Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Photocelecoxib  Probe Info 
Probe concentration 250 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
Experiment Method
SIM-PAL
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cells (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP00714  26S proteasome non-ATPase regulatory subunit 3 (PSMD3) E435
 LDTP05069  Actin, alpha cardiac muscle 1 (ACTC1) K86
 LDTP05069  Actin, alpha cardiac muscle 1 (ACTC1) L107
 LDTP04876  Actin, cytoplasmic 1 (ACTB) A97
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E99
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E100
 LDTP04876  Actin, cytoplasmic 1 (ACTB) H101
 LDTP04876  Actin, cytoplasmic 1 (ACTB) T106
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E107
 LDTP04876  Actin, cytoplasmic 1 (ACTB) V152
 LDTP04876  Actin, cytoplasmic 1 (ACTB) D157
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E167
 LDTP04876  Actin, cytoplasmic 1 (ACTB) Y169
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E253
 LDTP04876  Actin, cytoplasmic 1 (ACTB) R254
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) E249
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) A388
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) I394
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) Y395
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) D402
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) H46
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) V267
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) K273
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) V278
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) V289
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) D403
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) M410
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) S414
 LDTP02333  Glutathione S-transferase P (GSTP1) Q84
 LDTP02333  Glutathione S-transferase P (GSTP1) E86
 LDTP12233  Helicase MOV-10 (MOV10) I830
 LDTP13615  Histone-lysine N-methyltransferase 2B (KMT2B) G824
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) E339
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) D69
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) P72
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) V74
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) E279
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) K280
 LDTP06517  UDP-N-acetylhexosamine pyrophosphorylase (UAP1) P452
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) G208
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) L490
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) E491
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP01197  Filamin-B (FLNB) I2488
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) K1147
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) G118
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) D121
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) Y184
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) K332
Other
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP01920  Hemoglobin subunit zeta (HBZ) D23
 LDTP01920  Hemoglobin subunit zeta (HBZ) G26
 LDTP01920  Hemoglobin subunit zeta (HBZ) T27
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) M193
 LDTP02844  Histone H1.3 (H1-3) V74
 LDTP02844  Histone H1.3 (H1-3) E75
 LDTP02390  Histone H2A.Z (H2AZ1) G93
 LDTP02390  Histone H2A.Z (H2AZ1) E95
 LDTP01054  Histone H2B type 1-K (H2BC12) P51
 LDTP01054  Histone H2B type 1-K (H2BC12) D69
 LDTP01054  Histone H2B type 1-K (H2BC12) F71
 LDTP01054  Histone H2B type 1-K (H2BC12) R73
 LDTP05079  Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) E98
 LDTP07899  Histone H3.2 (H3C15; H3C14; H3C13) S97
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) D82
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Y52
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E54
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) D69
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) A70
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) V71
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) E75
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) L217
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) N222
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) E98
 LDTP00313  Nucleolar protein 56 (NOP56) L329
 LDTP02164  Nucleophosmin (NPM1) G90
 LDTP02164  Nucleophosmin (NPM1) E93
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) L242
 LDTP08224  Protein LYRIC (MTDH) T34
 LDTP04974  Small ribosomal subunit protein uS15 (RPS13) E119
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) E69
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) N70
 LDTP05998  Tubulin beta-2A chain (TUBB2A) D67
 LDTP05998  Tubulin beta-2A chain (TUBB2A) E69

References

1 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094