Details of the Target

General Information of Target

Target ID LDTP01920
Target Name Hemoglobin subunit zeta (HBZ)
Gene Name HBZ
Gene ID 3050
Synonyms
HBZ2; Hemoglobin subunit zeta; HBAZ; Hemoglobin zeta chain; Zeta-globin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHG
SKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTA
EAHAAWDKFLSVVSSVLTEKYR
Target Bioclass
Other
Family
Globin family
Function The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
Uniprot ID
P02008
Ensemble ID
ENST00000252951.3
HGNC ID
HGNC:4835

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.41  LDD0215  [1]
DBIA
 Probe Info  		C105(1.90)  LDD3335  [2]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		14.87  LDD0472  [3]
FFF probe13
 Probe Info  		7.08  LDD0476  [3]
FFF probe3
 Probe Info  		8.21  LDD0465  [3]
Photocelecoxib
 Probe Info  		D23(0.00); G26(0.00); T27(0.00)  LDD0153  [4]
Photonaproxen
 Probe Info  		T27(0.00); E28(0.00); E31(0.00)  LDD0156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C105(1.74)  LDD2302  [2]
 LDCM0023  KB03 CMK C105(4.19)  LDD2719  [2]
 LDCM0024  KB05 MONO-MAC-6 C105(1.90)  LDD3335  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit beta (HBB) Globin family P68871
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Hemoglobin subunit delta (HBD) Globin family P02042
Hemoglobin subunit epsilon (HBE1) Globin family P02100
Hemoglobin subunit mu (HBM) Globin family Q6B0K9
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
4 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094