Details of the Target

General Information of Target

Target ID LDTP02844
Target Name Histone H1.3 (H1-3)
Gene Name H1-3
Gene ID 3007
Synonyms
H1F3; HIST1H1D; Histone H1.3; Histone H1c; Histone H1s-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL
AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK
AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT
PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
Target Type
Literature-reported
Target Bioclass
Other
Family
Histone H1/H5 family
Subcellular location
Nucleus
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
TTD ID
T36325
Uniprot ID
P16402
DrugMap ID
TTBFWZJ
Ensemble ID
ENST00000244534.7
HGNC ID
HGNC:4717

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.70  LDD0066  [1]
ONAyne
 Probe Info  		K118(2.56)  LDD0274  [2]
AZ-9
 Probe Info  		D73(0.95); E43(10.00); E75(10.00)  LDD2208  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
aONE
 Probe Info  		N.A.  LDD0002  [5]
NHS
 Probe Info  		K47(0.00); K107(0.00); K17(0.00); K35(0.00)  LDD0010  [5]
OSF
 Probe Info  		N.A.  LDD0029  [6]
SF
 Probe Info  		K65(0.00); K131(0.00); K91(0.00); K76(0.00)  LDD0028  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		6.26  LDD0473  [7]
Photocelecoxib
 Probe Info  		V74(0.00); E75(0.00)  LDD0153  [8]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [8]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094