Details of the Target

General Information of Target

Target ID LDTP15778
Target Name Protein PRRC1 (PRRC1)
Gene Name PRRC1
Gene ID 133619
Synonyms
Protein PRRC1; Proline-rich and coiled-coil-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGAGVAAGTRPPSSPTPGSRRRRQRPSVGVQSLRPQSPQLRQSDPQKRNLDLEKSLQFL
QQQHSEMLAKLHEEIEHLKRENKDLRYKLIMNQTSQKKDGPSGNHLSRASAPLGARWVCI
NGVWVEPGGPSPARLKEGSSRTHRPGGKHGRLAGGSADTVRSPADSLSTSSFQSVKSISN
SGKARPQPGSFNKQDSKADVPQKADLEEEPLLHNSKLDKVPGVQGQARKEKAEASNAGAA
CMGNSQHQGRQMGAAAHPPMILPLPLRKPTTLRQCEVLIRELWNTNLLQTQELQHLKSLL
EGSQRPQAVPEEASFPRDQEATHFPKVSTKSLSKKCLLLSPPVAERAILPALKQTPKNNF
AERQKRLQAMQKRRLHRSVL
Target Bioclass
Other
Family
PRRC1 family
Subcellular location
Golgi apparatus
Function May act as a regulator of the protein kinase A (PKA) activity during embryonic development.
Uniprot ID
Q96M27
Ensemble ID
ENST00000296666.13
HGNC ID
HGNC:28164

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 Deletion: p.F277GfsTer36 .
CCK81 SNV: p.P170H .
HS936T SNV: p.S41F .
MINO SNV: p.K232E .
ONS76 SNV: p.G204C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		4.15  LDD0393  [1]
STPyne
 Probe Info  		K218(6.67); K227(2.66); K232(6.39); K234(4.02)  LDD0277  [2]
HHS-475
 Probe Info  		Y251(0.80)  LDD0264  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
DBIA
 Probe Info  		C348(0.94)  LDD1510  [5]
ATP probe
 Probe Info  		K266(0.00); K269(0.00)  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
AOyne
 Probe Info  		10.20  LDD0443  [8]
HHS-465
 Probe Info  		Y251(0.00); K253(0.00)  LDD2240  [9]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		21.71  LDD1799  [10]
C232
 Probe Info  		41.36  LDD1905  [10]
C235
 Probe Info  		21.11  LDD1908  [10]
C284
 Probe Info  		22.32  LDD1954  [10]
C362
 Probe Info  		36.76  LDD2023  [10]
C382
 Probe Info  		9.45  LDD2041  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C348(0.94)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C348(1.11)  LDD1512  [5]
 LDCM0280  AC20 HEK-293T C348(0.85)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C348(1.10)  LDD1521  [5]
 LDCM0288  AC28 HEK-293T C348(1.09)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C348(1.48)  LDD1530  [5]
 LDCM0297  AC36 HEK-293T C348(0.97)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C348(1.08)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C348(1.11)  LDD1540  [5]
 LDCM0306  AC44 HEK-293T C348(0.92)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C348(1.27)  LDD1547  [5]
 LDCM0315  AC52 HEK-293T C348(1.03)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C348(1.13)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C348(1.04)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C348(1.10)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C348(1.04)  LDD1565  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0368  CL10 HEK-293T C348(1.35)  LDD1572  [5]
 LDCM0371  CL102 HEK-293T C348(0.90)  LDD1575  [5]
 LDCM0375  CL106 HEK-293T C348(0.92)  LDD1579  [5]
 LDCM0380  CL110 HEK-293T C348(1.05)  LDD1584  [5]
 LDCM0384  CL114 HEK-293T C348(1.30)  LDD1588  [5]
 LDCM0388  CL118 HEK-293T C348(0.96)  LDD1592  [5]
 LDCM0393  CL122 HEK-293T C348(1.15)  LDD1597  [5]
 LDCM0397  CL126 HEK-293T C348(1.15)  LDD1601  [5]
 LDCM0401  CL14 HEK-293T C348(1.03)  LDD1605  [5]
 LDCM0407  CL2 HEK-293T C348(0.97)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C348(1.20)  LDD1612  [5]
 LDCM0410  CL22 HEK-293T C348(1.28)  LDD1614  [5]
 LDCM0414  CL26 HEK-293T C348(0.94)  LDD1618  [5]
 LDCM0421  CL32 HEK-293T C348(1.23)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C348(1.16)  LDD1627  [5]
 LDCM0434  CL44 HEK-293T C348(1.16)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C348(1.61)  LDD1640  [5]
 LDCM0441  CL50 HEK-293T C348(1.17)  LDD1645  [5]
 LDCM0447  CL56 HEK-293T C348(0.94)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C348(1.30)  LDD1652  [5]
 LDCM0454  CL62 HEK-293T C348(1.05)  LDD1657  [5]
 LDCM0460  CL68 HEK-293T C348(1.06)  LDD1663  [5]
 LDCM0463  CL70 HEK-293T C348(1.31)  LDD1666  [5]
 LDCM0467  CL74 HEK-293T C348(1.53)  LDD1670  [5]
 LDCM0473  CL8 HEK-293T C348(1.76)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C348(1.12)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C348(1.15)  LDD1679  [5]
 LDCM0480  CL86 HEK-293T C348(1.36)  LDD1683  [5]
 LDCM0487  CL92 HEK-293T C348(1.05)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C348(1.19)  LDD1692  [5]
 LDCM0493  CL98 HEK-293T C348(1.14)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C348(0.85)  LDD1631  [5]
 LDCM0116  HHS-0101 DM93 Y251(0.80)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y251(0.85)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y251(0.86)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y251(0.81)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y251(1.46)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein transport protein Sec23B (SEC23B) SEC23/SEC24 family Q15437

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587