Details of the Target

General Information of Target

Target ID LDTP03342
Target Name Integrin alpha-3 (ITGA3)
Gene Name ITGA3
Gene ID 3675
Synonyms
MSK18; Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNPGSLFGYSVALHR
QTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIE
DMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDSSDDWQTY
HNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYK
DPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEAGGDLRRRQVLEG
SQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLL
LHGPSGSAFGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGE
KLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDHIVLLRARPVINIVHKTLVPRPAVL
DPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFAGSESAVFH
GFFSMPEMRCQKLELLLMDNLRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQA
QALENHTEVQFQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNT
RTSERSGEDAHEALLTLVVPPALLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAF
EVIGVTLHTRDLQVQLQLSTSSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVM
GESGMKTVEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHG
NGSWPCRPPGDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSET
VLTCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRT
SIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFK
RARTRALYEAKRQKAEMKSQPSETERLTDDY
Target Bioclass
Other
Family
Integrin alpha chain family
Subcellular location
Cell membrane
Function
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.; (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
Uniprot ID
P26006
Ensemble ID
ENST00000007722.11
HGNC ID
HGNC:6139
ChEMBL ID
CHEMBL3525

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.86  LDD0324  [1]
ONAyne
 Probe Info  		K1031(1.15)  LDD0274  [2]
STPyne
 Probe Info  		K1031(7.41); K1034(5.26); K161(0.97); K407(10.00)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K897(1.68); K620(1.80); K895(2.18); K100(2.42)  LDD3494  [3]
BTD
 Probe Info  		C140(2.57); C621(1.34)  LDD1700  [4]
IPM
 Probe Info  		C621(1.78)  LDD1701  [4]
DBIA
 Probe Info  		C621(1.09); C140(1.03); C94(0.91)  LDD0078  [5]
5E-2FA
 Probe Info  		H540(0.00); H99(0.00)  LDD2235  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
IA-alkyne
 Probe Info  		C621(0.00); C615(0.00); C94(0.00); C904(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.15  LDD0398  [10]
STS-1
 Probe Info  		N.A.  LDD0136  [11]
A-DA
 Probe Info  		2.37  LDD0145  [12]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C621(0.30)  LDD2142  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C140(0.83)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C140(0.97); C904(0.87)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C140(1.14); C94(0.96); C615(0.94); C621(0.67)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C140(1.48); C621(1.03)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C94(1.00)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C140(0.79); C904(0.44)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C140(0.66); C94(0.77); C904(0.68)  LDD2131  [4]
 LDCM0545  Acetamide MDA-MB-231 C140(0.72); C904(0.65)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C621(0.76)  LDD2113  [4]
 LDCM0020  ARS-1620 HCC44 C621(1.09); C140(1.03); C94(0.91)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C140(0.81); C904(0.82)  LDD2091  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C94(2.80); C140(2.08)  LDD1702  [4]
 LDCM0022  KB02 42-MG-BA C904(1.25); C140(1.54)  LDD2244  [14]
 LDCM0023  KB03 MDA-MB-231 C621(1.78)  LDD1701  [4]
 LDCM0024  KB05 G361 C904(2.26); C621(2.38); C94(3.90)  LDD3311  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C140(0.80); C94(0.64); C904(0.91)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C140(0.88); C904(0.84)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C94(0.99)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C140(1.13); C94(1.09); C621(0.77); C904(1.04)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C94(0.91)  LDD2094  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C140(2.44); C615(1.09); C621(1.03); C904(1.18)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C94(1.28)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C140(1.72); C94(1.10); C615(1.82); C621(0.94)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C615(0.38)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C621(0.99)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C621(0.27)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C94(0.94)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C140(1.35); C615(0.96); C621(0.94); C904(0.73)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C140(0.69); C94(0.95); C621(1.31); C904(0.84)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C904(0.49)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C140(0.91); C615(1.22); C621(0.78); C904(1.07)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C140(0.53); C621(0.60); C904(0.98)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C140(0.77); C94(1.70); C621(2.05); C904(1.44)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C140(0.34); C904(0.81)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C140(0.79); C615(0.75); C621(0.72); C904(0.61)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C140(0.83); C94(0.78); C615(1.16); C621(0.61)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C140(0.77); C94(0.98); C621(0.62); C904(0.83)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C140(0.28)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C140(0.97); C94(1.00); C615(0.87); C621(0.68)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C140(0.98); C615(0.27); C621(0.54); C904(1.69)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C140(0.99); C615(0.63); C621(0.63); C904(1.37)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C140(0.65); C621(0.80); C904(0.88)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C140(1.40); C615(1.09); C621(0.91); C904(0.73)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C140(0.70); C94(1.08); C621(0.76); C904(0.67)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C140(2.57); C621(1.34)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C140(1.00); C94(0.76); C615(1.29); C621(0.65)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C140(0.26)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C140(1.12); C94(1.53); C621(2.18); C904(2.13)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C140(1.08); C94(1.04); C621(0.88)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C140(0.32)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C140(0.56); C621(0.52); C904(0.67)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C94(0.46); C904(0.67)  LDD2150  [4]
 LDCM0084  Ro 48-8071 A-549 2.37  LDD0145  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD151 antigen (CD151) Tetraspanin (TM4SF) family P48509

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
13 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840