Details of the Target

General Information of Target

Target ID LDTP15409
Target Name Metallothionein-1M (MT1M)
Gene Name MT1M
Gene ID 4499
Synonyms
MT1K; Metallothionein-1M; MT-1M; Metallothionein-IM; MT-IM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASGRGLCKAVAASPFPAWRRDNTEARGGLKPEYDAVVIGAGHNGLVAAAYLQRLGVNT
AVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLRLHLRNPYSFT
PMLEEGAGSKVPRCLLLGTDMAENQKQIAQFSQKDAQVFPKYEEFMHRLALAIDPLLDAA
PVDMAAFQHGSLLQRMRSLSTLKPLLKAGRILGAQLPRYYEVLTAPITKVLDQWFESEPL
KATLATDAVIGAMTSPHTPGSGYVLLHHVMGGLEGMQGAWGYVQGGMGALSDAIASSATT
HGASIFTEKTVAKVQVNSEGCVQGVVLEDGTEVRSKMVLSNTSPQITFLKLTPQEWLPEE
FLERISQLDTRSPVTKINVAVDRLPSFLAAPNAPRGQPLPHHQCSIHLNCEDTLLLHQAF
EDAMDGLPSHRPVIELCIPSSLDPTLAPPGCHVVSLFTQYMPYTLAGGKAWDEQERDAYA
DRVFDCIEVYAPGFKDSVVGRDILTPPDLERIFGLPGGNIFHCAMSLDQLYFARPVPLHS
GYRCPLQGLYLCGSGAHPGGGVMGAAGRNAAHVAFRDLKSM
Target Bioclass
Other
Family
Metallothionein superfamily, Type 1 family
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Uniprot ID
Q8N339
Ensemble ID
ENST00000379818.4
HGNC ID
HGNC:14296

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
BTD
 Probe Info  		C26(0.80)  LDD2092  [2]
Acrolein
 Probe Info  		C34(0.00); C36(0.00)  LDD0221  [3]
DBIA
 Probe Info  		C60(1.25); C33(0.98); C36(0.98); C34(0.94)  LDD0078  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C60(1.25); C33(0.98); C36(0.98); C34(0.94)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa C34(0.00); C36(0.00); C37(0.00); C41(0.00)  LDD0222  [3]
 LDCM0107  IAA HeLa C34(0.00); C36(0.00)  LDD0221  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C26(0.80)  LDD2092  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Keratin-associated protein 5-1 (KRTAP5-1) KRTAP type 5 family Q6L8H4
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Silver . DB12965

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.