Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	Kambe_31			Probe Info
Probe concentration	10 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	Kambe_cp3			Competitor Info
Competitor Concentration	10 uM
*In Vivo* Experiment Model**	Model Type		Living cell
	Derived Tissue		Prostate
	Disease Model	Prostate carcinoma [ICD-11:2C82]
	Model Name	Human prostate carcinoma cells (PC-3)

Interaction Altas of This Experiment [1]

Enzyme

Click to Show/Hide to Show 5 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP03816	Oxidized purine nucleoside triphosphate hydrolase (NUDT1)	9.4
LDTP08476	5'-3' exonuclease PLD3 (PLD3)	7.8
LDTP16032	Retinoid-inducible serine carboxypeptidase (SCPEP1)	6.0
LDTP04134	Retinaldehyde dehydrogenase 3 (ALDH1A3)	5.0
LDTP02198	Cathepsin D (CTSD)	3.6

Transporter and channel

Click to Show/Hide to Show 1 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP04501	Importin subunit alpha-1 (KPNA2)					5.3

Other

Click to Show/Hide to Show 3 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP01075	Protein CutA (CUTA)	17.1
LDTP13606	Mammalian ependymin-related protein 1 (EPDR1)	5.4
LDTP05484	Proteasome activator complex subunit 1 (PSME1)	3.1

References

1	Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.