-1 (KPNA2)
Gene Name KPNA2
Gene ID 3838
Synonyms
RCH1; SRP1; Importin subunit alpha-1; Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
Target Bioclass
Transporter and channel
Family
Importin alpha family
Subcellular location
Cytoplasm; Endoplasmic reticulum membrane
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Uniprot ID
P52292
Ensemble ID
ENST00000330459.8
HGNC ID
HGNC:6395
ChEMBL ID
CHEMBL1741187

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.82  LDD0215  [2]
CHEMBL5175495
 Probe Info  		6.52  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		16.14  LDD0235  [5]
TH216
 Probe Info  		Y485(13.56)  LDD0259  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
Probe 1
 Probe Info  		Y485(15.42)  LDD3495  [8]
THZ1-DTB
 Probe Info  		C133(1.08); C272(1.06)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C237(2.06); C223(2.83)  LDD0169  [10]
EA-probe
 Probe Info  		C223(0.97); C223(1.12)  LDD2210  [11]
HHS-475
 Probe Info  		Y203(1.00); Y277(1.07)  LDD0264  [12]
HHS-465
 Probe Info  		Y203(1.23)  LDD2237  [13]
Acrolein
 Probe Info  		N.A.  LDD0222  [14]
DBIA
 Probe Info  		C223(1.11)  LDD0078  [15]
5E-2FA
 Probe Info  		N.A.  LDD2235  [16]
AMP probe
 Probe Info  		N.A.  LDD0200  [17]
ATP probe
 Probe Info  		K108(0.00); K22(0.00); K240(0.00); K353(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C272(0.00); C237(0.00); C223(0.00); C467(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C272(0.00); C133(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C272(0.00); C467(0.00); C237(0.00); C223(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		N.A.  LDD0035  [21]
IPM
 Probe Info  		N.A.  LDD0025  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		C133(0.00); C223(0.00)  LDD2226  [23]
TFBX
 Probe Info  		N.A.  LDD0027  [22]
1d-yne
 Probe Info  		K300(0.00); K83(0.00)  LDD0356  [24]
NHS
 Probe Info  		N.A.  LDD0010  [25]
STPyne
 Probe Info  		N.A.  LDD0009  [25]
Phosphinate-6
 Probe Info  		C272(0.00); C237(0.00)  LDD0018  [26]
Ox-W18
 Probe Info  		W184(0.00); W273(0.00)  LDD2175  [27]
1c-yne
 Probe Info  		K353(0.00); K83(0.00); K240(0.00); K300(0.00)  LDD0228  [24]
AOyne
 Probe Info  		15.00  LDD0443  [28]
NAIA_5
 Probe Info  		C223(0.00); C467(0.00); C272(0.00); C133(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		13.27  LDD1728  [29]
C040
 Probe Info  		10.70  LDD1740  [29]
C106
 Probe Info  		28.64  LDD1793  [29]
C107
 Probe Info  		10.06  LDD1794  [29]
C108
 Probe Info  		12.21  LDD1795  [29]
C112
 Probe Info  		18.25  LDD1799  [29]
C153
 Probe Info  		21.56  LDD1834  [29]
C161
 Probe Info  		12.91  LDD1841  [29]
C163
 Probe Info  		9.78  LDD1843  [29]
C178
 Probe Info  		30.48  LDD1857  [29]
C220
 Probe Info  		12.47  LDD1894  [29]
C231
 Probe Info  		15.78  LDD1904  [29]
C232
 Probe Info  		41.07  LDD1905  [29]
C246
 Probe Info  		20.39  LDD1919  [29]
C273
 Probe Info  		5.46  LDD1943  [29]
C289
 Probe Info  		25.11  LDD1959  [29]
C307
 Probe Info  		5.78  LDD1975  [29]
C350
 Probe Info  		25.99  LDD2011  [29]
C376
 Probe Info  		10.85  LDD2036  [29]
C388
 Probe Info  		44.63  LDD2047  [29]
C390
 Probe Info  		21.41  LDD2049  [29]
C420
 Probe Info  		18.00  LDD2075  [29]
C423
 Probe Info  		11.71  LDD2078  [29]
FFF probe11
 Probe Info  		5.35  LDD0472  [30]
FFF probe13
 Probe Info  		20.00  LDD0475  [30]
FFF probe14
 Probe Info  		13.97  LDD0477  [30]
FFF probe15
 Probe Info  		12.09  LDD0478  [30]
FFF probe2
 Probe Info  		15.34  LDD0463  [30]
FFF probe3
 Probe Info  		13.15  LDD0464  [30]
FFF probe6
 Probe Info  		5.41  LDD0482  [30]
FFF probe9
 Probe Info  		5.64  LDD0470  [30]
JN0003
 Probe Info  		17.61  LDD0469  [30]
STS-2
 Probe Info  		1.00  LDD0139  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Kambe_31
 Probe Info  		5.27  LDD0128  [33]
BD-F
 Probe Info  		F138(0.00); D132(0.00)  LDD0024  [34]
LD-F
 Probe Info  		F138(0.00); E139(0.00); S134(0.00); A143(0.00)  LDD0015  [34]
OEA-DA
 Probe Info  		7.94  LDD0046  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C237(2.06); C223(2.83)  LDD0169  [10]
 LDCM0561  Abegg_cp(-)-10 HeLa C133(2.64)  LDD0312  [22]
 LDCM0214  AC1 HCT 116 C133(0.91); C223(0.84); C237(0.82); C272(0.85)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C133(0.96); C223(0.84); C237(0.87); C272(0.85)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C133(0.60); C223(0.92); C237(0.73); C272(0.60)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C133(0.58); C223(0.91); C237(0.80); C272(0.65)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C133(0.56); C223(0.98); C237(0.69); C272(0.64)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C133(0.72); C223(0.98); C237(0.67); C272(0.63)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C133(0.67); C223(1.01); C237(0.66); C272(0.53)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C133(0.60); C223(0.87); C237(0.71); C272(0.48)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C133(0.60); C223(0.91); C237(0.72); C272(0.52)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C133(0.52); C223(1.12); C237(0.66); C272(0.80)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C133(0.63); C223(0.77); C237(0.72); C272(0.48)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C133(0.80); C223(0.78); C237(0.73); C272(0.59)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C133(0.85); C223(1.10); C237(0.69); C272(0.92)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C133(0.62); C223(0.94); C237(0.66); C272(0.47)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C133(0.57); C223(1.04); C237(0.71); C272(0.46)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C133(0.62); C223(1.02); C237(0.58); C272(0.74)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C223(1.20); C237(0.90); C272(0.85); C467(0.81)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C223(1.48); C237(0.87); C272(0.57); C467(0.70)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C223(1.28); C237(0.82); C272(0.44); C467(0.70)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C223(1.03); C237(0.81); C272(0.56); C467(0.73)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C223(1.09); C237(0.84); C272(0.69); C467(0.78)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C223(1.08); C237(0.90); C272(0.58); C467(0.75)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C223(0.84); C237(0.74); C272(0.56); C467(0.73)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C133(0.85); C223(0.84); C237(0.88); C272(0.85)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C223(1.27); C237(0.72); C272(0.50); C467(0.65)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C223(1.00); C237(1.03); C272(0.60); C467(0.87)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C223(0.79); C237(0.88); C272(0.69); C467(0.87)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C223(1.01); C237(0.97); C272(0.82); C467(0.88)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C223(1.13); C237(1.01); C272(0.85); C467(0.72)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C223(1.09); C237(0.94); C272(0.60); C467(0.75)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C223(1.18); C237(0.90); C272(0.59); C467(0.76)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C223(0.96); C237(0.84); C272(0.74); C467(0.77)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C133(1.19); C223(1.25); C237(1.73); C272(0.84)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C133(1.14); C223(2.00); C237(1.63); C272(1.10)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C133(1.21); C223(1.13); C237(1.34); C272(0.98)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C133(1.07); C223(1.36); C237(1.28); C272(1.17)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C133(0.74); C223(1.07); C237(1.15); C272(0.95)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C133(0.95); C223(1.09); C237(1.42); C272(1.00)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C133(0.99); C223(1.24); C237(1.08); C272(0.86)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C133(0.99); C223(0.97); C237(1.28); C272(0.93)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C133(0.90); C223(1.05); C237(1.07); C272(0.98)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C133(0.85); C223(1.02); C237(1.19); C272(0.91)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C133(0.88); C223(1.19); C237(1.09); C272(0.76)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C133(0.92); C223(1.07); C237(1.10); C272(0.99)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C133(0.79); C223(1.28); C237(0.82); C272(0.92)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C133(0.86); C223(1.19); C237(1.02); C272(0.80)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C133(0.89); C223(1.21); C237(0.96); C272(1.10)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C133(0.85); C223(0.94); C237(1.12); C272(1.00)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C272(0.78); C467(0.81); C223(0.90); C237(0.90)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C237(0.78); C272(0.79); C467(0.89); C133(1.10)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C272(0.50); C467(0.81); C237(0.83); C223(1.01)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C272(0.51); C237(0.80); C467(0.95); C223(1.15)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C272(0.46); C237(0.81); C467(0.82); C223(1.13)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C272(0.58); C467(0.93); C237(0.96); C133(1.52)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C272(0.56); C237(0.85); C467(0.94); C223(1.22)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C237(0.82); C133(0.83); C467(0.89); C272(0.90)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C272(0.44); C237(0.82); C467(0.83); C223(1.00)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C272(0.58); C467(0.82); C237(0.88); C223(1.11)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C272(0.56); C237(0.74); C467(0.88); C133(1.42)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C272(0.83); C237(0.97); C467(1.12); C223(1.94)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C133(1.83); C223(1.25); C237(0.83); C272(0.76)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C133(1.02); C223(1.30); C237(0.76); C272(0.50)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C133(1.19); C223(1.19); C237(0.90); C272(0.88)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C133(1.05); C223(2.42); C237(1.17); C272(0.79)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C272(0.93); C237(0.96); C467(1.07); C133(1.21)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C272(0.63); C237(0.79); C467(0.89); C133(1.00)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C272(0.74); C237(0.91); C467(1.04); C133(1.46)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C223(0.71); C272(0.73); C237(0.79); C133(0.85)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C272(0.81); C467(0.95); C237(0.99); C133(1.33)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C237(0.87); C272(0.92); C133(1.03); C467(1.18)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C133(0.70); C272(0.89); C467(1.03); C237(1.11)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C272(0.90); C133(0.94); C237(1.04); C467(1.11)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C467(1.02); C133(1.02); C237(1.11); C272(1.18)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C467(0.78); C272(0.80); C237(0.94); C133(1.06)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C272(0.80); C467(0.85); C237(0.86); C133(1.10)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C272(0.65); C237(0.77); C467(0.80); C133(1.05)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C237(0.74); C467(0.76); C272(0.84); C133(1.07)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C467(0.77); C237(0.80); C133(1.07); C272(1.19)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C223(0.61); C272(0.70); C237(0.83); C133(0.85)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C237(0.68); C272(0.75); C467(0.76); C133(1.12)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C272(0.74); C467(0.81); C237(0.83); C133(1.07)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C272(0.55); C237(0.72); C467(0.76); C133(1.11)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C467(0.71); C237(0.72); C272(0.88); C133(1.22)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C467(0.71); C237(0.75); C272(0.87); C133(1.23)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C272(0.85); C133(0.87); C223(0.90); C237(0.99)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C133(0.74); C223(0.75); C272(0.92); C237(0.98)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C223(0.75); C133(0.76); C272(0.98); C467(0.99)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C272(0.76); C133(0.80); C223(0.85); C237(0.95)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C223(0.63); C272(0.73); C133(0.81); C237(0.93)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C223(0.63); C272(0.67); C237(0.80); C133(0.94)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C272(0.75); C223(0.86); C133(0.96); C467(1.04)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C272(0.66); C133(0.78); C223(0.82); C237(0.94)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C272(0.75); C133(0.82); C223(0.91); C467(0.96)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C272(0.80); C223(0.81); C133(0.89); C237(0.89)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C272(0.71); C223(0.89); C237(0.95); C467(1.03)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C272(0.76); C223(0.87); C133(0.88); C237(1.03)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C272(0.89); C223(0.92); C467(0.98); C237(1.06)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C223(0.79); C272(0.95); C467(1.07); C237(1.14)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C272(0.79); C223(0.83); C467(1.18); C237(1.30)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C223(0.92); C467(1.08); C237(1.11); C272(1.12)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C223(0.66); C272(0.68); C237(0.78); C133(0.97)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C272(0.94); C467(1.08); C223(1.16); C237(1.21)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C272(0.89); C467(1.08); C223(1.08); C237(1.35)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C223(0.91); C467(1.00); C272(1.06); C237(1.16)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C467(1.04); C237(1.05); C223(1.08); C272(1.35)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C223(0.86); C272(0.92); C467(1.02); C237(1.06)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C223(0.89); C467(1.18); C272(1.29); C237(1.29)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C223(0.98); C272(1.19); C467(1.32); C237(1.44)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C467(0.80); C223(0.81); C237(0.83); C272(0.94)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C467(0.80); C237(0.84); C133(0.99); C223(1.00)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C237(0.71); C467(0.85); C223(0.87); C133(1.08)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C237(0.84); C272(0.85); C133(0.87); C467(0.88)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C237(0.79); C467(0.80); C223(0.86); C133(0.88)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C237(0.81); C467(0.82); C223(0.88); C133(0.90)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C237(0.83); C223(0.86); C467(1.03); C133(1.12)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C467(0.81); C223(0.82); C237(0.85); C133(0.89)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C237(0.94); C467(0.94); C223(0.96); C133(0.99)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C223(0.77); C237(0.78); C133(0.97); C272(0.97)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C272(0.83); C237(0.83); C467(0.96); C133(0.97)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C237(0.77); C223(0.78); C467(0.96); C133(0.97)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C223(0.62); C272(0.82); C467(0.97); C237(1.01)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C223(0.87); C272(0.92); C467(0.97); C133(1.14)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C272(0.85); C237(0.86); C133(0.90); C467(1.00)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C223(0.65); C133(0.86); C272(0.92); C467(0.94)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C223(0.69); C133(0.84); C272(0.94); C467(0.95)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C223(0.75); C272(0.89); C467(0.90); C237(1.06)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C223(0.71); C272(1.09); C467(1.10); C133(1.20)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C223(0.79); C272(1.09); C467(1.15); C237(1.24)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C223(0.73); C272(1.17); C467(1.20); C133(1.26)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C223(0.69); C272(0.85); C467(1.00); C133(1.08)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C272(0.90); C223(0.91); C467(1.01); C133(1.10)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C223(0.85); C133(0.94); C272(0.95); C467(1.01)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C223(0.68); C272(0.92); C467(0.95); C133(0.96)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C237(0.78); C272(0.85); C133(0.86); C467(0.95)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C223(0.85); C272(0.95); C467(1.01); C237(1.14)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C223(0.81); C467(0.88); C237(1.00); C272(1.04)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C223(0.52); C272(1.07); C467(1.21); C237(1.37)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C272(0.67); C237(0.93); C467(0.96); C133(1.20)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C272(0.57); C467(0.87); C237(0.93); C133(1.17)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C272(0.62); C467(0.81); C237(0.90); C133(0.95)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C467(0.82); C237(0.88); C272(0.90); C133(0.93)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C272(0.84); C467(0.90); C237(0.98); C133(1.01)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C467(0.73); C272(0.78); C237(0.93); C133(1.00)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C467(0.78); C272(0.78); C133(0.95); C237(1.00)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C133(0.88); C467(1.04); C223(1.07); C237(1.07)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C272(0.64); C467(0.92); C237(1.02); C133(1.07)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C272(0.61); C467(0.84); C237(0.86); C133(1.12)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C272(0.72); C467(0.75); C237(0.90); C133(0.98)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C272(0.68); C467(0.82); C237(0.93); C133(0.97)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C272(0.74); C467(0.82); C237(0.83); C133(0.87)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C467(0.79); C272(0.80); C237(1.04); C133(1.04)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C272(0.67); C467(0.76); C237(0.77); C133(1.05)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C272(0.54); C237(0.55); C467(0.66); C133(0.73)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C133(0.49); C467(0.61); C237(0.72); C272(0.85)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C133(0.81); C223(1.04); C237(0.94); C272(1.27)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C133(0.82); C223(0.85); C237(0.89); C467(0.94)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C237(0.80); C467(0.94); C272(1.02); C223(1.04)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C223(1.11)  LDD0078  [15]
 LDCM0630  CCW28-3 231MFP C133(1.30); C223(0.96)  LDD2214  [37]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C133(2.20); C237(1.85)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C133(0.86); C467(0.92); C223(1.00); C272(1.05)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C237(0.83); C272(0.90); C223(1.07); C133(1.10)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C223(0.69); C237(0.74); C272(0.76); C133(0.92)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C133(0.76); C237(0.78); C467(0.89); C272(0.94)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C133(0.78); C272(0.81); C467(0.96); C237(0.99)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C133(0.84); C237(0.98); C467(1.02); C272(1.03)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C272(0.78); C467(0.95); C237(0.96); C133(0.99)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C272(0.71); C237(0.80); C133(0.87); C467(0.94)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C272(0.83); C237(0.95); C467(1.00); C223(1.41)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C272(0.74); C237(0.86); C133(0.89); C467(0.99)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C237(0.82); C133(1.15); C272(1.17); C467(1.25)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C133(0.73); C237(0.84); C272(0.84); C467(0.98)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C272(0.95); C237(1.03); C133(1.07); C467(1.11)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C272(0.70); C133(0.73); C237(0.87); C467(1.11)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C272(0.70); C237(0.84); C467(0.95); C223(1.41)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C237(0.82); C467(0.85); C272(0.99); C133(0.99)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C237(0.67); C467(0.70); C272(0.71); C133(1.18)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C467(0.68); C237(0.82); C133(1.12); C272(2.16)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C237(0.66); C272(0.66); C467(0.69); C133(1.03)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C272(0.50); C237(0.76); C467(0.79); C133(1.09)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C133(0.99); C223(1.04); C237(1.06); C272(1.21)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C223(0.74); C272(0.77); C237(0.93); C467(0.97)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C272(0.73); C223(0.87); C237(0.91); C133(1.03)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C237(1.10); C467(1.11); C272(1.14); C133(1.18)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C223(0.68); C272(0.72); C133(0.75); C237(0.87)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C223(0.81); C272(0.91); C237(0.93); C467(1.00)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C223(0.83); C272(0.85); C467(1.01); C237(1.09)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C223(0.77); C272(1.00); C467(1.03); C237(1.08)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C223(0.75); C272(0.91); C467(1.02); C237(1.10)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C223(0.72); C133(0.75); C237(0.91); C272(0.93)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C133(0.71); C467(0.77); C237(0.85); C223(0.95)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C237(0.76); C223(0.85); C467(0.90); C133(0.90)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C237(0.73); C467(0.82); C133(0.87); C223(0.93)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C467(0.98); C237(1.01); C133(1.03); C272(1.12)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C133(0.88); C272(0.92); C237(1.02); C467(1.03)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C467(0.78); C272(0.85); C133(0.98); C237(1.02)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C237(0.85); C133(0.93); C467(0.98); C223(1.10)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C467(0.71); C272(0.92); C133(0.96); C237(1.02)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C467(0.83); C133(1.00); C237(1.11); C223(1.25)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C467(0.93); C237(0.95); C223(1.06); C133(1.13)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C467(0.85); C133(0.90); C223(1.00); C272(1.02)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C467(0.88); C133(0.95); C237(0.99); C272(1.01)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C467(0.92); C237(1.16); C223(1.23); C133(1.23)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C237(1.14); C223(1.33); C467(1.45); C133(1.54)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C467(0.84); C133(0.92); C272(1.00); C237(1.02)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C467(0.94); C237(1.04); C272(1.09); C133(1.13)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C133(0.95); C223(1.11); C237(0.65); C272(1.40)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C133(0.98); C223(1.18); C237(0.85); C272(1.43)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C133(0.99); C223(0.89); C237(0.77); C272(1.00)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C133(1.05); C223(1.24); C237(0.78); C272(1.06)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C133(1.07); C223(1.12); C237(0.79); C272(0.96)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C133(0.91); C223(1.20); C237(1.00); C272(0.94)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C133(1.02); C223(1.15); C237(0.82); C272(0.92)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C133(0.92); C223(0.93); C237(0.94); C272(0.99)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C133(1.00); C223(1.02); C237(0.98); C272(0.85)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C133(0.97); C223(0.99); C237(0.98); C272(0.69)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C133(1.43); C223(1.18); C237(0.93); C272(0.88)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C133(1.26); C223(1.00); C237(1.00); C272(0.85)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C133(1.47); C223(1.37); C237(1.07); C272(0.98)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C133(1.25); C223(1.00); C237(1.17); C272(0.95)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C133(1.09); C223(1.10); C237(1.02); C272(0.92)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C133(0.87); C223(1.15); C237(0.87); C272(1.23)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C133(1.18); C223(1.12); C237(0.86); C272(0.80)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C133(1.26); C223(1.38); C237(0.94); C272(0.76)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C133(1.48); C223(1.40); C237(1.12); C272(1.10)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C133(1.40); C223(1.18); C237(1.06); C272(1.12)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C133(1.34); C223(0.92); C237(0.93); C272(0.94)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C133(1.07); C223(0.83); C237(0.94); C272(0.87)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C133(0.97); C223(1.00); C237(1.24); C272(0.92)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C133(0.95); C223(0.93); C237(1.24); C272(0.87)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C133(0.87); C223(0.98); C237(1.09); C272(1.17)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C133(1.23); C223(1.40); C237(1.28); C272(0.87)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C133(1.06); C223(1.14); C237(1.09); C272(0.98)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C133(1.37); C223(0.97); C237(1.36); C272(0.93)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C133(1.08); C223(0.90); C237(1.41); C272(0.87)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C133(1.00); C223(0.81); C237(1.30); C272(0.80)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C133(1.01); C223(1.24); C237(1.35); C272(1.00)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C133(0.85); C223(1.04); C237(1.15); C272(0.82)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C133(1.20); C223(1.34); C237(1.41); C272(0.94)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C133(0.91); C223(0.97); C237(1.08); C272(0.90)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C133(1.08); C223(0.82); C237(1.50); C272(0.88)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C133(0.90); C223(0.98); C237(1.19); C272(0.91)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C133(0.75); C223(0.86); C237(1.12); C272(0.87)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C133(0.85); C223(1.07); C237(0.94); C272(1.02)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C133(0.94); C223(1.17); C237(1.01); C272(0.83)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C133(0.91); C237(0.97); C272(0.88); C467(0.87)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C133(0.98); C237(0.90); C272(0.92); C467(0.93)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C133(0.89); C237(0.86); C272(0.79); C467(0.84)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C133(0.90); C237(0.81); C272(0.75); C467(0.77)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C133(0.90); C237(0.87); C272(0.78); C467(0.84)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C133(1.22); C237(0.83); C272(0.71); C467(0.97)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C133(0.95); C237(0.81); C272(0.74); C467(0.83)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C133(0.92); C237(0.92); C272(0.65); C467(0.77)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C133(0.98); C237(0.92); C272(0.81); C467(0.80)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C133(0.99); C223(1.21); C237(1.05); C272(1.02)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C133(0.85); C237(0.86); C272(0.69); C467(0.89)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C133(0.93); C237(0.79); C272(0.76); C467(0.79)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C133(1.08); C237(0.85); C272(0.77); C467(0.79)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C133(0.95); C237(0.85); C272(1.04); C467(0.81)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C133(1.09); C237(0.85); C272(0.73); C467(0.75)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C133(1.18); C223(0.91); C237(1.00); C272(0.88)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C133(0.98); C223(1.26); C237(1.06); C272(1.23)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C133(1.60); C223(0.94); C237(0.99); C272(0.87)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C133(1.31); C223(1.35); C237(1.00); C272(0.84)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C133(1.09); C223(1.64); C237(1.13); C272(1.10)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C133(1.26); C223(1.54); C237(1.14); C272(1.00)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C133(1.22); C223(1.05); C237(1.01); C272(0.81)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C133(1.31); C223(1.57); C237(1.08); C272(0.93)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C133(1.39); C223(1.30); C237(1.07); C272(0.90)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C133(1.65); C223(1.50); C237(1.11); C272(1.16)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C133(1.22); C223(1.08); C237(0.86); C272(0.81)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C133(1.12); C223(1.08); C237(0.91); C272(0.95)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C133(1.00); C223(1.06); C237(0.95); C272(0.81)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C133(1.27); C223(1.06); C237(1.02); C272(0.93)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C133(1.69); C223(1.82); C237(1.16); C272(1.20)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C133(1.08); C223(1.17); C237(1.04); C272(0.99)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C133(0.96); C223(1.02); C237(1.18); C272(1.00)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C133(0.78); C223(0.76); C237(0.78); C272(0.68)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C133(0.76); C223(0.62); C237(0.81); C272(0.81)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C133(0.83); C223(0.63); C237(0.90); C272(0.89)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C133(0.75); C223(0.58); C237(0.80); C272(0.79)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C133(0.78); C223(0.59); C237(0.74); C272(0.69)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C133(0.83); C223(0.61); C237(0.73); C272(0.65)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C133(0.83); C223(0.71); C237(0.74); C272(0.67)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C133(0.84); C223(0.85); C237(0.75); C272(0.67)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C133(0.86); C223(0.73); C237(0.76); C272(0.70)  LDD0811  [15]
 LDCM0185  Compound 17 HEK-293T 5.27  LDD0512  [30]
 LDCM0191  Compound 21 HEK-293T 6.35  LDD0508  [30]
 LDCM0190  Compound 34 HEK-293T 7.23  LDD0510  [30]
 LDCM0192  Compound 35 HEK-293T 5.10  LDD0509  [30]
 LDCM0193  Compound 36 HEK-293T 6.51  LDD0511  [30]
 LDCM0495  E2913 HEK-293T C237(1.16); C467(1.06); C272(1.08); C133(0.97)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C467(1.61)  LDD1702  [39]
 LDCM0175  Ethacrynic acid HeLa C223(0.97); C223(1.12)  LDD2210  [11]
 LDCM0625  F8 Ramos C223(0.26); C133(0.40); C272(1.11)  LDD2187  [40]
 LDCM0572  Fragment10 Ramos C223(1.76); C133(1.54)  LDD2189  [40]
 LDCM0573  Fragment11 Ramos C223(0.27); C272(0.20)  LDD2190  [40]
 LDCM0574  Fragment12 Ramos C133(1.40)  LDD2191  [40]
 LDCM0575  Fragment13 Ramos C223(1.12); C133(1.60)  LDD2192  [40]
 LDCM0576  Fragment14 Ramos C223(0.63); C133(1.29); C272(1.68)  LDD2193  [40]
 LDCM0579  Fragment20 Ramos C133(1.74)  LDD2194  [40]
 LDCM0580  Fragment21 Ramos C223(0.68); C133(2.13)  LDD2195  [40]
 LDCM0582  Fragment23 Ramos C223(0.63); C133(1.77)  LDD2196  [40]
 LDCM0578  Fragment27 Ramos C223(0.53); C133(1.59)  LDD2197  [40]
 LDCM0586  Fragment28 Ramos C223(0.48); C133(0.47); C272(0.65)  LDD2198  [40]
 LDCM0588  Fragment30 Ramos C223(0.24); C133(1.65)  LDD2199  [40]
 LDCM0589  Fragment31 Ramos C223(0.60); C133(1.32); C272(0.29)  LDD2200  [40]
 LDCM0590  Fragment32 Ramos C223(0.57); C133(1.11); C272(0.19)  LDD2201  [40]
 LDCM0468  Fragment33 HCT 116 C133(0.87); C237(0.71); C272(0.68); C467(0.86)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C223(0.23); C133(1.23)  LDD2203  [40]
 LDCM0566  Fragment4 Ramos C223(2.35); C133(0.60); C272(0.39)  LDD2184  [40]
 LDCM0427  Fragment51 HCT 116 C133(1.83); C223(1.44); C237(1.27); C272(0.96)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C223(0.61); C133(1.25)  LDD2204  [40]
 LDCM0614  Fragment56 Ramos C223(0.18); C133(2.37)  LDD2205  [40]
 LDCM0569  Fragment7 Ramos C223(1.00); C133(0.87)  LDD2186  [40]
 LDCM0571  Fragment9 Ramos C133(1.67); C272(0.37)  LDD2188  [40]
 LDCM0116  HHS-0101 DM93 Y203(1.00); Y277(1.07)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y203(0.74); Y277(1.25)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y203(0.57); Y277(0.98)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y203(0.85); Y277(1.07)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y203(0.86); Y277(1.39)  LDD0268  [12]
 LDCM0015  HNE MDA-MB-231 C223(1.03)  LDD0346  [40]
 LDCM0073  Kambe_cp3 PC-3 5.27  LDD0128  [33]
 LDCM0079  kambe_cp64 PC-3 2.00  LDD0135  [33]
 LDCM0022  KB02 HCT 116 C237(2.15); C467(1.09); C133(1.35); C223(1.46)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C237(1.37); C467(1.72); C133(1.50); C223(1.19)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C237(9.08); C467(1.77); C133(1.31); C223(1.06)  LDD0082  [15]
 LDCM0627  NUDT7-COV-1 HEK-293T C272(0.84); C133(0.80); C467(0.59); C467(0.27)  LDD2206  [41]
 LDCM0628  OTUB2-COV-1 HEK-293T C223(0.82); C467(0.61); C272(0.49); C133(0.46)  LDD2207  [41]
 LDCM0131  RA190 MM1.R C133(1.35)  LDD0304  [42]
 LDCM0021  THZ1 HeLa S3 C133(1.08); C272(1.06)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA cap guanine-N7 methyltransferase (RNMT) mRNA cap 0 methyltransferase family O43148
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
ATP-dependent DNA helicase Q1 (RECQL) Helicase family P46063
m7GpppX diphosphatase (DCPS) HIT family Q96C86
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
MyoD family inhibitor (MDFI) MDFI family Q99750
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nuclear pore complex protein Nup50 (NUP50) . Q9UKX7
SUN domain-containing protein 2 (SUN2) . Q9UH99
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Transcription factor Jun (JUN) BZIP family P05412
Interferon regulatory factor 3 (IRF3) IRF family Q14653
High mobility group protein 20A (HMG20A) . Q9NP66
Transcriptional adapter 2-alpha (TADA2A) . O75478
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 1 (SF1) BBP/SF1 family Q15637
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
NUT family member 1 (NUTM1) NUT family Q86Y26
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Protein S100-A2 (S100A2) S-100 family P29034
Protein S100-A6 (S100A6) S-100 family P06703
INO80 complex subunit E (INO80E) . Q8NBZ0
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
RNA-binding protein with multiple splicing (RBPMS) . Q93062
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
34 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
35 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
36 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
37 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
40 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
41 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
42 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.