Details of the Target

General Information of Target

Target ID LDTP02108
Target Name Large ribosomal subunit protein P2 (RPLP2)
Gene Name RPLP2
Gene ID 6181
Synonyms
D11S2243E; RPP2; Large ribosomal subunit protein P2; 60S acidic ribosomal protein P2; Renal carcinoma antigen NY-REN-44
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRYVASYLLAALGGNSSPSAKDIKKILDSVGIEADDDRLNKVISELNGKNIEDVIAQGIG
KLASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEKKEESEESDDDMGFGLFD
Target Bioclass
Other
Family
Eukaryotic ribosomal protein P1/P2 family
Function Plays an important role in the elongation step of protein synthesis.
Uniprot ID
P05387
Ensemble ID
ENST00000321153.9
HGNC ID
HGNC:10377
ChEMBL ID
CHEMBL4295698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [1]
P8
 Probe Info  		10.00  LDD0451  [1]
AZ-9
 Probe Info  		3.93  LDD0393  [2]
FBPP2
 Probe Info  		2.42  LDD0318  [3]
C-Sul
 Probe Info  		5.81  LDD0066  [4]
TH211
 Probe Info  		Y3(12.24)  LDD0257  [5]
ONAyne
 Probe Info  		K25(0.00); K41(0.00)  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K25(2.10)  LDD3494  [7]
D5yne
 Probe Info  		1.66  LDD0055  [8]
ATP probe
 Probe Info  		K25(0.00); K94(0.00); K95(0.00); K98(0.00)  LDD0199  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [11]
NHS
 Probe Info  		K95(0.00); K49(0.00); K94(0.00); K25(0.00)  LDD0010  [12]
SF
 Probe Info  		Y7(0.00); K21(0.00); K25(0.00)  LDD0028  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
1c-yne
 Probe Info  		K94(0.00); K25(0.00); K49(0.00); K41(0.00)  LDD0228  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		5.50  LDD0477  [14]
Diazir
 Probe Info  		E52(0.00); E93(0.00)  LDD0011  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0095  DC-LC3IN-D5 HeLa 1.66  LDD0055  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein P1 (RPLP1) Eukaryotic ribosomal protein P1/P2 family P05386

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.