Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe6  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP00150  Acyl-coenzyme A diphosphatase NUDT19 (NUDT19) 20.0
 LDTP04689  Adenosine kinase (ADK) 20.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 20.0
 LDTP03770  Alpha-adducin (ADD1) 20.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 20.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 20.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 20.0
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP13751  Exonuclease 1 (EXO1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 20.0
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 20.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 20.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 20.0
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 20.0
 LDTP03842  Squalene synthase (FDFT1) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 18.0
 LDTP00886  Nardilysin (NRDC) 17.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 17.5
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 16.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 16.0
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 15.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 15.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 14.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 14.2
 LDTP02141  Alpha-galactosidase A (GLA) 14.2
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 14.1
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 14.0
 LDTP02149  Cyclin-dependent kinase 1 (CDK1) 13.6
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) 13.0
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) 12.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 12.3
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 11.5
 LDTP04374  Dynamin-2 (DNM2) 11.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 10.9
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4) 10.5
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 10.3
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 9.9
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 9.5
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.3
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 9.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 8.7
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 8.6
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 8.0
 LDTP09110  NAD(P)H-hydrate epimerase (NAXE) 7.7
 LDTP03330  Proteasome subunit alpha type-1 (PSMA1) 7.4
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 7.1
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X) 6.7
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 6.3
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 5.9
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 5.9
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 5.3
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 5.2
Transporter and channel
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP02815  Desmoplakin (DSP) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP05900  Metaxin-1 (MTX1) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 20.0
 LDTP02612  Nucleoprotein TPR (TPR) 20.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP02215  Prosaposin (PSAP) 17.9
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 14.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.0
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) 12.7
 LDTP00592  Surfeit locus protein 4 (SURF4) 10.3
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 10.0
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 8.9
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 8.2
 LDTP02199  Annexin A2 (ANXA2) 7.5
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.2
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 5.5
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.4
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 5.2
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 7.3
 LDTP10868  Cell division cycle 5-like protein (CDC5L) 5.4
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00887  Calumenin (CALU) 20.0
 LDTP01652  Centrosomal protein 43 (CEP43) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP05922  Dynactin subunit 2 (DCTN2) 20.0
 LDTP01319  Eukaryotic translation initiation factor 3 subunit G (EIF3G) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP05400  Lamin-B2 (LMNB2) 20.0
 LDTP13630  Neudesin (NENF) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 20.0
 LDTP11239  Protein misato homolog 1 (MSTO1) 20.0
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 20.0
 LDTP06809  Tubulin beta-8 chain (TUBB8) 20.0
 LDTP06097  Reticulocalbin-2 (RCN2) 18.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 17.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 17.2
 LDTP06060  Ubiquitin-associated protein 2-like (UBAP2L) 16.9
 LDTP02205  Tubulin beta chain (TUBB) 16.6
 LDTP05904  Tubulin beta-3 chain (TUBB3) 16.5
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 16.5
 LDTP11233  Tubulin beta-6 chain (TUBB6) 16.4
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 16.3
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 16.2
 LDTP02297  Vimentin (VIM) 15.8
 LDTP03322  Bromodomain-containing protein 2 (BRD2) 15.0
 LDTP06352  Reticulocalbin-1 (RCN1) 14.7
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 13.5
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 13.1
 LDTP02756  Junction plakoglobin (JUP) 12.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 12.4
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 12.2
 LDTP01932  Prelamin-A/C (LMNA) 11.9
 LDTP03775  RNA-binding protein FUS (FUS) 11.9
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 10.0
 LDTP11324  RNA-binding protein 4 (RBM4) 9.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 9.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 9.3
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 8.4
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 7.7
 LDTP01053  Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) 7.7
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 7.2
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 7.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 7.1
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 7.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 7.1
 LDTP03030  Annexin A7 (ANXA7) 7.0
 LDTP10684  RNA-binding protein 14 (RBM14) 7.0
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 6.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 6.8
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 6.7
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 6.6
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 6.3
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 5.6

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.