Details of the Target

General Information of Target

Target ID LDTP06517
Target Name UDP-N-acetylhexosamine pyrophosphorylase (UAP1)
Gene Name UAP1
Gene ID 6675
Synonyms
SPAG2; UDP-N-acetylhexosamine pyrophosphorylase; Antigen X; AGX; Protein-pyrophosphorylation enzyme; EC 2.7.4.-; Sperm-associated antigen 2; UDP-N-acetylgalactosamine pyrophosphorylase; EC 2.7.7.83; UDP-N-acetylglucosamine pyrophosphorylase; EC 2.7.7.23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS
HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY
PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK
HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME
QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY
VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT
ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ
CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
Target Bioclass
Enzyme
Family
UDPGP type 1 family
Subcellular location
Cytoplasm
Function
Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses.; [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P).; [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P).
Uniprot ID
Q16222
Ensemble ID
ENST00000367925.6
HGNC ID
HGNC:12457

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Deletion: p.E189RfsTer3 DBIA    Probe Info 
CAMA1 SNV: p.R422K .
COLO320 SNV: p.G375V .
KMRC1 SNV: p.Q88P DBIA    Probe Info 
YSCCC SNV: p.D253N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.61  LDD0402  [1]
A-EBA
 Probe Info  		4.01  LDD0215  [2]
STPyne
 Probe Info  		K180(5.26); K356(8.19); K357(4.55); K377(8.77)  LDD0277  [3]
BTD
 Probe Info  		C293(1.69)  LDD1700  [4]
IPM
 Probe Info  		C268(0.71)  LDD1701  [4]
DBIA
 Probe Info  		C158(3.13)  LDD0080  [5]
ATP probe
 Probe Info  		K356(0.00); K357(0.00); K63(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C158(0.00); C268(0.00); C293(0.00); C251(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C158(0.00); C268(0.00); C251(0.00); C293(0.00)  LDD0037  [7]
PF-06672131
 Probe Info  		N.A.  LDD0017  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
YN-1
 Probe Info  		N.A.  LDD0447  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		13.10  LDD0443  [15]
NAIA_5
 Probe Info  		C158(0.00); C268(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		1.00  LDD0139  [17]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [18]
STS-1
 Probe Info  		N.A.  LDD0068  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C293(0.94); C275(1.09); C268(1.20)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C293(1.31); C275(1.97)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C275(2.13)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C268(1.21); C275(0.59); C293(1.09)  LDD0813  [5]
 LDCM0216  AC100 HCT 116 C158(0.83); C275(0.66); C268(0.42)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C158(0.73); C275(0.69); C268(0.46)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C158(1.03); C275(0.73); C268(0.68)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C158(0.80); C275(0.72); C268(0.45)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C158(1.45); C275(0.74); C268(0.71)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C158(0.66); C275(0.73); C268(0.47)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C158(0.77); C275(0.67); C268(0.38)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C158(0.96); C275(0.70); C268(0.48)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C158(0.73); C275(0.69); C268(0.41)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C158(1.05); C275(0.98); C268(0.87)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C268(1.15); C275(0.59); C293(1.11)  LDD0824  [5]
 LDCM0227  AC110 HCT 116 C158(0.68); C275(0.71); C268(0.43)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C158(0.56); C275(0.68); C268(0.40)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C158(0.72); C275(0.76); C268(0.44)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C158(1.05); C275(1.22); C268(1.14); C293(1.17)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C158(1.03); C275(1.11); C268(0.98); C293(1.32)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C158(1.06); C275(1.13); C268(0.99); C293(0.77)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C158(1.19); C275(1.01); C268(1.04); C293(1.10)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C158(1.10); C275(1.14); C268(1.11); C293(1.27)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C158(0.87); C275(1.11); C268(1.13); C293(1.19)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C158(1.01); C275(1.12); C268(0.97); C293(1.58)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C268(1.17); C275(0.58); C293(0.91)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C158(1.04); C275(1.04); C268(1.01); C293(1.67)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C158(0.98); C275(1.18); C268(1.17); C293(1.28)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C158(0.98); C275(1.17); C268(1.05); C293(1.30)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C158(0.91); C275(1.86); C268(1.43); C293(1.39)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C158(0.96); C275(1.08); C268(1.08); C293(1.24)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C158(1.05); C275(1.01); C268(0.94); C293(1.42)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C158(1.14); C275(1.03); C268(0.92); C293(1.27)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C158(1.04); C275(1.07); C268(1.07); C293(1.23)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C158(0.26); C268(1.05); C293(1.25)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C158(1.44); C268(0.99); C293(1.35)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C158(0.50); C268(1.04); C293(1.43)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C158(1.83); C268(1.13); C293(1.01)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C158(1.58); C268(0.91); C293(1.11)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C158(0.66); C268(0.94); C293(1.38)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C158(0.81); C268(1.02); C293(1.03)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C158(0.76); C268(0.95); C293(0.93)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C158(0.89); C268(0.95); C293(1.04)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C158(1.00); C268(0.84); C293(1.02)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C158(0.78); C268(0.87); C293(0.81)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C158(0.58); C268(0.81); C293(0.93)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C268(1.08); C275(0.40); C293(1.14)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C158(0.82); C268(0.90); C293(0.96)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C158(0.95); C268(1.06); C293(0.94)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C158(0.93); C268(0.87); C293(1.10)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C158(2.71)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C158(0.78)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C158(1.52)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C158(0.65)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C158(0.50)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C158(0.16)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C158(0.43)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C268(1.21); C275(0.56); C293(1.34)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C158(5.20)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C158(1.89)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C158(0.44)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C158(0.13)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C158(1.11)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C158(0.93)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C158(1.93)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C158(2.28)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C275(0.90); C158(1.22); C293(1.23)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C158(0.51); C275(0.99); C293(1.00)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C275(0.98); C293(1.18); C158(1.75)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C275(0.99)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C275(0.85); C293(0.98); C158(1.51)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C158(0.59); C275(0.92); C293(0.94)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C158(0.67); C275(0.84); C293(1.11)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C293(1.01); C158(1.01); C275(1.03)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C293(0.88); C275(0.92); C158(1.64)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C275(0.96); C158(1.22)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C275(0.69); C158(0.72)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C275(0.63); C158(0.86)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C158(0.81); C275(0.85)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C158(0.56); C275(0.58)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C275(1.44)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C275(0.47); C158(0.49)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C158(0.65); C275(1.29)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C158(0.46); C275(0.63)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C275(0.78); C158(0.93)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C275(0.67); C158(0.84)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C293(0.88); C275(2.24); C158(2.64)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C293(0.78); C275(1.74); C158(3.71)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C293(0.69); C158(1.38); C275(2.79)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C293(0.97); C158(1.58); C275(2.12)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C293(0.76); C158(0.93); C275(1.61)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C275(1.97)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C293(0.59); C158(0.70); C275(1.96)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C293(0.89); C158(1.24); C275(2.74)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C293(1.03); C158(1.04); C275(2.28)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C293(0.91); C158(0.99); C275(1.64)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C293(0.80); C158(0.96); C275(4.11)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C158(0.52); C293(0.76); C275(3.97)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C268(0.70); C158(0.90); C293(1.08)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C268(0.65); C158(0.78); C293(1.02)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C268(0.44); C158(0.48); C293(0.54)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C293(0.27); C158(0.37); C268(0.40)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C275(1.99)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C293(0.35); C158(0.37); C268(0.40)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C268(0.76); C158(1.59); C293(1.73)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C268(0.68); C158(0.95); C293(1.15)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C293(0.47); C268(0.63); C158(0.64)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C293(0.51); C158(0.55); C268(0.55)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C293(0.36); C158(0.55); C268(0.72)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C293(0.29); C158(0.41); C268(0.46)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C158(0.43); C268(0.48); C275(1.25)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C158(0.34); C268(0.41); C275(1.45)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C268(0.38); C158(0.39); C275(1.45)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C268(1.11); C275(0.64); C293(1.05)  LDD0921  [5]
 LDCM0324  AC60 HCT 116 C158(0.35); C268(0.37); C275(1.73)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C158(0.30); C268(0.36); C275(1.13)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C158(0.35); C268(0.37); C275(1.48)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C158(0.38); C268(0.42); C275(2.00)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C158(0.24); C268(0.29); C275(1.34)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C158(0.34); C268(0.37); C275(1.11)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C158(0.35); C268(0.40); C275(1.22)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C158(0.15); C268(0.17); C275(1.50)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C158(0.44); C268(0.68); C275(1.28)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C158(0.37); C268(0.62); C275(1.26)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C268(1.01); C275(0.75); C293(1.08)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C158(0.20); C268(0.41); C275(1.42)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C268(0.92); C158(1.15); C275(1.76)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C158(0.55); C268(0.61); C275(1.26)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C158(0.13); C275(1.35); C268(0.38)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C158(0.14); C268(0.54); C275(1.74)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C158(0.13); C268(0.41); C275(1.25)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C158(0.35); C268(0.67); C275(1.38)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C158(0.30); C268(0.53); C275(1.38)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C158(0.49); C268(0.73); C275(1.37)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C158(0.77); C268(0.82); C275(1.19)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C268(1.11); C275(0.62); C293(1.16)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C158(0.37); C268(0.72); C275(1.18)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C158(0.58); C268(0.73); C275(1.36)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C158(0.16); C268(0.55); C275(1.27)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C268(0.99); C275(1.08); C293(0.95)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C268(0.89); C275(0.70); C293(1.00)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C268(0.86); C275(0.71); C293(0.98)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C268(0.81); C275(0.70); C293(0.92)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C268(0.86); C275(0.71); C293(1.17)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C268(0.88); C275(0.80); C293(1.34)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C268(0.90); C275(0.61); C293(1.49)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C268(0.90); C275(0.69); C293(1.14)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C268(0.99); C275(0.74); C293(1.03)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C268(0.95); C275(0.89); C293(0.89)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C268(0.85); C275(1.03); C293(1.03)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C268(0.94); C275(0.64); C293(1.26)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C268(0.98); C275(1.06); C293(1.21)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C268(0.96); C275(0.89); C293(1.45)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C268(1.31); C275(1.17); C293(1.82)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C268(0.39); C275(0.61); C158(0.77)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C268(0.49); C158(0.62); C275(0.68)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C268(1.08); C275(0.55); C293(1.15)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C268(1.12); C275(0.74); C293(1.29)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C268(1.13); C275(0.33); C293(1.30)  LDD0873  [5]
 LDCM0498  BS-3668 MDA-MB-231 C293(1.00)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C158(1.35)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C158(0.23)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C275(1.68)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C268(1.09); C275(0.67); C293(1.26)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C268(1.01); C275(0.47); C293(1.44)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C268(1.03); C275(0.59); C293(1.23)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C268(1.05); C275(1.09); C293(1.22)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C158(0.61); C293(1.05); C275(1.24)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C158(0.16); C293(0.81); C275(1.30)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C158(0.35); C293(0.78); C275(1.05)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C158(0.20); C293(0.86); C275(1.02)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C158(0.74); C293(0.94); C275(0.99)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C158(0.15)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C158(0.30); C275(0.91); C293(1.04)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C275(0.73); C293(0.97); C158(1.53)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C158(0.84); C275(1.00)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C275(0.57); C158(0.58)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C158(0.53); C275(0.65)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C275(0.73); C158(0.78)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C275(0.74); C158(0.82)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C158(0.24); C293(0.78); C275(1.89)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C293(0.95); C158(1.26); C275(1.65)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C293(0.87); C158(0.99); C275(1.69)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C158(0.15)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C293(0.68); C158(1.26); C275(1.83)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C158(0.76); C268(0.79); C293(0.99)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C268(0.65); C158(0.69); C293(0.70)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C293(0.37); C268(0.55); C158(0.55)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C293(0.39); C158(0.43); C268(0.45)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C275(0.94); C268(0.98); C158(1.98)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C268(0.91); C275(1.03); C158(1.89)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C158(0.56); C268(0.90); C275(1.11)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C268(0.41); C158(0.49); C275(1.25)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C158(0.23)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C158(0.83)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C158(0.29)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C293(0.21); C158(0.74)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C293(0.28); C158(0.76)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C293(0.10); C158(0.42)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C293(0.18); C158(0.57)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C158(1.09)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C293(0.17); C158(0.58)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C293(0.11); C158(0.32)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C293(0.08); C158(0.17)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C293(0.28); C158(0.71)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C158(0.29); C293(0.10)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C158(0.36); C293(0.12)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C158(0.69); C293(0.17)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C158(0.59); C293(0.31)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C158(0.48); C293(0.18)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C158(0.48); C293(0.18)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C158(0.91)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C158(0.81); C293(0.26)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C158(20.00); C275(1.03); C293(0.63)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C158(0.58); C275(0.71); C293(0.27)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C158(0.70); C275(0.64); C293(0.33)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C158(0.42); C275(0.61); C293(0.30)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C158(0.49); C275(0.63); C293(0.37)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C158(0.83); C275(0.65); C293(0.37)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C158(0.38); C275(0.71); C293(0.31)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C158(0.37); C275(0.80); C293(0.26)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C158(0.68)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C158(0.69); C275(0.76); C293(0.37)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C158(0.65); C275(0.86); C293(0.49)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C158(0.20); C275(0.63); C293(0.18)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C158(0.34); C275(0.73); C293(0.23)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C158(0.38); C275(0.75); C293(0.23)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C158(0.31); C275(0.62); C293(0.22)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C268(0.98); C275(0.52)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C268(0.92); C275(0.96)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C268(0.91); C275(0.96)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C268(0.95); C275(0.54)  LDD1037  [5]
 LDCM0440  CL5 HCT 116 C158(0.63)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C268(1.20); C275(0.68)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C268(0.95); C275(0.37)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C268(1.10); C275(0.35)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C268(1.08); C275(0.28)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C268(0.95); C275(0.35)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C268(0.99); C275(0.49)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C268(0.94); C275(0.37)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C268(0.96); C275(0.33)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C268(0.96); C275(0.30)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C268(1.00); C275(0.39)  LDD1048  [5]
 LDCM0451  CL6 HCT 116 C158(0.29)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C268(1.18); C275(0.37)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C158(1.25); C275(0.73)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C158(1.01); C275(0.70)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C158(0.70); C275(0.74)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C158(0.61); C275(0.83)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C158(0.74); C275(0.99)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C158(0.29); C275(0.98)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C158(0.50); C275(1.09)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C158(0.43); C275(0.64)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C158(0.49); C275(0.53)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C158(0.26)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C158(0.50); C275(0.62)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C158(0.64); C275(0.69)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C158(1.12); C275(0.48)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C158(0.92); C275(0.75)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C158(0.67); C275(0.83)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C158(0.87); C275(0.81)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C158(1.53); C275(0.87)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C158(0.97); C275(1.00)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C158(0.63); C275(0.92)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C158(0.15)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C158(0.82); C275(1.27)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C158(0.88); C275(1.00)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C158(0.29); C275(0.95)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C158(0.43); C275(0.92)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C158(0.25); C275(0.87)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C158(1.28); C275(0.65)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C158(1.88); C275(0.88)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C158(1.43); C275(0.92)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C158(0.42); C275(1.15)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C158(0.24); C275(1.34)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C158(0.58)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C158(2.21); C275(0.68)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C275(0.67)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C275(0.73)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C275(1.12)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C275(1.23)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C275(0.69)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C275(0.72)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C275(0.73)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C275(1.00)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C275(1.50)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C293(0.91); C268(0.82); C158(1.07)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C158(0.58); C275(0.64)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C158(0.23); C275(0.48); C293(0.21)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C158(3.13)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C158(3.58)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C158(2.33)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C293(0.70); C275(0.46)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C293(1.05); C275(1.00)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C293(1.38)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C275(1.01)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C293(0.98); C275(1.10)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C268(0.80)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C293(0.84); C275(1.05)  LDD2101  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C293(0.81)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C293(1.04); C275(1.03)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C293(0.47); C275(0.54)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C293(1.09); C275(0.98)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C293(0.38); C275(0.76)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C293(1.85)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C293(0.76); C275(0.60)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C275(0.51)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C293(0.80); C275(1.00)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C293(0.71)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C293(0.99)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C293(1.38); C275(0.93)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C293(0.57)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C275(0.63)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C293(1.37); C275(0.89)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C293(1.14); C275(1.06)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C293(0.81); C275(1.00); C268(1.09)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C293(1.69)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C293(0.69); C275(0.86)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C293(0.41); C275(0.57); C268(0.44)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C293(1.76)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C293(0.90); C275(0.99)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C293(0.36)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C293(1.50)  LDD2149  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-N-acetylhexosamine pyrophosphorylase (UAP1) UDPGP type 1 family Q16222

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Uridine-diphosphate-n-acetylgalactosamine Small molecular drug DB02196
Uridine-diphosphate-n-acetylglucosamine Small molecular drug DB03397

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
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Mass spectrometry data entry: PXD044402