General Information of Experiment

Probe Name Alkylaryl probe 3  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Phenelzine  Competitor Info 
Competitor Concentration 10 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 20.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 20.0
 LDTP03109  Amine oxidase [flavin-containing] A (MAOA) 20.0
 LDTP03384  Amine oxidase [flavin-containing] B (MAOB) 20.0
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 20.0
 LDTP00616  Protein phosphatase 1G (PPM1G) 20.0
 LDTP15725  Secernin-2 (SCRN2) 20.0
 LDTP00344  Stearoyl-CoA desaturase (SCD) 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) 20.0
 LDTP03572  Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) 20.0
 LDTP00624  Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) 17.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 14.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 12.8
 LDTP13752  Cyclin-dependent kinase 11A (CDK11A) 12.4
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 11.8
 LDTP02198  Cathepsin D (CTSD) 10.3
 LDTP07662  DBH-like monooxygenase protein 1 (MOXD1) 8.3
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 8.0
 LDTP04581  Holocytochrome c-type synthase (HCCS) 7.9
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) 7.5
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) 7.3
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.6
 LDTP04581  Holocytochrome c-type synthase (HCCS) 5.4
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 5.1
 LDTP02824  Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) 5.0
 LDTP12473  Sialic acid synthase (NANS) 4.6
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 4.4
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 3.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 3.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.3
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) 3.2
 LDTP04030  Biotinidase (BTD) 3.1
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 3.1
 LDTP17022  Secernin-3 (SCRN3) 3.1
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 3.9
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00849  17S U2 SnRNP complex component HTATSF1 (HTATSF1) 20.0
 LDTP16193  Craniofacial development protein 1 (CFDP1) 20.0
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 20.0
 LDTP04668  Microfibrillar-associated protein 1 (MFAP1) 20.0
 LDTP09008  Probable RNA-binding protein EIF1AD (EIF1AD) 20.0
 LDTP10822  Protein IWS1 homolog (IWS1) 20.0
 LDTP00236  Transcription elongation factor SPT5 (SUPT5H) 20.0
 LDTP18478  WD repeat-containing protein 70 (WDR70) 20.0
 LDTP13920  WW domain-binding protein 11 (WBP11) 20.0
 LDTP05277  Protein SET (SET) 16.7
 LDTP19007  Small acidic protein (SMAP) 15.7
 LDTP17638  GPALPP motifs-containing protein 1 (GPALPP1) 13.0
 LDTP11138  Protein pelota homolog (PELO) 7.8
 LDTP08965  RNA polymerase II-associated factor 1 homolog (PAF1) 4.1
 LDTP07563  RNA polymerase-associated protein CTR9 homolog (CTR9) 3.6
 LDTP06030  Cytochrome c oxidase copper chaperone (COX17) 3.1

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.