Details of the Target

General Information of Target

Target ID LDTP03182
Target Name Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
Gene Name HNRNPA2B1
Gene ID 3181
Synonyms
HNRPA2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKR
SRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIK
EDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGH
NAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGF
GDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNY
NDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Also plays a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production.; (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.
TTD ID
T29095
Uniprot ID
P22626
DrugMap ID
TT8UPW6
Ensemble ID
ENST00000354667.8
HGNC ID
HGNC:5033
ChEMBL ID
CHEMBL3124741

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 58 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P3
 Probe Info  		1.90  LDD0450  [1]
P8
 Probe Info  		1.94  LDD0455  [1]
A-EBA
 Probe Info  		3.07  LDD0215  [2]
CY4
 Probe Info  		3.86  LDD0244  [3]
N1
 Probe Info  		2.24  LDD0242  [3]
C-Sul
 Probe Info  		6.70  LDD0066  [4]
TH211
 Probe Info  		Y244(20.00); Y247(20.00); Y262(20.00); Y331(20.00)  LDD0257  [5]
TH214
 Probe Info  		Y174(20.00)  LDD0258  [5]
TH216
 Probe Info  		Y174(20.00); Y234(20.00); Y336(20.00)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [7]
AZ-9
 Probe Info  		E134(1.02); E42(0.91); D211(1.22); E142(0.42)  LDD2208  [8]
ONAyne
 Probe Info  		K17(0.00); K104(0.00); K59(0.00); K112(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K120(5.33); K173(7.67)  LDD3494  [10]
Probe 1
 Probe Info  		Y40(55.53); Y41(28.20); Y131(18.54); Y135(47.82)  LDD3495  [11]
BTD
 Probe Info  		C50(2.07)  LDD1700  [12]
HHS-482
 Probe Info  		Y174(1.01); Y234(0.87); Y331(0.80); Y336(0.81)  LDD0285  [13]
HHS-475
 Probe Info  		Y331(0.71); Y174(0.74); Y347(0.74); Y336(0.75)  LDD0264  [14]
HHS-465
 Probe Info  		Y174(8.02); Y234(10.00); Y336(10.00); Y347(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C50(2.14)  LDD0531  [16]
5E-2FA
 Probe Info  		H108(0.00); H163(0.00); H84(0.00); H180(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K22(0.00); K173(0.00); K104(0.00); K112(0.00)  LDD0199  [18]
m-APA
 Probe Info  		H163(0.00); H126(0.00); H180(0.00); H108(0.00)  LDD2231  [17]
CY-1
 Probe Info  		M327(0.00); Y336(0.00); N335(0.00)  LDD0246  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [19]
2PCA
 Probe Info  		N.A.  LDD0034  [22]
ATP probe
 Probe Info  		K173(0.00); K168(0.00); K59(0.00)  LDD0035  [23]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [24]
TFBX
 Probe Info  		N.A.  LDD0027  [24]
WYneN
 Probe Info  		N.A.  LDD0021  [25]
WYneO
 Probe Info  		N.A.  LDD0022  [25]
1d-yne
 Probe Info  		N.A.  LDD0356  [26]
Compound 10
 Probe Info  		N.A.  LDD2216  [27]
ENE
 Probe Info  		N.A.  LDD0006  [25]
IPM
 Probe Info  		N.A.  LDD0005  [25]
NHS
 Probe Info  		K113(0.00); K112(0.00); K3(0.00); K104(0.00)  LDD0010  [25]
OSF
 Probe Info  		Y234(0.00); Y336(0.00); Y331(0.00)  LDD0029  [28]
PF-06672131
 Probe Info  		N.A.  LDD0152  [29]
PPMS
 Probe Info  		N.A.  LDD0008  [25]
SF
 Probe Info  		Y331(0.00); Y295(0.00); Y244(0.00); K59(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K112(0.00); K113(0.00)  LDD0009  [25]
VSF
 Probe Info  		N.A.  LDD0007  [25]
YN-1
 Probe Info  		N.A.  LDD0447  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [30]
Ox-W18
 Probe Info  		N.A.  LDD2175  [31]
1c-yne
 Probe Info  		K46(0.00); K173(0.00); K22(0.00); K168(0.00)  LDD0228  [26]
Acrolein
 Probe Info  		C50(0.00); H163(0.00); H180(0.00); H108(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [32]
Crotonaldehyde
 Probe Info  		C50(0.00); H175(0.00); H180(0.00); H108(0.00)  LDD0219  [32]
Methacrolein
 Probe Info  		C50(0.00); H180(0.00); H163(0.00); H108(0.00)  LDD0218  [32]
W1
 Probe Info  		N.A.  LDD0236  [33]
MPP-AC
 Probe Info  		N.A.  LDD0428  [34]
NAIA_5
 Probe Info  		N.A.  LDD2223  [35]
TER-AC
 Probe Info  		N.A.  LDD0426  [34]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		17.27  LDD1845  [36]
C191
 Probe Info  		11.63  LDD1868  [36]
C218
 Probe Info  		11.79  LDD1892  [36]
C220
 Probe Info  		12.47  LDD1894  [36]
C232
 Probe Info  		37.53  LDD1905  [36]
C338
 Probe Info  		18.77  LDD2001  [36]
C346
 Probe Info  		10.63  LDD2007  [36]
C348
 Probe Info  		10.41  LDD2009  [36]
C353
 Probe Info  		5.78  LDD2014  [36]
C355
 Probe Info  		22.47  LDD2016  [36]
C361
 Probe Info  		18.25  LDD2022  [36]
C382
 Probe Info  		8.57  LDD2041  [36]
C391
 Probe Info  		13.64  LDD2050  [36]
FFF probe11
 Probe Info  		13.86  LDD0471  [37]
FFF probe12
 Probe Info  		6.08  LDD0473  [37]
FFF probe13
 Probe Info  		16.00  LDD0475  [37]
FFF probe14
 Probe Info  		10.96  LDD0477  [37]
FFF probe2
 Probe Info  		18.09  LDD0463  [37]
FFF probe3
 Probe Info  		11.65  LDD0464  [37]
FFF probe6
 Probe Info  		7.82  LDD0468  [37]
FFF probe9
 Probe Info  		5.83  LDD0470  [37]
JN0003
 Probe Info  		13.71  LDD0469  [37]
STS-2
 Probe Info  		1.44  LDD0139  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
Diazir
 Probe Info  		Y347(0.00); E195(0.00)  LDD0011  [25]
BD-F
 Probe Info  		F256(0.00); G337(0.00); P251(0.00); G243(0.00)  LDD0024  [40]
LD-F
 Probe Info  		G337(0.00); G334(0.00); N335(0.00); N245(0.00)  LDD0015  [40]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [41]
DA-2
 Probe Info  		N.A.  LDD0071  [42]
OEA-DA
 Probe Info  		4.24  LDD0046  [43]
STS-1
 Probe Info  		N.A.  LDD0069  [44]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C50(0.81)  LDD2112  [12]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C50(0.49)  LDD2095  [12]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C50(1.10)  LDD2130  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C50(0.87)  LDD2117  [12]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C50(0.39)  LDD2132  [12]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C50(0.88)  LDD2131  [12]
 LDCM0214  AC1 HCT 116 C50(2.14)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C50(1.26)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C50(0.90)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C50(0.70)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C50(0.73)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C50(0.49)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C50(0.63)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C50(0.66)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C50(0.54)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C50(0.52)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C50(0.59)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C50(0.63)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C50(2.03)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C50(0.52)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C50(0.38)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C50(0.40)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C50(1.33)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C50(1.29)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C50(1.06)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C50(1.16)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C50(1.39)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C50(1.56)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C50(1.54)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C50(1.69)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C50(1.13)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C50(1.16)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C50(1.31)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C50(1.26)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C50(1.44)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C50(1.28)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C50(1.08)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C50(1.37)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C50(1.29)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C50(1.34)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C50(1.43)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C50(1.27)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C50(0.98)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C50(1.51)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C50(1.09)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C50(1.15)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C50(1.19)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C50(1.04)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C50(0.63)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C50(0.79)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C50(1.26)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C50(0.58)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C50(0.60)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C50(1.17)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C50(1.06)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C50(0.76)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C50(0.91)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C50(1.08)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C50(0.77)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C50(0.52)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C50(0.77)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C50(1.29)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C50(2.51)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C50(1.09)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C50(0.82)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C50(0.77)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C50(0.92)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C50(1.34)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C50(1.41)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C50(1.13)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C50(1.18)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C50(1.02)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C50(1.07)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C50(1.31)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C50(1.08)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C50(0.99)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C50(1.15)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C50(1.04)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C50(0.97)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C50(1.06)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C50(0.92)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C50(0.89)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C50(0.86)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C50(0.94)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C50(1.99)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C50(0.69)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C50(0.95)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C50(0.69)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C50(0.59)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C50(0.52)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C50(1.65)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C50(1.23)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C50(1.43)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C50(1.10)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C50(1.02)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C50(2.03)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C50(0.98)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C50(1.09)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C50(0.96)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C50(0.88)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C50(1.29)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C50(1.48)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C50(0.80)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C50(1.26)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C50(0.88)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C50(0.75)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C50(1.98)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C50(0.73)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C50(0.81)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C50(0.86)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C50(1.36)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C50(1.01)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C50(1.23)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C50(0.95)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C50(1.11)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C50(0.77)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C50(0.82)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C50(0.96)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C50(1.06)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C50(1.15)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C50(0.80)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C50(1.02)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C50(0.87)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C50(0.77)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C50(0.95)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C50(0.53)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C50(0.90)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C50(0.86)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C50(1.23)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C50(0.61)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C50(1.59)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C50(1.03)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C50(0.37)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C50(0.51)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C50(0.48)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C50(0.90)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C50(0.67)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C50(1.35)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C50(1.13)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C50(0.81)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C50(0.91)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C50(1.02)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C50(0.49)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C50(0.64)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C50(0.66)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C50(0.88)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C50(0.88)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C50(1.05)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C50(0.81)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C50(0.73)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C50(1.68)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C50(0.65)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C50(0.57)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C50(0.84)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C50(1.05)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C50(1.27)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C50(0.88)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C50(0.71)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C50(0.29)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C50(0.65)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C50(1.05)  LDD2138  [12]
 LDCM0248  AKOS034007472 HCT 116 C50(1.21)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C50(1.36)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C50(0.87)  LDD0592  [16]
 LDCM0498  BS-3668 MDA-MB-231 C50(0.86)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa C50(0.00); H180(0.00); H163(0.00); H108(0.00)  LDD0222  [32]
 LDCM0367  CL1 HCT 116 C50(0.84)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C50(1.39)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C50(1.34)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C50(1.08)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C50(1.52)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C50(1.88)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C50(1.10)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C50(0.87)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C50(0.72)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C50(0.80)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C50(0.61)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C50(0.85)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C50(1.51)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C50(0.69)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C50(0.75)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C50(1.05)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C50(0.78)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C50(1.00)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C50(0.87)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C50(0.84)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C50(0.84)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C50(1.16)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C50(1.15)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C50(0.92)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C50(0.90)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C50(1.04)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C50(0.95)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C50(1.06)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C50(0.99)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C50(1.39)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C50(1.06)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C50(1.13)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C50(0.88)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C50(1.27)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C50(1.06)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C50(1.11)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C50(0.76)  LDD0720  [16]
 LDCM0404  CL17 HEK-293T C50(0.55)  LDD1608  [45]
 LDCM0405  CL18 HEK-293T C50(0.63)  LDD1609  [45]
 LDCM0406  CL19 HEK-293T C50(0.58)  LDD1610  [45]
 LDCM0407  CL2 HCT 116 C50(1.04)  LDD0724  [16]
 LDCM0408  CL20 HEK-293T C50(0.65)  LDD1612  [45]
 LDCM0409  CL21 HEK-293T C50(0.67)  LDD1613  [45]
 LDCM0410  CL22 HEK-293T C50(0.61)  LDD1614  [45]
 LDCM0411  CL23 HEK-293T C50(0.83)  LDD1615  [45]
 LDCM0412  CL24 HEK-293T C50(0.53)  LDD1616  [45]
 LDCM0413  CL25 HEK-293T C50(0.90)  LDD1617  [45]
 LDCM0414  CL26 HEK-293T C50(0.95)  LDD1618  [45]
 LDCM0415  CL27 HEK-293T C50(0.86)  LDD1619  [45]
 LDCM0416  CL28 HEK-293T C50(0.90)  LDD1620  [45]
 LDCM0417  CL29 HEK-293T C50(0.83)  LDD1621  [45]
 LDCM0418  CL3 HCT 116 C50(1.21)  LDD0735  [16]
 LDCM0419  CL30 HEK-293T C50(0.79)  LDD1623  [45]
 LDCM0420  CL31 HCT 116 C50(0.80)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C50(0.68)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C50(0.67)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C50(0.54)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C50(0.56)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C50(0.57)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C50(0.53)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C50(0.62)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C50(1.02)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C50(0.63)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C50(0.70)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C50(0.59)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C50(0.51)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C50(0.68)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C50(0.65)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C50(1.36)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C50(1.35)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C50(1.58)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C50(1.12)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C50(1.56)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C50(1.26)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C50(1.52)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C50(1.20)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C50(1.05)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C50(1.27)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C50(1.16)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C50(0.88)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C50(1.20)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C50(1.32)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C50(1.08)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C50(1.07)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C50(1.29)  LDD0769  [16]
 LDCM0453  CL61 PaTu 8988t C50(0.86)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C50(2.15)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C50(1.63)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C50(1.07)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C50(1.03)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C50(0.87)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C50(0.45)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C50(0.28)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C50(0.42)  LDD1340  [16]
 LDCM0462  CL7 HCT 116 C50(1.44)  LDD0779  [16]
 LDCM0463  CL70 PaTu 8988t C50(0.45)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C50(1.76)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C50(4.06)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C50(0.49)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C50(1.92)  LDD1346  [16]
 LDCM0469  CL76 HCT 116 C50(0.59)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C50(0.49)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C50(0.55)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C50(0.35)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C50(0.64)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C50(1.26)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C50(0.42)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C50(0.14)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C50(0.25)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C50(0.09)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C50(0.62)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C50(1.24)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C50(0.50)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C50(0.24)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C50(0.05)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C50(1.06)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C50(0.74)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C50(0.93)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C50(1.26)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C50(2.15)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C50(1.95)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C50(1.67)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C50(1.57)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C50(1.53)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C50(1.37)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C50(1.69)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C50(0.82)  LDD1698  [45]
 LDCM0625  F8 Ramos C50(0.54)  LDD2187  [46]
 LDCM0572  Fragment10 Ramos C50(0.68)  LDD2189  [46]
 LDCM0573  Fragment11 Ramos C50(0.03)  LDD2190  [46]
 LDCM0574  Fragment12 Ramos C50(0.68)  LDD2191  [46]
 LDCM0575  Fragment13 Ramos C50(1.27)  LDD2192  [46]
 LDCM0576  Fragment14 Ramos C50(0.82)  LDD2193  [46]
 LDCM0579  Fragment20 Ramos C50(0.54)  LDD2194  [46]
 LDCM0580  Fragment21 Ramos C50(0.93)  LDD2195  [46]
 LDCM0582  Fragment23 Ramos C50(1.44)  LDD2196  [46]
 LDCM0578  Fragment27 Ramos C50(1.31)  LDD2197  [46]
 LDCM0586  Fragment28 Ramos C50(0.65)  LDD2198  [46]
 LDCM0588  Fragment30 Ramos C50(1.51)  LDD2199  [46]
 LDCM0589  Fragment31 Ramos C50(1.29)  LDD2200  [46]
 LDCM0590  Fragment32 Ramos C50(0.71)  LDD2201  [46]
 LDCM0468  Fragment33 PaTu 8988t C50(0.88)  LDD1347  [16]
 LDCM0596  Fragment38 Ramos C50(1.24)  LDD2203  [46]
 LDCM0566  Fragment4 Ramos C50(0.68)  LDD2184  [46]
 LDCM0427  Fragment51 HCT 116 C50(0.47)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C50(1.63)  LDD2204  [46]
 LDCM0614  Fragment56 Ramos C50(1.24)  LDD2205  [46]
 LDCM0569  Fragment7 Ramos C50(0.61)  LDD2186  [46]
 LDCM0571  Fragment9 Ramos C50(0.55)  LDD2188  [46]
 LDCM0116  HHS-0101 DM93 Y331(0.71); Y174(0.74); Y347(0.74); Y336(0.75)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y234(0.71); Y331(0.72); Y347(0.77); Y174(0.78)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y262(0.05); Y247(0.35); Y244(0.48); Y331(0.54)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y244(0.75); Y331(0.79); Y336(0.83); Y347(0.83)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y262(0.09); Y234(0.68); Y174(0.76); Y347(0.80)  LDD0268  [14]
 LDCM0107  IAA HeLa H163(0.00); H180(0.00); C50(0.00); H175(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y174(1.01); Y234(0.87); Y331(0.80); Y336(0.81)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y174(0.76); Y234(0.61); Y331(0.57); Y336(0.51)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y174(0.97); Y234(1.13); Y331(1.50); Y336(1.01)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y174(2.77); Y234(2.21); Y331(1.72); Y336(2.75)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y174(2.14); Y234(1.87); Y331(2.71); Y336(3.04)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y174(1.16); Y234(0.98); Y331(1.01); Y336(0.95)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y174(0.73); Y234(0.41); Y331(0.36); Y336(0.33)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y174(1.00); Y234(0.88); Y331(0.98); Y336(0.93)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C50(1.01)  LDD1492  [45]
 LDCM0023  KB03 HEK-293T C50(0.98)  LDD1497  [45]
 LDCM0024  KB05 COLO792 C50(1.34)  LDD3310  [47]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C50(0.94)  LDD2121  [12]
 LDCM0109  NEM HeLa H163(0.00); H180(0.00); C50(0.00); H108(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C50(1.38)  LDD2089  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C50(3.59)  LDD2090  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C50(2.50)  LDD2092  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C50(2.44)  LDD2094  [12]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C50(0.07)  LDD2096  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C50(2.47)  LDD2098  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C50(0.41)  LDD2104  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C50(1.12)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C50(0.26)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C50(0.44)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C50(0.51)  LDD2110  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C50(0.14)  LDD2116  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C50(1.00)  LDD2120  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C50(0.19)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C50(0.73)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C50(0.11)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C50(0.74)  LDD2127  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C50(0.36)  LDD2128  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C50(1.01)  LDD2129  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C50(0.91)  LDD2135  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C50(0.89)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C50(2.07)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C50(0.52)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C50(0.29)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C50(0.35)  LDD2143  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C50(2.83)  LDD2144  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C50(0.43)  LDD2145  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C50(0.73)  LDD2146  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C50(0.93)  LDD2147  [12]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C50(0.13)  LDD2149  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C50(1.41)  LDD2150  [12]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C50(5.42)  LDD2153  [12]
 LDCM0131  RA190 MM1.R C50(1.26)  LDD0304  [48]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LINE-1 type transposase domain-containing protein 1 (L1TD1) Transposase 22 family Q5T7N2
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) . P09651
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) . Q14103
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) . P14866
Zinc finger matrin-type protein 3 (ZMAT3) . Q9HA38

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Copper . DB09130

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
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