Details of the Target

General Information of Target

Target ID LDTP10868
Target Name Cell division cycle 5-like protein (CDC5L)
Gene Name CDC5L
Gene ID 988
Synonyms
KIAA0432; PCDC5RP; Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAA
SMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGL
LSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYY
PLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLD
ELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLND
MRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQ
SQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKA
RLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNG
EVVSSQVQEIEELM
Target Bioclass
Transcription factor
Family
CEF1 family
Subcellular location
Nucleus
Function
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Uniprot ID
Q99459
Ensemble ID
ENST00000371477.4
HGNC ID
HGNC:1743

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.28  LDD0402  [1]
AZ-9
 Probe Info  		3.94  LDD0393  [2]
TH211
 Probe Info  		Y100(16.98); Y210(14.93); Y232(9.25); Y51(7.58)  LDD0257  [3]
TH216
 Probe Info  		Y100(7.83)  LDD0259  [3]
STPyne
 Probe Info  		K187(10.00); K20(0.42); K539(7.30); K626(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y210(10.01); Y459(9.41); Y511(22.16); Y724(16.28)  LDD3495  [5]
DBIA
 Probe Info  		C96(2.38)  LDD3312  [6]
BTD
 Probe Info  		C769(0.92)  LDD2090  [7]
HHS-475
 Probe Info  		Y232(0.73)  LDD0264  [8]
HHS-465
 Probe Info  		Y232(7.54)  LDD2237  [9]
ATP probe
 Probe Info  		K601(0.00); K200(0.00); K201(0.00); K106(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C96(0.00); C769(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C769(0.00); C96(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		Y724(0.00); Y210(0.00)  LDD0028  [17]
TFBX
 Probe Info  		C96(0.00); C769(0.00)  LDD0148  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
1c-yne
 Probe Info  		K294(0.00); K380(0.00); K487(0.00)  LDD0228  [20]
1d-yne
 Probe Info  		K733(0.00); K219(0.00); K294(0.00); K380(0.00)  LDD0357  [20]
Acrolein
 Probe Info  		C96(0.00); H618(0.00); H612(0.00); H758(0.00)  LDD0217  [21]
AOyne
 Probe Info  		7.00  LDD0443  [22]
NAIA_5
 Probe Info  		C769(0.00); C96(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		13.16  LDD0475  [23]
FFF probe2
 Probe Info  		5.29  LDD0463  [23]
FFF probe3
 Probe Info  		14.05  LDD0464  [23]
FFF probe6
 Probe Info  		5.33  LDD0467  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C769(0.59)  LDD2142  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C769(1.06)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C769(0.90)  LDD2103  [7]
 LDCM0214  AC1 HEK-293T C96(0.89)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C96(0.96); C664(1.14)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C96(1.03)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C96(0.96)  LDD1510  [25]
 LDCM0270  AC15 HEK-293T C96(0.99); C664(1.10)  LDD1513  [25]
 LDCM0276  AC17 PaTu 8988t C664(1.08)  LDD1155  [26]
 LDCM0277  AC18 PaTu 8988t C664(1.80)  LDD1156  [26]
 LDCM0278  AC19 PaTu 8988t C664(1.08)  LDD1157  [26]
 LDCM0279  AC2 HEK-293T C96(0.98); C664(0.99)  LDD1518  [25]
 LDCM0280  AC20 PaTu 8988t C664(1.40)  LDD1159  [26]
 LDCM0281  AC21 PaTu 8988t C664(1.37)  LDD1160  [26]
 LDCM0282  AC22 PaTu 8988t C664(1.54)  LDD1161  [26]
 LDCM0283  AC23 PaTu 8988t C664(1.58)  LDD1162  [26]
 LDCM0284  AC24 PaTu 8988t C664(1.22)  LDD1163  [26]
 LDCM0285  AC25 PaTu 8988t C664(0.89)  LDD1164  [26]
 LDCM0286  AC26 PaTu 8988t C664(0.94)  LDD1165  [26]
 LDCM0287  AC27 PaTu 8988t C664(1.17)  LDD1166  [26]
 LDCM0288  AC28 PaTu 8988t C664(1.24)  LDD1167  [26]
 LDCM0289  AC29 PaTu 8988t C664(0.96)  LDD1168  [26]
 LDCM0290  AC3 HEK-293T C96(0.98)  LDD1529  [25]
 LDCM0291  AC30 PaTu 8988t C664(0.93)  LDD1170  [26]
 LDCM0292  AC31 PaTu 8988t C664(0.95)  LDD1171  [26]
 LDCM0293  AC32 PaTu 8988t C664(1.06)  LDD1172  [26]
 LDCM0294  AC33 PaTu 8988t C664(1.08)  LDD1173  [26]
 LDCM0295  AC34 PaTu 8988t C664(0.89)  LDD1174  [26]
 LDCM0296  AC35 PaTu 8988t C664(1.10)  LDD1175  [26]
 LDCM0297  AC36 PaTu 8988t C664(1.15)  LDD1176  [26]
 LDCM0298  AC37 PaTu 8988t C664(1.09)  LDD1177  [26]
 LDCM0299  AC38 PaTu 8988t C664(1.06)  LDD1178  [26]
 LDCM0300  AC39 PaTu 8988t C664(1.01)  LDD1179  [26]
 LDCM0301  AC4 HEK-293T C96(1.00)  LDD1540  [25]
 LDCM0302  AC40 PaTu 8988t C664(1.13)  LDD1181  [26]
 LDCM0303  AC41 PaTu 8988t C664(0.93)  LDD1182  [26]
 LDCM0304  AC42 PaTu 8988t C664(0.86)  LDD1183  [26]
 LDCM0305  AC43 PaTu 8988t C664(0.85)  LDD1184  [26]
 LDCM0306  AC44 PaTu 8988t C664(0.92)  LDD1185  [26]
 LDCM0307  AC45 PaTu 8988t C664(1.24)  LDD1186  [26]
 LDCM0309  AC47 HEK-293T C96(1.07); C664(0.98)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C96(1.10)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C96(0.99)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C96(1.11)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C96(1.02); C664(1.24)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C96(0.99)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C96(0.98)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C96(1.05)  LDD1555  [25]
 LDCM0318  AC55 HEK-293T C96(0.93); C664(0.99)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C96(1.01)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C96(0.89)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C96(0.96); C664(1.28)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C96(1.08)  LDD1561  [25]
 LDCM0324  AC60 HEK-293T C96(0.93)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C96(0.96)  LDD1564  [25]
 LDCM0327  AC63 HEK-293T C96(0.95); C664(1.75)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C96(1.01)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C96(1.04); C664(1.31)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C96(1.01)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C96(1.04)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C96(0.90)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C96(1.02)  LDD1514  [25]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C769(0.86)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C96(0.95)  LDD1571  [25]
 LDCM0369  CL100 HEK-293T C96(0.93); C664(1.20)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C96(0.87)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C96(0.89); C664(1.10)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C96(1.03)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C96(1.03); C664(1.42)  LDD1577  [25]
 LDCM0374  CL105 PaTu 8988t C664(1.09)  LDD1253  [26]
 LDCM0375  CL106 PaTu 8988t C664(1.32)  LDD1254  [26]
 LDCM0376  CL107 PaTu 8988t C664(1.35)  LDD1255  [26]
 LDCM0377  CL108 PaTu 8988t C664(1.30)  LDD1256  [26]
 LDCM0378  CL109 PaTu 8988t C664(1.49)  LDD1257  [26]
 LDCM0379  CL11 HEK-293T C96(0.89); C664(0.87)  LDD1583  [25]
 LDCM0380  CL110 PaTu 8988t C664(1.44)  LDD1259  [26]
 LDCM0381  CL111 PaTu 8988t C664(1.88)  LDD1260  [26]
 LDCM0382  CL112 PaTu 8988t C664(0.90)  LDD1261  [26]
 LDCM0383  CL113 PaTu 8988t C664(0.98)  LDD1262  [26]
 LDCM0384  CL114 PaTu 8988t C664(1.04)  LDD1263  [26]
 LDCM0385  CL115 PaTu 8988t C664(0.87)  LDD1264  [26]
 LDCM0386  CL116 PaTu 8988t C664(1.08)  LDD1265  [26]
 LDCM0387  CL117 PaTu 8988t C664(1.05)  LDD1266  [26]
 LDCM0388  CL118 PaTu 8988t C664(0.78)  LDD1267  [26]
 LDCM0389  CL119 PaTu 8988t C664(0.95)  LDD1268  [26]
 LDCM0390  CL12 HEK-293T C96(0.92)  LDD1594  [25]
 LDCM0391  CL120 PaTu 8988t C664(1.06)  LDD1270  [26]
 LDCM0392  CL121 HEK-293T C96(0.89)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C96(0.96); C664(0.97)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C96(0.91)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C96(0.95); C664(1.19)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C96(0.98)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C96(0.94); C664(1.13)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C96(0.96)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C96(1.04); C664(1.21)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C96(0.95)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C96(1.06); C664(1.50)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C96(0.89)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C96(1.05); C664(1.23)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C96(0.90)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C96(1.06); C664(1.22)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C96(1.15)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C96(0.95); C664(1.24)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C96(1.01)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C96(0.89)  LDD1613  [25]
 LDCM0411  CL23 HEK-293T C96(1.06); C664(1.14)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C96(1.05)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C96(0.86)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C96(1.07); C664(1.45)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C96(0.90)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C96(1.09); C664(1.34)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C96(1.05)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C96(1.03)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C96(1.14); C664(1.38)  LDD1623  [25]
 LDCM0420  CL31 PaTu 8988t C664(1.06)  LDD1299  [26]
 LDCM0421  CL32 PaTu 8988t C664(0.98)  LDD1300  [26]
 LDCM0422  CL33 PaTu 8988t C664(1.59)  LDD1301  [26]
 LDCM0423  CL34 PaTu 8988t C664(1.38)  LDD1302  [26]
 LDCM0424  CL35 PaTu 8988t C664(1.49)  LDD1303  [26]
 LDCM0425  CL36 PaTu 8988t C664(1.26)  LDD1304  [26]
 LDCM0426  CL37 PaTu 8988t C664(1.39)  LDD1305  [26]
 LDCM0428  CL39 PaTu 8988t C664(1.29)  LDD1307  [26]
 LDCM0429  CL4 HEK-293T C96(0.98); C664(1.29)  LDD1633  [25]
 LDCM0430  CL40 PaTu 8988t C664(1.60)  LDD1309  [26]
 LDCM0431  CL41 PaTu 8988t C664(1.47)  LDD1310  [26]
 LDCM0432  CL42 PaTu 8988t C664(1.76)  LDD1311  [26]
 LDCM0433  CL43 PaTu 8988t C664(2.33)  LDD1312  [26]
 LDCM0434  CL44 PaTu 8988t C664(1.39)  LDD1313  [26]
 LDCM0435  CL45 PaTu 8988t C664(1.40)  LDD1314  [26]
 LDCM0437  CL47 HEK-293T C96(0.90); C664(1.07)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C96(0.96)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C96(1.04)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C96(0.96)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C96(1.07); C664(1.26)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C96(1.05); C664(1.44)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C96(0.87)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C96(0.86); C664(1.05)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C96(1.06)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C96(0.99)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C96(0.85)  LDD1651  [25]
 LDCM0450  CL59 HEK-293T C96(1.01); C664(1.10)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C96(0.87); C664(1.26)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C96(1.00)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C96(1.06)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C96(1.05); C664(1.37)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C96(1.06)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C96(0.92); C664(1.26)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C96(0.97)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C96(1.00); C664(0.97)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C96(1.06)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C96(0.98)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C96(0.94)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C96(1.10)  LDD1665  [25]
 LDCM0464  CL71 HEK-293T C96(0.98); C664(1.00)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C96(1.03)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C96(0.90)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C96(1.03); C664(0.99)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C96(1.04); C664(1.46)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C96(0.94)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C96(0.99); C664(1.05)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C96(1.11)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C96(0.63)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C96(1.02)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C96(0.98)  LDD1678  [25]
 LDCM0477  CL83 HEK-293T C96(1.04); C664(0.92)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C96(0.93)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C96(0.94)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C96(1.09); C664(0.95)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C96(0.95)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C96(1.06); C664(1.25)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C96(0.99)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C96(1.02)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C96(0.69); C664(1.04)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C96(1.18)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C96(0.93)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C96(0.89)  LDD1691  [25]
 LDCM0490  CL95 HEK-293T C96(0.76); C664(0.97)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C96(0.87)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C96(0.89)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C96(0.96); C664(1.16)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C96(0.93)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C96(1.04)  LDD1698  [25]
 LDCM0573  Fragment11 Ramos C769(1.12)  LDD2190  [27]
 LDCM0576  Fragment14 Ramos C769(0.94)  LDD2193  [27]
 LDCM0586  Fragment28 Ramos C769(1.21)  LDD2198  [27]
 LDCM0468  Fragment33 HEK-293T C96(1.03)  LDD1671  [25]
 LDCM0566  Fragment4 Ramos C769(1.10)  LDD2184  [27]
 LDCM0427  Fragment51 PaTu 8988t C664(1.72)  LDD1306  [26]
 LDCM0569  Fragment7 Ramos C769(0.60)  LDD2186  [27]
 LDCM0116  HHS-0101 DM93 Y232(0.73)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y232(0.44)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y232(0.85)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y232(0.38)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y232(1.04)  LDD0268  [8]
 LDCM0107  IAA HeLa H758(0.00); H99(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C96(1.08)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C96(1.06)  LDD1497  [25]
 LDCM0024  KB05 HMCB C96(2.38)  LDD3312  [6]
 LDCM0109  NEM HeLa H758(0.00); H612(0.00); H99(0.00)  LDD0223  [21]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C769(0.92)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C769(0.98)  LDD2092  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C769(1.67)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C769(1.12)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C769(1.08)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C769(0.80)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C769(0.50)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C769(0.72)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C769(7.73)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C96(0.85)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C769(0.67)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C769(1.54)  LDD2109  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C769(0.23)  LDD2116  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C96(1.29)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C96(1.17)  LDD2123  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C96(1.30)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C769(0.86)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C769(0.66)  LDD2141  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C769(7.24)  LDD2145  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C769(0.48)  LDD2147  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C769(1.32)  LDD2151  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Serine/threonine-protein kinase ATR (ATR) PI3/PI4-kinase family Q13535
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Transcription termination factor 2 (TTF2) SNF2/RAD54 helicase family Q9UNY4
Pre-mRNA-processing factor 19 (PRPF19) WD repeat PRP19 family Q9UMS4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) Spectrin family Q01082
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
. GOLGA8 family Q08AF8
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Protein LDOC1 (LDOC1) LDOC1 family O95751
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Origin recognition complex subunit 2 (ORC2) ORC2 family Q13416
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Synaptopodin (SYNPO) Synaptopodin family Q8N3V7
Alpha-taxilin (TXLNA) Taxilin family P40222
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Pleiotropic regulator 1 (PLRG1) WD repeat PRL1/PRL2 family O43660
Beta-catenin-like protein 1 (CTNNBL1) . Q8WYA6
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578