Details of the Target

General Information of Target

Target ID LDTP05998
Target Name Tubulin beta-2A chain (TUBB2A)
Gene Name TUBB2A
Gene ID 7280
Synonyms
TUBB2; Tubulin beta-2A chain; Tubulin beta class IIa
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
Target Type
Successful
Target Bioclass
Other
Family
Tubulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
TTD ID
T28661
Uniprot ID
Q13885
DrugMap ID
TTJ2PTI
Ensemble ID
ENST00000333628.4
HGNC ID
HGNC:12412
ChEMBL ID
CHEMBL3797012

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y50(20.00); Y51(20.00); Y59(14.47)  LDD0257  [1]
TH214
 Probe Info  		Y51(20.00)  LDD0258  [1]
TH216
 Probe Info  		Y51(20.00); Y50(11.48)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
ONAyne
 Probe Info  		K297(6.25); K58(8.33)  LDD0274  [3]
STPyne
 Probe Info  		K297(5.89); K58(8.33)  LDD0277  [3]
AZ-9
 Probe Info  		D74(0.84); E383(0.90)  LDD2208  [4]
JZ128-DTB
 Probe Info  		C239(0.00); C354(0.00); C129(0.00); C211(0.00)  LDD0462  [5]
THZ1-DTB
 Probe Info  		C129(1.00)  LDD0460  [5]
BTD
 Probe Info  		C354(1.67); C12(1.51)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C303(2.15)  LDD0168  [7]
HPAP
 Probe Info  		3.38  LDD0063  [8]
HHS-482
 Probe Info  		Y310(0.94); Y36(0.89); Y50(0.90); Y51(0.74)  LDD0285  [9]
HHS-475
 Probe Info  		Y222(0.69); Y106(0.78); Y281(0.79); Y340(0.90)  LDD0264  [10]
HHS-465
 Probe Info  		Y106(10.00); Y159(8.69); Y222(8.37); Y281(7.61)  LDD2237  [11]
DBIA
 Probe Info  		C127(1.11); C129(1.11)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C127(0.00); C129(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C239(0.00); C354(0.00); C303(0.00); C12(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C303(0.00); C12(0.00); C239(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C303(0.00); C12(0.00); C239(0.00); C127(0.00)  LDD0031  [17]
IPM
 Probe Info  		C239(0.00); C303(0.00); C129(0.00); C12(0.00)  LDD0025  [18]
NAIA_4
 Probe Info  		C12(0.00); C129(0.00); C127(0.00); C211(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C303(0.00); C239(0.00); C354(0.00); C12(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C303(0.00); C239(0.00); C12(0.00); C354(0.00)  LDD0021  [20]
ENE
 Probe Info  		C303(0.00); C12(0.00); C354(0.00)  LDD0006  [20]
PPMS
 Probe Info  		C354(0.00); C12(0.00)  LDD0008  [20]
SF
 Probe Info  		Y159(0.00); K252(0.00); Y106(0.00); Y310(0.00)  LDD0028  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [22]
1c-yne
 Probe Info  		K297(0.00); K362(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C239(0.00); H227(0.00); H37(0.00); C127(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		N.A.  LDD0218  [24]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C018
 Probe Info  		6.36  LDD1726  [25]
C049
 Probe Info  		7.73  LDD1747  [25]
C153
 Probe Info  		16.91  LDD1834  [25]
C198
 Probe Info  		58.08  LDD1874  [25]
C218
 Probe Info  		11.55  LDD1892  [25]
C255
 Probe Info  		6.63  LDD1928  [25]
C264
 Probe Info  		72.00  LDD1935  [25]
C270
 Probe Info  		8.34  LDD1940  [25]
C287
 Probe Info  		21.41  LDD1957  [25]
C363
 Probe Info  		16.00  LDD2024  [25]
C382
 Probe Info  		22.32  LDD2041  [25]
C390
 Probe Info  		22.32  LDD2049  [25]
C413
 Probe Info  		14.22  LDD2069  [25]
FFF probe11
 Probe Info  		20.00  LDD0472  [26]
FFF probe3
 Probe Info  		20.00  LDD0465  [26]
SAHA-CA-8PAP
 Probe Info  		N.A.  LDD0362  [27]
LD-F
 Probe Info  		E69(0.00); D67(0.00); V66(0.00)  LDD0015  [28]
Photocelecoxib
 Probe Info  		D67(0.00); E69(0.00)  LDD0153  [29]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C303(2.15)  LDD0168  [7]
 LDCM0214  AC1 HCT 116 C12(1.37); C127(0.54); C129(0.54); C239(1.10)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C12(1.17); C239(0.89); C354(1.10)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C12(0.95); C127(0.80); C129(0.80); C239(1.10)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C12(0.94); C127(0.93); C129(0.93); C239(0.83)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C12(0.96); C127(1.32); C129(1.32); C239(1.59)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C12(1.10); C127(1.44); C129(1.44); C239(1.11)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C12(1.13); C127(0.90); C129(0.90); C239(1.18)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C12(1.12); C127(0.90); C129(0.90); C239(1.30)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C12(1.14); C127(1.00); C129(1.00); C239(1.22)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C12(1.30); C127(1.12); C129(1.12); C239(1.40)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C12(0.89); C127(0.81); C129(0.81); C239(0.80)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C12(0.95); C127(0.82); C129(0.82); C239(0.82)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C12(1.38); C239(1.02); C354(1.09)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C12(0.91); C127(1.05); C129(1.05); C239(0.98)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C12(1.08); C127(1.20); C129(1.20); C239(1.15)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C12(1.08); C127(1.03); C129(1.03); C239(1.05)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C12(1.10); C127(1.05); C129(1.05); C239(1.23)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C12(1.28); C127(0.90); C129(0.91); C239(1.44)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C12(1.51); C127(0.97); C129(0.98); C239(1.52)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C12(1.17); C127(1.00); C129(0.94); C239(1.01)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C12(1.18); C127(0.87); C129(1.21); C239(1.15)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C12(1.04); C127(0.91); C129(1.05); C239(0.88)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C12(1.14); C127(0.94); C129(1.24); C239(0.93)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C12(1.28); C239(1.03); C354(0.99)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C12(1.30); C127(0.96); C129(1.10); C239(1.25)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C12(1.00); C127(0.92); C129(1.09); C239(0.73)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C12(1.21); C127(1.20); C129(1.12); C239(1.09)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C12(1.17); C127(0.94); C129(1.11); C239(0.98)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C12(1.09); C127(0.96); C129(1.11); C239(1.24)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C12(1.03); C127(1.06); C129(0.98); C239(0.89)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C12(1.28); C127(1.14); C129(0.71); C239(1.20)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C12(1.23); C127(1.00); C129(0.93); C239(1.21)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C12(1.22); C129(0.87); C239(0.85); C354(1.09)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C12(0.89); C129(0.78); C239(1.09); C354(1.05)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C12(1.12); C129(0.92); C239(0.83); C354(1.08)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C12(0.78); C129(1.16); C239(1.11); C354(1.03)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C12(1.09); C129(0.81); C239(0.84); C354(1.36)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C12(1.05); C129(0.90); C239(0.89); C354(1.10)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C12(1.08); C129(1.32); C239(1.08); C354(1.29)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C12(1.08); C129(0.90); C239(0.77); C354(1.10)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C12(0.94); C129(1.06); C239(0.80); C354(1.05)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C12(1.18); C129(1.11); C239(1.03); C354(1.08)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C12(1.10); C129(1.67); C239(0.95); C354(1.26)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C12(1.04); C129(1.07); C239(0.94); C354(1.23)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C12(1.30); C239(1.07); C354(1.25)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C12(1.15); C129(1.30); C239(0.97); C354(1.49)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C12(1.11); C129(1.37); C239(1.01); C354(1.43)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C12(0.83); C129(0.92); C239(0.73); C354(0.99)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C239(0.79); C12(0.94); C354(1.02)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C239(0.93); C354(1.01); C12(1.23)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C239(0.93); C354(1.03); C12(1.06)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C12(1.15); C354(1.16); C239(1.26)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C239(1.07); C12(1.39); C354(1.40)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C354(0.96); C239(1.23); C12(1.68)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C354(1.05); C12(1.32); C239(1.37)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C239(1.12); C354(1.18); C12(1.30)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C239(0.91); C354(0.95); C12(1.07)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C239(0.74); C354(0.90); C12(1.03)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C354(0.88); C12(1.43); C239(1.45)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C354(1.25); C239(1.46); C12(1.75)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C12(1.26); C239(1.38); C354(1.29)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C12(1.13); C239(1.16); C354(1.01)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C12(0.99); C239(1.15); C354(0.84)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C12(0.92); C239(1.03); C354(0.92)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C354(0.82); C127(0.92); C129(0.92); C12(0.94)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C354(0.86); C127(0.86); C129(0.86); C239(1.33)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C127(0.71); C129(0.71); C354(0.98); C12(1.00)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C127(0.68); C129(0.68); C239(1.11); C12(1.20)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C354(0.79); C12(0.90); C239(0.94); C127(1.03)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C354(0.75); C12(0.98); C127(1.00); C129(1.00)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C354(0.75); C239(0.95); C12(0.98); C127(1.13)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C354(0.72); C127(0.82); C129(0.82); C239(0.93)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C127(0.93); C129(0.93); C12(0.95); C354(0.98)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C239(0.98); C354(1.09); C12(1.14)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C239(0.98); C354(1.23); C12(1.28)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C239(1.00); C12(1.02); C354(1.18)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C354(1.13); C12(1.17); C239(1.17)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C239(1.14); C12(1.15); C354(1.36)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C127(0.57); C129(0.57); C239(1.19); C12(1.26)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C12(1.09); C239(1.28); C354(1.37)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C239(1.18); C12(1.19); C354(1.38)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C239(1.27); C12(1.43); C354(1.76)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C239(1.21); C12(1.23); C354(1.34)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C12(1.39); C354(1.48); C239(1.56)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C239(0.73); C354(0.81); C12(0.93)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C239(0.75); C354(0.89); C12(1.00)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C239(0.73); C354(0.91); C12(1.00)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C12(0.85); C239(0.85); C354(0.95)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C239(0.74); C12(0.90); C354(1.00)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C127(0.50); C129(0.50); C239(1.27); C12(1.42)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C239(0.88); C354(1.04); C12(1.04)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C239(0.94); C354(1.08); C12(1.28)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C239(0.89); C12(1.08); C354(1.13)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C239(0.87); C12(1.03); C354(1.06)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C239(0.89); C12(1.10); C354(1.10)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C239(0.91); C354(1.09); C12(1.16)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C12(1.00); C127(1.02); C129(1.02); C354(1.19)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C127(0.67); C129(0.67); C239(0.87); C12(1.05)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C239(0.97); C12(1.04); C127(1.05); C129(1.05)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C127(0.97); C129(0.97); C239(1.14); C354(1.21)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C127(0.47); C129(0.47); C239(1.19); C12(1.46)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C127(0.95); C129(0.95); C239(0.97); C354(1.21)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C12(0.93); C239(0.95); C354(1.10); C127(1.12)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C127(0.98); C129(0.98); C239(0.99); C12(1.03)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C127(0.61); C129(0.61); C239(0.85); C12(1.05)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C354(0.95); C12(0.97); C239(1.01); C127(1.04)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C127(0.57); C129(0.57); C239(0.78); C354(1.05)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C127(0.84); C129(0.84); C239(0.96); C354(1.09)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C239(0.94); C354(1.01); C12(1.23)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C354(1.06); C239(1.11); C12(1.35)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C354(1.03); C239(1.04); C12(1.28)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C239(1.01); C12(1.17); C354(1.18)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C239(1.02); C354(1.21); C12(1.38)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C239(0.84); C12(1.19); C354(1.72)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C239(1.09); C354(1.37); C12(1.66)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C239(0.92); C354(0.96); C12(1.35)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C239(1.02); C12(1.42); C354(1.48)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C239(1.01); C12(1.41); C354(1.51)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C239(0.86); C354(1.06); C12(1.15)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C239(1.06); C354(1.37); C12(1.52)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C354(0.82); C239(1.06); C127(1.06); C129(1.06)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C354(0.81); C127(0.94); C129(0.94); C12(1.08)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C239(0.91); C354(1.06); C12(1.17)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C127(0.69); C129(0.69); C354(1.01); C239(1.22)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C354(0.83); C127(0.96); C129(0.96); C12(1.07)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C127(0.76); C129(0.76); C354(0.93); C12(1.17)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C127(0.86); C129(0.86); C354(1.00); C239(1.32)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C127(0.92); C129(0.92); C354(0.94); C12(1.30)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C127(0.73); C129(0.73); C354(0.94); C239(1.09)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C127(0.76); C129(0.76); C354(0.84); C239(1.07)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C354(0.81); C239(0.91); C127(1.16); C129(1.16)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C239(0.77); C354(0.86); C12(1.06); C127(1.35)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C354(0.92); C127(1.05); C129(1.05); C12(1.07)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C354(1.11); C239(1.24); C12(1.33)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C354(0.88); C127(0.98); C129(0.98); C12(1.20)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C354(0.85); C127(0.88); C129(0.88); C239(1.01)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C127(0.83); C129(0.83); C354(0.87); C239(1.21)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C239(1.42); C354(1.52); C12(1.69); C127(2.13)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C354(1.62); C12(1.71); C239(1.74); C127(2.78)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C239(1.35); C354(1.36); C12(1.38); C127(1.69)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C239(1.13); C12(1.26); C354(1.29); C127(1.73)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C239(1.02); C12(1.09); C354(1.26); C127(1.69)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C12(1.23); C354(1.46); C239(1.47); C127(2.27)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C12(1.40); C239(1.51); C354(1.59); C127(2.31)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C239(0.72); C12(0.96); C127(1.02); C129(1.02)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C239(1.53); C354(1.62); C12(1.66); C127(2.46)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C12(1.60); C354(1.65); C239(1.76); C127(2.37)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C354(1.25); C12(1.34); C239(1.41); C127(1.92)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C354(1.33); C12(1.35); C239(1.52); C127(2.52)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C12(1.18); C239(1.28); C354(1.34); C127(1.91)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C12(1.34); C354(1.42); C239(1.50); C127(2.30)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C12(1.48); C354(1.54); C239(1.60); C127(2.18)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C354(0.84); C239(0.90); C127(1.18); C129(1.18)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C127(0.91); C129(0.91); C354(0.99); C12(1.02)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C12(1.02); C239(0.78); C354(0.98)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C239(0.81); C354(0.95); C12(1.08)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C239(1.14); C354(1.29); C12(1.53)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C127(1.11); C129(1.11)  LDD0078  [12]
 LDCM0108  Chloroacetamide HeLa H227(0.00); C239(0.00); H37(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C127(0.68); C129(0.68); C12(0.71); C354(0.74)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C127(0.52); C129(0.52); C239(1.07); C12(1.12)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C127(0.53); C129(0.53); C239(1.13); C12(1.37)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C239(0.97); C12(1.12); C354(1.14)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C239(0.94); C354(0.94); C12(1.00)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C239(0.88); C354(0.90); C12(1.04)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C354(0.91); C239(0.95); C12(1.04)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C354(0.78); C127(0.91); C129(0.91); C12(0.94)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C127(0.87); C129(0.87); C354(0.89); C239(1.09)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C127(0.85); C129(0.85); C239(1.12); C354(1.15)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C127(0.81); C129(0.81); C354(1.05); C12(1.27)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C354(0.86); C12(1.03); C127(1.08); C129(1.08)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C127(0.45); C129(0.45); C354(0.95); C239(0.97)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C127(0.85); C129(0.85); C354(1.12); C12(1.20)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C127(0.84); C129(0.84); C354(1.07); C12(1.16)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C12(1.00); C354(1.12); C239(1.12)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C239(1.27); C354(1.41); C12(1.47)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C354(1.22); C12(1.30); C239(1.31)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C12(1.07); C354(1.16); C239(1.18)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C239(1.10); C12(1.19); C354(1.37)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C239(1.05); C12(1.14); C354(1.17)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C239(0.86); C12(1.07); C354(1.09)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C239(0.93); C354(0.96); C12(1.03)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C127(0.50); C129(0.50); C239(1.07); C354(1.08)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C239(0.73); C354(0.93); C12(1.04)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C12(0.86); C354(0.94); C127(1.03); C129(1.03)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C12(0.96); C354(0.99); C239(1.06); C127(1.25)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C127(0.84); C129(0.84); C12(0.97); C239(0.98)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C127(0.87); C129(0.87); C12(1.04); C354(1.19)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C239(0.77); C354(0.92); C12(0.93)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C354(0.84); C239(0.97); C12(0.99)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C239(0.88); C354(1.20); C12(1.23)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C239(1.03); C12(1.16); C354(1.33)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C127(0.94); C129(0.94); C354(1.05); C12(1.06)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C127(0.74); C129(0.74); C12(0.97); C239(0.99)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C354(0.97); C239(1.02); C127(1.04); C129(1.04)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C239(1.00); C354(1.09); C12(1.13)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C239(0.71); C354(0.98); C12(1.08)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C239(0.72); C354(1.02); C12(1.24)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C239(0.97); C12(1.03); C354(1.05)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C127(0.82); C129(0.82); C354(0.85); C239(0.87)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C239(0.88); C354(1.19); C12(1.23)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C239(1.06); C354(1.18); C12(1.35)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C239(0.98); C354(1.33); C12(1.49)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C239(0.98); C12(1.14); C354(1.26)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C12(1.42); C239(0.94); C354(1.33)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C12(1.32); C239(0.82); C354(1.25)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C12(1.32); C239(0.96); C354(1.19)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C12(1.10); C239(0.76); C354(1.14)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C12(1.14); C239(0.79); C354(1.12)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C12(1.17); C239(0.80); C354(1.13)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C12(0.97); C127(0.69); C129(0.69); C239(1.04)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C12(1.09); C239(0.80); C354(0.95)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C12(1.15); C127(0.83); C129(0.83); C239(1.19)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C12(1.46); C127(0.78); C129(0.78); C239(1.28)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C12(1.33); C127(0.77); C129(0.77); C239(2.05)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C12(1.51); C127(0.69); C129(0.69); C239(1.63)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C12(1.55); C127(1.34); C129(1.34); C239(1.71)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C12(1.49); C127(0.91); C129(0.91); C239(1.59)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C12(1.42); C127(1.02); C129(1.02); C239(1.48)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C12(1.48); C127(0.90); C129(0.90); C239(1.37)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C12(0.92); C127(1.21); C129(1.21); C239(1.09)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C12(1.43); C127(0.95); C129(0.95); C239(1.32)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C12(1.45); C127(0.86); C129(0.86); C239(1.56)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C12(2.04); C127(1.10); C129(1.10); C239(1.72)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C12(1.72); C127(0.63); C129(0.63); C239(1.83)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C12(1.62); C127(0.76); C129(0.76); C239(1.57)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C12(1.74); C127(0.71); C129(0.71); C239(1.64)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C12(0.75); C127(0.63); C129(0.63); C239(0.84)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C12(0.77); C127(0.99); C129(0.99); C239(0.79)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C12(0.96); C127(0.84); C129(0.84); C239(0.88)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C12(0.89); C127(0.64); C129(0.64); C239(0.93)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C12(0.99); C127(0.77); C129(0.77); C239(1.04)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C12(0.95); C127(0.84); C129(0.84); C239(1.00)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C12(0.84); C127(0.60); C129(0.60); C239(0.94)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C12(0.84); C127(0.65); C129(0.65); C239(1.03)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C12(0.84); C127(1.63); C129(1.63); C239(1.18)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C12(0.85); C127(0.82); C129(0.82); C239(0.96)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C12(0.86); C127(0.89); C129(0.89); C239(0.93)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C12(0.90); C127(1.17); C129(1.17); C239(0.93)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C12(0.82); C127(1.18); C129(1.18); C239(1.01)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C12(0.85); C127(0.73); C129(0.73); C239(0.91)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C12(1.03); C127(0.94); C129(0.94); C239(0.98)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C12(1.12); C127(0.68); C129(0.68); C239(1.11)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C12(1.05); C127(0.63); C129(0.63); C239(1.01)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C12(1.01); C127(0.88); C129(0.88); C239(1.14)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C12(1.10); C127(0.87); C129(0.87); C239(1.09)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C12(1.15); C127(0.98); C129(0.98); C239(1.27)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C12(1.10); C127(0.87); C129(0.87); C239(1.32)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C12(1.04); C127(1.07); C129(1.07); C239(1.45)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C12(1.33); C127(1.02); C129(1.02); C239(1.23)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C12(1.25); C127(1.18); C129(1.18); C239(1.58)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C12(1.15); C127(1.60); C129(1.60); C239(1.37)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C12(0.96); C127(0.98); C129(0.98); C239(1.27)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C12(1.22); C127(0.71); C129(0.71); C239(1.19)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C12(1.05); C127(1.24); C129(1.24); C239(1.26)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C12(1.10); C127(1.00); C129(1.00); C239(1.16)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C12(0.98); C127(0.99); C129(0.99); C239(1.29)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C12(1.06); C127(1.05); C129(1.05); C239(1.43)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C12(1.13); C127(1.21); C129(1.21); C239(1.43)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C12(1.03); C127(1.66); C129(1.66); C239(1.02)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C12(0.93); C127(1.69); C129(1.69); C239(1.09)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C12(1.10); C127(1.12); C129(1.12); C239(0.88)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C12(1.17); C127(1.43); C129(1.43); C239(1.07)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C12(1.15); C127(0.73); C129(0.73); C239(1.14)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C12(1.09); C127(0.99); C129(0.99); C239(0.99)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C12(1.12); C127(0.97); C129(0.97); C239(0.99)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C12(1.33); C127(1.30); C129(1.30); C239(1.12)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C12(1.21); C127(0.98); C129(0.98); C239(1.12)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C12(1.26); C127(0.90); C129(0.90); C239(1.08)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C12(1.11); C127(1.51); C129(1.51); C239(0.94)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C12(1.03); C127(1.43); C129(1.43); C239(0.93)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C12(1.00); C127(1.47); C129(1.47); C239(0.97)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C12(1.25); C127(1.68); C129(1.68); C239(1.30)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C12(1.33); C127(1.10); C129(1.10); C239(1.26)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C12(1.08); C127(0.91); C129(0.91); C239(1.00)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C12(0.81); C127(1.51); C129(1.51); C239(0.87)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C12(1.16); C127(1.02); C129(1.02); C239(1.07)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C12(1.07); C127(0.97); C129(0.97); C239(1.03)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C12(1.03); C127(0.77); C129(0.77); C239(0.90)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C12(1.26); C127(0.86); C129(0.86); C239(1.24)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C12(1.21); C127(1.15); C129(1.15); C239(1.35)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C12(1.00); C127(0.92); C129(0.92); C239(0.97)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C12(1.17); C127(0.92); C129(0.92); C239(1.10)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C12(1.32); C127(0.54); C129(0.54); C239(1.17)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C12(1.24); C127(0.48); C129(0.48); C239(1.19)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C127(1.07); C211(1.01)  LDD1698  [32]
 LDCM0468  Fragment33 HCT 116 C12(1.10); C127(1.14); C129(1.14); C239(1.32)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C12(1.76); C127(1.21); C129(1.21); C239(1.67)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y222(0.69); Y106(0.78); Y281(0.79); Y340(0.90)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y222(0.59); Y106(0.68); Y281(0.80); Y340(0.92)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y222(0.62); Y106(0.66); Y281(0.85); Y340(0.89)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y222(0.63); Y106(0.63); Y281(0.91); Y340(1.26)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y106(0.62); Y222(0.63); Y281(0.76); Y340(1.21)  LDD0268  [10]
 LDCM0107  IAA HeLa H227(0.00); H37(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y310(0.94); Y36(0.89); Y50(0.90); Y51(0.74)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y183(20.00); Y208(0.19); Y310(0.75); Y36(0.63)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y200(0.14); Y310(1.49); Y36(1.11); Y50(1.11)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y183(20.00); Y208(2.10); Y310(2.86); Y36(2.34)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y183(10.03); Y200(0.07); Y208(4.96); Y310(1.95)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y310(1.16); Y36(1.12); Y50(0.94); Y51(0.70)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y208(0.09); Y310(0.46); Y36(0.44); Y50(0.39)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y200(0.05); Y208(1.08); Y310(1.05); Y36(0.94)  LDD0292  [9]
 LDCM0179  JZ128 PC-3 C239(0.00); C354(0.00); C129(0.00); C211(0.00)  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C12(3.26); C239(2.65); C354(1.22); C127(1.27)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C12(3.53); C239(2.56); C354(2.17); C127(1.92)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C12(3.58); C239(2.03); C354(1.61); C127(1.39)  LDD0082  [12]
 LDCM0109  NEM HeLa H227(0.00); H37(0.00)  LDD0223  [24]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C354(1.67); C12(1.51)  LDD1700  [6]
 LDCM0014  Panhematin K562 3.38  LDD0063  [8]
 LDCM0096  SAHA K562 N.A.  LDD0362  [27]
 LDCM0021  THZ1 HeLa S3 C129(1.00)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vinblastine Small molecular drug D0W9MM
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dolastatin-10 Small molecular drug D0PF3J
Investigative
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2'-amino-3,4,4',5-tetramethoxy-(Z)-stillbene Small molecular drug D0W5RQ
2,3'-diamino-3,4,4',5-tetramethoxy-(Z)-stillbene Small molecular drug D0OW6Q
2-amino-3,4',5-trimethoxy-(Z)-stillbene Small molecular drug D0X9OV
3,4',5-trimethoxy-(Z)-stilbene Small molecular drug D03NTD
3,4,4',5-tetramethoxy-(Z)-stilbene Small molecular drug D0LH3S
3-bromo-4,4',5-trimethoxy-(Z)-stilbene Small molecular drug D02XKD
6-ile-ustiloxin Small molecular drug D03CYV
N-(4-(3-(Pyridin-2-yl)Acryloyl)Phenyl)Acetamide Small molecular drug D0VH8A
Phenethyl Isothiocyanate Small molecular drug DB12695
Ustiloxin A Small molecular drug D0S6FK
Ustiloxin D Small molecular drug D07UWD
Ustiloxin F Small molecular drug D0C6EW
Cyt997 . DB05147

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
28 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
29 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
30 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402