Details of the Target

General Information of Target

Target ID LDTP05394
Target Name Caveolin-1 (CAV1)
Gene Name CAV1
Gene ID 857
Synonyms
CAV; Caveolin-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLN
DDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFA
ILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Caveolin family
Subcellular location
Golgi apparatus membrane
Function
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)-hydroxycholesterol (20(S)-OHC).
TTD ID
T93945
Uniprot ID
Q03135
DrugMap ID
TTXUBN2
Ensemble ID
ENST00000341049.7
HGNC ID
HGNC:1527
ChEMBL ID
CHEMBL3808270

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.62  LDD0402  [1]
CY4
 Probe Info  		4.85  LDD0244  [2]
ONAyne
 Probe Info  		K26(3.01); K47(3.27)  LDD0274  [3]
STPyne
 Probe Info  		K176(10.00); K26(6.83); K30(8.06); K39(8.75)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K47(1.22)  LDD3494  [4]
Jackson_14
 Probe Info  		2.00  LDD0123  [5]
DBIA
 Probe Info  		C143(0.91)  LDD0532  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AX-1
 Probe Info  		2.44  LDD0441  [9]
A-DA
 Probe Info  		2.19  LDD0144  [10]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0176  9im MDA-MB-231 2.44  LDD0441  [9]
 LDCM0215  AC10 HCT 116 C143(0.91)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C143(0.66)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C143(0.65)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C143(0.72)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C143(0.82)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C143(0.68)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C143(0.87)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C143(0.72)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C143(0.66)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C143(0.76)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C143(1.01)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C143(1.00)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C143(0.79)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C143(0.83)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C143(0.64)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C143(1.07)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C143(0.98)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C143(1.05)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C143(1.14)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C143(1.00)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C143(1.01)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C143(1.00)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C143(0.83)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C143(1.01)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C143(1.03)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C143(0.98)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C143(1.01)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C143(0.99)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C143(0.90)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C143(0.92)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C143(1.19)  LDD0562  [6]
 LDCM0259  AC14 HCT 116 C143(0.95)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C143(0.97)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C143(1.08)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C143(1.16)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C143(1.23)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C143(1.07)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C143(1.63)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C143(1.46)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C143(0.97)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C143(1.19)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C143(1.17)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C143(1.15)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C143(1.45)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C143(1.19)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C143(1.22)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C143(1.22)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C143(1.24)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C143(1.28)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C143(0.92)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C143(1.01)  LDD0595  [6]
 LDCM0280  AC20 HCT 116 C143(0.98)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C143(0.94)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C143(1.19)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C143(1.15)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C143(0.96)  LDD0601  [6]
 LDCM0296  AC35 HCT 116 C143(1.01)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C143(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C143(1.15)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C143(1.10)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C143(0.98)  LDD0617  [6]
 LDCM0302  AC40 HCT 116 C143(1.18)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C143(1.16)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C143(1.25)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C143(1.21)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C143(1.14)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C143(1.16)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C143(0.90)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C143(1.36)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C143(1.11)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C143(0.87)  LDD0628  [6]
 LDCM0313  AC50 HCT 116 C143(1.05)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C143(0.94)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C143(1.15)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C143(1.28)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C143(1.25)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C143(1.04)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C143(1.07)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C143(1.21)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C143(1.00)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C143(1.03)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C143(0.88)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C143(1.08)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C143(1.08)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C143(1.29)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C143(1.28)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C143(1.21)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C143(1.52)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C143(1.45)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C143(1.36)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C143(1.04)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C143(1.00)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C143(0.93)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C143(0.93)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C143(0.99)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C143(0.97)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C143(1.07)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C143(1.05)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C143(1.03)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C143(0.98)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C143(0.90)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C143(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C143(0.97)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C143(1.02)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C143(0.95)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C143(0.84)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C143(0.90)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C143(1.21)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C143(1.13)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C143(1.24)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C143(1.16)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C143(1.06)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C143(1.21)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C143(1.20)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C143(1.20)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C143(1.28)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C143(1.21)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C143(1.11)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C143(1.25)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C143(1.05)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C143(1.11)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C143(1.15)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C143(0.72)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C143(0.64)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C143(0.97)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C143(0.83)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C143(0.79)  LDD0592  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C143(0.97)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C143(1.27)  LDD0685  [6]
 LDCM0370  CL101 HCT 116 C143(0.76)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C143(0.92)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C143(0.95)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C143(0.94)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C143(1.06)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C143(1.20)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C143(1.33)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C143(1.48)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C143(1.04)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C143(1.46)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C143(1.27)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C143(0.98)  LDD0698  [6]
 LDCM0387  CL117 HCT 116 C143(1.28)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C143(1.08)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C143(1.04)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C143(1.34)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C143(1.08)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C143(1.09)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C143(0.80)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C143(1.39)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C143(1.19)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C143(1.06)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C143(1.12)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C143(1.08)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C143(1.03)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C143(1.07)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C143(1.02)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C143(0.87)  LDD0719  [6]
 LDCM0407  CL2 HCT 116 C143(0.94)  LDD0724  [6]
 LDCM0418  CL3 HCT 116 C143(0.92)  LDD0735  [6]
 LDCM0420  CL31 HCT 116 C143(1.24)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C143(1.06)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C143(1.09)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C143(1.29)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C143(1.07)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C143(1.06)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C143(1.12)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C143(1.13)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C143(0.94)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C143(1.09)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C143(1.01)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C143(1.01)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C143(1.32)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C143(1.14)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C143(1.41)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C143(1.50)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C143(1.20)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C143(1.17)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C143(1.35)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C143(0.87)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C143(1.18)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C143(1.37)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C143(1.36)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C143(0.58)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C143(1.13)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C143(1.18)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C143(0.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C143(0.85)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C143(1.10)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C143(1.09)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C143(0.84)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C143(1.12)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C143(1.07)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C143(1.23)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C143(1.08)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C143(1.07)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C143(1.10)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C143(1.20)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C143(1.11)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C143(1.01)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C143(0.99)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C143(1.20)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C143(1.09)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C143(0.98)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C143(0.97)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C143(1.06)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C143(1.00)  LDD0784  [6]
 LDCM0473  CL8 HCT 116 C143(1.02)  LDD0790  [6]
 LDCM0484  CL9 HCT 116 C143(1.15)  LDD0801  [6]
 LDCM0468  Fragment33 HCT 116 C143(1.04)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C143(1.13)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 DAN-G C143(1.20)  LDD2313  [12]
 LDCM0023  KB03 DAN-G C143(5.29)  LDD2730  [12]
 LDCM0024  KB05 SW1990 C143(7.66)  LDD3456  [12]
 LDCM0109  NEM HeLa H58(0.00); H79(0.00); H45(0.00)  LDD0223  [8]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [5]
 LDCM0084  Ro 48-8071 A-549 2.19  LDD0144  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin reductase 1, cytoplasmic (TXNRD1) Class-I pyridine nucleotide-disulfide oxidoreductase family Q16881
Serine/threonine-protein kinase 38 (STK38) AGC Ser/Thr protein kinase family Q15208
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Ras-related protein Rab-27B (RAB27B) Rab family O00194
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Sterol carrier protein 2 (SCP2) Thiolase family P22307
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Caveolin-2 (CAV2) Caveolin family P51636
NPC intracellular cholesterol transporter 1 (NPC1) Patched family O15118
Potassium voltage-gated channel subfamily H member 2 (KCNH2) Potassium channel family Q12809
Short transient receptor potential channel 1 (TRPC1) Transient receptor family P48995
Guanine nucleotide exchange factor VAV2 (VAV2) . P52735
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein inhibitor ID-1 (ID1) . P41134
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteinase-activated receptor 1 (F2R) G-protein coupled receptor 1 family P25116
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 6 (FAS) . P25445
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Bcl-2 family Q07820
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Caveolae-associated protein 2 (CAVIN2) CAVIN family O95810
Caveolae-associated protein 3 (CAVIN3) CAVIN family Q969G5
Low-density lipoprotein receptor-related protein 6 (LRP6) LDLR family O75581
BH3-interacting domain death agonist (BID) . P55957
Ras GTPase-activating protein 1 (RASA1) . P20936

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor. Chem Asian J. 2018 Sep 17;13(18):2601-2605. doi: 10.1002/asia.201800605. Epub 2018 Aug 7.
10 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
11 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840