Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name AZ-9  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cells (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03144  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (BCKDHB) 29.9
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 10.0
 LDTP09176  Casein kinase II subunit alpha 3 (CSNK2A3) 10.0
 LDTP09925  COP9 signalosome complex subunit 5 (COPS5) 10.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 10.0
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 10.0
 LDTP04992  Ras-related protein Rab-11A (RAB11A) 10.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 7.7
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 7.2
 LDTP02557  Ras-related protein Ral-A (RALA) 7.1
 LDTP05991  Spliceosome RNA helicase DDX39B (DDX39B) 7.0
 LDTP02204  Calpain-1 catalytic subunit (CAPN1) 6.9
 LDTP10878  Parkinson disease protein 7 (PARK7) 5.9
 LDTP10163  m7GpppX diphosphatase (DCPS) 5.7
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.6
 LDTP05736  Bifunctional coenzyme A synthase (COASY) 5.6
 LDTP10514  Cytosolic non-specific dipeptidase (CNDP2) 5.5
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL) 5.3
 LDTP13462  ADP-sugar pyrophosphatase (NUDT5) 4.5
 LDTP03816  Oxidized purine nucleoside triphosphate hydrolase (NUDT1) 4.5
 LDTP13156  SUMO-activating enzyme subunit 2 (UBA2) 4.3
 LDTP03519  UMP-CMP kinase (CMPK1) 4.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 4.2
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 4.1
 LDTP03515  Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) 4.1
 LDTP11535  Ras-related protein Rab-34 (RAB34) 4.0
 LDTP05652  Aspartyl/asparaginyl beta-hydroxylase (ASPH) 4.0
 LDTP04084  Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (NOP2) 4.0
 LDTP11529  GTP-binding protein 4 (GTPBP4) 3.8
 LDTP02502  Thioredoxin (TXN) 2.7
 LDTP12163  Calcyclin-binding protein (CACYBP) 2.4
 LDTP05372  Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) 2.2
 LDTP03510  Peroxiredoxin-6 (PRDX6) 2.2
 LDTP04901  Ras-related protein Rab-14 (RAB14) 2.1
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05165  Brain acid soluble protein 1 (BASP1) 12.2
 LDTP00328  Importin subunit alpha-3 (KPNA4) 10.0
 LDTP05938  Sorting nexin-1 (SNX1) 10.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) 4.1
 LDTP01455  Erlin-2 (ERLIN2) 4.0
 LDTP07236  Protein GPR107 (GPR107) 3.9
 LDTP02823  CD44 antigen (CD44) 2.7
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 10.0
 LDTP09996  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) 10.0
 LDTP09572  RelA-associated inhibitor (PPP1R13L) 4.4
 LDTP10868  Cell division cycle 5-like protein (CDC5L) 3.9
 LDTP05065  Y-box-binding protein 1 (YBX1) 2.0
Other
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09967  Stathmin-2 (STMN2) 12.1
 LDTP05277  Protein SET (SET) 12.0
 LDTP02234  Tropomyosin beta chain (TPM2) 10.2
 LDTP02177  Acyl-CoA-binding protein (DBI) 10.1
 LDTP04903  Actin-related protein 2 (ACTR2) 10.0
 LDTP07009  APC membrane recruitment protein 1 (AMER1) 10.0
 LDTP02443  Calmodulin-3 (CALM3) 10.0
 LDTP07495  Caveolae-associated protein 1 (CAVIN1) 10.0
 LDTP19852  FLYWCH family member 2 (FLYWCH2) 10.0
 LDTP07758  GRB10-interacting GYF protein 2 (GIGYF2) 10.0
 LDTP04156  LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) 10.0
 LDTP04224  MARCKS-related protein (MARCKSL1) 10.0
 LDTP15409  Metallothionein-1M (MT1M) 10.0
 LDTP09633  PEST proteolytic signal-containing nuclear protein (PCNP) 10.0
 LDTP18547  Protein CDV3 homolog (CDV3) 10.0
 LDTP13647  Ras GTPase-activating protein-binding protein 2 (G3BP2) 10.0
 LDTP06583  Serine/arginine-rich splicing factor 7 (SRSF7) 10.0
 LDTP00862  Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) 10.0
 LDTP02869  Stathmin (STMN1) 10.0
 LDTP06557  Synaptophysin-like protein 1 (SYPL1) 10.0
 LDTP05867  Treacle protein (TCOF1) 10.0
 LDTP04703  Tumor protein D52 (TPD52) 10.0
 LDTP13920  WW domain-binding protein 11 (WBP11) 10.0
 LDTP14778  Thymosin beta-10 (TMSB10) 9.5
 LDTP02148  Prothymosin alpha (PTMA) 9.1
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) 8.9
 LDTP03079  Calpastatin (CAST) 8.4
 LDTP13626  Ubiquilin-1 (UBQLN1) 8.4
 LDTP05977  Nascent polypeptide-associated complex subunit alpha (NACA) 8.0
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 8.0
 LDTP11597  182 kDa tankyrase-1-binding protein (TNKS1BP1) 7.7
 LDTP06507  Zyxin (ZYX) 7.6
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 7.4
 LDTP04483  Hepatoma-derived growth factor (HDGF) 7.4
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) 7.4
 LDTP05898  Sequestosome-1 (SQSTM1) 7.0
 LDTP04434  Host cell factor 1 (HCFC1) 5.8
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 5.6
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 5.6
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 5.6
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) 5.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 5.6
 LDTP05719  Cleavage stimulation factor subunit 3 (CSTF3) 5.5
 LDTP05400  Lamin-B2 (LMNB2) 5.5
 LDTP13817  Nuclear migration protein nudC (NUDC) 5.3
 LDTP05462  Caldesmon (CALD1) 5.1
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 4.9
 LDTP01075  Protein CutA (CUTA) 4.7
 LDTP11207  Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E) 4.7
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 4.6
 LDTP04875  Myosin light polypeptide 6 (MYL6) 4.6
 LDTP03404  Microtubule-associated protein 4 (MAP4) 4.5
 LDTP04945  Small ubiquitin-related modifier 2 (SUMO2) 4.4
 LDTP03871  Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) 4.4
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 4.4
 LDTP04914  Large ribosomal subunit protein uL24 (RPL26) 4.4
 LDTP03209  Transcription elongation factor A protein 1 (TCEA1) 4.3
 LDTP00727  U4/U6.U5 tri-snRNP-associated protein 1 (SART1) 4.2
 LDTP15778  Protein PRRC1 (PRRC1) 4.2
 LDTP13143  Eukaryotic translation initiation factor 3 subunit K (EIF3K) 4.1
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 4.1
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) 3.9
 LDTP04595  Activated RNA polymerase II transcriptional coactivator p15 (SUB1) 3.8
 LDTP15922  Large ribosomal subunit protein mL37 (MRPL37) 3.7
 LDTP03503  Myristoylated alanine-rich C-kinase substrate (MARCKS) 3.3
 LDTP00759  Tumor protein D54 (TPD52L2) 3.2
 LDTP01522  Reticulon-3 (RTN3) 3.0
 LDTP06220  LIM and SH3 domain protein 1 (LASP1) 3.0
 LDTP02990  Nucleolin (NCL) 3.0
 LDTP04935  Prefoldin subunit 3 (VBP1) 2.9
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 2.9
 LDTP13260  LIM domain and actin-binding protein 1 (LIMA1) 2.9
 LDTP04049  Ran-specific GTPase-activating protein (RANBP1) 2.9
 LDTP02116  Lupus La protein (SSB) 2.6
 LDTP01932  Prelamin-A/C (LMNA) 2.6
 LDTP01021  Perilipin-3 (PLIN3) 2.5
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) 2.5
 LDTP03620  Protein S100-A11 (S100A11) 2.4
 LDTP05211  Disabled homolog 2 (DAB2) 2.4
 LDTP12412  Reticulon-4 (RTN4) 2.4
 LDTP03065  Lamin-B1 (LMNB1) 2.3
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) 2.3
 LDTP10924  Prohibitin-2 (PHB2) 2.3
 LDTP03618  14-3-3 protein sigma (SFN) 2.3
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 2.3
 LDTP06121  Caprin-1 (CAPRIN1) 2.2
 LDTP00495  Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) 2.2
 LDTP15299  Protein FAM228A (FAM228A) 2.2
 LDTP13691  Protein bassoon (BSN) 2.2
 LDTP03244  Cofilin-1 (CFL1) 2.2
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 2.2
 LDTP06094  Src substrate cortactin (CTTN) 2.2
 LDTP04995  CCHC-type zinc finger nucleic acid binding protein (CNBP) 2.1
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) 2.0
 LDTP04958  Small ribosomal subunit protein eS7 (RPS7) 2.0

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.