Details of the Target

General Information of Target

Target ID LDTP13920
Target Name WW domain-binding protein 11 (WBP11)
Gene Name WBP11
Gene ID 51729
Synonyms
NPWBP; SIPP1; SNP70; WW domain-binding protein 11; WBP-11; Npw38-binding protein; NpwBP; SH3 domain-binding protein SNP70; Splicing factor that interacts with PQBP-1 and PP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSLSRSRKRRLSSRSRSRSYSPAHNR
ERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRGGYGNYRSNWQNYRQAYSP
RRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSAKEK
KSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDTKASESSKPWPDATYGTGSASRASAVS
ELSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSSTSQMGSTLPSGAGYQSGTHQG
QFDHGSGSLSPSKKSPVGKSPPSTGSTYGSSQKEESAASGGAAYTKRYLEEQKTENGKDK
EQKQTNTDKEKIKEKGSFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQSPKRYKLRDDFEK
KMADFHKEEMDDQDKDKAKGRKESEFDDEPKFMSKVIGANKNQEEEKSGKWEGLVYAPPG
KEKQRKTEELEEESFPERSKKEDRGKRSEGGHRGFVPEKNFRVTAYKAVQEKSSSPPPRK
TSESRDKLGAKGDFPTGKSSFSITREAQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHS
NKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKR
GTEQEAAKNKKSPEIHRRIDISPSTFRKHGLAHDEMKSPREPGYKAEGKYKDDPVDLRLD
IERRKKHKERDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSS
SSSSQSSHSYKAEEYTEETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARG
RGWGRGNYSGNNNNNSNNDFQKRNREEEWDPEYTPKSKKYYLHDDREGEGSDKWVSRGRG
RGAFPRGRGRFMFRKSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDNIQPTTE
Target Bioclass
Other
Subcellular location
Nucleus
Function Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.
Uniprot ID
Q9Y2W2
Ensemble ID
ENST00000261167.7
HGNC ID
HGNC:16461

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
STPyne
 Probe Info  		K169(6.62); K81(6.64); K98(5.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y124(16.85); Y173(33.18); Y236(5.60)  LDD3495  [3]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0382  [4]
HHS-475
 Probe Info  		Y173(0.84)  LDD0264  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
5E-2FA
 Probe Info  		H188(0.00); H133(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
m-APA
 Probe Info  		H188(0.00); H133(0.00); H146(0.00)  LDD2231  [7]
NHS
 Probe Info  		N.A.  LDD0010  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
HHS-465
 Probe Info  		N.A.  LDD2240  [11]
HHS-482
 Probe Info  		Y173(0.78)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0116  HHS-0101 DM93 Y173(0.84)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y173(0.95)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y173(1.30)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y173(1.15)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y173(1.10)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0382  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcineurin B homologous protein 3 (TESC) Calcineurin regulatory subunit family Q96BS2
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
UPF0489 protein C5orf22 (C5orf22) UPF0489 family Q49AR2
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
Microspherule protein 1 (MCRS1) . Q96EZ8
MORN repeat-containing protein 4 (MORN4) . Q8NDC4
Poly(rC)-binding protein 1 (PCBP1) . Q15365
Polyglutamine-binding protein 1 (PQBP1) . O60828

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.