Details of the Probe

General Information of Probe

Probe ID
LDPC0582
Probe Name
C361
Synonyms
Z3433405250
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 287.34
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C13H13N5OS
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]imidazo[5,1-b][1,3]thiazole-3-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=CSC3=CN=CN32
InChI
InChI=1S/C13H13N5OS/c1-2-3-4-13(16-17-13)5-6-15-12(19)10-8-20-11-7-14-9-18(10)11/h1,7-9H,3-6H2,(H,15,19)
InChIKey
SULNIEVCQSYQLB-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

96 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 17.51  LDD2022 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 18.25  LDD2022 
Adenosine deaminase (ADA) LDTP01803 25.63  LDD2022 
Adenosine kinase (ADK) LDTP04689 34.30  LDD2022 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 18.51  LDD2022 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 26.91  LDD2022 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 34.30  LDD2022 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 32.67  LDD2022 
ATPase GET3 (GET3) LDTP00836 17.63  LDD2022 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 33.59  LDD2022 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 19.70  LDD2022 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 23.10  LDD2022 
Ceramide glucosyltransferase (UGCG) LDTP06617 17.03  LDD2022 
Ceramide synthase 2 (CERS2) LDTP10329 19.84  LDD2022 
Choline kinase alpha (CHKA) LDTP03787 21.41  LDD2022 
Cytochrome b-c1 complex subunit 7 (UQCRB) LDTP02757 17.88  LDD2022 
Cytochrome b5 type B (CYB5B) LDTP00697 25.81  LDD2022 
Cytosolic purine 5'-nucleotidase (NT5C2) LDTP04327 26.91  LDD2022 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 34.06  LDD2022 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 20.82  LDD2022 
Deoxyhypusine synthase (DHPS) LDTP04248 18.77  LDD2022 
Dihydrofolate reductase (DHFR) LDTP01769 30.70  LDD2022 
Dual specificity protein kinase CLK3 (CLK3) LDTP04299 17.51  LDD2022 
E3 ubiquitin-protein ligase NEDD4 (NEDD4) LDTP04114 24.59  LDD2022 
E3 ubiquitin-protein ligase RAD18 (RAD18) LDTP12573 17.63  LDD2022 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 19.29  LDD2022 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 18.25  LDD2022 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 22.32  LDD2022 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 45.57  LDD2022 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 18.00  LDD2022 
Epimerase family protein SDR39U1 (SDR39U1) LDTP16070 36.00  LDD2022 
Epoxide hydrolase 1 (EPHX1) LDTP02175 37.79  LDD2022 
Ethanolamine kinase 1 (ETNK1) LDTP12197 30.70  LDD2022 
Exonuclease 1 (EXO1) LDTP13751 17.03  LDD2022 
Ferrochelatase, mitochondrial (FECH) LDTP03198 52.35  LDD2022 
Geranylgeranyl pyrophosphate synthase (GGPS1) LDTP01665 19.43  LDD2022 
Glutathione S-transferase Mu 3 (GSTM3) LDTP03103 25.28  LDD2022 
Heme oxygenase 2 (HMOX2) LDTP03540 61.82  LDD2022 
Histone lysine demethylase PHF8 (PHF8) LDTP13703 20.97  LDD2022 
Holocytochrome c-type synthase (HCCS) LDTP04581 21.71  LDD2022 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 22.47  LDD2022 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 20.11  LDD2022 
Lysocardiolipin acyltransferase 1 (LCLAT1) LDTP07679 19.03  LDD2022 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 18.90  LDD2022 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 21.41  LDD2022 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 20.11  LDD2022 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) LDTP12227 17.39  LDD2022 
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) LDTP05346 26.35  LDD2022 
Multidrug resistance-associated protein 1 (ABCC1) LDTP03671 19.70  LDD2022 
N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) LDTP07259 18.25  LDD2022 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 18.13  LDD2022 
NAD-capped RNA hydrolase NUDT12 (NUDT12) LDTP11081 26.17  LDD2022 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 61.82  LDD2022 
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) LDTP12603 26.54  LDD2022 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 18.90  LDD2022 
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) LDTP01515 20.68  LDD2022 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 25.99  LDD2022 
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) LDTP08617 20.97  LDD2022 
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) LDTP10101 75.06  LDD2022 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 19.97  LDD2022 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 18.64  LDD2022 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 60.55  LDD2022 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 17.88  LDD2022 
Phospholipase A2 group XV (PLA2G15) LDTP09088 18.38  LDD2022 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 20.97  LDD2022 
Poly [ADP-ribose] polymerase 2 (PARP2) LDTP13240 25.81  LDD2022 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 42.81  LDD2022 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 21.26  LDD2022 
Prolyl endopeptidase-like (PREPL) LDTP06849 18.13  LDD2022 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 23.26  LDD2022 
Prostaglandin reductase 3 (PTGR3) LDTP15422 17.27  LDD2022 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 21.86  LDD2022 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 17.51  LDD2022 
Protein kinase C beta type (PRKCB) LDTP02123 19.16  LDD2022 
Protein O-GlcNAcase (OGA) LDTP00988 25.81  LDD2022 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 18.51  LDD2022 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 32.90  LDD2022 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 22.01  LDD2022 
RAC-alpha serine/threonine-protein kinase (AKT1) LDTP03607 17.51  LDD2022 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 17.15  LDD2022 
Retinal dehydrogenase 2 (ALDH1A2) LDTP01419 32.90  LDD2022 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 17.88  LDD2022 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 23.43  LDD2022 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 23.92  LDD2022 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 19.03  LDD2022 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 29.86  LDD2022 
Secernin-1 (SCRN1) LDTP05640 25.81  LDD2022 
Serine/threonine-protein phosphatase 2A activator (PTPA) LDTP06343 18.51  LDD2022 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 19.84  LDD2022 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 19.03  LDD2022 
Squalene synthase (FDFT1) LDTP03842 82.14  LDD2022 
Transcription initiation factor IIB (GTF2B) LDTP05240 18.13  LDD2022 
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) LDTP13938 33.36  LDD2022 
Ubiquitin carboxyl-terminal hydrolase 28 (USP28) LDTP10785 20.53  LDD2022 
UDP-glucuronic acid decarboxylase 1 (UXS1) LDTP09074 27.67  LDD2022 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 18.51  LDD2022 
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⏷ Show the Full List of 96 Enzyme
28 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 18.00  LDD2022 
Amyloid-beta precursor protein (APP) LDTP02071 19.56  LDD2022 
ATP synthase subunit a (MT-ATP6) LDTP01804 46.21  LDD2022 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 20.25  LDD2022 
Equilibrative nucleoside transporter 1 (SLC29A1) LDTP10985 29.65  LDD2022 
Heme transporter FLVCR1 (FLVCR1) LDTP14178 17.51  LDD2022 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 23.26  LDD2022 
Major facilitator superfamily domain-containing protein 10 (MFSD10) LDTP06198 24.59  LDD2022 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 17.03  LDD2022 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 38.32  LDD2022 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 21.11  LDD2022 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 76.64  LDD2022 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 63.12  LDD2022 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 18.13  LDD2022 
Nuclear pore glycoprotein p62 (NUP62) LDTP03839 17.39  LDD2022 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 17.03  LDD2022 
Phosphorylated adapter RNA export protein (PHAX) LDTP12043 18.51  LDD2022 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 38.05  LDD2022 
Sideroflexin-2 (SFXN2) LDTP10621 21.26  LDD2022 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 20.68  LDD2022 
Tetraspanin-10 (TSPAN10) LDTP15967 19.97  LDD2022 
THO complex subunit 7 homolog (THOC7) LDTP07397 17.03  LDD2022 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 19.97  LDD2022 
Translocator protein (TSPO) LDTP03546 27.86  LDD2022 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 20.11  LDD2022 
Transmembrane protein 205 (TMEM205) LDTP07667 18.38  LDD2022 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 19.16  LDD2022 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 22.94  LDD2022 
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⏷ Show the Full List of 28 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 28.25  LDD2022 
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81 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 8 (AKAP8) LDTP00880 21.86  LDD2022 
A-kinase anchor protein 8-like (AKAP8L) LDTP13591 18.77  LDD2022 
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) LDTP04595 19.16  LDD2022 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 18.51  LDD2022 
Apolipoprotein L2 (APOL2) LDTP11076 18.13  LDD2022 
Arfaptin-1 (ARFIP1) LDTP04558 23.43  LDD2022 
Bifunctional purine biosynthesis protein ATIC (ATIC) LDTP03612 27.10  LDD2022 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 23.92  LDD2022 
Cell cycle and apoptosis regulator protein 2 (CCAR2) LDTP08760 18.77  LDD2022 
Centrosomal protein 43 (CEP43) LDTP01652 34.06  LDD2022 
Charged multivesicular body protein 1a (CHMP1A) LDTP12285 17.51  LDD2022 
Coiled-coil domain-containing protein 97 (CCDC97) LDTP19860 40.22  LDD2022 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 32.00  LDD2022 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 34.54  LDD2022 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 23.75  LDD2022 
DnaJ homolog subfamily C member 8 (DNAJC8) LDTP01361 19.97  LDD2022 
Dynactin subunit 3 (DCTN3) LDTP01359 21.86  LDD2022 
Eukaryotic translation initiation factor 4B (EIF4B) LDTP03247 23.92  LDD2022 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 23.92  LDD2022 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 20.53  LDD2022 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 18.51  LDD2022 
HCLS1-associated protein X-1 (HAX1) LDTP00199 18.00  LDD2022 
Heme-binding protein 1 (HEBP1) LDTP16078 39.40  LDD2022 
Hepatoma-derived growth factor (HDGF) LDTP04483 18.38  LDD2022 
Hepatoma-derived growth factor-related protein 3 (HDGFL3) LDTP13987 23.43  LDD2022 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 18.13  LDD2022 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 18.25  LDD2022 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 21.26  LDD2022 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 19.97  LDD2022 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 20.53  LDD2022 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 25.46  LDD2022 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 18.25  LDD2022 
Histone H2AX (H2AX) LDTP02825 18.90  LDD2022 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 21.86  LDD2022 
IQ calmodulin-binding motif-containing protein 1 (IQCB1) LDTP06298 21.56  LDD2022 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 26.54  LDD2022 
Lamin-B1 (LMNB1) LDTP03065 18.13  LDD2022 
Large ribosomal subunit protein uL23m (MRPL23) LDTP06548 20.82  LDD2022 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 45.25  LDD2022 
Mediator of RNA polymerase II transcription subunit 4 (MED4) LDTP12377 24.25  LDD2022 
Microfibrillar-associated protein 1 (MFAP1) LDTP04668 22.78  LDD2022 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 42.52  LDD2022 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 20.11  LDD2022 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 40.50  LDD2022 
NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) LDTP08761 18.00  LDD2022 
Neudesin (NENF) LDTP13630 18.00  LDD2022 
Neuferricin (CYB5D2) LDTP15623 36.50  LDD2022 
Neurofilament medium polypeptide (NEFM) LDTP02181 17.51  LDD2022 
Nucleobindin-1 (NUCB1) LDTP05375 20.82  LDD2022 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 17.15  LDD2022 
Oxysterol-binding protein-related protein 3 (OSBPL3) LDTP11930 17.63  LDD2022 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 61.82  LDD2022 
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) LDTP07655 17.03  LDD2022 
Pre-mRNA-splicing factor SLU7 (SLU7) LDTP01582 17.75  LDD2022 
Prefoldin subunit 6 (PFDN6) LDTP00573 18.51  LDD2022 
Proline-rich protein PRCC (PRCC) LDTP09850 25.99  LDD2022 
Protein angel homolog 1 (ANGEL1) LDTP16249 18.90  LDD2022 
Protein CDV3 homolog (CDV3) LDTP18547 17.88  LDD2022 
Protein CutA (CUTA) LDTP01075 18.51  LDD2022 
Protein FAM114A2 (FAM114A2) LDTP16080 18.90  LDD2022 
Protein Hook homolog 2 (HOOK2) LDTP10255 17.15  LDD2022 
Protein SET (SET) LDTP05277 24.76  LDD2022 
Protein Spindly (SPDL1) LDTP10251 22.32  LDD2022 
Protein unc-119 homolog B (UNC119B) LDTP00105 33.59  LDD2022 
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) LDTP16730 19.70  LDD2022 
Reticulocalbin-2 (RCN2) LDTP06097 32.00  LDD2022 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 25.81  LDD2022 
RNA-binding protein 3 (RBM3) LDTP05226 32.00  LDD2022 
RNA-binding protein FUS (FUS) LDTP03775 23.26  LDD2022 
Survival motor neuron protein (SMN1; SMN2) LDTP06587 17.15  LDD2022 
Survival of motor neuron-related-splicing factor 30 (SMNDC1) LDTP01362 64.00  LDD2022 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 21.86  LDD2022 
Testis-expressed protein 264 (TEX264) LDTP14259 29.45  LDD2022 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 19.97  LDD2022 
TraB domain-containing protein (TRABD) LDTP19963 24.08  LDD2022 
Transformer-2 protein homolog beta (TRA2B) LDTP05036 17.63  LDD2022 
Tropomodulin-3 (TMOD3) LDTP18494 17.03  LDD2022 
U6 snRNA-associated Sm-like protein LSm3 (LSM3) LDTP04979 17.63  LDD2022 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 29.24  LDD2022 
Vimentin (VIM) LDTP02297 23.75  LDD2022 
YLP motif-containing protein 1 (YLPM1) LDTP04290 17.63  LDD2022 
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⏷ Show the Full List of 81 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2022 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587