Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	KIRA6 AfBP			Probe Info
Probe concentration	10 uM
Criteria	Other data
Quantitative Method	LFQ
*In Vivo* Experiment Model**	Model Type		Cell lysate
	Derived Tissue		Skin
	Disease Model	Amelanotic melanoma [ICD-11:2C30]
	Model Name	Human amelanotic melanoma cell lysate (A-375)

Interaction Altas of This Experiment [1]

Enzyme

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Target ID	Target Name
LDTP04262	Alanine--tRNA ligase, cytoplasmic (AARS1)
LDTP02222	Bifunctional glutamate/proline--tRNA ligase (EPRS1)
LDTP01328	CAAX prenyl protease 1 homolog (ZMPSTE24)
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)
LDTP02179	L-lactate dehydrogenase B chain (LDHB)
LDTP01787	Phosphoglycerate kinase 1 (PGK1)
LDTP13814	Phospholipase A-2-activating protein (PLAA)
LDTP00616	Protein phosphatase 1G (PPM1G)
LDTP02067	Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)
LDTP03859	V-type proton ATPase catalytic subunit A (ATP6V1A)

Transporter and channel

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Target ID	Target Name
LDTP05528	Apoptosis regulator BAX (BAX)
LDTP04426	B-cell receptor-associated protein 31 (BCAP31)
LDTP05394	Caveolin-1 (CAV1)
LDTP06242	Importin subunit beta-1 (KPNB1)
LDTP01574	Importin-7 (IPO7)
LDTP06462	Neutral amino acid transporter B(0) (SLC1A5)
LDTP00451	Secretory carrier-associated membrane protein 3 (SCAMP3)
LDTP03132	Voltage-dependent anion-selective channel protein 1 (VDAC1)

Other

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References

1	Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8. Mass spectrometry data entry: PXD022628