Details of the Target

General Information of Target

Target ID LDTP00616
Target Name Protein phosphatase 1G (PPM1G)
Gene Name PPM1G
Gene ID 5496
Synonyms
PPM1C; Protein phosphatase 1G; EC 3.1.3.16; Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYD
GHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGR
PTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEE
PGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPS
CSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEE
AEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL
DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISA
LPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELL
DQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKK
KKAKRD
Target Bioclass
Enzyme
Family
PP2C family
Subcellular location
Cytoplasm
Uniprot ID
O15355
Ensemble ID
ENST00000344034.5
HGNC ID
HGNC:9278
ChEMBL ID
CHEMBL3351199

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.36  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TG42
 Probe Info  		5.06  LDD0326  [4]
TH211
 Probe Info  		Y160(20.00); Y211(20.00)  LDD0257  [5]
TH214
 Probe Info  		Y364(20.00); Y74(19.99); Y405(14.68); Y160(11.73)  LDD0258  [5]
TH216
 Probe Info  		Y160(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K166(9.13); K339(2.33); K383(4.52)  LDD0277  [7]
BTD
 Probe Info  		C164(3.80)  LDD1699  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
Probe 1
 Probe Info  		Y74(105.25); Y364(20.58); Y405(61.75)  LDD3495  [9]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0382  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
AHL-Pu-1
 Probe Info  		C241(11.53)  LDD0168  [12]
HHS-482
 Probe Info  		Y211(20.00)  LDD0288  [13]
HHS-475
 Probe Info  		Y160(0.73); Y364(0.83); Y211(0.90)  LDD0264  [14]
HHS-465
 Probe Info  		Y160(10.00); Y211(9.48); Y27(8.50); Y364(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C241(1.04); C13(0.93)  LDD0078  [16]
5E-2FA
 Probe Info  		N.A.  LDD2235  [17]
ATP probe
 Probe Info  		K247(0.00); K339(0.00); K519(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C13(0.00); C351(0.00); C241(0.00); C164(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C13(0.00); C241(0.00)  LDD0032  [20]
IPIAA_L
 Probe Info  		C164(0.00); C241(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C13(0.00); C351(0.00); C241(0.00); C440(0.00)  LDD0037  [19]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		N.A.  LDD2226  [23]
TFBX
 Probe Info  		C13(0.00); C241(0.00); C351(0.00)  LDD0027  [22]
WYneN
 Probe Info  		C351(0.00); C241(0.00); C164(0.00); C13(0.00)  LDD0021  [24]
WYneO
 Probe Info  		C164(0.00); C241(0.00); C13(0.00); C351(0.00)  LDD0022  [24]
DA-P3
 Probe Info  		N.A.  LDD0178  [25]
Compound 10
 Probe Info  		C13(0.00); C241(0.00); C351(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C13(0.00); C241(0.00)  LDD2213  [26]
ENE
 Probe Info  		C241(0.00); C13(0.00); C164(0.00)  LDD0006  [24]
IPM
 Probe Info  		N.A.  LDD0005  [24]
NHS
 Probe Info  		N.A.  LDD0010  [24]
NPM
 Probe Info  		C351(0.00); C13(0.00)  LDD0016  [24]
PF-06672131
 Probe Info  		N.A.  LDD0152  [27]
PPMS
 Probe Info  		N.A.  LDD0008  [24]
SF
 Probe Info  		N.A.  LDD0028  [28]
VSF
 Probe Info  		C13(0.00); C241(0.00)  LDD0007  [24]
Phosphinate-6
 Probe Info  		C164(0.00); C241(0.00)  LDD0018  [29]
1c-yne
 Probe Info  		K128(0.00); K209(0.00); K247(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		N.A.  LDD0217  [31]
Methacrolein
 Probe Info  		C241(0.00); C164(0.00)  LDD0218  [31]
W1
 Probe Info  		C241(0.00); C164(0.00)  LDD0236  [32]
AOyne
 Probe Info  		15.00  LDD0443  [33]
NAIA_5
 Probe Info  		C13(0.00); C351(0.00); C241(0.00); C164(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.32  LDD0475  [34]
FFF probe2
 Probe Info  		15.70  LDD0463  [34]
FFF probe3
 Probe Info  		5.19  LDD0465  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [36]
STS-1
 Probe Info  		N.A.  LDD0068  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C164(0.62); C241(0.77)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C13(0.96); C351(1.23); C164(0.84); C241(1.02)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C13(0.85); C351(0.75); C164(0.61)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C351(0.99); C164(0.98); C241(0.86)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C13(0.92); C351(0.85); C164(0.82)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C164(1.35)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C164(0.46); C241(0.64)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C164(0.65)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C241(11.53)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C241(2.12); C164(2.04)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C241(1.02); C13(1.16); C164(1.28); C351(1.70)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C241(1.53); C13(1.18); C164(0.95); C351(1.28)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C241(0.91); C13(0.73); C164(1.08); C351(0.51)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C241(0.98); C13(0.77); C164(1.07); C351(0.52)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C241(0.92); C13(0.72); C164(1.15); C351(0.66)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C241(1.38); C13(0.64); C164(1.40); C351(0.48)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C241(1.13); C13(0.57); C164(1.27); C351(0.81)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C241(1.18); C13(0.67); C164(1.40); C351(0.67)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C241(1.35); C13(0.73); C164(1.35); C351(0.54)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C241(1.14); C13(0.67); C164(1.31); C351(0.65)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C241(0.88); C13(0.85); C164(1.16); C351(0.60)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C241(0.85); C13(0.73); C164(1.01); C351(0.98)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C241(1.29); C13(1.09); C164(1.08); C351(1.27)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C241(0.96); C13(0.70); C164(1.08); C351(0.57)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C241(0.95); C13(0.74); C164(1.06); C351(0.45)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C241(1.18); C13(0.64); C164(1.42); C351(0.50)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C241(1.00); C13(1.10); C164(0.99); C351(0.91)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C241(1.12); C13(1.18); C164(1.03); C351(0.92)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C241(1.37); C13(0.98); C164(1.24); C351(0.84)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C241(1.30); C13(1.08); C164(1.25); C351(0.87)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C241(1.23); C13(1.48); C164(1.13); C351(0.95)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C241(1.00); C13(1.30); C164(1.04); C351(1.03)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C241(1.17); C13(1.07); C164(1.05); C351(0.94)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C241(0.96); C13(1.19); C164(0.93); C351(1.69)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C241(1.29); C13(0.72); C164(1.25); C351(1.00)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C241(1.03); C13(1.36); C164(0.94); C351(1.00)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C241(1.18); C13(1.19); C164(1.05); C351(0.90)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C241(0.97); C13(1.02); C164(0.97); C351(0.77)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C241(0.94); C13(1.16); C164(0.83); C351(1.04)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C241(1.08); C13(1.28); C164(0.94); C351(1.02)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C241(1.44); C13(1.12); C164(1.05); C351(0.98)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C241(1.32); C13(1.15); C164(1.14); C351(0.96)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C241(0.95); C13(1.19); C164(0.91); C351(0.51)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C241(0.60); C13(1.86); C164(0.82); C351(0.43)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C241(0.82); C13(1.37); C164(0.86); C351(0.33)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C241(0.62); C13(1.59); C164(0.70); C351(0.32)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C241(0.61); C13(1.71); C164(0.70); C351(0.27)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C241(0.69); C13(1.28); C164(0.81); C351(0.30)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C241(0.77); C13(1.37); C164(0.73); C351(0.27)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C241(0.89); C13(1.41); C164(0.80); C351(0.34)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C241(0.79); C13(1.04); C164(0.79); C351(0.31)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C241(0.68); C13(1.21); C164(0.71); C351(0.30)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C241(0.73); C13(1.27); C164(0.86); C351(0.23)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C241(0.77); C13(1.38); C164(0.61); C351(0.20)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C241(0.89); C13(1.12); C164(0.96); C351(1.12)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C241(0.85); C13(1.28); C164(0.87); C351(0.21)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C241(0.76); C13(1.52); C164(0.67); C351(0.21)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C241(0.62); C13(1.67); C164(0.61); C351(0.26)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C241(1.10); C351(0.73); C164(1.04); C13(1.15)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C351(0.18); C13(1.02); C164(1.25); C241(1.27)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C351(0.59); C164(1.06); C13(1.10); C241(1.13)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C351(0.28); C13(1.18); C241(1.21); C164(1.26)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C351(0.18); C13(1.00); C164(1.18); C241(1.18)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C351(0.20); C13(1.11); C164(1.54); C241(1.64)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C351(0.19); C13(1.22); C164(1.29); C241(1.40)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C164(1.03); C241(1.13); C13(1.14); C351(1.31)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C351(0.84); C164(1.03); C241(1.07); C13(1.21)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C164(0.93); C351(0.94); C241(1.07); C13(1.32)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C351(0.18); C13(0.97); C164(1.26); C241(1.33)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C351(0.28); C13(1.43); C164(1.70); C241(2.26)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C241(1.28); C13(1.07); C164(1.02); C351(0.23)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C241(1.32); C13(1.05); C164(1.08); C351(0.29)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C241(1.09); C13(1.10); C164(0.84); C351(0.99)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C241(1.02); C13(1.38); C164(0.67); C351(1.21)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C351(0.75); C164(1.04); C13(1.09); C241(1.17)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C351(0.78); C13(0.80); C241(1.42); C164(1.81)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C351(0.70); C241(0.84); C164(0.93); C13(1.00)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C241(0.82); C351(1.07); C164(1.07); C13(1.14)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C351(0.67); C13(1.01); C164(1.02); C241(1.10)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C351(0.71); C13(1.01); C164(1.17); C241(2.08)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C351(0.64); C164(1.01); C13(1.01); C241(1.48)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C351(0.80); C241(1.03); C164(1.04); C13(1.07)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C351(0.78); C164(0.82); C13(0.93); C241(0.96)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C241(0.94); C164(1.07); C13(1.28); C351(1.48)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C241(1.12); C164(1.23); C13(1.41); C351(1.91)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C164(1.23); C13(1.25); C241(1.28); C351(1.85)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C13(1.21); C164(1.31); C241(1.76); C351(1.94)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C164(1.19); C351(1.21); C13(1.32); C241(1.34)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C241(0.84); C164(1.06); C13(1.29); C351(1.34)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C164(1.13); C241(1.14); C351(1.15); C13(1.26)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C164(1.22); C241(1.23); C13(1.32); C351(1.51)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C351(1.30); C13(1.35); C241(1.59); C164(1.65)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C164(1.31); C13(1.32); C241(1.53); C351(2.07)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C13(1.24); C351(1.67); C164(1.69); C241(1.97)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C164(0.70); C241(0.73); C351(0.82); C13(0.82)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C241(0.71); C164(0.74); C351(0.91); C13(1.16)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C164(0.70); C241(0.78); C351(1.11); C13(1.15)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C164(0.73); C241(1.03); C351(1.05); C13(1.06)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C164(0.83); C13(0.96); C351(1.19); C241(1.20)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C241(0.96); C164(1.21); C13(1.40); C351(1.59)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C164(0.91); C351(0.96); C13(1.19); C241(1.84)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C351(0.83); C164(0.85); C241(1.05); C13(1.09)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C351(0.91); C13(0.96); C164(0.97); C241(1.82)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C351(0.82); C164(0.95); C13(1.07); C241(1.39)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C164(0.82); C13(1.06); C351(1.13); C241(1.20)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C351(0.88); C164(0.97); C13(1.16); C241(1.91)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C351(0.55); C164(0.94); C13(1.11); C241(1.18)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C351(0.78); C164(1.03); C13(1.07); C241(1.45)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C351(0.52); C164(0.97); C241(1.15); C13(1.27)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C351(0.48); C13(1.11); C164(1.58); C241(4.31)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C241(0.92); C351(1.27); C13(1.27); C164(1.37)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C351(0.49); C13(1.23); C164(1.25); C241(3.34)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C351(0.62); C164(0.71); C241(1.01); C13(1.08)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C351(0.58); C164(0.98); C13(1.08); C241(3.04)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C351(1.17); C13(1.20); C164(1.20); C241(1.94)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C351(0.68); C13(0.95); C164(1.18); C241(2.87)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C164(1.23); C351(1.35); C13(1.58); C241(2.68)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C351(0.61); C13(1.46); C164(1.63); C241(20.00)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C13(1.11); C351(1.19); C164(1.32); C241(1.75)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C13(1.28); C164(1.32); C351(1.58); C241(1.80)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C351(1.00); C13(1.09); C164(1.48); C241(1.69)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C351(0.93); C241(1.07); C164(1.08); C13(1.29)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C351(0.77); C13(1.12); C164(1.37); C241(1.41)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C351(1.18); C241(1.25); C164(1.25); C13(1.26)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C351(1.04); C13(1.44); C164(1.48); C241(2.32)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C351(1.09); C13(1.31); C241(1.32); C164(1.35)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C351(1.12); C13(1.25); C164(1.52); C241(2.09)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C241(0.34); C351(0.91); C13(1.09); C164(1.20)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C241(0.35); C13(1.05); C351(1.12); C164(1.13)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C241(0.47); C351(0.75); C13(1.13); C164(1.50)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C241(0.99); C13(1.01); C164(1.20); C351(1.74)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C13(0.92); C241(1.11); C164(1.38); C351(2.23)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C241(0.87); C164(1.02); C351(1.06); C13(1.24)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C13(0.99); C241(1.05); C164(1.59); C351(1.89)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C241(1.01); C13(1.05); C164(1.08); C351(2.34)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C13(1.01); C164(1.26); C241(1.27); C351(1.75)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C13(1.39); C351(1.60); C164(1.68); C241(1.90)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C13(1.20); C164(1.65); C241(1.65); C351(1.90)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C13(1.30); C351(1.70); C164(1.75); C241(2.25)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C13(1.15); C164(1.16); C241(1.29); C351(2.36)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C164(1.21); C13(1.25); C241(1.26); C351(1.80)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C164(1.12); C241(1.17); C13(1.22); C351(1.93)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C13(0.92); C241(1.05); C164(1.06); C351(1.58)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C351(0.98); C241(1.00); C13(1.05); C164(1.12)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C13(1.03); C164(1.15); C241(1.40); C351(2.51)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C13(0.91); C164(1.01); C241(1.08); C351(1.69)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C13(1.31); C164(1.57); C351(1.69); C241(2.05)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C13(1.01); C351(1.03); C164(1.84); C241(2.11)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C13(0.90); C351(1.00); C164(1.78); C241(2.11)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C13(0.93); C351(0.94); C241(1.25); C164(1.62)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C351(0.89); C13(1.16); C241(1.32); C164(1.44)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C351(1.00); C13(1.01); C164(1.03); C241(1.15)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C13(0.97); C351(0.99); C164(1.25); C241(1.52)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C351(0.83); C13(1.01); C164(1.41); C241(1.69)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C241(0.90); C351(0.92); C164(0.96); C13(1.38)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C13(1.05); C351(1.07); C164(1.55); C241(2.78)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C13(1.01); C351(1.05); C164(1.60); C241(2.21)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C351(0.90); C13(0.97); C241(1.38); C164(1.59)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C13(0.92); C351(1.21); C164(1.24); C241(1.38)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C351(0.86); C13(1.10); C164(1.36); C241(1.38)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C13(1.03); C164(1.23); C351(1.32); C241(1.88)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C351(0.79); C13(0.85); C164(1.55); C241(1.96)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C351(0.47); C13(0.72); C164(2.09); C241(2.64)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C351(0.50); C13(0.65); C241(0.92); C164(1.18)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C351(0.82); C164(0.29); C241(0.52)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C164(0.77)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C241(0.99); C13(1.14); C164(0.88); C351(1.39)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C164(0.97); C351(1.07); C13(1.25); C241(1.34)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C351(1.21); C13(1.34); C164(1.57); C241(2.89)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C241(1.04); C13(0.93)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C13(1.27); C164(0.50); C241(0.48)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C13(1.87); C164(1.26); C164(0.66); C241(0.66)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C13(0.87); C241(0.87); C164(1.01); C351(1.57)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C351(0.79); C241(1.00); C13(1.08); C164(1.41)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C241(0.92); C164(1.21); C13(1.29); C351(1.47)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C241(0.97); C351(1.06); C164(1.11); C13(1.16)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C241(0.86); C164(0.93); C351(1.22); C13(1.30)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C164(0.90); C241(1.13); C13(1.16); C351(1.44)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C164(0.91); C13(0.97); C241(1.04); C351(1.04)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C351(0.82); C13(1.11); C241(1.24); C164(1.31)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C351(0.85); C13(0.98); C241(1.56); C164(1.93)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C351(0.76); C13(1.04); C241(1.46); C164(1.84)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C351(0.80); C13(0.88); C241(1.72); C164(1.86)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C351(0.58); C13(1.05); C164(1.12); C241(1.29)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C241(0.83); C351(1.02); C13(1.12); C164(1.62)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C351(0.68); C13(0.97); C241(1.31); C164(1.39)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C351(0.39); C13(0.95); C241(1.00); C164(1.18)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C241(0.94); C13(1.01); C164(1.09); C351(1.20)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C13(1.15); C164(1.47); C241(1.51); C351(1.75)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C241(1.14); C164(1.17); C351(1.22); C13(1.23)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C164(1.14); C13(1.15); C241(1.47); C351(1.73)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C164(1.12); C241(1.22); C13(1.31); C351(1.63)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C351(0.99); C13(1.21); C164(1.61); C241(2.69)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C351(0.79); C241(0.89); C13(0.93); C164(1.05)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C351(0.78); C13(0.94); C241(1.07); C164(1.07)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C351(0.89); C241(1.13); C13(1.46); C164(1.56)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C351(0.70); C241(0.87); C164(0.88); C13(1.18)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C351(0.73); C164(1.03); C13(1.04); C241(1.78)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C351(0.81); C13(0.98); C164(1.07); C241(1.26)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C351(0.68); C13(0.98); C164(1.24); C241(1.37)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C351(0.66); C13(1.09); C164(1.30); C241(2.15)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C241(0.88); C351(0.94); C164(1.05); C13(1.12)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C241(0.89); C351(1.05); C13(1.08); C164(1.31)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C241(0.83); C351(0.94); C164(1.13); C13(1.24)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C351(1.10); C13(1.24); C164(1.47); C241(2.20)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C241(0.89); C351(0.99); C13(1.08); C164(1.20)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C164(0.97); C351(0.98); C241(1.00); C13(1.06)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C241(0.74); C351(1.07); C13(1.09); C164(1.19)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C351(0.64); C164(0.99); C13(1.06); C241(1.22)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C13(1.00); C241(1.04); C164(1.26); C351(1.52)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C351(0.96); C241(1.02); C164(1.07); C13(1.18)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C164(0.97); C13(1.03); C241(1.05); C351(1.19)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C241(0.93); C164(1.03); C13(1.03); C351(1.48)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C351(1.07); C164(1.10); C241(1.13); C13(1.22)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C241(0.90); C164(0.98); C13(1.19); C351(1.63)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C164(0.76); C241(0.90); C351(1.12); C13(1.49)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C351(0.70); C164(0.99); C13(1.06); C241(1.11)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C164(0.69); C351(0.88); C241(1.01); C13(1.25)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C241(1.09); C13(1.23); C164(0.76); C351(0.74)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C241(1.31); C13(1.05); C164(0.93); C351(0.65)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C241(1.06); C13(1.20); C164(0.78); C351(0.97)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C241(1.20); C13(1.16); C164(0.74); C351(0.69)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C241(0.96); C13(1.27); C164(0.70); C351(1.08)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C241(0.83); C13(1.00); C164(1.04); C351(1.06)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C241(1.01); C13(1.05); C164(0.67); C351(1.09)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C241(0.96); C13(1.01); C164(1.00); C351(1.09)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C241(1.27); C13(0.94); C164(1.55); C351(0.79)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C241(1.08); C13(0.99); C164(1.15); C351(0.76)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C241(0.94); C13(1.08); C164(1.15); C351(0.76)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C241(1.12); C13(1.13); C164(1.28); C351(0.80)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C241(0.80); C13(1.05); C164(1.32); C351(0.97)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C241(1.03); C13(1.12); C164(1.18); C351(1.03)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C241(1.10); C13(1.18); C164(0.96); C351(1.01)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C241(0.80); C13(0.98); C164(1.05); C351(1.05)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C241(1.03); C13(0.97); C164(0.95); C351(0.94)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C241(0.94); C13(0.99); C164(1.32); C351(0.88)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C241(1.00); C13(0.98); C164(0.75); C351(1.10)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C241(1.02); C13(1.03); C164(1.05); C351(0.92)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C241(0.92); C13(1.22); C164(0.82); C351(1.09)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C241(0.83); C13(1.19); C164(1.01); C351(0.97)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C241(0.77); C13(1.06); C164(0.79); C351(0.94)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C241(0.84); C13(1.10); C164(0.89); C351(1.23)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C241(0.73); C13(1.18); C164(0.88); C351(0.82)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C241(0.90); C13(0.99); C164(0.80); C351(0.80)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C241(0.75); C13(1.02); C164(1.07); C351(1.07)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C241(0.80); C13(1.06); C164(0.80); C351(0.93)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C241(0.76); C13(1.06); C164(0.79); C351(1.21)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C241(0.79); C13(1.11); C164(0.70); C351(0.70)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C241(0.86); C13(1.04); C164(0.86); C351(0.81)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C241(0.79); C13(1.07); C164(0.62); C351(0.75)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C241(0.76); C13(1.10); C164(0.67); C351(1.14)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C241(0.84); C13(1.14); C164(0.82); C351(1.05)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C241(0.78); C13(1.03); C164(0.63); C351(0.94)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C241(0.82); C13(1.05); C164(0.63); C351(0.57)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C241(0.87); C13(1.12); C164(0.77); C351(0.92)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C241(0.87); C13(0.99); C164(1.22); C351(0.82)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C241(0.65); C13(1.14); C164(0.67); C351(0.67)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C241(0.84); C13(1.09); C164(0.98); C351(0.94)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C241(0.96); C13(0.97); C164(1.11); C351(0.95)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C241(0.95); C13(1.40); C164(1.32); C351(0.73)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C241(0.83); C13(1.12); C164(1.23); C351(0.70)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C241(0.79); C13(0.92); C164(1.03); C351(0.74)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C241(0.91); C13(1.05); C164(1.75); C351(0.69)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C241(0.85); C13(1.02); C164(1.41); C351(0.64)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C241(0.81); C13(1.10); C164(1.23); C351(0.74)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C241(0.99); C13(0.91); C164(1.00); C351(0.65)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C241(0.86); C13(1.13); C164(1.48); C351(0.91)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C241(0.95); C13(1.15); C164(1.05); C351(0.82)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C241(0.89); C13(1.03); C164(1.31); C351(0.58)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C241(0.91); C13(0.96); C164(0.86); C351(0.85)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C241(0.86); C13(0.97); C164(1.05); C351(0.63)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C241(0.93); C13(1.07); C164(1.12); C351(0.52)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C241(0.94); C13(1.09); C164(1.09); C351(1.55)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C241(0.96); C13(0.96); C164(1.05); C351(1.40)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C241(1.08); C13(1.25); C164(1.22); C351(1.08)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C241(0.91); C13(1.15); C164(1.58); C351(1.40)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C241(1.05); C13(1.17); C164(1.92); C351(0.67)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C241(0.97); C13(0.95); C164(1.09); C351(1.27)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C241(0.83); C13(1.11); C164(1.28); C351(1.78)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C241(0.78); C13(1.33); C164(1.88); C351(2.02)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C241(0.97); C13(1.12); C164(1.79); C351(1.50)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C241(0.99); C13(1.64); C164(2.23); C351(1.33)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C241(0.96); C13(1.22); C164(1.25); C351(1.21)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C241(0.99); C13(0.97); C164(1.03); C351(1.59)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C241(0.83); C13(1.05); C164(1.21); C351(2.00)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C241(0.85); C13(1.25); C164(1.63); C351(2.43)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C241(0.85); C13(1.32); C164(2.58); C351(1.41)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C241(0.95); C13(1.15); C164(1.26); C351(0.91)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C241(0.77); C13(0.89); C164(0.86); C351(1.81)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C241(1.30); C13(1.43); C164(1.30); C351(0.91)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C241(1.24); C13(1.07); C164(1.34); C351(1.09)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C241(1.11); C13(1.21); C164(1.19); C351(1.49)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C241(1.49); C13(1.19); C164(1.34); C351(1.26)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C241(1.45); C13(1.44); C164(1.57); C351(1.21)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C241(1.28); C13(1.25); C164(1.24); C351(1.05)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C241(0.80); C13(1.27); C164(1.05); C351(0.87)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C241(0.94); C13(1.16); C164(1.36); C351(1.05)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C241(0.87); C13(1.18); C164(1.24); C351(1.21)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C241(0.79); C13(0.60)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C13(1.01); C351(1.13); C164(0.91); C241(0.92)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C351(1.91); C164(1.55); C13(1.25); C241(0.97)  LDD1702  [8]
 LDCM0625  F8 Ramos C13(1.12); C164(1.34); C351(0.53); C241(13.85)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C13(1.47); C164(1.18); C351(0.78); C241(0.34)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C13(0.07); C164(0.25); C351(0.35); C241(0.16)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C13(0.82); C164(0.94); C351(0.62); C241(0.33)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C13(0.99); C164(0.88); C241(0.61)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C13(0.72); C164(0.57); C351(0.53); C241(0.55)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C13(0.74); C164(1.57); C351(0.43); C241(0.19)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C13(1.01); C164(0.93); C351(1.04); C241(0.96)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C13(0.43); C164(1.17); C351(0.18); C241(0.36)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C13(1.00); C164(0.86); C241(0.70)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C13(0.88); C164(0.55); C351(0.92); C241(0.50)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C13(1.36); C164(1.62); C351(2.13); C241(0.78)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C13(1.02); C164(0.80); C351(1.13); C241(0.93)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C13(0.85); C351(0.44); C241(0.50)  LDD2201  [39]
 LDCM0468  Fragment33 HCT 116 C241(0.79); C13(1.16); C164(1.12); C351(0.96)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos C13(1.13); C164(1.08); C351(1.29); C241(0.52)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C13(1.04); C164(0.65); C351(0.54); C241(1.02)  LDD2184  [39]
 LDCM0427  Fragment51 HCT 116 C241(0.88); C13(0.91); C164(1.08); C351(0.94)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C13(1.21); C164(1.31); C241(0.44)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C13(1.62); C164(0.97); C351(0.87); C241(0.74)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C13(0.78); C164(0.93); C351(0.38); C241(0.82)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C13(0.84); C164(1.40); C351(0.45); C241(0.28)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y160(0.73); Y364(0.83); Y211(0.90)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y211(0.60); Y160(0.66); Y364(0.75)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y211(0.58); Y160(0.72); Y364(0.95)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y211(0.28); Y160(0.64); Y364(0.89)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y160(0.55); Y211(0.75); Y364(0.91)  LDD0268  [14]
 LDCM0126  JWB150 DM93 Y211(20.00)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y211(20.00)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y211(20.00)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y211(15.49)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y211(20.00)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C164(1.70); C241(1.43)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C164(1.31); C241(1.12)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C164(1.84); C241(1.46)  LDD0082  [16]
 LDCM0030  Luteolin HEK-293T 6.79  LDD0182  [25]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C351(0.97); C241(0.51)  LDD2121  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C351(0.73); C164(0.40); C241(0.69)  LDD2089  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C164(0.90); C241(0.80)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C164(1.12)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C164(1.00)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C164(0.87)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C164(0.96)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C164(0.82)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C13(0.99); C164(0.90); C241(0.84)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C13(0.98); C351(0.50); C164(0.51)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C164(1.06)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C164(0.60)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C164(1.26); C241(0.97)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C164(0.70)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C13(0.91); C351(1.05); C241(0.96)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C351(0.64); C164(0.63); C241(0.82)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C351(0.43); C164(0.80)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C164(0.88)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C13(0.56); C164(0.65)  LDD2114  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C164(1.05)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C351(0.21); C164(1.00)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C164(2.34)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C164(0.58)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C164(1.14); C241(0.18)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C13(1.01)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C164(1.16)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C13(0.99); C164(0.90)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C164(1.14)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C164(0.98)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C164(0.55)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C164(0.91)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C164(0.61)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C164(0.76)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C164(0.85)  LDD2135  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C13(0.86); C164(1.00)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C164(1.40)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C13(0.94); C164(0.72); C241(0.82)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C351(0.72); C164(0.72); C241(0.93)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C164(0.72)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C164(2.10)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C164(4.03)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C164(0.99)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C351(2.35); C164(1.83)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C164(0.52)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C164(1.46)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C351(0.37); C164(0.30); C241(0.46)  LDD2150  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C164(2.11); C241(2.11)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C241(0.75); C13(0.70); C164(0.32)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C13(0.80); C164(0.59); C351(0.07)  LDD2207  [40]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0382  [10]
 LDCM0131  RA190 MM1.R C241(1.45); C13(1.24)  LDD0304  [41]
 LDCM0021  THZ1 HCT 116 C164(1.04); C241(1.02); C13(1.11)  LDD2173  [16]
 LDCM0112  W16 Hep-G2 C164(0.52)  LDD0239  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Serine/threonine-protein kinase Chk2 (CHEK2) CAMK Ser/Thr protein kinase family O96017
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Y-box-binding protein 1 (YBX1) YBX1 family P67809
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
35 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
36 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
37 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.