Details of the Target

General Information of Target

Target ID LDTP06748
Target Name Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)
Gene Name LRRFIP1
Gene ID 9208
Synonyms
GCF2; TRIP; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR
SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS
GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ
LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA
LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS
EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG
TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT
ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE
AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT
QNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT
DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG
DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS
EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE
PGHFNPESREDTRGGNEKGKSKEDCTMS
Target Bioclass
Transcription factor
Family
LRRFIP family
Subcellular location
Nucleus
Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Uniprot ID
Q32MZ4
Ensemble ID
ENST00000244815.9
HGNC ID
HGNC:6702
ChEMBL ID
CHEMBL4295838

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		10.00  LDD0393  [2]
DA-P2
 Probe Info  		5.63  LDD0348  [3]
TG42
 Probe Info  		8.96  LDD0326  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K21(6.25); K224(0.39); K289(9.38)  LDD0277  [6]
BTD
 Probe Info  		C14(2.52); C644(4.11)  LDD1699  [7]
P12
 Probe Info  		10.48  LDD0202  [8]
DA-P3
 Probe Info  		25.83  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C750(2.25); C726(2.05); C644(2.83)  LDD0168  [9]
HHS-475
 Probe Info  		Y597(1.04)  LDD0264  [10]
HHS-465
 Probe Info  		Y597(9.52)  LDD2237  [11]
DBIA
 Probe Info  		C726(1.11); C742(1.11); C14(1.04); C334(1.04)  LDD0078  [12]
5E-2FA
 Probe Info  		H755(0.00); H490(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C750(0.00); C456(0.00); C334(0.00); C644(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C750(0.00); C456(0.00); C14(0.00); C644(0.00)  LDD0036  [15]
IPIAA_L
 Probe Info  		C14(0.00); C644(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C456(0.00); C334(0.00); C14(0.00); C644(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		C14(0.00); C334(0.00); C644(0.00); C750(0.00)  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneN
 Probe Info  		C644(0.00); C750(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C644(0.00); C750(0.00)  LDD0022  [19]
Compound 10
 Probe Info  		C14(0.00); C644(0.00); C750(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C14(0.00); C644(0.00); C726(0.00)  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NPM
 Probe Info  		N.A.  LDD0016  [19]
PF-06672131
 Probe Info  		N.A.  LDD0017  [21]
VSF
 Probe Info  		C14(0.00); C644(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C644(0.00); C14(0.00); C726(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K706(0.00); K633(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C750(0.00); C644(0.00); C14(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		C644(0.00); C334(0.00); C14(0.00)  LDD0218  [24]
W1
 Probe Info  		C14(0.00); C644(0.00)  LDD0236  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		C750(0.00); C456(0.00); C644(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C644(1.19)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C644(1.20)  LDD2130  [7]
 LDCM0025  4SU-RNA HEK-293T C750(2.25); C726(2.05); C644(2.83)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C742(2.45); C529(7.28); C750(3.17); C726(3.03)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C14(0.87); C334(1.23); C644(0.72)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C334(1.14); C644(0.93)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C14(1.21); C726(1.03); C742(1.03); C334(0.94)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C14(1.27); C726(1.09); C742(1.09); C334(0.98)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C14(1.08); C726(1.10); C742(1.10); C334(1.02)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C14(1.44); C726(1.89); C742(1.89); C334(1.30)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C14(1.18); C726(2.62); C742(2.62); C334(1.18)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C14(1.90); C726(0.87); C742(0.87); C334(1.18)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C14(1.84); C726(1.31); C742(1.31); C334(1.37)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C14(1.38); C726(1.33); C742(1.33); C334(1.20)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C14(1.34); C726(0.96); C742(0.96); C334(0.92)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C14(1.14); C726(1.31); C742(1.31); C334(0.73)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C334(1.30); C644(0.85)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C14(1.58); C726(1.16); C742(1.16); C334(0.73)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C14(1.52); C726(1.53); C742(1.53); C334(0.74)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C14(1.37); C726(1.37); C742(1.37); C334(0.95)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C14(0.81); C334(1.02); C644(0.90)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C14(0.96); C334(1.18); C644(0.95)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C14(1.44); C334(1.29); C644(1.01)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C14(1.16); C334(1.25); C644(1.01)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C14(1.10); C334(1.23); C644(1.24)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C14(0.73); C334(1.21); C644(1.05)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C14(1.50); C334(1.26); C644(1.06)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C334(1.09); C644(0.73)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C14(1.03); C334(0.98); C644(0.81)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C14(0.86); C334(1.09); C644(1.02)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C14(0.81); C334(1.21); C644(1.11)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C14(0.66); C334(0.90); C644(0.99)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C14(0.97); C334(1.07); C644(0.85)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C14(0.97); C334(1.20); C644(0.95)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C14(1.51); C334(1.17); C644(0.90)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C14(1.89); C334(1.28); C644(0.82)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C14(0.22); C334(1.65); C644(1.14)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C14(0.24); C334(1.11); C644(0.89)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C14(0.25); C334(1.41); C644(1.19)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C14(0.28); C334(1.12); C644(0.90)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C14(0.33); C334(1.18); C644(0.96)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C14(0.32); C334(1.21); C644(1.00)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C14(0.43); C334(1.59); C644(1.22)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C14(0.32); C334(1.69); C644(1.06)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C14(0.46); C334(1.15); C644(1.17)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C14(0.33); C334(1.15); C644(1.03)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C14(0.40); C334(1.41); C644(1.28)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C14(0.44); C334(1.31); C644(1.21)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C334(1.12); C644(0.90)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C14(0.41); C334(1.44); C644(1.42)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C14(0.53); C334(1.37); C644(1.26)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C14(0.34); C334(1.13); C644(0.98)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C14(1.27); C644(1.04); C334(1.25)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C644(0.92); C334(1.26); C14(1.68)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C644(0.97); C334(1.20); C14(1.32)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C644(0.80); C334(1.18); C14(1.27)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C644(1.12); C334(1.27); C14(1.40)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C644(0.78); C14(1.58); C334(1.65)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C644(0.88); C334(1.34); C14(1.44)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C644(0.85); C334(1.01)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C334(1.04); C644(1.06); C14(1.26)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C334(0.94); C644(0.97); C14(1.22)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C644(0.91); C334(1.39); C14(1.47)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C644(0.77); C334(1.80); C14(2.24)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C14(1.90); C334(1.45); C644(0.87)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C14(1.87); C334(1.16); C644(0.92)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C14(1.16); C334(0.90); C644(0.93)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C14(1.48); C334(0.99); C644(0.90)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C644(0.93); C334(1.01)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C644(0.97); C334(1.05)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C644(1.02); C334(1.26)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C14(0.85); C644(0.95); C334(1.14)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C334(1.14); C644(1.17)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C334(1.11); C644(1.24)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C334(0.95); C644(1.02)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C644(0.93); C334(1.01)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C644(0.97); C334(1.00)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C410(0.86); C441(0.86); C644(0.95); C334(0.98)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C410(0.92); C441(0.92); C334(1.01); C644(1.09)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C644(1.02); C334(1.10); C410(1.23); C441(1.23)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C644(1.02); C410(1.07); C441(1.07); C334(1.17)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C334(1.05); C644(1.36); C410(1.37); C441(1.37)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C14(0.73); C644(0.90); C334(1.09)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C644(1.28); C410(1.31); C441(1.31); C334(1.32)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C644(1.01); C334(1.32); C410(1.36); C441(1.36)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C644(1.12); C334(1.13); C410(1.44); C441(1.44)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C410(1.22); C441(1.22); C334(1.22); C644(1.25)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C334(1.16); C644(1.45); C410(1.66); C441(1.66)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C644(0.97)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C644(1.00)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C644(0.91)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C644(1.11)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C644(1.05)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C14(0.57); C644(0.76); C334(1.09)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C644(1.05)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C644(1.07)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C644(0.98)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C644(1.30)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C644(1.26)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C644(1.29)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C644(1.52)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C644(1.13)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C644(1.32)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C644(1.32)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C14(0.58); C644(0.85); C334(1.07)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C644(1.14)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C644(1.05)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C644(1.10)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C644(1.00)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C644(1.05)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C644(1.18)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C644(1.25)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C644(0.83); C334(0.91)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C644(0.91); C334(0.92)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C644(0.84); C334(0.93)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C644(0.99); C334(1.12)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C644(0.86); C334(0.98)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C644(0.81); C334(0.94)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C644(0.80); C334(1.03)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C644(0.72); C334(0.82)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C644(0.76); C334(0.91)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C644(0.79); C334(0.95)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C644(0.76); C334(0.97)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C644(0.91); C334(0.94)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C726(0.85); C742(0.85); C334(0.85); C644(1.02)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C726(0.78); C742(0.78); C644(0.84); C410(0.92)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C644(0.80); C334(1.00)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C726(0.63); C742(0.63); C644(1.07); C410(1.15)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C726(0.74); C742(0.74); C334(0.79); C410(0.80)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C726(0.83); C742(0.83); C334(1.08); C410(1.22)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C726(0.84); C742(0.84); C334(0.93); C410(0.99)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C334(0.77); C410(0.83); C441(0.83); C726(0.97)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C726(0.72); C742(0.72); C644(1.20); C410(1.31)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C726(0.53); C742(0.53); C644(0.91); C410(0.94)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C334(0.88); C726(0.92); C742(0.92); C644(1.07)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C334(0.92); C644(0.98); C410(0.99); C441(0.99)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C726(0.91); C742(0.91); C644(1.18); C334(1.23)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C644(0.90); C334(1.39)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C726(0.80); C742(0.80); C410(0.91); C441(0.91)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C726(0.57); C742(0.57); C644(0.96); C334(1.13)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C726(0.70); C742(0.70); C644(0.92); C334(0.94)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C726(1.38); C742(1.38); C334(1.47); C644(1.66)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C644(1.38); C14(1.43); C726(1.45); C742(1.45)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C14(1.13); C334(1.17); C644(1.24); C726(1.54)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C334(1.25); C644(1.27); C14(1.41); C726(1.50)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C726(1.06); C742(1.06); C334(1.07); C644(1.10)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C334(1.16); C644(1.17); C14(1.36); C726(1.42)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C334(1.32); C726(1.38); C742(1.38); C644(1.40)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C726(1.03); C742(1.03); C644(1.10); C334(1.18)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C334(1.48); C726(1.58); C742(1.58); C644(1.60)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C726(1.40); C742(1.40); C644(1.43); C334(1.50)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C334(1.15); C644(1.18); C14(1.23); C726(1.39)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C14(1.05); C644(1.13); C334(1.18); C726(1.27)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C726(1.10); C742(1.10); C334(1.25); C644(1.28)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C14(1.16); C726(1.20); C742(1.20); C644(1.33)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C334(1.31); C644(1.56); C14(1.69); C726(2.04)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C726(1.25); C742(1.25); C334(1.58); C644(1.84)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C334(0.78); C14(1.02); C726(1.04); C742(1.04)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C334(1.53); C644(1.01)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C644(0.95); C334(1.03)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C644(0.97); C334(1.40)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C726(1.11); C742(1.11); C14(1.04); C334(1.04)  LDD0078  [12]
 LDCM0102  BDHI 8 Jurkat C726(12.85); C742(12.85)  LDD0204  [28]
 LDCM0498  BS-3668 MDA-MB-231 C644(0.98)  LDD2091  [7]
 LDCM0088  C45 HEK-293T 10.48  LDD0202  [8]
 LDCM0087  Capsaicin HEK-293T 23.26  LDD0185  [3]
 LDCM0108  Chloroacetamide HeLa C644(0.00); C750(0.00); C14(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C456(20.00); C644(2.92); C750(0.71); C456(0.66)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C334(0.89); C644(1.03)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C644(1.05); C334(1.18)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C644(0.79); C334(1.03); C14(1.06)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C644(0.81); C334(1.12)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C644(0.64); C334(0.93)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C644(0.77); C334(0.92)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C644(0.81); C334(1.13)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C644(1.10); C334(1.15)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C334(1.23); C644(1.39)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C334(1.17); C644(1.19)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C334(1.26); C644(1.27)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C644(1.10); C334(1.14)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C644(1.04); C334(1.05)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C644(1.25); C334(1.30)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C334(1.09); C644(1.17)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C334(0.91); C644(0.91); C410(0.95); C441(0.95)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C644(1.05); C334(1.24); C410(1.48); C441(1.48)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C334(0.95); C644(1.11); C410(1.45); C441(1.45)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C334(1.28); C644(1.39); C410(1.57); C441(1.57)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C334(0.97); C410(1.24); C441(1.24); C644(1.30)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C644(1.24)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C644(1.16)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C644(1.20)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C644(1.04); C334(1.35)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C644(1.11)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C644(1.13)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C644(1.05)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C644(1.04)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C644(1.29)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C644(0.86); C334(0.93)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C644(0.76); C334(0.81)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C644(0.76); C334(0.81)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C644(0.81); C334(0.89)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C644(1.05); C334(1.19)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C334(1.07); C644(1.16)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C644(0.87); C334(0.99)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C334(0.97); C644(1.00)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C726(0.73); C742(0.73); C644(0.87); C334(1.01)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C726(0.87); C742(0.87); C644(0.87); C334(1.09)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C644(0.92); C334(0.96); C726(1.06); C742(1.06)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C334(0.98); C644(1.09)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C644(1.03); C726(1.18); C742(1.18); C334(1.36)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C726(0.81); C742(0.81); C644(0.90); C334(0.98)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C644(0.82); C334(0.94); C726(1.33); C742(1.33)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C334(0.93); C644(1.01); C726(1.14); C742(1.14)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C726(0.93); C742(0.93); C644(0.96); C334(1.10)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C726(0.59); C742(0.59); C334(1.12); C644(0.84)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C726(0.89); C742(0.89); C334(0.94); C644(0.93)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C726(0.83); C742(0.83); C334(1.11); C644(0.86)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C726(1.24); C742(1.24); C334(1.20); C644(1.11)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C726(1.52); C742(1.52); C334(1.22); C644(1.01)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C334(0.92); C644(1.21)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C726(0.95); C742(0.95); C334(0.98); C644(0.89)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C726(0.85); C742(0.85); C334(0.92); C410(0.81)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C334(1.15); C410(0.92); C441(0.92); C644(1.10)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C334(1.08); C410(0.99); C441(0.99); C644(1.06)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C334(1.09); C410(1.23); C441(1.23); C644(1.30)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C334(1.14); C410(1.02); C441(1.02); C644(1.40)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C334(1.02); C410(1.02); C441(1.02); C644(1.21)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C334(1.04); C410(0.89); C441(0.89); C644(1.50)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C334(0.98); C410(0.93); C441(0.93); C644(1.31)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C334(1.00); C644(1.05)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C334(0.93); C410(1.02); C441(1.02); C644(1.23)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C334(1.00); C410(1.07); C441(1.07); C644(1.16)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C334(0.92); C410(1.06); C441(1.06); C644(1.91)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C334(1.05); C410(0.72); C441(0.72); C644(1.49)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C334(1.10); C410(0.84); C441(0.84); C644(1.24)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C334(1.06); C410(0.92); C441(0.92); C644(1.40)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C14(1.10); C726(0.65); C742(0.65); C334(1.17)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C14(1.10); C726(0.63); C742(0.63); C334(1.04)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C14(0.96); C726(0.71); C742(0.71); C334(0.91)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C14(0.81); C726(0.57); C742(0.57); C334(0.99)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C334(1.06); C644(0.95)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C14(0.99); C726(0.67); C742(0.67); C334(0.97)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C14(0.83); C726(0.50); C742(0.50); C334(1.07)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C14(1.17); C726(0.87); C742(0.87); C334(1.20)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C14(1.30); C726(1.30); C742(1.30); C334(1.01)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C14(1.07); C726(0.94); C742(0.94); C334(1.15)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C14(0.90); C726(0.78); C742(0.78); C334(0.94)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C14(0.90); C726(0.91); C742(0.91); C334(1.10)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C14(0.94); C726(0.79); C742(0.79); C334(0.96)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C14(0.96); C726(0.64); C742(0.64); C334(1.08)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C14(0.94); C726(0.84); C742(0.84); C334(0.97)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C334(1.03); C644(1.06)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C14(0.96); C726(0.51); C742(0.51); C334(1.23)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C14(0.89); C726(0.85); C742(0.85); C334(1.07)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C14(0.94); C726(0.46); C742(0.46); C334(1.02)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C14(0.97); C726(0.95); C742(0.95); C334(1.05)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C14(0.63); C726(0.64); C742(0.64); C334(1.13)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C14(0.84); C726(0.93); C742(0.93); C334(0.95)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C14(1.04); C726(0.46); C742(0.46); C334(1.20)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C14(0.94); C726(1.02); C742(1.02); C334(1.05)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C14(0.94); C726(4.65); C742(4.65); C334(1.15)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C14(1.14); C726(0.76); C742(0.76); C334(1.00)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C334(1.26); C644(0.92)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C14(1.05); C726(1.14); C742(1.14); C334(0.99)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C14(1.03); C726(1.15); C742(1.15); C334(0.90)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C14(0.89); C726(1.75); C742(1.75); C334(1.21)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C14(0.93); C726(1.24); C742(1.24); C334(1.14)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C14(1.17); C726(1.71); C742(1.71); C334(1.01)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C14(0.80); C334(0.98); C410(0.96); C441(0.96)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C14(0.80); C334(0.97); C410(1.13); C441(1.13)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C14(0.96); C334(1.08); C410(0.69); C441(0.69)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C14(0.91); C334(1.29); C410(0.79); C441(0.79)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C334(1.23); C644(1.21)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C14(0.83); C334(1.04); C410(0.68); C441(0.68)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C14(0.74); C334(1.08); C410(0.78); C441(0.78)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C14(0.66); C334(1.41); C410(0.66); C441(0.66)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C14(0.76); C334(1.25); C410(1.12); C441(1.12)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C14(0.84); C334(1.45); C410(0.62); C441(0.62)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C14(0.86); C334(1.12); C410(0.88); C441(0.88)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C14(0.73); C334(1.01); C410(0.70); C441(0.70)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C14(0.79); C334(1.04); C410(0.76); C441(0.76)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C14(0.73); C334(1.31); C410(0.96); C441(0.96)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C14(0.79); C334(1.46); C410(0.76); C441(0.76)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C334(1.18); C644(1.17)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C14(0.67); C334(0.88); C410(0.85); C441(0.85)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C14(0.80); C334(1.16); C644(0.91)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C14(0.73); C334(1.10); C644(0.76)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C14(0.65); C334(1.11); C644(0.67)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C14(0.88); C334(1.07); C644(0.79)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C14(0.65); C334(1.07); C644(0.73)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C14(0.60); C334(1.38); C644(0.85)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C14(0.71); C334(1.15); C644(0.84)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C14(1.03); C334(1.24); C644(1.01)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C14(0.94); C334(1.34); C644(0.93)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C644(2.84); C14(0.87); C750(0.67); C456(0.62)  LDD2228  [18]
 LDCM0028  Dobutamine HEK-293T 12.00  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 25.83  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C750(1.13); C14(0.89); C334(0.97); C644(0.99)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C750(1.10); C456(0.90)  LDD1702  [7]
 LDCM0625  F8 Ramos C805(0.73); C14(1.30); C750(0.70)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C805(1.91); C14(1.19); C750(2.54)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C805(1.52)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C805(1.22); C14(0.90); C750(2.25)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C805(1.47); C14(1.05)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C805(0.76); C14(0.60); C750(0.68)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C805(1.28); C14(0.71); C750(2.51)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C805(1.61); C14(1.07); C750(1.28)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C805(1.72); C14(1.39); C750(3.40)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C805(1.86); C14(1.21); C750(1.95)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C805(0.50); C14(0.62)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C805(2.07); C14(1.43); C750(3.45)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C14(1.04); C750(4.19)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C805(2.01); C14(1.28); C750(3.11)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C14(0.86); C726(0.77); C742(0.77); C334(1.23)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C805(1.12); C14(1.01); C750(4.99)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C14(0.86); C750(0.47)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C334(1.08); C410(1.11); C441(1.11); C644(1.86)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C14(1.49)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C805(2.29); C14(1.29); C750(1.96)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C14(0.90); C750(0.71)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C805(1.79); C14(1.07); C750(2.00)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y597(1.04)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y597(0.83)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y597(0.77)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y597(0.74)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y597(1.70)  LDD0268  [10]
 LDCM0022  KB02 HCT 116 C750(1.73); C644(1.15)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C750(1.13); C644(0.94)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C750(1.75); C644(0.80)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 118.40  LDD0182  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C644(1.42)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C644(1.60)  LDD2090  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C644(0.98); C14(1.24)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C644(0.83)  LDD2100  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C644(1.42)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C644(1.01); C14(0.97)  LDD2107  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C644(1.20)  LDD2123  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C644(0.96)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C644(1.03)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C644(1.09)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C644(1.28)  LDD2141  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C644(0.80)  LDD2150  [7]
 LDCM0029  Quercetin HEK-293T 64.04  LDD0181  [3]
 LDCM0131  RA190 MM1.R C14(1.17); C726(0.87)  LDD0304  [31]
 LDCM0021  THZ1 HCT 116 C726(1.38); C742(1.38)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Protein flightless-1 homolog (FLII) . Q13045

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.