Details of the Target

General Information of Target

Target ID LDTP03079
Target Name Calpastatin (CAST)
Gene Name CAST
Gene ID 831
Synonyms
Calpastatin; Calpain inhibitor; Sperm BS-17 component
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Target Bioclass
Other
Family
Protease inhibitor I27 (calpastatin) family
Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Uniprot ID
P20810
Ensemble ID
ENST00000309190.9
HGNC ID
HGNC:1515

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		8.42  LDD0393  [2]
ONAyne
 Probe Info  		K324(0.45); K384(0.46); K443(0.29); K678(0.38)  LDD0274  [3]
STPyne
 Probe Info  		K102(6.62); K132(7.96); K277(4.89); K283(8.75)  LDD0277  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
Sulforaphane-probe2
 Probe Info  		1.74  LDD0160  [5]
AHL-Pu-1
 Probe Info  		C241(4.73)  LDD0168  [6]
HHS-475
 Probe Info  		Y339(0.82)  LDD0264  [7]
DBIA
 Probe Info  		C328(0.95); C408(0.99); C413(0.98); C661(0.96)  LDD1492  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C408(0.00); C381(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C408(0.00); C381(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C408(0.00); C381(0.00); C241(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
BTD
 Probe Info  		C413(0.00); C328(0.00)  LDD0004  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		C241(0.00); C328(0.00); C381(0.00); C408(0.00)  LDD2226  [13]
TFBX
 Probe Info  		C408(0.00); C413(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C408(0.00); C241(0.00); C413(0.00)  LDD0021  [11]
WYneO
 Probe Info  		C413(0.00); C408(0.00)  LDD0022  [11]
DA-P3
 Probe Info  		N.A.  LDD0178  [14]
1d-yne
 Probe Info  		N.A.  LDD0356  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		C241(0.00); C413(0.00); C661(0.00)  LDD0007  [11]
Acrolein
 Probe Info  		C381(0.00); C241(0.00); C408(0.00); C328(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C408(0.00); C413(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C381(0.00); C413(0.00); C241(0.00); C408(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		11.30  LDD0443  [19]
NAIA_5
 Probe Info  		C413(0.00); C408(0.00); C328(0.00); C381(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe3
 Probe Info  		20.00  LDD0465  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C328(0.68)  LDD2142  [22]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C408(0.78); C328(1.14)  LDD2117  [22]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C408(0.92)  LDD2152  [22]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C328(0.99)  LDD2103  [22]
 LDCM0025  4SU-RNA HEK-293T C241(4.73)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C241(11.25); C381(2.07)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C328(0.88); C408(1.10); C413(1.03); C241(0.99)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C328(1.02); C408(1.06); C413(1.05); C661(0.82)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C328(1.10); C408(1.12); C413(1.08); C661(1.01)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C328(1.29); C408(1.00); C413(0.98); C661(1.01)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C328(1.02); C408(1.02); C413(1.06); C661(1.07)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C328(1.11); C408(1.07); C413(1.11); C661(0.96)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C328(1.09); C408(1.07); C413(1.08); C241(1.02)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C328(1.00); C408(1.02); C413(1.04); C661(0.95)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C328(1.44); C408(1.42); C413(1.48); C661(1.65)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C328(0.91); C408(1.07); C413(0.91); C661(0.88)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C328(0.99); C408(1.01); C413(1.01); C661(1.01)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C328(1.07); C408(0.99); C413(1.06); C661(1.13)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C328(1.03); C408(1.05); C413(1.00); C661(1.03)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C328(1.09); C408(1.03); C413(1.00); C661(0.85)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C328(1.20); C408(0.74); C413(0.99); C241(0.99)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C328(1.19); C408(1.14); C413(1.09); C241(1.04)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C328(0.99); C408(0.96); C413(0.96); C661(0.92)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C328(1.05); C408(1.10); C413(1.03); C661(1.16)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C328(1.08); C408(0.96); C413(1.06); C661(1.04)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C328(1.06); C408(0.96); C413(1.02); C661(1.01)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C328(0.88); C408(1.00); C413(1.08); C661(1.12)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C328(1.12); C408(1.23); C413(1.03); C661(1.02)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C328(1.14); C408(0.93); C413(1.03); C661(0.91)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C328(1.15); C408(0.84); C413(1.03); C241(0.98)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C328(1.42); C408(1.16); C413(1.11); C241(0.93)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C328(1.02); C408(1.12); C413(1.01); C661(0.92)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C328(1.00); C408(1.05); C413(1.11); C661(0.98)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C328(1.09); C408(1.08); C413(1.05); C661(0.96)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C328(1.05); C408(1.09); C413(1.00); C661(0.99)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C328(0.98); C408(1.04); C413(1.00); C661(1.27)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C328(1.00); C408(0.92); C413(1.03); C661(0.89)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C328(1.07); C408(1.04); C413(1.01); C661(0.99)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C328(1.12); C408(0.92); C413(1.05); C241(0.95)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C328(1.11); C408(1.07); C413(1.13); C241(1.11)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C328(1.02); C408(1.13); C413(1.11); C661(0.85)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C328(1.05); C408(1.18); C413(1.12); C661(1.07)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C328(1.10); C408(1.10); C413(1.03); C661(1.07)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C328(1.08); C408(1.10); C413(1.02); C661(1.02)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C328(1.05); C408(1.08); C413(1.05); C661(1.18)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C328(1.12); C408(1.00); C413(1.07); C661(1.02)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C328(1.22); C408(0.82); C413(1.03); C241(1.01)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C328(1.15); C408(1.14); C413(1.08); C241(1.05)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C328(1.04); C408(1.02); C413(1.07); C661(0.92)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C328(1.12); C408(1.06); C413(0.95); C661(0.82)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C328(1.07); C408(1.09); C413(1.06); C661(0.99)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C328(1.11); C408(1.04); C413(1.05); C661(1.06)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C328(1.22); C408(1.00); C413(1.07); C661(0.98)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C328(1.08); C408(1.09); C413(1.00); C661(1.10)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C328(1.10); C408(1.03); C413(1.11); C661(0.96)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C328(1.15); C408(0.96); C413(1.07); C241(1.02)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C328(1.15); C408(1.13); C413(1.08); C241(1.08)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C328(0.93); C408(1.09); C413(1.06); C661(0.89)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C328(1.06); C408(1.02); C413(1.02); C661(1.07)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C328(0.98); C408(0.91); C413(1.10); C661(1.25)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C328(1.11); C408(1.07); C413(1.01); C661(1.01)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C328(1.13); C408(0.98); C413(1.04); C661(0.97)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C328(0.87); C408(1.01); C413(0.99); C661(1.32)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C328(1.02); C408(0.94); C413(1.05); C661(0.89)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C328(1.19); C408(0.81); C413(0.97); C241(0.98)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C328(0.86); C408(0.96); C413(0.99); C661(0.88)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C328(1.02); C408(1.03); C413(0.99); C241(0.94)  LDD1569  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C408(0.97)  LDD2113  [22]
 LDCM0248  AKOS034007472 HEK-293T C328(1.03); C408(1.02); C413(1.04); C661(0.91)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C328(1.38); C408(1.18); C413(1.07); C241(0.99)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C328(1.11); C408(0.88); C413(0.99); C241(1.00)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 12.61  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C328(0.64)  LDD2091  [22]
 LDCM0087  Capsaicin HEK-293T 8.95  LDD0185  [14]
 LDCM0630  CCW28-3 231MFP C408(1.00)  LDD2214  [23]
 LDCM0108  Chloroacetamide HeLa C381(0.00); C241(0.00); C413(0.00); C408(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C661(1.60); C408(0.84); C381(0.76); C381(0.54)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C328(0.93); C408(1.06); C413(0.93); C241(0.96)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C328(0.88); C408(1.01); C413(0.97); C661(1.12)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C328(1.06); C408(0.99); C413(1.02); C661(1.07)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C328(1.23); C408(1.07); C413(1.01); C241(1.09)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C328(1.08); C408(0.97); C413(1.00); C241(1.04)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C328(1.14); C408(1.07); C413(1.09); C661(1.25)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C328(1.07); C408(1.04); C413(0.99); C661(0.97)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C328(1.06); C408(1.05); C413(1.05); C241(1.13)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C328(1.14); C408(1.08); C413(1.11); C241(0.99)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C328(1.02); C408(1.05); C413(1.07); C661(1.18)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C328(1.16); C408(0.94); C413(1.06); C661(0.88)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C328(1.05); C408(0.97); C413(0.98); C241(1.07)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C328(1.14); C408(1.09); C413(0.96); C661(1.01)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C328(0.94); C408(0.94); C413(1.01); C241(0.97)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C328(0.98); C408(1.02); C413(0.98); C661(1.03)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C328(1.22); C408(1.03); C413(1.07); C661(1.08)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C328(0.92); C408(1.06); C413(1.01); C241(1.19)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C328(1.04); C408(1.06); C413(1.02); C241(0.98)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C328(1.05); C408(1.16); C413(1.04); C661(1.26)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C328(1.11); C408(1.04); C413(1.03); C661(1.28)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C328(0.94); C408(1.09); C413(0.99); C241(1.10)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C328(1.33); C408(1.12); C413(1.23); C241(1.06)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C328(1.08); C408(1.14); C413(1.03); C661(1.16)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C328(1.22); C408(0.87); C413(1.03); C241(0.85)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C328(1.13); C408(1.06); C413(1.04); C661(1.15)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C328(1.01); C408(1.09); C413(1.03); C241(1.17)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C328(1.15); C408(1.09); C413(1.09); C241(1.09)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C328(1.01); C408(1.08); C413(0.99); C661(1.13)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C328(1.19); C408(1.01); C413(1.04); C661(0.98)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C328(0.95); C408(1.05); C413(0.98); C241(1.00)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C328(0.97); C408(1.09); C413(1.07); C241(0.95)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C328(0.91); C408(1.07); C413(1.07); C661(1.13)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C328(1.10); C408(1.14); C413(1.02); C661(1.19)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C328(1.16); C408(1.10); C413(1.19); C241(1.41)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C328(1.14); C408(1.10); C413(1.04); C241(1.13)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C328(1.00); C408(1.06); C413(1.03); C661(1.66)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C328(1.12); C408(1.15); C413(1.03); C661(0.96)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C328(1.04); C408(1.25); C413(1.08); C241(0.95)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C328(1.46); C408(1.05); C413(0.98); C661(0.85)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C328(1.33); C408(1.02); C413(1.10); C661(1.10)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C328(1.12); C408(1.02); C413(1.11); C241(1.14)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C328(1.06); C408(1.01); C413(1.00); C661(1.15)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C328(1.06); C408(1.14); C413(1.13); C661(0.98)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C328(1.00); C408(1.06); C413(1.09); C661(0.99)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C328(1.24); C408(0.99); C413(1.08); C661(0.94)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C328(1.11); C408(0.83); C413(0.99); C241(0.94)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C328(0.91); C408(1.00); C413(0.91); C241(0.89)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C328(1.11); C408(0.97); C413(0.96); C241(0.98)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C328(1.11); C408(1.05); C413(0.97); C661(1.23)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C328(1.21); C408(1.02); C413(0.96); C661(0.92)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C328(0.97); C408(0.98); C413(1.01); C241(1.04)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C328(0.97); C408(1.14); C413(0.94); C661(1.13)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C328(0.96); C408(1.03); C413(0.92); C661(0.90)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C328(1.13); C408(1.00); C413(1.07); C661(0.91)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C328(1.22); C408(1.00); C413(1.09); C661(0.99)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C328(0.93); C408(0.92); C413(0.95); C661(1.02)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C328(0.89); C408(0.98); C413(0.94); C661(1.18)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C328(1.13); C408(1.00); C413(1.11); C661(1.01)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C328(1.29); C408(1.07); C413(0.99); C241(0.85)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C328(1.20); C408(1.07); C413(0.95); C241(0.95)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C328(1.06); C408(1.11); C413(1.00); C661(1.14)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C328(1.04); C408(1.13); C413(0.94); C661(1.07)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C328(1.33); C408(1.12); C413(1.00); C661(1.00)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C328(0.92); C408(1.03); C413(1.06); C241(0.94)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C328(0.98); C408(0.97); C413(0.88); C661(1.02)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C328(1.06); C408(1.11); C413(1.03); C661(1.09)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C328(1.16); C408(1.03); C413(1.01); C661(0.98)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C328(1.12); C408(1.03); C413(1.14); C661(0.98)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C328(0.97); C408(1.13); C413(0.98); C661(1.03)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C328(1.09); C408(1.03); C413(1.11); C661(0.89)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C328(1.07); C408(0.93); C413(1.06); C241(0.80)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C328(0.91); C408(1.04); C413(0.89); C241(1.01)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C328(1.00); C408(1.20); C413(1.05); C241(1.06)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C328(1.00); C408(1.04); C413(0.99); C241(1.01)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C328(1.16); C408(1.01); C413(0.89); C661(1.10)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C328(0.90); C408(1.16); C413(1.08); C241(0.98)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C328(1.04); C408(1.03); C413(0.94); C661(0.76)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C328(1.15); C408(1.03); C413(1.07); C661(1.00)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C328(1.22); C408(1.07); C413(1.01); C661(1.09)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C328(0.94); C408(1.12); C413(1.12); C661(1.28)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C328(0.88); C408(0.94); C413(1.02); C661(1.15)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C328(1.19); C408(1.00); C413(1.04); C661(0.99)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C328(1.00); C408(1.05); C413(0.94); C661(0.95)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C328(1.07); C408(1.01); C413(0.99); C241(0.83)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C328(1.04); C408(1.03); C413(0.93); C241(0.97)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C328(1.13); C408(1.08); C413(1.06); C241(1.01)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C328(1.12); C408(1.15); C413(0.97); C661(1.05)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C328(0.94); C408(1.10); C413(0.89); C661(1.03)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C328(1.19); C408(1.24); C413(1.10); C241(1.09)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C328(1.14); C408(1.16); C413(0.94); C661(0.78)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C328(1.07); C408(1.11); C413(1.03); C661(1.01)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C328(1.19); C408(1.02); C413(1.03); C661(0.99)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C328(1.18); C408(1.12); C413(1.02); C661(0.89)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C328(0.96); C408(1.07); C413(1.06); C661(1.04)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C328(0.92); C408(0.94); C413(1.02); C661(1.22)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C328(1.15); C408(0.95); C413(1.09); C661(1.12)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C328(1.21); C408(0.96); C413(1.11); C241(0.95)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C328(1.04); C408(1.09); C413(0.98); C241(1.10)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C328(1.18); C408(1.05); C413(1.13); C241(0.95)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C328(1.10); C408(1.05); C413(0.95); C661(0.93)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C328(1.15); C408(1.09); C413(0.98); C241(1.00)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C328(0.99); C408(1.08); C413(0.99); C661(1.00)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C328(1.22); C408(1.19); C413(1.10); C661(1.00)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C328(0.84); C408(1.01); C413(0.90); C661(1.07)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C328(1.12); C408(1.02); C413(1.03); C661(1.04)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C328(1.21); C408(1.12); C413(1.11); C661(0.94)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C328(1.11); C408(1.08); C413(0.97); C661(1.19)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C328(1.02); C408(1.01); C413(1.01); C661(1.21)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C328(0.92); C408(0.90); C413(1.01); C241(0.91)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C328(0.88); C408(1.04); C413(0.98); C241(0.94)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C328(1.00); C408(1.08); C413(1.04); C241(1.01)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C328(1.01); C408(1.13); C413(0.98); C661(1.19)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C328(1.13); C408(1.03); C413(0.99); C661(1.01)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C328(1.07); C408(1.05); C413(1.05); C241(1.03)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C328(1.15); C408(1.16); C413(1.06); C661(0.96)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C328(0.78); C408(1.04); C413(0.80); C661(0.75)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C328(0.99); C408(1.21); C413(1.03); C661(0.96)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C328(1.10); C408(1.06); C413(1.00); C661(1.01)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C328(1.17); C408(1.13); C413(1.03); C661(1.01)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C328(0.90); C408(1.15); C413(0.99); C661(1.08)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C328(1.04); C408(1.05); C413(1.01); C661(1.17)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C328(0.92); C408(0.93); C413(1.01); C241(0.89)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C328(0.85); C408(1.01); C413(0.99); C241(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C328(1.06); C408(1.06); C413(1.05); C241(1.05)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C328(0.97); C408(1.08); C413(0.94); C661(1.10)  LDD1697  [8]
 LDCM0028  Dobutamine HEK-293T 6.08  LDD0180  [14]
 LDCM0027  Dopamine HEK-293T 31.03  LDD0179  [14]
 LDCM0495  E2913 HEK-293T C328(1.09); C408(1.20); C413(1.08); C661(0.96)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C241(0.85); C408(0.78)  LDD1702  [22]
 LDCM0031  Epigallocatechin gallate HEK-293T 31.43  LDD0183  [14]
 LDCM0468  Fragment33 HEK-293T C328(1.00); C408(1.01); C413(0.99); C661(1.12)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C328(1.02); C408(0.98); C413(1.02); C241(1.11)  LDD1631  [8]
 LDCM0116  HHS-0101 DM93 Y339(0.82)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y339(0.72)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y339(0.73)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y339(0.75)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y339(0.77)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HEK-293T C328(0.95); C408(0.99); C413(0.98); C661(0.96)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C328(1.05); C408(1.10); C413(1.02); C661(1.00)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C328(0.99); C408(1.03); C413(0.92); C661(0.93)  LDD1502  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C408(0.85); C328(0.91)  LDD2102  [22]
 LDCM0109  NEM HeLa N.A.  LDD0225  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C328(1.02)  LDD2089  [22]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C408(1.50); C328(1.32)  LDD2090  [22]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C408(0.53); C328(1.02)  LDD2092  [22]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C408(1.17)  LDD2093  [22]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C408(0.81)  LDD2094  [22]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C408(0.56); C381(0.93)  LDD2096  [22]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C408(0.58); C328(0.87)  LDD2098  [22]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C408(1.19)  LDD2099  [22]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C408(1.02); C328(0.99)  LDD2101  [22]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C328(0.81)  LDD2104  [22]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C408(0.96); C328(1.16)  LDD2105  [22]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C328(0.72)  LDD2106  [22]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C408(0.69)  LDD2107  [22]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C328(1.13)  LDD2108  [22]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C408(0.90)  LDD2109  [22]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C328(1.70)  LDD2110  [22]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C408(0.86)  LDD2111  [22]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C328(0.80)  LDD2114  [22]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C408(0.62); C328(0.57)  LDD2115  [22]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C381(0.81)  LDD2116  [22]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C408(0.45); C328(1.37)  LDD2118  [22]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C408(1.88)  LDD2119  [22]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C408(0.72)  LDD2120  [22]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C408(0.58); C328(0.97); C381(1.40)  LDD2122  [22]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C408(0.67); C328(0.79)  LDD2123  [22]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C381(0.84)  LDD2124  [22]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C408(0.89)  LDD2125  [22]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C408(0.45)  LDD2126  [22]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C408(0.98)  LDD2127  [22]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C328(0.82)  LDD2128  [22]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C408(1.08)  LDD2129  [22]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C408(0.80)  LDD2133  [22]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C408(0.61); C328(0.58)  LDD2134  [22]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C408(1.04)  LDD2135  [22]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C408(0.88); C328(1.08)  LDD2136  [22]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C408(1.02); C328(1.29)  LDD2137  [22]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C408(1.39)  LDD1700  [22]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C408(0.90)  LDD2140  [22]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C408(0.36); C328(1.06)  LDD2141  [22]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C408(1.05); C328(0.84)  LDD2143  [22]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C408(3.74)  LDD2144  [22]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C408(0.34); C328(3.91)  LDD2145  [22]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C408(0.90)  LDD2146  [22]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C408(0.59); C328(0.63)  LDD2148  [22]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C408(1.18)  LDD2150  [22]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C381(3.61)  LDD2151  [22]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C408(1.26); C328(2.18)  LDD2153  [22]
 LDCM0029  Quercetin HEK-293T 29.96  LDD0181  [14]
 LDCM0131  RA190 MM1.R C241(2.05); C328(1.49)  LDD0304  [24]
 LDCM0003  Sulforaphane MDA-MB-231 1.74  LDD0160  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium . DB01373

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.